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循環動態制御部

スタッフ
川田 徹

スタッフ紹介 [川田 徹]

氏名川田 徹NoPhoto
よみかわだ とおる
所属・職務循環動態制御部 循環制御研究室長
内線番号41026
FAX番号06-6170-1752
Eメールtorukawa@ncvc.go.jp     @は半角にしてください。
棟/部屋番号研究棟4階 40206
専門自律神経系による循環調節系のシステム解析と循環器疾患の病態解明
主要論文・著書論文
  • Kawada T, Yokoi A, Nishiura A, Kakuuchi M, Li M, Uemura K, Suehara S, Sawada S, Saku K. Impact of neurally mediated antidiuretic effect relative to pressure diuresis during acute changes in sympathetic nerve activity. Am J Physiol Integr Comp Physiol 2023;324(1):R82-R89. doi: 10.1152/ajpregu.00205.2022.
  • Kawada T, Miyamoto T, Mukkamala R, Saku K. Linear and nonlinear identification of the carotid sinus baroreflex in the very low-frequency range. Physiol Rep. 2022;10(14):e15392. doi: 10.14814/phy2.15392.
  • Li M, Zheng C, Kawada T, Uemura K, Inagaki M, Saku K, Sugimachi M. Early donepezil monotherapy or combination with metoprolol significantly prevents subsequent chronic heart failure in rats with reperfused myocardial infarction. J Physiol Sci. 2022;72(1):12. doi: 10.1186/s12576-022-00836-2.
  • Kawada T, Li M, Suehara S, Sawada S, Zheng C, Uemura K, Sugimachi M, Saku K. Angiotensin II inhibition increases diuresis during acute sympathetic activation in intact and denervated kidneys in rats with chronic myocardial infarction. Heart Vessesls. 2022;37(9):1636-1646. doi: 10.1007/s00380-022-02110-2.
  • Kawada T, Nishikawa T, Hayama Y, Li M, Zheng C, Uemura K, Saku K, Miyamoto T, Sugimachi M. Quantitative assessment of the central versus peripheral effect of intravenous clonidine using baroreflex equilibrium diagrams. J Physiol Sci. 2021;71(1):39. doi: 10.1186/s12576-021-00824-y.
  • Kawada T, Yamamoto H, Miyamoto T, Hayama Y, Li M, Zheng C, Uemura K, Sugimachi M, Saku K. Ivabradine increases the high frequency gain ratio in the vagal heart rate transfer function via an interaction with muscarinic potassium channels. Physiol Rep. 2021;9(23):e15134. doi: 10.14814/phy2.15134.
  • Kawada T, Saku K, Miyamoto T. Closed-loop identification of baroreflex properties in the frequency domain. Front Neurosci 2021;15:694512. doi: 10.3389/fnins.2021.694512.
  • Kawada T, Yamamoto H, Uemura K, Hayama Y, Nishikawa T, Zheng C, Li M, Miyamoto T, Sugimachi M. Ivabradine augments high-frequency dynamic gain of the heart rate response to low- and moderate-intensity vagal nerve stimulation under β-blockade. Am J Physiol Heart Circ Physiol 2021;320(6):H2201-H2210. doi: 10.1152/ajpheart.00057.2021.
  • Kawada T, Nishikawa T, Suehara S, Sawada S, Tanaka T, Uenohara M, Yamamoto H, Sugimachi M. Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation. J Physiol Sci 2021;71(1):13. doi: 10.1186/s12576-021-00798-x.
  • Kawada T, Sonobe T, Nishikawa T, Hayama Y, Li M, Zheng C, Uemura K, Akiyama T, Pearson JT, Sugimachi M. Contribution of afferent pathway to vagal nerve stimulation-induced myocardial interstitial acetylcholine release. Am J Physiol Regul Integr Comp Physiol 2020;319(5):R517-R525. doi: 10.1152/ajpregu.00080.2020.
  • Kawada T, Hayama Y, Nishikawa T, Suehara S, Sawada S, Tanaka T, Uenohara M, Sugimachi M. Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in rats: effect of renal denervation. J Physiol Sci. 2020;70(1):32. doi: 10.1186/s12576-020-00759-w.
  • Kawada T, Sata Y, Akiyama T, Shimizu S, Sonobe T, Pearson JT, Sugimachi M. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 2020;102657. doi: 10.1016/j.autneu.2020.102657.
  • Nakahara H, Kawada T, Ueda SY, Kawai E, Yamamoto H, Sugimachi M, Miyamoto T. Acupoint dependence of depressor and bradycardic responses elicited by manual acupuncture stimulation in humans. J Physiol Sci. 2019;69(6):1077-1084. doi: 10.1007/s12576-019-00728-y.
