メニュー

  1. 国立循環器病研究センター 研究所 TOP
  2. 各部のご紹介
  3. 心臓生理機能部
  4. 業績

心臓生理機能部

業績

2019～2020年の業績

  1. Sukumaran V, H Tsuchimochi, T Sonobe, MT Waddingham, M Shirai, JT Pearson. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 19:24, 2020.
  2. Kawada T, Y Sata, T Akiyama, S Shimizu, T Sonobe, JT Pearson, M Sugimachi. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 225:102657, 2020.
  3. Sonobe T, CK Du, T Akiyama, JT Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological Reports 7(22):e14297, 2019.
  4. Kakehi K, Y Iwanaga, H Watanabe, T Sonobe, T Akiyama, S Shimizu, H Yamamoto, S Miyazaki. Modulation of sympathetic activity and innervation with chronic ivabradine and β-blocker therapies: Analysis of hypertensive rats with heart failure. J Cardiovasc Pharmacol Ther. 24(4):387-396.
  5. Yoshimoto M, Y Onishi, N Mineyama, S Ikegame, M Shirai, JW Osborn, K Miki. Renal and lumbar sympathetic nerve activity during development of hypertension in Dahl salt-sensitive rats. Hypertension 74:888-895, 2019.
  6. Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Central activation of cardiac vagal nerve by α2-adrenergic stimulation in impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci 216:39-45, 2019.
  7. Wilmanns, J.C., R. Pandey, O. Hon, A. Chandran, J.M. Schilling, E. Forte, Q. Wu, G. Cagnone, P. Bais, V. Phillip, D. Coleman, H. Kocalis, S.K. Archer, J.T. Pearson, M. Ramialison, J. Heineke, H.H. Patel, N.A. Rosenthal, M.B. Furtado, M.W. Costa. Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism. 20:102-114, 2019.
  8. Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci.218:25-30, 2019.
  9. Sukumaran, V., H. Tsuchimochi, T. Sonobe, M. Shirai, J.T. Pearson. Liraglutide improves renal endothelial function in obese Zucker rats on a high salt diet. J Pharmacol Exp Ther 369(3):375-388, 2019.
  10. Bui CB, M Kolodziej, E Lamanna, K Elgass, A Sehgal, I Rudloff, DO Schwenke, H Tsuchimochi, MAGM Kroon, SX Cho, A Maksimenko, M Cholewa, PJ Berger, MJ Young, JE Bourke, JT Pearson, MF Nold, CA Nold-Petry. Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension. Front Immunol 10:1480, 2019.
  11. Nagano K, C Kwon, J Ishida, T Hashimoto, JD Kim, N Kisikawa, M Murao, K Kimura, Y Kasuya, S Kimura, YC Chen, H Tsuchimochi, M Shirai, JT Pearson, A Fukamizu. Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem 166(5):283-392, 2019.
  12. Waddingham MT, T. Sonobe, H. Tsuchimochi, A.J. Edgley, V. Sukumaran, Y-C Chen, S.S. Hansra, D.O. Schwenke, K. Umetani, K. Aoyama, N. Yagi, D.J. Kelly, S. Gaderi, M. Herwig, D. Kolijn, A. Mügge, W.J. Paulus, T. Ogo, M. Shirai, N. Hamdani, J.T. Pearson. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J. Mole. Cell Cardiol. 137:119-131, 2019.
  13. Pearson JT, M Shirai, V Sukumaran, CK Du, H Tsuchimochi, T Sonobe, MT Waddingham, R Katare, DO Schwenke. Ghrelin and vascular protection. Vascular Biology 1:H97-H102, 2019.
  14. Honda M, H Tsuchimochi, K Hitachi, S Ohno. Transcriptional cofactor Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload. J Cell Physiol. 234(9):15809-15824, 2019.

