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循環動態制御部

スタッフ
西川　拓也

スタッフ紹介 [西川　拓也]

氏名西川　拓也
よみにしかわ　たくや
所属・職務研究推進支援部　上級研究員
内線番号40340
FAX番号 
Eメールnishikawa.takuya75＠ncvc.go.jp ＠は半角にしてください。
棟/部屋番号研究棟(C棟)4階：40503
専門心臓力学、PV loop、循環平衡、循環シミュレータ、循環モニタリング、自動治療、生体医工学
主要論文・著書
  1. Matsushita H, Saku K, Nishikawa T, Yokota S, Sato K, Morita H, Yoshida Y, Fukumitsu M, Uemura K, Kawada T, Yamaura K. The impact of ECPELLA on haemodynamics and global oxygen delivery: a comprehensive simulation of biventricular failure. Intensive Care Med Exp. 2024 Feb 16.
  2. Nakata J, Saku K, Nishikawa T, Kimura T, Sangen H, Asano K, Kadooka K, Hosokawa Y, Tara S, Shimizu W, Yamamoto T, Asai K. Substantial Reduction of Acute Ischemic Mitral Regurgitation Using Impella in AMI Complicated with Cardiogenic Shock. Int Heart J. 2023;64(2):294-298. doi: 10.1536/ihj.22-572.
  3. Uemura K, Nishikawa T, Hasebe N, Yokota S, Kakuuchi M, Saku K, Kawada T, Morodome S, Furukoshi M, Sugimachi M. A Novel Triple-Bladder Cuff Method for Blood Pressure Estimation Based on Pulse Wave Dynamics in Brachial Artery: Theoretical and Experimental Analyses. IEEE Trans Biomed Eng. 2023 Feb;70(2):703-714.
  4. Saku K, Yokota S, Nishikawa T, Kinugawa K. Interventional heart failure therapy: A new concept fighting against heart failure. J Cardiol. 2022 Aug;80(2):101-109.
  5. Uemura K, Nishikawa T, Kawada T, Zheng C, Li M, Saku K, Sugimachi M. A novel method of trans-esophageal Doppler cardiac output monitoring utilizing peripheral arterial pulse contour with/without machine learning approach. J Clin Monit Comput. 2022 Apr;36(2):437-449.
  6. Nishikawa T, Uemura K, Hayama Y, Kawada T, Saku K, Suimachi M. Development of an automated closed-loop β-blocker delivery system to stably reduce myocardial oxygen consumption without inducing circulatory collapse in a canine heart failure model: a proof of concept study. J Clin Monit Comput. 2022 Jun;36(3):849-860.
  7. Kawada T, Nishikawa T, Hayama Y, Li M, Zheng C, Uemura K, Saku K, Miyamoto T, Sugimachi M. Quantitative assessment of the central versus peripheral effect of intravenous clonidine using baroreflex equilibrium diagrams. J Physiol Sci. 2021 Dec 31;71(1):39.
  8. Hiraoka A, Saku K, Nishikawa T, Sunagawa K. A case report of unexpected right-to-left shunt under mechanical support for post-infarction ventricular septal defect: evaluation with hemodynamic simulator. EHJ Case Report. 2021 Aug 31;5(8).
  9. Kawada T, Nishikawa T, Suehara S, Sawada S, Tanaka T, Uenohara M, Yamamoto H, Sugimachi M. Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation. The Journal of Physiological Sciences. 2021 Apr 20;71(1):13.
  10. Uemura K#, Nishikawa T# (Contributed equally), Kawada T, Zheng C, Li M, Saku K, Sugimachi M. A novel method of trans-esophageal Doppler cardiac output monitoring utilizing peripheral arterial pulse contour with/without machine learning approach. J Clin Monit Comput. 2021 Feb 17.
  11. Kawada T, Yamamoto H, Uemura K, Hayama Y, Nishikawa T, Zheng C, Li M, Miyamoto T, Sugimachi M. Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under β-blockade. Am J Physiol Heart Circ Physiol. 2021 Jun 1;320(6):H2201-H2210.
  12. Uike K, Saku K, Nishikawa T, Yamaura K, Nagato H, Muraoka M, Ohga S, Tsutsui H, Sunagawa K. Prediction of hemodynamics after atrial septal defect closure using a framework of circulatory equilibrium in dogs. Am J Physiol Heart Circ Physiol. 2020 Nov 1;319(5):H938-H947.
  13. Kawada T, Sonobe T, Nishikawa T, Hayama Y, Li M, Zheng C, Uemura K, Akiyama T, Pearson JT, Sugimachi M. Contribution of afferent pathway to vagal nerve stimulation-induced myocardial interstitial acetylcholine release in rats. Am J Physiol Regul Integr Comp Physiol. 2020 Nov 1;319(5):R517-R525.
  14. Nishikawa T, Saku K, Uike K, Uemura K, Sunagawa G, Tohyama T, Yoshida K, Kishi T, Sunagawa K, Tsutsui H. Prediction of haemodynamics after interatrial shunt for heart failure using the generalized circulatory equilibrium. ESC Heart Fail. 2020 Oct;7(5):3075-3085.
  15. Kakino T, Saku K, Nishikawa T, Sunagawa K. The partial support of the left ventricular assist device shifts the systemic cardiac output curve upward in proportion to the effective left ventricular ejection fraction in pressure-volume loop. Front Cardiovasc Med. 2020 Sep 15;7:163.
  16. Uemura K, Nishikawa T, Kawada T, Sugimachi T. Comprehensive Analysis of Effective Reflection Distance and Its Association With Wave Reflection Strength Under Diverse Hemodynamic Conditions in Anesthetized Dogs. J Biomech. 2020 May 7;104:109753.
  17. Kawada T, Yamamoto H, Hayama Y, Nishikawa T, Tanaka K, Sugimachi M. Contrasting Open-Loop Dynamic Characteristics of Sympathetic and Vagal Systems During Baroreflex-Mediated Heart Rate Control in Rats. Am J Physiol Regul Integr Comp Physiol. 2019 Dec 1;317(6):R879-R890.
