さらに詳しく

• 診療科等の概要
• 対象疾患・治療法
• スタッフ紹介
• 医療関係者の皆様へ
• 研修希望の皆様へ
• さらに詳しく

脳神経外科の研究業績（2019–2024）｜英文Publications

Recent English-Language Publications from NCVC Department of Neurosurgery (2019–2024)

国立循環器病研究センター（National Cerebral and Cardiovascular Center, NCVC）脳神経外科では、脳卒中、脳血管障害、脳神経外科的治療に関する最先端の診療・研究を行っています。以下に、主要な疾患別の研究業績を掲載しています。各論文はPubMedやGoogle Scholarで検索可能です。

• AVM（脳動静脈奇形）・dAVF（硬膜動静脈瘻）｜Brain Arteriovenous Malformation and Dural AVF
•  もやもや病｜Moyamoya Disease
• 脳動脈瘤（未破裂・くも膜下出血）｜Cerebral Aneurysms (UIA and SAH)
• 頚動脈狭窄症・動脈硬化性疾患｜Carotid Artery Stenosis and Atherosclerosis
• 脳卒中関連（出血性／虚血性疾患）｜Stroke and Intracranial Arterial Diseases
• その他（脳腫瘍・機能的疾患など）｜Brain Tumors, Trigeminal Neuralgia, and Functional Neurosurgery

AVM（脳動静脈奇形）・dAVF（硬膜動静脈瘻）｜Brain Arteriovenous Malformation and Dural AVF

Multimodal Neurosurgical Strategies for Brain AVMs and dAVFs

国立循環器病研究センター脳神経外科では、AVMおよびdAVFに対し、出血リスクに応じた個別化治療、閉塞率向上を目指した戦略的なガンマナイフ再照射、ならびにdAVFにおける低侵襲かつ確実な塞栓術の技術革新に取り組んでいます。

• Maruyama D, Iida H, Koshino K, Nakagawara J, Morita Y, Hashimura N, Mori H, Satow T, Takahashi JC, Fukuda T, Iihara K, Kataoka H.
  Comparative analysis of peri-nidal cerebral blood flow and metabolism using a novel quantitative 15O-PET method in patients with arteriovenous malformations.
  J Cereb Blood Flow Metab 45:259–274, 2025.
  https://doi.org/10.1177/0271678X231200757
• Ikedo T, Yamamoto EH, Mori H, Niwa A, Ozaki S, Kushi Y, Satow T, Hamano E, Kataoka H.
  Impact of tailored multimodal treatment for unruptured brain arteriovenous malformation: comparison with a randomized trial.
  Acta Neurochir (Wien) 165:3779–3785, 2023.
  https://doi.org/10.1007/s00701-023-05666-2
• Sasagasako T, Mori H, Hattori EY, Ikedo T, Hamano E, Kataoka H.
  Radiation-Induced Changes Associated with Obliteration of Brain AVMs after Repeat Radiosurgery.
  AJNR Am J Neuroradiol 44:143–149, 2023.
  https://doi.org/10.3174/ajnr.A7707
• Kushi Y, Satow T, Ikedo T, Ohta T, Kataoka H.
  Transvenous Coil-plugging Technique for a Symptomatic Giant Varix Associated with AVM.
  NMC Case Rep J 8:479–483, 2021.
  https://doi.org/10.2176/nmccrj.cr.2020-0215
• Ishiguro T, Satow T, Hamano E, Ikeda G, Chikuie H, Hashimura N, Nishimura M, Takahashi JC, Kataoka H.
  Outcome of Endovascular Therapy Aiming for Single-session Obliteration of Intracranial Dural AVFs.
  Neurol Med Chir (Tokyo) 61:563–569, 2021.
  https://doi.org/10.2176/nmc.oa.2021-0059
• Ono I, Satow T, Ito Y, Hamano E, Matsubara H, Kataoka H, Takahashi JC.
  Case of Iatrogenic Vertebro-Vertebral AVF Treated by Combination of Double-Catheter and Balloon Anchoring Techniques.
  World Neurosurg 128:98–101, 2019.
  https://doi.org/10.1016/j.wneu.2019.04.236
• Ito Y, Satow T, Matsubara H, Kataoka H, Takahashi JC.
  Selective Shunt Occlusion of Direct Carotid-Cavernous Fistula with Vascular Ehlers-Danlos Syndrome.
  World Neurosurg 122:123–128, 2019.
  https://doi.org/10.1016/j.wneu.2018.10.158
• Ishiguro T, Satow T, Okada A, Hamano E, Ikeda G, Chikuie H, Koiso T, Hashimura N, Nishimura M, Takahashi JC.
  Spontaneous Persistent Primitive Trigeminal Artery-Cavernous Sinus Fistula Treated by Coil Embolization.
  World Neurosurg 128:122–126, 2019.
  https://doi.org/10.1016/j.wneu.2019.05.003