2018年の業績

  1. Pearson, J.T., N. Collie, R.R. Lamberts, T. Inagaki, M. Yoshimoto, K. Umetani, P. Davis, G. Wilkins, P.P. Jones, M. Shirai, D.O. Schwenke. Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology 159(4):1763-1773, 2018.
  2. Khan, Z., J.P. Ngo, B. Le, R.G. Evans, J.T. Pearson, B. Gardiner, D.Smith. Three-dimensional morphometric analysis of the renal vasculature. Am J Physiol Renal Physiol 314(5):F715-F725, 2018.
  3. Katayama, K., T. Sakamoto, K. Saito, H. Tsuchimochi, H. Kaiya, T. Watanabe, J.T. Pearson, Y. Takei. Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization. Sci. Rep. 8(1):625, 2018.
  4. Katare, R., J.T. Pearson, J.K.S. Lew, M. Wei, H. Tsuchimochi, C.K. Du, D.Y. Zhan, K. Umetani, M. Shirai, D.O. Schwenke. Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Front. Physiol. 9:696, 2018.
  5. Sukumaran, V., H. Tsuchimochi, Y. Fujii, H. Hosoda, K. Kangawa, T. Akiyama, M. Shirai, J.T. Pearson. Ghrelin pre-treatment attenuates local oxidative stress and end-organ damage during cardiopulmonary bypass in anesthetized rats. Front. Physiol. 9:196, 2018.
  6. Takeshita H, K. Yamamoto, S Nozato, M Takeda, SI Fukada, T Inagaki, H Tsuchimochi, M Shirai, Y Nozato, T Fujimoto, Y Imaizumi, S Yokoyama, M Nagasawa, G Hamano, K Hongyo, T Kawai, H Hanasaki-Yamamoto, S Takeda, T Takahashi, H Akasaka, N Itoh, Y Takami, Y Takeya, K Sugimoto, H Nakagami, H Rakugi. Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice. J Cachexia Sarcopenia Muscle 9:975-986, 2018.

