* 責任著者原著論文（英文）

1. Unoki T, Uemura K, Yokota S, Matsushita H, Kakuuchi M, Morita H, Sato K, Yoshida Y, Sasaki K, Kataoka Y, Nishikawa T, Fukumitsu M, Kawada T, Sunagawa K, Alexander J, Saku K. Closed-loop automated control system of extracorporeal membrane oxygenation and left ventricular assist device support in cardiogenic shock. ASAIO J. 2024, in press.
2. Matsushita H, Saku K*, Nishikawa T, Unoki T, Yokota S, Sato K, Morita H, Yoshida Y, Fukumitsu M, Uemura K, Kawada T, Kikuchi A, Yamaura K. Impact of right ventricular and pulmonary vascular characteristics on Impella hemodynamic support in biventricular heart failure: A simulation study. J of Cardiol. 2024, S0914-5087: 00145-X.
3. Nishikawa T, Kamada K, Morita H, Matsushita H, Yokota S, Sato K, Unoki T, Tsutsui H, Sunagawa K, Saku K*. Automated control of Impella maintains optimal left ventricular unloading during periods of unstable hemodynamics and prevents myocardial damage in acute myocardial infarction. Int J Cardiol. 2024, 410: 132244.
4. Matsushita H, Saku K*, Nishikawa T, Yokota S, Sato K, Morita H, Yoshida Y, Fukumitsu M, Uemura K, Kawada T, Yamaura K. The impact of ECPELLA on haemodynamics and global oxygen delivery: a comprehensive simulation of biventricular failure. Intensive Care Medicine Experimental. 2024, 12:13.
5. Yoshida K, Saku K*, Jan Bogaard H, Abe K, Sunagawa K, Tsutsui H. Vagal nerve stimulation preserves right ventricular function in a rat model of right ventricular pressure overload. Pulm Circ. 2022, 1; 12(4): e12154.
6. Kinoshita H, Saku K*, Mano J, Mannoji H, Kanaya S, Sunagawa K. Very short-term beat-by-beat blood pressure variability in the supine position at rest correlates well with the nocturnal blood pressure variability assessed by ambulatory blood pressure monitoring. Hypertension Research. 2022, 45(6): 1008-1017.
7. Mano J, Saku K*, Kinoshita H, Mannoji H, Kanaya S, Sunagawa K. Aging steepens the slope of power spectrum density of 30-minute continuous blood pressure recording in healthy human subjects. PLoS One. 2021, 18; 16(3): e0248428.
8. Nishikawa T, Saku K*, Uike K, Uemura K, Sunagawa G, Tohyama T, Yoshida K, Kishi T, Sunagawa K, Tsutsui H. Prediction of haemodynamics after interatrial shunt for heart failure using the generalized circulatory equilibrium. ESC Heart Fail. 2021, 7(5): 3075-3085.
9. Kakino T, Saku K*, Nishikawa T, Sunagawa K. The Partial Support of the Left Ventricular Assist Device Shifts the Systemic Cardiac Output Curve Upward in Proportion to the Effective Left Ventricular Ejection Fraction in Pressure-Volume Loop. Front Cardiovasc Med. 2020, 7: 163.
10. Toyama T, Hosokawa K, Saku K*, Oga Y, Tsutsui H, Sunagawa K. Smart baroreceptor activation therapy strikingly attenuates blood pressure variability in hypertensive rats with impaired baroreceptor. Hypertension. 2020, 75: 885-892.
11. Mannoji H, Saku K*, Nishikawa T, Tohyama T, Kamada K, Abe K, Sunagawa G, Kishi T, Sunagawa K, Tsutsui H. Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings. Am J Physiol Heart Circ Physiol. 2019, 316: H828-H839.
12. Yoshida K, Saku K*, Kamada K, Abe K, Tanaka-Ishikawa M, Tohyama T, Nishikawa T, Kishi T, Sunagawa K, Tsutsui H. Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. JACC Basic Transl Sci. 2018, 3: 657-671.
13. Saku K*, Kakino T, Arimura T, Sunagawa G, Nishikawa T, Sakamoto T, Kishi T, Tsutsui H, Sunagawa K. Left Ventricular Mechanical Unloading by Total Support of Impella in Myocardial Infarction Reduces Infarct Size, Preserves Left Ventricular Function, and Prevents Subsequent Heart Failure in Dogs. Circ Heart Fail. 2018, 11: e004397.
14. Saku K*, Tohyama T, Shinoda M, Kishi T, Hosokawa K, Nishikawa T, Oga Y, Sakamoto T, Tsutsui H, Miyamoto T, Sunagawa K. Central chemoreflex activation induces sympatho-excitation without altering static or dynamic baroreflex function in normal rats. Physiol Rep. 2017, 5(17): e13406.
15. Fujii K, Saku K*, Kishi T, Oga Y, Tohyama T, Nishikawa T, Sakamoto T, Ikeda M, Ide T, Tsutsui H, Sunagawa K. Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure. Am J Hypertens. 2017, 30: 791-798.
16. Arimura T, Saku K*, Kakino T, Nishikawa T, Tohyama T, Sakamoto T, Sakamoto K, Kishi T, Ide T, Sunagawa K. Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure. Int J Cardiol. 2017, 27: 704-710.
17. Saku K*, Kakino T, Arimura T, Sakamoto T, Nishikawa T, Sakamoto K, Ikeda M, Kishi T, Ide T, Sunagawa K. Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction. PLoS One. 2016, 11: e0152911.
18. Sakamoto K*, Hosokawa K, Saku K, Sakamoto T, Tobushi T, Oga Y, Kishi T, Ide T, Sunagawa K: Baroreflex failure increases the risk of pulmonary edema in conscious rats with normal left ventricular function. Am J Physiol Heart Circ Physiol. 2016, 310: H199-205.
19. Sakamoto K*, Saku K, Kishi T, Kakino T, Tanaka A, Sakamoto T, Ide T, Sunagawa K. Prediction of the impact of veno-arterial extracorporeal membrane oxygenation on hemodynamics. Am J Physiol Heart Circ Physiol. 2015, 308: H921-930.
20. Sakamoto T*, Kakino T, Sakamoto K, Tobushi T, Tanaka A, Saku K, Hosokawa K, Onitsuka K, Murayama Y, Tsutsumi T, Ide T, Sunagawa K. Changes in vascular properties, not ventricular properties, predominantly contribute to baroreflex regulation of arterial pressure. Am J Physiol Heart Circ Physiol. 2015, 308: H49-58.
21. Saku K*, Kishi T, Sakamoto K, Hosokawa K, Sakamoto T, Murayama Y, Kakino T, Ikeda M, Ide T, Sunagawa K. Afferent vagal nerve stimulation resets baroreflex neural arc and inhibits sympathetic nerve activity. Physiol Rep. 2014, 2: e12136.
22. Hosokawa K, Ide T*, Tobushi T, Sakamoto K, Onitsuka K, Sakamoto T, Fujino T, Saku K, Sunagawa K. Bionic baroreceptor corrects postural hypotension in rats with impaired baroreceptor. Circulation. 2012, 126: 1278-1285.