  18. Shinoda M, Saku K, Oga Y, Tohyama T, Nishikawa T, Abe K, Yoshida K, Kuwabara Y, Ishikita T, Fujii K, Kishi T, Sunagawa K, Tsutsui H. Suppressed baroreflex peripheral arc overwhelms augmented neural arc and incapacitates baroreflex function in pulmonary arterial hypertension rats. Exp Physiol. 2019 Aug:104 (8), 1164-1178
  19. Kawada T, Sonobe T, Hayama Y, Nishikawa T, Miyamoto T, Akiyama T, Pearson JT, Sugimachi M. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci. 2019 May;218:25-30.
  20. Sunagawa G, Saku K, Arimura T, Nishikawa T, Mannoji H, Kamada K, Abe K, Kishi T, Tsutsui H, Sunagawa K. Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption. J Cardiovasc Transl Res. 2019 Apr 27; 12 (2), 124-134
  21. Yamashita Y, Oishi Y, Motomatsu Y, Hirayama K, Harada T, Ushijima T, Fujita S, Kimura S, Sonoda H, Tatewaki H, Tanoue Y, Sunagawa G, Nishikawa T, Saku K, Shiose A. Thoracic endografting increases cardiac afterload and leads to left ventricular hypertrophy in dogs. Eur J Cardiothorac Surg. 2019 Apr 1;55(4):618-625.
  22. Mannoji H, Saku K, Nishikawa T, Tohyama T, Kamada K, Abe K, Sunagawa G, Kishi T, Sunagawa K, Tsutsui H. Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings. Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H828-H839.
  23. Kawada T, Shimizu S, Uemura K, Hayama Y, Yamamoto H, Shishido T, Nishikawa T, Sugimachi M. Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats. Physiol. Sci. 2019 Mar 69 (2), 211-222.
  24. Kawada T, Hayama Y, Nishikawa T, Yamamoto H, Tanaka K, Sugimachi M. Even weak vasoconstriction from rilmenidine can be unmasked in vivo by opening the baroreflex feedback loop. Life Sci. 2019 Feb 15;219:144-151.
  25. Kamada K, Saku K, Tohyama T, Kawada T, Mannoji H, Abe K, Nishikawa T, Sunagawa G, Kishi T, Sunagawa K, Tsutsui H. Diabetes mellitus attenuates the pressure response against hypotensive stress by impairing the sympathetic regulation of the baroreflex afferent arc. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H35-H44.
  26. Yoshida K, Saku K, Kamada K, Abe K, Tanaka-Ishikawa M, Tohyama T, Nishikawa T, Kishi T, Sunagawa K, Tsutsui H. Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension. JACC Basic Transl Sci. 2018 Nov 12;3(5):657-671.
  27. Nishikawa T, Saku K, Kishi T, Tohyama T, Abe K, Oga Y, Arimura T, Sakamoto T, Yoshida K, Sunagawa K, Tsutsui H. Pulmonary arterial input impedance reflects the mechanical properties of pulmonary arterial remodeling in rats with pulmonary hypertension. Life Sci. 2018 Nov 1;212:225-232.
  28. Oga Y, Saku K, Nishikawa T, Kishi T, Tobushi T, Hosokawa K, Tohyama T, Sakamoto T, Sunagawa K, Tsutsui H. The impact of volume loading-induced low pressure baroreflex activation on arterial baroreflex-controlled sympathetic arterial pressure regulation in normal rats. Physiol Rep. 2018 Sep;6(19):e13887.
  29. Saku K, Kakino T, Arimura T, Sunagawa G, Nishikawa T, Sakamoto T, Kishi T, Tsutsui H, Sunagawa K. Left ventricular mechanical unloading by total support of Impella in myocardial infarction strikingly reduces infarct size, preserves left ventricular function and prevents subsequent heart failure in dogs. Circ Heart Fail. 2018 May 8;11;e004397.
  30. Tohyama T, Saku K, Kawada T, Kishi T, Yoshida K, Nishikawa T, Mannoji H, Kamada K, Sunagawa K, Tsutsui H. Impact of lipopolysaccharide-induced acute inflammation on baroreflex-controlled sympathetic arterial pressure regulation. PLoS One. 2018 Jan 12;13(1):e0190830.
  31. Saku K, Tohyama T, Shinoda M, Kishi T, Hosokawa K, Nishikawa T, Oga Y, Sakamoto T, Tsutsui H, Miyamoto T, Sunagawa K. Central Chemoreflex Activation Induces Sympatho-excitation Without Altering Static or Dynamic Baroreflex Function in Normal Rats. Phisiol Rep. 2017.Sep;5(17). pii: e13406.
  32. Nishikawa T, Saku K, Todaka K, Kuwabara Y, Arai S, Kishi T, Ide T, Tsutsui H, Sunagawa K. The challenge of magnetic vagal nerve stimulation for myocardial infarction -preliminary clinical trial. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:4321-4324.
  33. Fujii K, Saku K, Kishi T, Oga Y, Tohyama T, Nishikawa T, Sakamoto T, Ikeda M, Ide T, Tsutsui H, Sunagawa K. Carotid Body Denervation Markedly Improves Survival in Rats With Hypertensive Heart Failure. Am J Hypertens. 2017 Apr 19. doi: 10.1093/ajh/hpx062.
  34. Arimura T, Saku K, Kakino T, Nishikawa T, Tohyama T, Sakamoto T, Sakamoto K, Kishi T, Ide T, Sunagawa K. Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure. Int J Cardiol. 2017 Jan 15;227:704-710.
  35. Saku K, Kakino T, Arimura T, Sakamoto T, Nishikawa T, Sakamoto K, Ikeda M, Kishi T, Ide T, Sunagawa K. Total Mechanical Unloading Minimizes Metabolic Demand of Left Ventricle and Dramatically Reduces Infarct Size in Myocardial Infarction. PLoS One. 2016 Apr 28;11(4):e0152911.