2017年の業績

  1. Lang J.A., Pearson, J.T., Binder-Heschl, C., Wallace, M.J., Siew ML, Kitchen, M.J., te Pas, A.B., Fouras, A., Lewis, R.A., Polglase, G.R., Shirai, M. & Hooper, S.B. Vagal denervation inhibits the increase in pulmonary blood flow during partial aeration without oxygen at birth. J. Physiol. 595(5):1593-1606, 2017.
  2. Du, C.K., D.Y. Zhan, T. Akiyama, T. Inagaki, T. Shishido, M. Shirai, J.T. Pearson. Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 312(1):H60-H67, 2017.
  3. Furtado, M.B., J.C. Wilmanns, A. Chandran, J. Perera, O. Hon, C. Biben, T.J. Willow, H.T. Nim, G. Kaur, S. Simonds, Q. Wu, D. Willians, E. Salimova, N. Plachta, J.M. Denegre, S.A. Murray, D. Fatkin, M. Cowley, J.T. Pearson, D. Kaye, M. Ramialison, R.P. Harvey, N. A. Rosenthal, M.W. Costa. Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling. JCI Insight. 2(6):e88271, 2017.
  4. Alahmari, D.M., B. Skiold, S.K. Barton, I. Nitsos, C. McDonald, S.L. Miller, V. Zahra, R. Galinksy, Q. Wu, M. Farrell, T.J. Moss, S.B. Hooper, J.T. Pearson, G.R. Polglase. Diffusion tensor imaging colour mapping threshold for identification of ventilation-induced brain injury after intrauterine inflammation in preterm lambs. Frontiers Pediatr 5:70, 2017.
  5. Zhan, D.Y., C.K. Du, T. Akiyama, S. Morimoto, S. Shimizu, T. Kawada, M. Shirai, J.T. Pearson. Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation. Auton Neurosci pii:S1566-0702(16)30133-3, 2017.
  6. Gao, X.M., Q. Wu, H. Kiriazis, Y. Su, L.P. Han, J.T. Pearson, A. Taylor, X.J. Du. Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry and magnetic resonance imaging. Am J Physiol Heart Circ Physiol 312(5):H1068-H1075, 2017.
  7. Flemmer, A.W., M. Thio, M.J. Wallace, K. Lee, M.J. Kitchen, L. Kerr, C.C. Roehr, A. Fouras, R. Carnibella, J. Jani, P. DeKoninck, A.B. te Pas, J.T. Pearson, S.B. Hooper. Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion. Pediatric Res 82(3):536-543, 2017.
  8. Torii, M., T. Fukui, M. Inoue, S. Kanao, K. Umetani, M. Shirai, T. Inagaki, H. Tsuchimochi, J.T. Pearson, M. Toi. Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography. J Synchrotron Rad 24(5):1039-1047, 2017.
  9. Alahmari, D.M., S.K. Barton, R. Galinsky, I. Nitsos, A. Atik, M. Farrell, J.T. Pearson*, G.R. Polglase*. Correlation between diffusion tensor imaging and histological brain injury in ventilated preterm lambs. Imaging Med 9(3):67-76, 2017. *equal
  10. Sukumaran, V., H. Tsuchimochi, E. Tatsumi, M. Shirai, J.T. Pearson. Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade. Biochem. Pharmacol. 144:90-99, 2017.
  11. Ngo, J., B. Le, Z. Khan, M.M. Kett, B.S. Gardner, D.W. Smith, M.M. Melhem, A. Maksimenko, J.T. Pearson*, R.G. Evans*. Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: comparison with light microscopy. Clin Exper Pharmacol Physiol, 44(12):1241-1253, 2017. *equal
  12. Kainuma, S., S. Miyagawa, S Fukushima, H. Tsuchimochi, T. Sonobe, Y. Fujii, J.T. Pearson, A. Saito, A. Harada, K. Toda, M. Shirai, Y. Sawa. Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats. PLoS One 12(8):e0183323, 2017.
  13. Alahmari, D.M.*, K.Y.Y. Chan, V. Stojanovska, D. LaRosa, S.K. Barton, I. Nitsos, V. Zahra, J. Barbuto, M. Farrell, S. Yamaoka, S.B. Hooper, J.T. Pearson*, G.R. Polglase*. Diffusion tensor imaging detects ventilation-induced brain injury in preterm lambs. PLoS One 12(12):e0188737, 2017. *equal
  14. Pearson, J.T., M. Yoshimoto, Y.C. Chen, R. Sultani, A.J. Edgley, H. Nakaoka, M. Nishida, K. Umetani, M.T. Waddingham, H.L. Jin, Y. Zhang, D.J. Kelly, D.O. Schwenke, T. Inagaki, H. Tsuchimochi, I. Komuro, S. Yamashita, M. Shirai. Widespread coronary dysfunction in the absence of HDL Receptor SR-B1 in an ischemic cardiomyopathy mouse model. Sci. Rep. 7(1):18108, 2017.
  15. Kawada T, T Akiyama, S Shimizu, M Fukumitsu, A Kamiya, M Sugimachi. Desipramine increases cardiac parasympathetic activity via alpha(2)-adrenergic mechanism in rats. Autonomic Neuroscience-Basic & Clinical, 205: 21-25, 2017.
  16. Takeshita H, K Yamamoto, S Nozato, T Inagaki, H Tsuchimochi, M Shirai, R Yamamoto, Y Imaizumi, K Hongyo, S Yokoyama, M Takeda, R Oguro, Y Takami, N Itoh, Y Takeya, K Sugimoto, S Fukada, H Rakugi. Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice. Scientific Reports, 7: 9, 2017.
  17. Hino J, M Nakatani, Y Arai, K Tsuchida, M Shirai, M Miyazato, K Kangawa. Overexpression of bone morphogenetic protein-3b (BMP-3b) in adipose tissues protects against high-fat diet-induced obesity. International Journal of Obesity, 41(4): 483-488, 2017.
  18. Neale J., J.T. Pearson, R. Katare, D.O. Schwenke. Ghrelin, microRNAs, and critical limb ischaemia: hungering for a novel treatment option. Frontiers in Endocrinology 8:350, 2017.
  19. Mochizuki, N., J.T. Pearson, S. Kitamura. Beyond proof of concepts for ideal cardiac regenerative therapy. J Thorac Cardiovasc Surg pii:S0022-5223(17)30915-7, 2017.

過去の業績

最終更新日：2021年10月01日

各部の紹介About

設定メニュー