心臓生理機能部
業績
2019~2020年の業績
- Sukumaran V, H Tsuchimochi, T Sonobe, MT Waddingham, M Shirai, JT Pearson. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 19:24, 2020.
- Kawada T, Y Sata, T Akiyama, S Shimizu, T Sonobe, JT Pearson, M Sugimachi. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 225:102657, 2020.
- Sonobe T, CK Du, T Akiyama, JT Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological Reports 7(22):e14297, 2019.
- Kakehi K, Y Iwanaga, H Watanabe, T Sonobe, T Akiyama, S Shimizu, H Yamamoto, S Miyazaki. Modulation of sympathetic activity and innervation with chronic ivabradine and β-blocker therapies: Analysis of hypertensive rats with heart failure. J Cardiovasc Pharmacol Ther. 24(4):387-396.
- Yoshimoto M, Y Onishi, N Mineyama, S Ikegame, M Shirai, JW Osborn, K Miki. Renal and lumbar sympathetic nerve activity during development of hypertension in Dahl salt-sensitive rats. Hypertension 74:888-895, 2019.
- Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Central activation of cardiac vagal nerve by α2-adrenergic stimulation in impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci 216:39-45, 2019.
- Wilmanns, J.C., R. Pandey, O. Hon, A. Chandran, J.M. Schilling, E. Forte, Q. Wu, G. Cagnone, P. Bais, V. Phillip, D. Coleman, H. Kocalis, S.K. Archer, J.T. Pearson, M. Ramialison, J. Heineke, H.H. Patel, N.A. Rosenthal, M.B. Furtado, M.W. Costa. Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism. 20:102-114, 2019.
- Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci.218:25-30, 2019.
- Sukumaran, V., H. Tsuchimochi, T. Sonobe, M. Shirai, J.T. Pearson. Liraglutide improves renal endothelial function in obese Zucker rats on a high salt diet. J Pharmacol Exp Ther 369(3):375-388, 2019.
- Bui CB, M Kolodziej, E Lamanna, K Elgass, A Sehgal, I Rudloff, DO Schwenke, H Tsuchimochi, MAGM Kroon, SX Cho, A Maksimenko, M Cholewa, PJ Berger, MJ Young, JE Bourke, JT Pearson, MF Nold, CA Nold-Petry. Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension. Front Immunol 10:1480, 2019.
- Nagano K, C Kwon, J Ishida, T Hashimoto, JD Kim, N Kisikawa, M Murao, K Kimura, Y Kasuya, S Kimura, YC Chen, H Tsuchimochi, M Shirai, JT Pearson, A Fukamizu. Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem 166(5):283-392, 2019.
- Waddingham MT, T. Sonobe, H. Tsuchimochi, A.J. Edgley, V. Sukumaran, Y-C Chen, S.S. Hansra, D.O. Schwenke, K. Umetani, K. Aoyama, N. Yagi, D.J. Kelly, S. Gaderi, M. Herwig, D. Kolijn, A. Mügge, W.J. Paulus, T. Ogo, M. Shirai, N. Hamdani, J.T. Pearson. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J. Mole. Cell Cardiol. 137:119-131, 2019.
- Pearson JT, M Shirai, V Sukumaran, CK Du, H Tsuchimochi, T Sonobe, MT Waddingham, R Katare, DO Schwenke. Ghrelin and vascular protection. Vascular Biology 1:H97-H102, 2019.
- Honda M, H Tsuchimochi, K Hitachi, S Ohno. Transcriptional cofactor Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload. J Cell Physiol. 234(9):15809-15824, 2019.
2018年の業績
- Pearson, J.T., N. Collie, R.R. Lamberts, T. Inagaki, M. Yoshimoto, K. Umetani, P. Davis, G. Wilkins, P.P. Jones, M. Shirai, D.O. Schwenke. Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology 159(4):1763-1773, 2018.
