2022年の業績

1. Stainsby AV, PLJ DeKoninck, KJ Crossley, A Thiel, MJ Wallace, JT Pearson, AJ Kashyap, MK Croughan, BA Allison, R Hodges, M Thio, AW Flemmer, AB te Pas, SB Hooper, EV McGillick, MJ Kitchen. Effect of prenatal diaphragmatic hernia on pulmonary arterial morphology. Anatomical Record. Accepted 19 Dec, 2022.
2. Lao JC, CB Bui, MA Pang, SX Cho, I Rudloff, K Elgass, J Schröder, A Maksimenko, NE Mangan, MR Starkey, EM Skuza, YBY Sun, F Beker, CL Collins, OF Kamlin, K König, A Malhotra, K Tan, C Theda, MJ Young, CA McLean, NJ Wilson, A Sehgal, PM Hansboro, JT Pearson, JM Polo, A Veldman, PJ Berger, CA Nold-Petry, MF Nold. Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants. Sci Transl Med 14:eaaz8454, 2022.
3. Tokudome T, K Otani, Y Mao, LL Jensen, Y Arai, T Miyazaki, T Sonobe, JT Pearson, T Osaki, N Minamino, J Ishida, A Fukamizu, H Kawakami, D Onozuka, K Nishimura, M Miyazato, H Nishimura. Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension 79(7):1409-1422, 2022.
4. Sonobe T, H Tsuchimochi, H Maeda, JT Pearson. Increased contribution of KCa channels to muscle contraction induced vascular and blood flow responses in sedentary and exercise trained ZFDM rats. J Physiol 600(12):2919-2938, 2022.
5. Martherus T, MK Croughan, KJ Crossley, MJ Wallace, EV McGillick, M Thio, CC Roehr, JT Pearson, K Lee, G Ruben, MJ Kitchen, AB te Pas, SB Hooper. Higher CPAP levels improve functional residual capacity at birth in preterm rabbits. Pedatric Res 91(7):1686-1694, 2022.
6. Sonobe T, T Akiyama, JT Pearson. Transporter-dependent uptake and metabolism of myocardial interstitial serotonin in the rat heart. J Physiol Sci 72(1);27, 2022.
7. Szulcek R, CN Johnson, JT Pearson, V Sequeira. Bridging techniques: Basic science of molecules, cellular systems, and whole-organ physiology. Frontiers in Physiology 13:879396, 2022.
8. Waddingham MT, H Tsuchimochi, T Sonobe, R Asano, H Jin, CPC Ow, DO Schwenke, R Katare, K Aoyama, K Umetani, M Hoshino, K Uesugi, M Shirai, T Ogo, JT Pearson. Using synchrotron radiation imaging techniques to elucidate the actions of hexarelin in the heart of small animal models. Front Physiol. 12;766818, 2022.
9. Noe KM, Ngo JP, MZL Zhu, A Martin, M Ollason, AD Cochrane, JA Smith, AG Thrift, RG Evans. Intraoperative renal hypoxia and risk of cardiac surgery-associated acute kidney injury. Clin Exper Pharmacol Physiol. 49(2);228-241, 2022.
10. Evans RG, AD Cochrane, SG Hood, N Iguchi, B Marino, R Bellomo, PR McCall, N Okazaki, JA Smith, MZ Zhu, JP Ngo, KM Noe, A Martin, AG Thrift, YR Lankadeva, CN May. Dynamic responses of renal oxygenation at the onset of cardiopulmonary bypass in sheep and man. Perfusion. 37(6);624-632, 2022.