総説・ガイドライン

1. Nishikawa T, Morita H, Sunagawa K, Saku K*. The need for definition of optimal left ventricular unloading.  Int J Cardiol. 2024, 417: 132573.
2. Yokota S, Nishikawa T, Saku K*. Impella as an optimizing tool for heart failure interventions. Journal of coronary artery disease. 2024, 30: 127-137.
3. Nishimura T, Hirata Y, Ise T, Iwano H, Izutani H, Kinugawa K, Kitai T, Ohno T, Ohtani T, Okumura T, Ono M, Satomi K, Shiose A, Toda K, Tsukamoto Y, Yamaguchi O, Fujino T, Hashimoto T, Higashi H, Higashino A, Kondo T, Kurobe H, Miyoshi T, Nakamoto K, Nakamura M, Saito T, Saku K, Shimada S, Sonoda H, Unai S, Ushijima T, Watanabe T, Yahagi K, Fukushima N, Inomata T, Kyo S, Minamino T, Minatoya K, Sakata Y, Sawa Y. JCS/JSCVS/JCC/CVIT 2023 Guideline Focused Update on Indication and Operation of PCPS/ECMO/IMPELLA. Japanese Circulation Society, the Japanese Society for Cardiovascular Surgery, Japanese College of Cardiology, Japanese Association of Cardiovascular Intervention and Therapeutics Joint Working Group. Circ J. 2024, 8: 1010-1046.
4. Fukumitsu M, Saku K*. Reconsidering coronary circulation in the era of LV unloading - the underlying physiology in the non-physiological setting. J Physiol. 2024, 602: 1661-1662.
5. Nakata J*, Yamamoto T, Saku K, Ikeda Y, Unoki T, Asai K. Mechanical circulatory support in cardiogenic shock. J Intensive Care. 2023, 19; 11(1): 64.
6. Saku K*, Yokota S, Nishikawa T, Kinugawa K. Interventional heart failure therapy: A new concept fighting against heart failure. J Cardiol. 2022, 80: 101-109.
7. Saku K*, Nakata J. How Should We Develop New Risk Scores for Cardiogenic Shock? Circ J. 2022, 25; 86(4): 695-698.

書籍

1. 循環動態攻略A to Z　急性心不全Case Live!　2025年2月4日刊行予定
   朔　啓太（編集）　奥村　貴裕（編集）
2. 心原性ショック　最強の教科書. メジカルビュー社.　2024年3月31日刊行
   朔 啓太（編集）　中田 淳（編集協力）　丸橋 孝昭 (編集協力)

※その他の論文や出版物については、部の紹介ページ（https://www.ncvc.go.jp/res/divisions/cardiovascular_dynamics/achievement/）をご参照ください。

• European Society of Cardiology Congress 2013, Travel Grant Award
• AHA Scientific Sessions 2013, BCVS Abstract Travel Award
• The 29th ISHR Japanese Section, Poster Award
• AHA Scientific Sessions 2015, Best Abstract Award / BCVS International Travel Award
• 2017年 アクテリオン アカデミアプライズ
• 第2回日本医療開発大賞　AMED理事長賞
• 韓国循環器病学会（KSC）2019, Young investigator's award
• 大学発ベンチャー表彰2022　日本ベンチャー学会会長賞　支援機関

福岡大学循環器内科　客員教授
大阪大学薬学研究科　招へい准教授
神戸大学医学研究科　非常勤講師（生理学分野）
香川大学医学研究科　非常勤講師（生理学分野）
東京電機大学　ME講座　講師

日本医療研究開発機構　課題評価委員
日本医療研究開発機構　医療機器開発の重点化に関する検討委員会
日本循環制御医学会　理事
日本生体医工学会　代議員
循環動態アカデミー　代表幹事
日本医療研究開発機構　プログラムオフィサー
Cubec社社外取締役・CTO
WiON社取締役・CTO
ニューロシューティカルズ社技術顧問

循環動態アカデミー：https://circ-dynamics.jp
迷走神経刺激カテーテル開発：http://circucon.jp/ivns.html
Cubec社HP：https://cubec.jp/