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分子生理部

業績

分子生理部では現在心血管系の発生・形態形成・成熟機能獲得の分子機構研究、特に転写調節因子・シグナル伝達分子に関する研究を行っています。詳しくはスタッフのResearchmap情報もご覧ください。

研究テーマ関連業績(前所属における業績を含む)

  • Harada Y, et al., ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes Cells 2021.
  • Kinugasa-Katayama Y, et al., Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation. genesis 2021.
  • Seya D, et al., A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis. Dev Growth Differ 2021.
  • Watanabe Y, et al., Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. J Biol Chem 2020.
  • Ihara D, et al., Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Dev Biol 2020.
  • Araki M, et al., Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis 2018.
  • Fujita M, et al. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev 2016.
  • Mizuta K, et al. Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos. Dev Dyn 2015.
  • Morioka T, et al. An important role of endothelial Hairy-related transcription factors in mouse vascular development. genesis 2014.
  • Somekawa S, et al. Tmem100, an ALK1 signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Nat Acad Sci USA 2012.
  • Watanabe Y, et al. Fgf10 regulation in the second heart field by Tbx1, Nkx2-5 and Islet1 reveals a genetic switch for down-regulation of transcription in the myocardium. Proc Natl Acad Sci U S A 2012.
  • Watanabe Y, et al. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res 2010.
  • Park EJ*, Watanabe Y*, et al. (* Equal contribution) An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development 2008.
  • Xin M, et al. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Nat Acad Sci USA 2007.
  • Watanabe Y, et al. Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development 2006.
  • Murakami M, et al. A WW domain protein TAZ is a critical co-activator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Nat Acad Sci USA 2005.
  • Kathiriya IS, et al. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem 2004.
  • Gottlieb PD, et al. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nature Genet 2002.
  • Nakagawa O, et al. Members of the HRT family of bHLH proteins act as transcriptional repressors downstream of Notch signaling. Proc Nat Acad Sci USA 2000.

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最終更新日:2021年11月08日

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