もやもや病｜Moyamoya Disease

Revascularization and Genetic Research in Moyamoya Disease

もやもや病において、出血機序の解明、年齢差に基づく血管構築の比較、そしてRNF213遺伝子多型を通じた疾患感受性と発症リスクの解析を進め、診断・治療の個別化に貢献しています。

• Hashio A, Hamano E, Ozaki S, Hatyakeyama K, Ikeda Y, Niwa A, Yamada N, Ikedo T, Yamada K, Imamura H, Mori H, Iihara K, Kataoka H.
  Pathological changes in the lenticulostriate artery indicate the mechanisms leading to intracranial hemorrhage in Moyamoya disease: a case report.
  Acta Neurochir (Wien) 166:116, 2024.
  https://doi.org/10.1007/s00701-024-05992-5
• Ryu J, Hamano E, Nishimura M, Satow T, Takahashi JC.
  Difference in periventricular anastomosis in child and adult moyamoya disease: a vascular morphology study.
  Acta Neurochir (Wien) 162:1333–1339, 2020.
  https://doi.org/10.1007/s00701-020-04354-1
• Okazaki S, Morimoto T, Kamatani Y, Kamimura T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Takahashi JC, Nakagawara J, et al.
  Moyamoya Disease Susceptibility Variant RNF213 p.R4810K Increases the Risk of Ischemic Stroke Attributable to Large-Artery Atherosclerosis.
  Circulation 139:295–298, 2019.
  https://doi.org/10.1161/CIRCULATIONAHA.118.038439
• Kamimura T, Okazaki S, Morimoto T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Yoshimoto T, Takahashi JC, Nakagawara J, et al.
  Prevalence of RNF213 p.R4810K Variant in Early-Onset Stroke With Intracranial Arterial Stenosis.
  Stroke 50:1561–1563, 2019.
  https://doi.org/10.1161/STROKEAHA.118.024712

脳動脈瘤（未破裂・くも膜下出血）｜Cerebral Aneurysms (UIA and SAH)

Surgical and Endovascular Treatments for Intracranial Aneurysms

脳動脈瘤に対して、破裂リスクの予測、外科・血管内治療の併用最適化、高齢者における認知機能や再発予測など、個別化医療と術後評価に基づいた総合的な治療戦略を構築しています。