- Khan, Z., J.P. Ngo, B. Le, R.G. Evans, J.T. Pearson, B. Gardiner, D.Smith. Three-dimensional morphometric analysis of the renal vasculature. Am J Physiol Renal Physiol 314(5):F715-F725, 2018.
- Katayama, K., T. Sakamoto, K. Saito, H. Tsuchimochi, H. Kaiya, T. Watanabe, J.T. Pearson, Y. Takei. Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization. Sci. Rep. 8(1):625, 2018.
- Katare, R., J.T. Pearson, J.K.S. Lew, M. Wei, H. Tsuchimochi, C.K. Du, D.Y. Zhan, K. Umetani, M. Shirai, D.O. Schwenke. Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Front. Physiol. 9:696, 2018.
- Sukumaran, V., H. Tsuchimochi, Y. Fujii, H. Hosoda, K. Kangawa, T. Akiyama, M. Shirai, J.T. Pearson. Ghrelin pre-treatment attenuates local oxidative stress and end-organ damage during cardiopulmonary bypass in anesthetized rats. Front. Physiol. 9:196, 2018.
- Takeshita H, K. Yamamoto, S Nozato, M Takeda, SI Fukada, T Inagaki, H Tsuchimochi, M Shirai, Y Nozato, T Fujimoto, Y Imaizumi, S Yokoyama, M Nagasawa, G Hamano, K Hongyo, T Kawai, H Hanasaki-Yamamoto, S Takeda, T Takahashi, H Akasaka, N Itoh, Y Takami, Y Takeya, K Sugimoto, H Nakagami, H Rakugi. Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice. J Cachexia Sarcopenia Muscle 9:975-986, 2018.
2017年の業績
- Lang J.A., Pearson, J.T., Binder-Heschl, C., Wallace, M.J., Siew ML, Kitchen, M.J., te Pas, A.B., Fouras, A., Lewis, R.A., Polglase, G.R., Shirai, M. & Hooper, S.B. Vagal denervation inhibits the increase in pulmonary blood flow during partial aeration without oxygen at birth. J. Physiol. 595(5):1593-1606, 2017.
- Du, C.K., D.Y. Zhan, T. Akiyama, T. Inagaki, T. Shishido, M. Shirai, J.T. Pearson. Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 312(1):H60-H67, 2017.
- Furtado, M.B., J.C. Wilmanns, A. Chandran, J. Perera, O. Hon, C. Biben, T.J. Willow, H.T. Nim, G. Kaur, S. Simonds, Q. Wu, D. Willians, E. Salimova, N. Plachta, J.M. Denegre, S.A. Murray, D. Fatkin, M. Cowley, J.T. Pearson, D. Kaye, M. Ramialison, R.P. Harvey, N. A. Rosenthal, M.W. Costa. Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling. JCI Insight. 2(6):e88271, 2017.
- Alahmari, D.M., B. Skiold, S.K. Barton, I. Nitsos, C. McDonald, S.L. Miller, V. Zahra, R. Galinksy, Q. Wu, M. Farrell, T.J. Moss, S.B. Hooper, J.T. Pearson, G.R. Polglase. Diffusion tensor imaging colour mapping threshold for identification of ventilation-induced brain injury after intrauterine inflammation in preterm lambs. Frontiers Pediatr 5:70, 2017.
- Zhan, D.Y., C.K. Du, T. Akiyama, S. Morimoto, S. Shimizu, T. Kawada, M. Shirai, J.T. Pearson. Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation. Auton Neurosci pii:S1566-0702(16)30133-3, 2017.
- Gao, X.M., Q. Wu, H. Kiriazis, Y. Su, L.P. Han, J.T. Pearson, A. Taylor, X.J. Du. Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry and magnetic resonance imaging. Am J Physiol Heart Circ Physiol 312(5):H1068-H1075, 2017.
- Flemmer, A.W., M. Thio, M.J. Wallace, K. Lee, M.J. Kitchen, L. Kerr, C.C. Roehr, A. Fouras, R. Carnibella, J. Jani, P. DeKoninck, A.B. te Pas, J.T. Pearson, S.B. Hooper. Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion. Pediatric Res 82(3):536-543, 2017.
