循環動態制御部は設立より一貫して、① 循環動態を巨視的・システム的に記述し、介入ポイントを探索する基礎研究、② 循環動態を操るための手法を探る基礎研究、③ 臨床にいきる医療機器開発を3つの柱として成果を蓄積している。2025年度は、循環制御に関する基礎研究成果や新しい医療機器開発や自動治療システム開発に関する多くの成果が得られた。

研究業績（2025年度）

【英文】

1. Kitai T, Junyi Zhang, Saku K. Hemodynamic Implications After Left Ventricular Outflow Tract Obstruction Relief With Mavacamten. JACC. 2026, 31(14): 107538.
2. Hiraki N, Morita H, Nakamura Y, Ohba K, Sato K, Otake M, Yoshida Y, Nishikawa T, Fukumitsu M, Uemura K, Kawada T, Maruhashi T, Saku K. Understanding the hemodynamic effects of milrinone in normal and failing hearts: an experimental study using the circulatory equilibrium framework in canines. Am J Physiol Heart Circ Physiol. 2026, 330: H1241-H1256.
3. Matsushita　H, Oba K, Kurono K, Nakabayashi M, Yoshida Y, Sato K, Morita H, Otake M, Hiraki N, Fukumitsu M, Nishikawa T, Uemura K, Kawada T, Ichinose M, Ono Y, Saku K. Diffuse Correlation Spectroscopy for Non-invasive Monitoring of Peripheral Perfusion During Cardiogenic Shock and VA-ECMO Support: An Experimental Study. Shock. 2026, in press
4. Matsushita H, Nishikawa T, Uemura K, Sasaki K, Nakamura Y, Sato K, Morita H, Ohba K, Kawada T, Kataoka Y, Alexander J Jr, Saku K. Automated Hemodynamic Management System for the Prevention of Hypotension and Cardiac Output Reduction During General Anesthesia: Preclinical Experimental Validation. Journal of Anesthesia. 2026, in press
5. Yokota S, Maruhashi T, Kakuuchi M, Nishikawa T, Matsushita H, Morita H, Sato K, Yoshida Y, Kawada T, Uemura K, Nishinaka T, Saku K. Impella preserves haemodynamics with adequate stressed blood volume and normal pulmonary vascular resistance in a goat model of ventricular fibrillation. Eur Heart J Open. 2025, 6: oeaf173.
6. Nishikawa T, Matsushita H, Otake M, Yokota S, Kakuuchi M, Sato K, Morita H, Hiraki N, Ohba K, Yoshida Y, Fukumitsu M, Uemura K, Kawada T, Kusano K, Saku K. Impaired atrioventricular time interaction contributes to tachycardia-induced hemodynamic deterioration: In vivo and in silico hybrid approach. Int J Cardiol. 2026, 12. 134192.
7. Sasaki K, Ito T, Shiga T, Uemura K, Ishikawa T. An evaluation of the feasibility of a transoral endotracheal intubation method in mice using a combination of commercially available. Journal of Veterinary Medical Science. 2025, 87: 589-593.
8. Kataoka Y, Uemura K, Sampei M, Fukuda Y, Peterson J, Funada R, Saku K, Joe Alexander, Sunagawa K. A Discrete Hemodynamic Control Framework: Proof-of-Concept Studyfor Autonomous Drug Therapy in Acute Heart Failure. IEEE Trans Biomed Eng. 2025, 12. in press
9. Nakamura Y, Saku K, Homma S, Moriyama N, Ota T. Rare Intraoperative Left Coronary Artery Dissection in Acute Type A Aortic Dissection: VA- ECMO- Assisted Coronary Artery Bypass Grafting. Clin Case Rep. 2025, 13(12): e71692.
10. Nishikawa M, Kawada T, Saku K, Kinoshita H, Kawahito S. Effects of sugammadex on heart rate variability in anesthetized male rats. Physiol Rep. 2025, 13: e70507.
11. Nishikawa M, Kawada T, Hiraki N, Fukumitsu M, Sato K, Kinoshita H, Kawahito S, Saku K. Acute effects of vericiguat on urine excretion during baroreflex-mediated sympathetic arterial pressure regulation in male rats. Autonomic Neuroscience. 2025, 262: 103363.
12. Ikeda Y, Saku K, Nakata J, Unoki T, Nakahara S, Iwaya T, Iikura S, Takigami Y, Yamamoto T, Sakamoto T, Ako J. UNLOADERS-PVAD Investigators. UNLOADERS-PVAD Weaning Score: predicting post-weaning adverse events in cardiogenic shock patients supported by microaxial flow pump. Journal of Intensive Care. 2025, 13(1): 62.
13. Kamada K, Mannoji H, Tohyama T, Nishikawa T, Tsutsui H, Sunagawa K, Saku K. Simulated microgravity exposure markedly attenuates the baroreflex total loop gain and induces orthostatic hypotension in male rats. Physiol Rep. 2025, 13: e70637.
14. Yokoi A, Kawada T, Fukumitsu M, Hiraki N, Sato K, Kakuuchi M, Joe Alexander Jr, Nishikawa T, Tanaka R, Saku K. Vericiguat attenuates the dynamic gain of open-loop baroreflex function in a low-frequency range. Autonomic Neuroscience: Basic and Clinical. 2025, 262: 103354.
15. Okumura T, Kusunose K, Tsuji T, Kotoku J, Todaka K, Saku K. Overcoming Clinical Inertia in the Context of Non-Adherence With Guideline-Directed Medical Therapy for Heart Failure. Cardiology Discovery. 2025, 5: 245-256.
16. Sato K, Peterson J, Uemura K, Ohba K, Nishikawa T, Sasaki K, Yokota S, Matsushita H, Morita H, Yoshida Y, Hiraki N, Otake M, Nakamura Y, Fukumitsu M, Kawada T, Kataoka Y, Alexander J, Sunagawa K, Saku K. One Surface Fits All: Validating the Venous Return Model Across Species and Scales in Circulatory Equilibrium. Am J Physiol Heart Circ Physiol. 2025, 329(4): H853-H866.