• Kushi Y, Imamura H, Itazu T, Ozaki S, Niwa A, Shimonaga K, Ikedo T, Hamano E, Yamada K, Ohta T, Satow T, Yamamoto T, Iihara K, Kataoka H.
  One-stage combined open and endovascular treatment using a hybrid operating room is safe and effective for distal middle cerebral artery aneurysms.
  World Neurosurg. 187:e731–e739, 2024.
  https://doi.org/10.1016/j.wneu.2024.04.159
• Nagano Y, Ikedo T, Shimonaga K, Kushi Y, Hamano E, Imamura H, Mori H, Hanaya R, Iihara K, Kataoka H.
  Preoperative simulation of intraoperative findings in surgical clipping of posterior communicating artery aneurysms using T2-weighted 3D images.
  Cureus 16(8):e66851, 2024.
  https://doi.org/10.7759/cureus.66851
• Sakurada K, Ikedo T, Hosokawa Y, Sugasawa S, Shimonaga K, Kushi Y, Niwa A, Ozaki S, Hattori EY, Hamano E, Yamada K, Imamura H, Mori H, Iihara K, Kataoka H.
  Irreversible postoperative cognitive impairment after unruptured intracranial aneurysm treatment in the elderly.
  Acta Neurochir (Wien) 166:30, 2024.
  https://doi.org/10.1007/s00701-024-05933-2
• Ozaki S, Imamura H, Niwa A, Tsutsui T, Yamada N, Ikedo T, Hamano E, Yamada K, Mori H, Iihara K, Kataoka H.
  Treatment outcome of flow diverter device for medium-sized cerebral aneurysms: A single-center report.
  J Neuroendovasc Ther 18(9):231–239, 2024.
  https://doi.org/10.5797/jnet.oa.2024-0025
• Nishiwaki T, Ikedo T, Kushi Y, Shimonaga K, Kobayashi H, Itazu T, Otsuka R, Tega J, Hamano E, Imamura H, Mori H, Nakamura M, Kato T, Shirakami S, Iihara K, Iwama T, Kataoka H.
  Hemodynamic differences determining rupture and non-rupture in middle cerebral aneurysms after growth.
  PLoS One 19(8):e0307495, 2024.
  https://doi.org/10.1371/journal.pone.0307495
• Tsutsui T, Ikedo T, Kitazawa Y, Otsuka R, Nishiwaki T, Kushi Y, Niwa A, Ozaki S, Hattori EY, Shimonaga K, Hamano E, Yamada K, Imamura H, Mori H, Iihara K, Kataoka H.
  Impact of morphological factors on the future growth of unruptured posterior communicating artery aneurysms.
  World Neurosurg 175:e897–e903, 2023.
  https://doi.org/10.1016/j.wneu.2023.04.039
• Hara T, Satow T, Hamano E, Hashimura N, Sumi M, Ikedo T, Ohta T, Takahashi JC, Kataoka H.
  Aspect ratio is associated with recanalization after coiling of unruptured intracranial aneurysms.
  Neurol Med Chir (Tokyo) 62(8):377–383, 2022.
  https://doi.org/10.2176/jns-nmc.2022-0052
• Kimura T, Ikedo T, Ohta-Ogo K, Hamano E, Ohta T, Mori H, Satow T, Sumi M, Hashimura N, Hara T, Shimonaga K, Kushi Y, Ikeda Y, Hatakeyama K, Iihara K, Kataoka H.
  A pathologically verified case of peripheral intracranial aneurysmal formation with massively infiltrating meningioma cells.
  J Neuropathol Exp Neurol 81(3):242-245, 2022.
  https://doi.org/10.1093/jnen/nlab130
• Koiso T, Satow T, Hamano E, Nishimura M, Takahashi JC, Kataoka H.
  Coiling for ruptured aneurysms in the vasospasm period: Safety and efficacy based on a propensity score analysis.
  J Neuroendovasc Ther 16(3):141–146, 2022.
  https://doi.org/10.5797/jnet.oa.2021-0034
• Yasuda R, Satow T, Hashimura N, Nishimura M, Takahashi JC, Kataoka H.
  Usefulness of craniograms in discriminating coiled intracranial aneurysms requiring retreatment.
  Neurol Med Chir (Tokyo) 62(3):118–124, 2022.
  https://doi.org/10.2176/nmc.oa.2021-0225
• Koiso T, Maruyama D, Hamano E, Mori H, Satow T, Kataoka H, Nakagawara J, Takahashi JC.
  Hyperperfusion syndrome detected by 15O-gas PET after clipping of a large unruptured internal carotid artery aneurysm: A case report.
  NMC Case Rep J 8(1):275–279, 2021.
  https://doi.org/10.2176/nmccrj.cr.2020-0240

頚動脈狭窄症・動脈硬化性疾患｜Carotid Artery Stenosis and Atherosclerosis

CEA, CAS, and Plaque Morphology in Carotid Stenosis

頚動脈狭窄症に対して、プラーク性状・潰瘍形成・石灰化などの詳細な病理評価をもとに、CEA／CASの適応と再発リスクを予測する個別化治療の確立を目指しています。

• Yamada K, Hatakeyama K, Amemiya K, Kawasaki M, Abe S, Imamura H, Mori H, Shirakawa M, Yoshimura S, Iihara K, Kataoka H.
  Pathological and clinical findings of calcified nodules in carotid artery stenosis: A study of 508 consecutive carotid endarterectomies.
  Vasc Med 2025 Mar 13.
  https://doi.org/10.1177/1358863X251324159
• Shimonaga K, Ikedo T, Yamada N, Niwa A, Kushi Y, Hamano E, Yamada K, Imamura H, Mori H, Hatakeyama K, Iihara K, Kataoka H.
  Plaque ulcerations are associated with recurrence in symptomatic low-grade carotid stenosis.
  World Neurosurg 183:e886–e891, 2024.
  https://doi.org/10.1016/j.wneu.2024.01.051
• Sakurada K, Shimonaga K, Tabata S, Sugasawa S, Niwa A, Kushi Y, Ozaki S, Ikedo T, Hamano E, Yamada K, Imamura H, Mori H, Koga M, Ihara M, Hatakeyama K, Iihara K, Kataoka H.
  Ulceration location is associated with clinical course in carotid stenosis.
  J Vasc Surg 80(4):1111–1119.e3, 2024.
  https://doi.org/10.1016/j.jvs.2024.06.004
• Yamada K, Imamura H, Ozaki S, Niwa A, Kushi Y, Yamada N, Ikedo T, Hamano E, Mori H, Iihara K, Yoshimura S, Kataoka H.
  A review of current flow diverters.
  J Neuroendovasc Ther 18(3):59–64, 2024.
  https://doi.org/10.5797/jnet.ra.2023-0078
• Sakurada K, Yamada K, Amemiya K, Yamaguchi E, Kataoka H.
  Difficulties in carotid artery stenting due to calcified nodules: A case report.
  Cureus 15(9):e46233, 2023.
  https://doi.org/10.7759/cureus.46233