- Torii, M., T. Fukui, M. Inoue, S. Kanao, K. Umetani, M. Shirai, T. Inagaki, H. Tsuchimochi, J.T. Pearson, M. Toi. Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography. J Synchrotron Rad 24(5):1039-1047, 2017.
- Alahmari, D.M., S.K. Barton, R. Galinsky, I. Nitsos, A. Atik, M. Farrell, J.T. Pearson*, G.R. Polglase*. Correlation between diffusion tensor imaging and histological brain injury in ventilated preterm lambs. Imaging Med 9(3):67-76, 2017. *equal
- Sukumaran, V., H. Tsuchimochi, E. Tatsumi, M. Shirai, J.T. Pearson. Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade. Biochem. Pharmacol. 144:90-99, 2017.
- Ngo, J., B. Le, Z. Khan, M.M. Kett, B.S. Gardner, D.W. Smith, M.M. Melhem, A. Maksimenko, J.T. Pearson*, R.G. Evans*. Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: comparison with light microscopy. Clin Exper Pharmacol Physiol, 44(12):1241-1253, 2017. *equal
- Kainuma, S., S. Miyagawa, S Fukushima, H. Tsuchimochi, T. Sonobe, Y. Fujii, J.T. Pearson, A. Saito, A. Harada, K. Toda, M. Shirai, Y. Sawa. Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats. PLoS One 12(8):e0183323, 2017.
- Alahmari, D.M.*, K.Y.Y. Chan, V. Stojanovska, D. LaRosa, S.K. Barton, I. Nitsos, V. Zahra, J. Barbuto, M. Farrell, S. Yamaoka, S.B. Hooper, J.T. Pearson*, G.R. Polglase*. Diffusion tensor imaging detects ventilation-induced brain injury in preterm lambs. PLoS One 12(12):e0188737, 2017. *equal
- Pearson, J.T., M. Yoshimoto, Y.C. Chen, R. Sultani, A.J. Edgley, H. Nakaoka, M. Nishida, K. Umetani, M.T. Waddingham, H.L. Jin, Y. Zhang, D.J. Kelly, D.O. Schwenke, T. Inagaki, H. Tsuchimochi, I. Komuro, S. Yamashita, M. Shirai. Widespread coronary dysfunction in the absence of HDL Receptor SR-B1 in an ischemic cardiomyopathy mouse model. Sci. Rep. 7(1):18108, 2017.
- Kawada T, T Akiyama, S Shimizu, M Fukumitsu, A Kamiya, M Sugimachi. Desipramine increases cardiac parasympathetic activity via alpha(2)-adrenergic mechanism in rats. Autonomic Neuroscience-Basic & Clinical, 205: 21-25, 2017.
- Takeshita H, K Yamamoto, S Nozato, T Inagaki, H Tsuchimochi, M Shirai, R Yamamoto, Y Imaizumi, K Hongyo, S Yokoyama, M Takeda, R Oguro, Y Takami, N Itoh, Y Takeya, K Sugimoto, S Fukada, H Rakugi. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice. Scientific Reports, 7: 9, 2017.
- Hino J, M Nakatani, Y Arai, K Tsuchida, M Shirai, M Miyazato, K Kangawa. Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity. International Journal of Obesity, 41(4): 483-488, 2017.
- Neale J., J.T. Pearson, R. Katare, D.O. Schwenke. Ghrelin, microRNAs, and critical limb ischaemia: hungering for a novel treatment option. Frontiers in Endocrinology 8:350, 2017.
- Mochizuki, N., J.T. Pearson, S. Kitamura. Beyond proof of concepts for ideal cardiac regenerative therapy. J Thorac Cardiovasc Surg pii:S0022-5223(17)30915-7, 2017.
過去の業績
最終更新日:2021年10月01日