 

著書/総説

  1. 田伏 真理, 月村 英利子, 朔 啓太, 西川 拓也, 金川 武司, 吉松 淳. 心力学で紐解く妊娠の循環動態 ～正常妊娠と左心機能障害合併妊娠～/ 循環制御. 44(2): 87-94, 2023.
  2. 西川 拓也. 循環生理を理解し診療に活かそう！/ Heart View. 27(9), 2023.
  3. 朔 啓太*, 西川 拓也. PV loop の視点から考察する経皮的循環補助デバイスにおけるImpellaの立ち位置 / 循環制御. 40(2): 95-100, 2019.
  4. 朔 啓太*, 西川 拓也, 遠山 岳詩. ここまできた循環器領域の低侵襲治療 循環補助用心内留置型ポンプカテーテルImpellaのデバイス特性と循環器治療における有用性 / 内科. 122(2): 317-320, 2018.
受賞
  • 2022年度 電気情報通信学会 ヘルスケア・医療情報通信技術研究専門委員会　ヘルスケア・医療情報通信技術研究賞 優秀研究賞
  • 第41回日本循環制御医学会総会・学術集会　会長賞
  • MATLAB EXPO2021 Best Poster Award
  • 2019年　日本生体医工学会 研究奨励賞・阿部賞
  • European Society of Cardiology Congress 2016: Travel Grant Award
学位博士（医学）
所属学会

日本内科学会、日本循環器学会、日本集中治療学会、日本生体医工学会、日本生理学会、日本循環制御医学会、ヘルスケア・医療情報通信技術研究専門委員会（MICT）

教育活動 
その他の活動

日本医療研究開発機構 科学技術調査員
日本生体医工学会 編集委員
日本生体医工学会 若手研究者活動ワーキンググループ
電子情報通信学会 ヘルスケア・医療情報通信技術研究専門委員会 専門委員
循環動態アカデミー　幹事

研究者情報

Research map ID; https://researchmap.jp/0543513

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最終更新日：2024年05月30日

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