脳卒中関連（出血性／虚血性疾患）｜Stroke and Intracranial Arterial Diseases

Stroke Intervention and Perioperative Neurosurgical Management

主幹動脈閉塞、頚動脈病変、脳梗塞などに対し、血管内治療や外科治療を軸とした診療成績と、希少疾患における症例報告を通じて、実臨床に即した知見の蓄積を進めています。

• Tsutsui T, Yamada K, Ikedo T, Morita Y, Hamano E, Imamura H, Mori H, Iihara K, Kataoka H.
  Risk factors for recurrent ischemic events in symptomatic carotid artery stenosis on CT angiography.
  Vasc Med 29(2):211–212, 2024.
  https://doi.org/10.1177/1358863X231225463
• Itazu T, Ikedo T, Tsutsui T, Niwa A, Kushi Y, Ozaki S, Yamada N, Shimonaga K, Hamano E, Yamada K, Imamura H, Mori H, Iihara K, Kataoka H.
  Impact of strict fluid management on the treatment outcome of clazosentan for cerebral vasospasm.
  Brain Hemorrhages 5:69-73, 2024.
• Ohta T, Tanaka K, Koge J, Yoshimoto T, Kushi Y, Shiozawa M, Ikedo T, Hamano E, Yamada K, Imamura H, Mori H, Iihara K, Kataoka H.
  Stent Retriever or Aspiration Catheter Alone vs Their Combination as the First-Line Thrombectomy in Acute Stroke.
  Neurosurgery 92(1):159–166, 2023.
  https://doi.org/10.1227/NEU.0000000000001871
• Nishiwaki T, Ikedo T, Hashimura N, Tanaka K, Ikeda Y, Hatakeyama K, Ohta-Ogo K, Kushi Y, Shimonaga K, Hamano E, Ohta T, Imamura H, Mori H, Iihara K, Kataoka H.
  A case of rheumatoid meningitis with symptomatic middle cerebral artery stenosis.
  J Neuropathol Exp Neurol 82(2):180–182, 2023.
  https://doi.org/10.1093/jnen/nlac099
• Ohta T, Satow T, Inoue M, Tanaka K, Koge J, Yoshimoto T, Kushi Y, Shiozawa M, Ikedo T, Hamano E, Yamada K, Imamura H, Mori H, Iihara K, Kataoka H.
  Impact on Clinical Outcomes of Changes in the Practice of Mechanical Thrombectomy due to the COVID-19 Pandemic.
  J Neuroendovasc Ther 16(10):498–502, 2022.
  https://doi.org/10.5797/jnet.oa.2022-0018
• Maeda T, Satow T, Hamano E, Hashimura N, Koge J, Tanaka K, Ikedo T, Mori H, Iihara K, Kataoka H.
  A Case of Internal Carotid Artery Dissection with Ischemic Onset, Followed by Subarachnoid Hemorrhage during Diagnostic Angiography.
  J Neuroendovasc Ther 14(10):420–427, 2020.
  https://doi.org/10.5797/jnet.cr.2019-0126
• Hamano E, Nishimura M, Mori H, Satow T, Takahashi JC.
  Intracranial arterial stenosis associated with Hashimoto's disease: angiographic features and clinical outcomes.
  BMC Neurol 20(1):345, 2020.
  https://doi.org/10.1186/s12883-020-01923-w

その他（脳腫瘍・機能的疾患など）｜Brain Tumors, Trigeminal Neuralgia, and Functional Neurosurgery

• Yamamoto Hattori E, Mori H, Niwa A, Kushi Y, Ozaki S, Shimonaga K, Ikedo T, Hamano E, Yamada K, Imamura H, Iihara K, Kataoka H.
   [Changes in Gamma Knife Radiosurgery(GKRS)in Patients with Metastatic Brain Tumors before and after COVID-19].
  Gan To Kagaku Ryoho. 2023 Aug;50(8):881-884. PMID: 37608413

最終更新日：2025年05月12日