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健診部

さらに詳しく

健診部は循環器病の疫学研究を通して、私たちの健康長寿を目指します。これまでは脳卒中、虚血性心疾患の対策を立てることが急務でありましたが、最近は世界でも最も高齢化率が高くなり、臓器終末像の疾患対策が必要になってきました。しかし、心不全と認知症の研究はわが国では極めて少なく、その両方を追跡していく研究はわが国ではありません。当センターでは、脳と心臓の専門医のいる病院であり、両者をしっかりと見据えて追跡することから、大変貴重な追跡研究の成果が得られるものと確信しております。

最近の研究成果

総頚動脈狭窄率は循環器病発症リスクに関連する ：都市部地域住民を対象とした吹田研究(2023年12月20日)
Teramoto M, Kokubo Y, Arafa Ahmed, Kashima R, Nakao YM, Sheerah HA, Kataoka H. Common Carotid Artery Stenosis Degree as a Predictor of Cardiovascular Disease in a General Population: The Suita Study. J Am Heart Assoc. 2023;0:e030828.

都市部地域住民における咀嚼機能と循環器病発症との関連について (2021年4月21日)
Hashimoto S, Kosaka T, Nakai M, Kida M, Fushida S, Kokubo Y, et al. A lower maximum bite force is a risk factor for developing cardiovascular disease: The Suita study. Sci Rep. 2021;11:7671

都市部地域住民における継続的な歯科定期受診と咀嚼能率との関係について (2020年3月6日)
Fujii K, Kosaka T, Hasegawa Y, Kida M, Hashimoto S, Fushida S, et al. Periodical utilization of dental services is an effective breakthrough for declining masticatory performance: The Suita study. Odontology. 2020;108:715-22

都市部地域住民における冠動脈疾患・脳卒中発症予測スコアの開発 (2020年2月28日)
Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, et al. Development of a cardiovascular disease risk prediction model using the Suita study, a population-based prospective cohort study in Japan. J Atheroscler Thromb. 2020;27:1160-75

わが国における空腹時血糖値の長期的な推移と中年以降の循環器病発症リスクの関係を示唆(2019年02月20日)
Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, et al. Longitudinal trajectories of fasting plasma glucose and risks of cardiovascular diseases in middle age to elderly people within the general Japanese population: The Suita study. J Am Heart Assoc. 2019;8:e010628

頚動脈プラーク進展はその後の循環器病発症リスクに関係する (2018年6月1日) Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, Miyamoto Y. Impact of intima-media thickness progression in the common carotid arteries on the risk of incident cardiovascular disease in the Suita study. J Am Heart Assoc. 2018;7:e007720.

研究内容

吹田研究NEXT
都市部地域住民を対象とした心不全と認知症をエンドポイントした追跡研究で、これらリスク因子となる感覚器（視覚、聴覚、嗅覚）機能障害も併せて追跡研究を行う。

共創の場形成支援プログラム
産・学・官・民の実質的融合連携ができる「共創の場」を北大阪健康医療都市「健都」に設け、難治性心血管疾患・がん、認知症、新興再興ウイルス感染症を克服できるレジリエントな社会を実現するため、住民参加型バイオコミュニティの形成を目指す研究

心不全重症化予防対策事業(2020年10月～)
吹田市民の心不全予防のために共同事業に取り組み、市民への新しい保健指導をおこないながら非薬物介入研究に取り組み、さらに心不全の予後因子（医療費、介護、死因）に関する長期追跡研究に取り組む事業