  • Kawada T, Yamamoto H, Hayama Y, Nishikawa T, Tanaka K, Sugimachi M. Contrasting open-loop dynamic characteristics of sympathetic and vagal systems during baroreflex-mediated heart rate control in rats. Am J Physiol Regul Integr Comp Physiol. 2019;317(6):R879-R890. doi: 10.1152/ajpregu.00231.2019.
  • Kawada T, Yamamoto H, Uemura K, Hayama Y, Nishikawa T, Sugimachi M. Intravenous ivabradine augments the dynamic heart rate response to moderate vagal nerve stimulation in anesthetized rats. Am J Physiol Heart Circ Physiol. 2019;317(3):H597-H606. doi: 10.1152/ajpheart.00288.2019.
  • Kawada T, Mukkamala R, Sugimachi M. Linear and nonlinear analysis of the carotid sinus baroreflex dynamic characteristics. ABE. 2019;8:110-123. doi: 10.14326/abe.8.110. (invited review).
  • Kawada T, Sonobe T, Hayama Y, Nishikawa T, Miyamoto T, Akiyama T, Pearson JT, Sugimachi M. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci. 2019;218:25-30. doi: 10.1016/j.autneu.2019.02.005.
  • Yamamoto H, Kawada T, Shimizu S, Hayama Y, Shishido T, Iwanaga Y, Fukuda K, Miyazaki S, Sugimachi M. Acute effects of intravenous carvedilol versus metoprolol on baroreflex-mediated sympathetic circulatory regulation in rats. Int J Cardiol. 2019;285:65-71. doi: 10.1016/j.ijcard.2019.02.062.
  • Kawada T, Hayama Y, Nishikawa T, Yamamoto H, Tanaka K, Sugimachi M. Even weak vasoconstriction from rilmenidine can be unmasked in vivo by opening the baroreflex feedback loop. Life Sci. 2019;219:144-151. doi: 10.1016/j.lfs.2019.01.009.
  • Kawada T, Yamazaki T, Akiyama T, Hayama Y, Sugimachi M. Mild Hypothermia Is Ineffective to Protect Against Myocardial Injury Induced by Chemical Anoxia or Forced Calcium Overload. J Cardiovasc Pharmacol. 2019;73(2):100-104. doi: 10.1097/FJC.0000000000000639.
  • Kawada T, Akiyama T, Sonobe T, Shimizu S, Hayama Y, Pearson JT, Shishido T, Sugimachi M. Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci. 2019;216:39-45. doi: 10.1016/j.autneu.2018.09.001.
  • Kawada T, Shimizu S, Uemura K, Hayama Y, Yamamoto H, Shishido T, Nishikawa T, Sugimachi M. Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats. J Physiol Sci. 2019;69(2):211-222. doi: 10.1007/s12576-018-0636-2.
  • Uemura K, Kawada T, Sugimachi M. A Novel Minimally Occlusive Cuff Method Utilizing Ultrasound Vascular Imaging for Stress-Free Blood Pressure Measurement: A-Proof-of-Concept Study. IEEE Trans Biomed Eng. 2019;66(4):934-945. doi: 10.1109/TBME.2018.2865556.
  • Uemura K, Kawada T, Zheng C, Li M, Sugimachi M. Low-Dose Landiolol Reduces Heart Rate and Cardiac Oxygen Consumption Without Compromising Initial Hemodynamic Resuscitation in a Canine Model of Endotoxin Shock. Shock. 2019;52(1):102-110. doi: 10.1097/SHK.0000000000001224.
  • Fukumitsu M, Kawada T, Shimizu S, Sugimachi M. The pulsatile component of left atrial pressure has little effect on pulmonary artery impedance estimation in normal rats. Physiol Rep. 2018;6(24):e13946. doi: 10.14814/phy2.13946.
  • Kawada T, Shimizu S, Hayama Y, Yamamoto H, Saku K, Shishido T, Sugimachi M. Derangement of open-loop static and dynamic characteristics of the carotid sinus baroreflex in streptozotocin-induced type 1 diabetic rats. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R553-R567. doi: 10.1152/ajpregu.00092.2018.
  • Yamamoto H, Kawada T, Shimizu S, Uemura K, Inagaki M, Kakehi K, Iwanaga Y, Fukuda K, Miyamoto T, Miyazaki S, Sugimachi M. Ivabradine does not acutely affect open-loop baroreflex static characteristics and spares sympathetic heart rate control in rats. Int J Cardiol. 2018;257:255-261. doi: 10.1016/j.ijcard.2017.11.115.
  • Kawada T, Turner MJ, Shimizu S, Kamiya A, Shishido T, Sugimachi M. Tonic aortic depressor nerve stimulation does not impede baroreflex dynamic characteristics concomitantly mediated by the stimulated nerve. Am J Physiol Regul Integr Comp Physiol. 2018;314(3):R459-R467. doi: 10.1152/ajpregu.00328.2017.