17. Fukumitsu M, Hotta N, Kawada T, Nishikawa T, Saku K. A rapid increase in left atrial pressure reduces pulmonary arterial compliance in rats: Insights from pulmonary arterial impedance analysis. Journal of Applied Physiology. 2025, 1985.
18. Hiraki N, KawadaT, Fukumitsu M, Nishikawa T, Matsushita H, Yoshida Y, Sato K, Morita H, Otake M, Ohba K, Uemura K, Joe Alexander Jr., Saku K. Impact of dopamine on baroreflex-mediated sympathetic arterial pressureregulation in rats: an open-loop analysis. Am J Physiol Regul Integr Comp Physiol. 2025, 329(2): R329-R339.
19. Takata M, Nishikawa M, Hayashi H, Yamamura A, Saku K, Kawada T, Sato M, Kawahito S, Kinoshita H. Lack of Effect of Omecamtiv Mecarbil on Smooth Muscle Myosin Phosphatase Target Subunit-1 (MYPT1) Phosphorylation and Hemodynamics in Rats. Cureus. 2025, 17(7): e87854.
20. Otake M, Morita H, Sato K, Saku K. Impact of Venoarterial Extracorporeal Membrane Oxygenation on Hemodynamics and Cardiac Mechanics: Insights From Pressure-Volume Loop Analysis. Int J Heart Fail. 2025, 7(3): e18.
21. Ota I, Sawada K, Saku K, Noguchi T. Case Report: Intra-aortic balloon pump in a patient with refractory cardiogenic shock complicating severe aortic stenosis—enhanced hemodynamic response with low aortic compliance. Frontiers in Cardiovascular Medicine.2025, 12
22. Matsushita H, Kurono K, Nakabayashi M, Sato K, Morita H, Yoshida Y, Fukumitsu M, Uemura K, Kawada T, Ichinose M, Ono Y, Saku K. Non-invasive monitoring of microcirculation dynamics in hypovolemic shock: a novel application of diffuse correlation spectroscopy. Intensive Care Medicine Experimental. 2025, 13: 53
23. Ikeda Y, Saku K, Nakata J, Unok T, Yamamoto T, Sakamoto T, Ako J. Phase-Specific Hemodynamic Criteria and Outcomes in Patients With Cardiogenic Shock Receiving Percutaneous Ventricular Assist Devices. J Am Heart Assoc. 2025, 14: e042249.
24. Watanabe Y, Kataoka A, Kito K, Nishikawa T, Saku K. Evaluation with a haemodynamic simulator undergoing mitral transcatheter edge-to-edge repair in a giant left atrium. European Heart Journal - Case Reports. 2025, 9: ytaf261
25. Watanabe Y, Nakata J, Matsushita H, Saku K, Mozawa K, Seki T, Tokita Y, Izumi Y, Tsutsumi M, Hoshika Y, Kimura T, Hino M, Shiomura R, Sangen H, Yamamoto T, Asai K. Case Report: Balloon aortic valvuloplasty with subsequent Impella support as bridge therapy to transcatheter aortic valve replacement in cardiogenic shock with severe aortic stenosis. Frontiers in Cardiovascular Medicine. 2025, 12: 1583801.
26. Tadokoro N, Saku K, Tonai K, Tadokoro Y, Kutsuzawa R, Fukushima S. Rapid-onset postoperative acutekidney injury is associated withmortality in patients with postcardiotomy cardiogenic shock. Frontiers in Cardiovascular Medicine. 2025, 13: 1580599.
27. Sato K, Yoshida Y, Yokota S, Matsushita H, Morita H, Fukumitsu M, Nishikawa T, Uemura K, Kawada T, Saku K. Pressure-strain product reflects left ventricular stroke work under a wide range of left ventricular assist device support levels. Frontiers in Cardiovascular Medicine. 2025, 12.
28. Nakashima T, Kondo T, Nakata J, Saku K, Kawakami S, Kuwabara M, Yamamoto T, Kikuchi M, Takeuchi I, Asai K, Sato N. Expert Consensus Statement on the Evaluation, Treatment, and Transfer of Cardiogenic Shock Using a Delphi Method Approach　- A Report of the Japan Critical Care Cardiology C. J Intensive Care. 2025, 13: 50.
29. Ikeda T, Ashihara T, Iwasaki YK, Ono M, Kagiyama N, Kimura T, Kusano K, Kohno R, Saku K, Sasano T, Senoo K, Takatsuki S, Takahashi N, Takami M, Nakano Y, Hashimoto K, Fujiu K, Fujino T, Mizuno A, Yoshioka K, Watanabe E, Shimizu W, Node K. 2025 Japanese Heart Rhythm Society / Japanese Circulation Society Consensus Statement on the Appropriate Use of Ambulatory and Wearable Electrocardiographs. Circ J. 2025, 89: 850-876.
30. Ikeda T, Ashihara T, Iwasaki YK, Ono M, Kagiyama N, Kimura T, Kusano K, Kohno R, Saku K, Sasano T, Senoo K, Takatsuki S, Takahashi N, Takami M, Nakano Y, Hashimoto K, Fujiu K, Fujino T, Mizuno A, Yoshioka K, Watanabe E, Shimizu W, Node K. 2025 Japanese Heart Rhythm Society / Japanese Circulation Society Consensus Statement on the Appropriate Use of Ambulatory and Wearable Electrocardiographs. J Arrhythm. 2025, 41(3): e70059.
31. Fukumitsu M, Saku K. Pulmonary artery denervation: From hope to clinical reality. Int J Cardiol. 2025, 15;431:133225.
32. Nakamura Y, Saku K, Homma S, Midorikawa Y, Yamabe T, Ota T. Pulmonary artery rupture by pulmonary artery catheter in cardiac surgery: a case report and review of literature. Frontiers in Cardiovascular Medicine. 2025, in press.
33. Unoki T, Saku K. Author's reply. J Cardiol. 2025, S0914-5087(25)00096-6.
34. Matsushita H, Saku K. Author's reply. J Cardiol. 2025 Mar 4:S0914-5087(25)00068-1.