吹田研究(1989年4月～)
都市部地域住民を対象とした循環器コホート研究

  1. Higashiyama A, Wakabayashi I, Okamura T, Kokubo Y, Watanabe M, et al. The risk of fasting triglycerides and its related indices for ischemic cardiovascular diseases in Japanese community dwellers: The Suita study. J Atheroscler Thromb. 2021 (in press)
  2. Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, et al. Development of a cardiovascular disease risk prediction model using the Suita study, a population-based prospective cohort study in Japan. J Atheroscler Thromb. 2020;27:1160-1175
  3. Higashiyama A, Kokubo Y, Watanabe M, Nakao YM, Okamura T, et al. Echocardiographic parameters and the risk of incident atrial fibrillation: The Suita study. J Epidemiol. 2020;30:183-187
  4. Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, et al. Longitudinal trajectories of fasting plasma glucose and risks of cardiovascular diseases in middle age to elderly people within the general Japanese population: The Suita study. J Am Heart Assoc. 2019;8:e010628
  5. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, et al. Impact of Intima-Media Thickness Progression in the Common Carotid Arteries on the Risk of Incident Cardiovascular Disease in the Suita Study. J Am Heart Assoc. 2018;7(11). pii: e007720
  6. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kusano K, et al. Development of a Basic Risk Score for Incident Atrial Fibrillation in a Japanese General Population - The Suita Study. Circ J. 2017; 81:1580-1588.
  7. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, et al. Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. Am J Hypertens. 2015;28:1355-61.
  8. Tsukinoki R, Okamura T, Watanabe M, Kokubo Y, Higashiyama A, et al. Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in japanese: The Suita study. Am J Hypertens. 2014;27:1362-1369
  9. Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, et al. Predicting coronary heart disease using risk factor categories for a Japanese urban population, and comparison with the Framingham risk score: The Suita study. J Atheroscler Thromb. 2014;21:784-798
  10. Tatsumi Y, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Okamura T, et al. Effect of age on the association between waist-to-height ratio and incidence of cardiovascular disease: The Suita study. J Epidemiol. 2013;23:351-359
  11. Higashiyama A, Okamura T, Watanabe M, Kokubo Y, Wakabayashi I, Okayama A, et al. Alcohol consumption and cardiovascular disease incidence in men with and without hypertension: The Suita study. Hypertens Res. 2013;36:58-64
  12. Arai H, Kokubo Y, Watanabe M, Sawamura T, Ito Y, Minagawa A, et al. Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: The Suita Study. J Atheroscler Thromb. 2013;20:195-203
  13. Watanabe M, Kokubo Y, Higashiyama A, Ono Y, Miyamoto Y, et al. Serum 1,5-anhydro-d-glucitol levels predict first-ever cardiovascular disease: An 11-year population-based cohort study in Japan, the Suita study. Atherosclerosis. 2011;216:477-483
  14. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, et al. A revised definition of the metabolic syndrome predicts coronary artery disease and ischemic stroke after adjusting for low density lipoprotein cholesterol in a 13-year cohort study of Japanese: The Suita study. Atherosclerosis. 2011;217:201-206
  15. Higashiyama A, Wakabayashi I, Ono Y, Watanabe M, Kokubo Y, et al. Association with serum gamma-glutamyltransferase levels and alcohol consumption on stroke and coronary artery disease: The Suita study. Stroke. 2011;42:1764-1767
  16. Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, et al. The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study. Hypertens Res. 2010;33:1238-43.
  17. Watanabe M, Kokubo Y, Higashiyama A, Ono Y, Okayama A, et al. New diagnosis criteria for diabetes with hemoglobin a1c and risks of macro-vascular complications in an urban Japanese cohort: The Suita study. Diabetes Res Clin Pract. 2010;88:e20-23
  18. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, et al. Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort: The Suita study. Atherosclerosis. 2010;209:290-294
  19. Furukawa Y, Kokubo Y, Okamura T, Watanabe M, Higashiyama A, et al. The relationship between waist circumference and the risk of stroke and myocardial infarction in a Japanese urban cohort: The Suita study. Stroke. 2010;41:550-553
  20. Kokubo Y, Nakamura S, Okamura T, Yoshimasa Y, et al. Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study. Stroke. 2009;40:2674-9.
  21. Higashiyama A, Okamura T, Ono Y, Watanabe M, Kokubo Y, et al. Risk of smoking and metabolic syndrome for incidence of cardiovascular disease--comparison of relative contribution in urban Japanese population: The Suita study. Circ J. 2009;73:2258-2263.
  22. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, et al. Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study. Atherosclerosis. 2008
  23. Kokubo Y, Okamura T, Yoshimasa Y, Miyamoto Y, Kawanishi K, et al. Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the suita study. Hypertens Res. 2008;31:2027-35.
  24. Kokubo Y, Kamide K, Okamura T, Watanabe M, Higashiyama A, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort: the Suita study. Hypertension. 2008;52:652-9