著書

  • 心不全における動脈圧反射性交感神経調節の破綻-システム生理学的アプローチによる評価. 川田 徹, 杉町 勝.「別冊・医学のあゆみ 自律神経による調節とその破綻」熊谷裕生 編, 114-122ページ, 医歯薬出版株式会社, 東京, 2013.
  • 圧受容器反射. 川田 徹. 「高血圧ナビゲーター第3版」 熊谷裕生, 小室一成, 堀内正嗣, 森下竜一 編, 128-129ページ, メディカルレビュー社, 東京, 2011.
  • 交感神経系の循環制御系への関与. 川田 徹, 杉町 勝. 「新・心臓病診療プラクティス11, 高血圧を識る・個別診療に活かす」 苅尾七臣, 島田和幸 編, 27-32ページ, 文光堂, 東京, 2008.
  • 心機能の神経性調節機序. 川田 徹, 砂川賢二. 「新・心臓病診療プラクティス3, 心機能を識る」 松﨑益德, 本郷 実 編, 54-61ページ, 文光堂, 東京, 2004.
  • 心臓血管系の調節. 川田 徹, 佐藤隆幸, 宍戸稔聡, 宮野博史, 砂川賢二(著者五十音順). 「心臓力学とエナジェティクス」 菅 弘之, 高木 都, 後藤葉一, 砂川賢二 編著, 日本エム・イー学会編, 127-140ページ, コロナ社, 東京, 2000.
  • 神経性循環調節のシステム解析. 細見 弘, 川田 徹, 藤木通弘. 「心臓の適応と制御」 菅 弘之, 堀 正二 編, 146-157ページ, 朝倉書店, 東京, 1992.
受賞

第2回日本生理学会奨励賞
平成22年度日本生理学会入澤宏・彩記念JPS心臓・循環論文賞

学位博士(医学)
所属学会日本循環器学会、日本生理学会、日本生体医工学会、日本循環制御医学会、アメリカ心臓学会、アメリカ生理学会
教育活動 
その他の活動

Journal of Physiological Sciences (JPS)編集委員
Advanced Biomedical Engineering (ABE)編集委員
循環制御編集委員

研究者情報 
リンク 

最終更新日:2023年01月10日

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