【和文】

1. 上村 和紀. 自動心不全治療装置 血圧自動制御. 循環制御. 2025, 46(1): 5-10.
2. 上村 和紀, 横田 翔平, 鵜木 崇, 松下 裕貴, 此内 緑, 吉田 祐希, 佐々木 一益, 西川 拓也, 川田 徹, 朔 啓太. 完全置換型人工心臓の循環平衡自動制御システムの開発. 人工臓器. 2025, 54(1): 51.
3. 福満 雅史, 朔 啓太. 肺高血圧症の右心機能評価. 臨床と研究. 2025, 102 (6): 589-594.
4. 大竹 正紘. 新著紹介 心不全診療の歩き方. 循環制御. 2025, 46(1): 53-54.
5. 中村 優太, 朔 啓太, 濱 大介, 浅井 徹, 太田 隆嗣, 倉橋 清泰. 宗教的輸血拒否患者の心室中隔破裂に対し Impella® による循環補助を確立するも 血小板減少により早期閉鎖手術を判断した一例. 循環制御. 2025, 46(2): 105-110.
6. 平木 那奈, 朔 啓太. GDMTが実践できない理由とは？～〝わかっていてもできない”の正体に迫る～. Heart View. 2026, 30: 109-115.
7. 大竹 正紘. 循環生理・心力学・循環平衡. 循環器ジャーナル. 2026, 74: 178-186.
8. 大竹 正紘, 朔 啓太. 地域及び施設内におけるショックチームおよび心原性ショック治療に携わる若手循環器医の教育システム. 循環器ジャーナル. 2026, 74: 320-325.
9. 松下 裕貴, 朔 啓太. 心原性ショックは微小循環で語れ！ Heart View. 2026, 30: 208-217.