吹田研究：歯科
都市部地域住民を対象とした循環器コホート研究に歯科検診を行った研究

  1. Kosaka T, Ono T, Kida M, Fushida S, Nokubi T, Kokubo Y, et al. Deterioration of periodontal status affects declines in masticatory performance: the Suita study. J Clin Periodontol. 2021 (in press)
  2. Kosaka T, Ono T, Kida M, Fushida S, Nokubi T, Kokubo Y, et al. Association between declines in objective masticatory performance and salivary stress markers: The Suita study. J Oral Rehabil. 2021;48:575-81
  3. Kosaka T, Ono T, Kida M, Fushida S, Nokubi T, Kokubo Y, et al. A prediction model of masticatory performance change in 50- to 70-year-old Japanese: The Suita study. J Dent. 2021;104:103535
  4. Hashimoto S, Kosaka T, Nakai M, Kida M, Fushida S, Kokubo Y, et al. A lower maximum bite force is a risk factor for developing cardiovascular disease: the Suita study. Sci Rep. 2021;11:7671
  5. Fushida S, Kosaka T, Kida M, Kokubo Y, Watanabe M, Higashiyama A, et al. Decrease in posterior occlusal support area can accelerate tooth loss: The Suita study. J Prosthodont Res. 2021 (in press)
  6. Kida M, Ono T, Kokubo Y, Yoshimuta Y, Kosaka T, Kikui M, et al. Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study. J Prosthodont Res. 2020;64:346-53
  7. Fujii K, Kosaka T, Hasegawa Y, Kida M, Hashimoto S, Fushida S, et al. Periodical utilization of dental services is an effective breakthrough for declining masticatory performance: the Suita study. Odontology. 2020;108:715-22
  8. Kosaka T, Kida M, Kikui M, Hashimoto S, Fujii K, Yamamoto M, et al. Factors Influencing the Changes in Masticatory Performance: The Suita Study. JDR Clin Trans Res. 2018;3:405-12
  9. Choi YH, Kosaka T, Ojima M, Sekine S, Kokubo Y, Watanabe M, et al. Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study. BMC Oral Health. 2018;18:77
  10. Kikui M, Ono T, Kokubo Y, Kida M, Kosaka T, Yamamoto M, et al. Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population: The Suita study. J Dent. 2017;56:53-7
  11. Kikui M, Kokubo Y, Ono T, Kida M, Kosaka T, Yamamoto M, et al. Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study. J Atheroscler Thromb. 2017;24:495-507
  12. Kosaka T, Ono T, Kida M, Kikui M, Yamamoto M, Yasui S, et al. A multifactorial model of masticatory performance: the Suita study. J Oral Rehabil. 2016;43:340-7
  13. Kikui M, Ono T, Kida M, Kosaka T, Yamamoto M, Yoshimuta Y, et al. Does the utilization of dental services associate with masticatory performance in a Japanese urban population?: the Suita study. Clin Exp Dent Res. 2015;1:57-62.
  14. Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, et al. Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study. Atherosclerosis. 2014;237:123-8.
  15. Kosaka T, Ono T, Yoshimuta Y, Kida M, Kikui M, Nokubi T, et al. The effect of periodontal status and occlusal support on masticatory performance: the Suita study. J Clin Periodontol. 2014;41:497-503.

健康長寿社会の実現を目指した大規模認知症コホート研究（JPSC-AD研究：2015年4月～）
全国8地区1万人を対象に、認知症の危険因子・防御因子を同定すると共にその病態を解明する研究

  1. 1. Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y; JPSFC-AD Study Group. Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). Environ Health Prev Med. 2020 Oct 31;25(1):64

多目的コホート研究(1989年4月～)
全国11保健所管区の地域住民を対象とし、がん、循環器、糖尿病をはじめとしたさまざまな疾患コホート研究で、生活習慣についての情報を集め、20年以上の長期にわたって疾病の発症に関する追跡を行い、どの様な生活習慣が疾病の発症に関連しているのかを明らかにすることを目的として、本研究が行われています。

  1. Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Clin Nutr. 2017. pii: S0261-5614(17)30274-1.
  2. Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S. The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population. Stroke. 2013;44:1369-74.
  3. Kokubo Y, Iso H, Saito I, Yamagishi K, Ishihara J, Inoue M, Tsugane S; JPHC Study Group. Dietary fiber intake and risk of cardiovascular disease in the Japanese population. Eur J Clin Nutr. 2011;65:1233-41.
  4. Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations. Circulation. 2007;116:2553-62.
  5. Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation. 2006;113:195-202.

電子化医療情報を活用した疾患横断的コホート研究情報基盤整備事業
国内6つの国立高度専門医療研究センター（ナショナルセンター：NC）の保有する疫学データを統合して、疾患横断的にコホート研究を推進する研究基盤事業である。期待される成果は、
1）疾患横断的研究実施体制の強化
2）疾患横断的予防のためのエビデンスづくりの連携
3）疾患横断的予防のための取り組みの連携
が挙げられます。

最終更新日：2023年12月22日

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