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再生医療センター

業績

近年の主要な業績

  1. Fields L, Ito T, Kobayashi K, Ichihara Y, Podaru MN, Hussain M, Yamashita K, Machado V, Lewis-McDougall F, Suzuki K. Epicardial placement of fibrin sealant film-incorporating human mesenchymal stromal cells for the treatment of heart failure: towards clinical translation and mechanistic implication. Mol Ther. 2021;29:2554-70.
  2. Ito T, Shintani Y, Fields L, Shiraishi M, Podaru MN, Kainuma S, Yamashita K, Kobayashi K, Perretti M, Lewis-McDougall F, Suzuki K. Cell barrier function of resident peritoneal macrophages in post-operative adhesions. Nat Commun. 2021;12:2232.
  3. You Y, Kobayashi K, Colak B, Luo P, Cozen E, Fields L, Suzuki K (co-last author), Gautrot J. Engineered cell-degradable poly(2-alkyl-2-oxazoline) hydrogels improve epicardial placement of MSCs by stimulating paracrine signaling for cardiac repair. Biomaterials. 2021;269:120356.
  4. Podaru M, Fields L, Kainuma S, Ichihara Y, Hussain M, Ito T, Kobayashi K, Mathur A, D’Acquisto F, Lewis-McDougall F, Suzuki K. Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. Basic Res Cardiol. 2019;114:34.
  5. Kobayashi K, Ichihara Y, Sato N, Umeda N, Fields L, Fukumitsu M, Tago Y, Ito T, Kainuma S, Podaru M, Lewis-McDougall FC, Yamahara K, Suzuki K. On-site fabrication of bi-layered adhesive MSC dressings for the treatment of heart failure. Biomaterials. 2019;209:41-53.
  6. Ichihara Y, Kaneko M, Yamahara K, Koulouroudias M, Sato N, Uppal R, Yamazaki K, Saito S, Suzuki K. Self-assembling peptide hydrogel enables instant epicardial coating of the heart with mesenchymal stromal cells for the treatment of heart failure. Biomaterials. 2018;154:12-23.
  7. Kobayashi K, Ichihara Y, Tano N, Fields L, Ito T, Ikebe C, Lewis F, Yashiro K, Shintani Y, Uppal R, Suzuki K. Fibrin glue-aided, instant epicardial placement enhances the efficacy of mesenchymal stromal cell-based therapy for heart failure. Sci Rep. 2018; 8:9448.
  8. Shintani Y, Ito T, Fields L, Shiraishi M, Ichihara Y, Sato N, Podaru M, Kainuma S, Tanaka H, Suzuki K. IL-4 as a repurposed biological drug for myocardial infarction through augmentation of alternatively activated cardiac macrophages. Sci Rep. 2017;7:6877.
  9. Shiraishi M, Shintani Ya, Shintani Yu, Ishida H, Saba R, Yamaguchi A, Adachi H, Yashiro K, Suzuki K. Alternatively activated macrophages determine repair of the infarcted adult murine heart. J Clin Invest. 2016;126:2151-66.
  10. Ishida H, Saba R, Kokkinopoulos I, Hashimoto M, Yamaguchi O, Nowotschin S, Shiraishi M, Ruchaya P, Miller D, Harmer S, Poliandri A, Kogaki S, Sakata Y, Dunkel L, Tinker A, Hadjantonakis AK, Sawa Y, Sasaki H, Ozono K, Suzuki K, Yashiro K. GFRA2 identifies cardiac progenitors and mediates cardiomyocyte differentiation in a RET-independent signaling pathway. Cell Report. 2016;16:1026-38.

  11. Tokudome T, Otani K. Molecular mechanism of blood pressure regulation through the atrial natriuretic peptide. Biology. 2022;11:1351.
  12. Tokudome T*, Otani K*, Mao Y, Jensen LJ, Miyazaki T, Sonobe T, Pearson JT, Osaki T, Minamino N, Ishida J, Fukamizu A, Kawakami H, Onozuka D, Nishimura K, Miyazato M, Nishimura H*. Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension. 2022;79:1409-1422. (*:equal contribution)
  13. Otani K*, Tokudome T*, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K. Deficiency of natriuretic peptide signaling promotes peripartum cardiomyopathy-like remodeling in the mouse heart. Circulation. 2020;141:571-588. (*:equal contribution)
  14. Toita R, Asai D, Otani K, Kawano T, Murata M, Kang JH. Suppression of lysophosphatidylcholine-induced human aortic smooth muscle cell calcification by protein kinase A inhibition. Lipids. 2019;54:465-70.
  15. Otani K, Kamiya A, Miyazaki T, Koga A, Inatomi A, Harada-Shiba M. Surface modification with lactadherin augments the attachment of Sonazoid microbubbles to glycoprotein IIb/IIIa. Ultrasound Med Biol. 2019;45:1455-65.
  16. Toita R, Otani K, Kawano T, Fujita S, Murata M, Kang JH. Protein kinase A (PKA) inhibition reduces human aortic smooth muscle cell calcification stimulated by inflammatory response and inorganic phosphate. Life Sci. 2018;209:466-71.
  17. Tokudome T, Otani K, Miyazato M, Kangawa K. Ghrelin and the heart. Peptides. 2019;111: 42-46.
  18. Otani K, Nishimura H, Kamiya A, Harada-Shiba M. Simplified preparation of v3 integrin-targeted bubbles based on clinically available ultrasound contrast agent: validation in a tumor-bearing mice model. Ultrasound Med Biol. 2018;44:1063-73.
  19. Miyazaki T, Otani K, Chiba A, Nishimura H, Tokudome T, Takano-Watanabe H, Matsuo A, Ishikawa H, Shimamoto K, Fukui H, Kanai Y, Yasoda A, Ogata S, Nishimura K, Minamino N, Mochizuki N. A new secretory peptide of natriuretic peptide family, osteocrin, suppresses the progression of congestive heart failure after myocardial infarction. Circ Res. 2018;122:742-51.

  20. Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu and Hitoshi Okada. KDM4B promotes acute myeloid leukemia associated with AML1-ETO by regulating chromatin accessibility. FASEB BioAdvances. 2021;3:1020–1033.
  21. Naohiro Oka, Akiyoshi Komuro, Hisayuki Amano, Suman Dash, Masahiko Honda, Kazushige Ota, Shunji Nishimura, Takeshi Ueda, Masao Akagi and Hitoshi Okada. Ascorbate sensitizes human osteosarcoma cells to the cytostatic effects of cisplatin. Pharmacology Research Perspectives 2020;8:e00632.
  22. Hisayuki Amano, Arindam Chaudhury, Cristian Rodriguez-Aguayo, Lan Lu, Vikto Akhanov, Andre Catic, Yury V Popov, Eric Verdin, Hannah Johnson, Fabio Stossi, David A Sinclair, Eiko Nakamaru-Ogiso, Gabrial Lopez-Berestein, Jeffrey T Chang, Joel R Neilson, Alan Meeker, Milton Finegold, Joseph A Baur and Ergun Sahin. Telomere dysfunction leads to Sirtuin repression that drives telomere-dependent disease. Cell Metabolism 2019;29:1274-1290.e9.
  23. Hisayuki Amano and Ergun Sahin. Telomeres and sirtuins: at the end we meet again. Molecular & Cellular Oncology 2019;6:e1632613.
  24. Kazushige Ota, Akiyoshi Komuro, Hisayuki Amano, Akinori Kanai A, Kai Ge, Takeshi Ueda and Hitoshi Okada. High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase. Scientific Reports 2019;9:10036.

最終更新日:2023年01月20日

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