2021年の業績

1. Pearson JT, HP Thambyah, MT Waddingham, T Inagaki, V Sukumaran, JP Ngo, CPC Ow, T Sonobe, YC Chen, AJ Edgley, Y Fujii, C-K Du, D-Y Zhan, K Umetani, DJ Kelly, H Tsuchimochi, M Shirai. Beta-blockade prevents coronary macro and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat. Clinical Sci. 135(2);327-346, 2021.
2. Sonobe T, T Akiyama, JT Pearson. Carrier-mediated serotonin efflux induced by pharmacological anoxia in the rat heart in vivo. Clin Exp Pharmacol Physiol. 48:1685-1692, 2021.
3. Inocencio I, NT Tran, S Nakamura, SJ Khor, M Wiersma, K Stoecker, A Maksimenko, GR Polglase, DW Walker, JT Pearson, FY Wong. Cerebral haemodynamic response to somatosensory stimulation in preterm and 7-10-day old term lambs: direct synchrotron microangiography assessment. J Cerebral Blood Flow Metab. 42(2):315-328, 2021.
4. Rabaglino MB, M. Wakabayashi, JT Pearson, LL Jensen. Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice. Mechanisms of Ageing and Development 200;111594, 2021.

5. Inagaki T, JT Pearson, H Tsuchimochi, DO Schwenke, S Saito, T Higuchi, T Masaki, K Umetani, M Shirai, Y Nakaoka. Evaluation of right coronary vascular dysfunction in severe pulmonary hypertensive rats using synchrotron radiation microangiography. Am J Physiol Heart Circ Physiol 320(3);H1021-H1036, 2021.
6. Pearson JT, HP Thambyah, MT Waddingham, T Inagaki, V Sukumaran, JP Ngo, CPC Ow, T Sonobe, YC Chen, AJ Edgley, Y Fujii, C-K Du, D-Y Zhan, K Umetani, DJ Kelly, H Tsuchimochi, M Shirai. Beta-blockade prevents coronary macro and microvascular dysfunction induced by a high salt diet and insulin resistance in the Goto-Kakizaki rat. Clinical Science 135(2);327-346, 2021.
7. Masaki T, M Okazawa, R Asano, T Inagaki, T Ishibashi, A Yamagishi, S Mizushima, M Nishimura, Y Manabe, H Ishibashi-Ueda, M Shirai, H Tsuchimochi, JT Pearson, A Kumanogoh, Y Sakata, T Ogo, T Kishimoto, Y Nakaoka. Aryl hydrocarbon receptor is essential for the pathogenesis of pulmonary arterial hypertension. Proc Natl Acad Sci USA 118(11);e2023899118, 2021.
8. Saw EL, JT Pearson, DO Schwenke, PE Munasinghe, H Tsuchimochi, S Rawai, S Coffey, P Davis, R Bunton, I Van-Hout, Y Kai, MJA Williams, Y Kakinuma, M Fronius, R Katare. Activation of the cardiac non-neuronal cholinergic system prevents the development of diabetes-associated cardiovascular complications. Cardiovasc Diabetol 20;50, 2021.
9. Sonobe T, T Akiyama, JT Pearson. Carrier-mediated serotonin efflux induced by pharmacological anoxia in the rat heart in vivo. Clin Exper Pharmacol Physiol 48;1685-1692, 2021.
10. Abe I, T Terabayashi, K Hanada, H Kondo, Y Teshima, Y Ishii, M Miyoshi, S Kira, S Saito, H Tsuchimochi, M Shirai, K Yufu, M Arakane, T Daa, D Thumkeo, S Narumiya, N Takahashi, T Ishizaki. Disruption of actin dynamics regulated by Rho effector mDia1 attenuates pressure overload-induced cardiac hypertrophic responses and exacerbates dysfunction. Cardiovasc Res. 117;1103-1117, 2021.
11. Ngo JP, KM Noe, A Martin, MZL Zhu, AD Cochrane, JA Smith, AG Thrift, RG Evans. Intra-operative and early post-operative prediction of cardiac surgery-associated acute kidney injury: Urinary oxygen tension compared with plasma and urianary biomarkers. J Cardiac Surgery. 36;3577-3585, 2021.
12. Ow CPC, A Trask-Marino, A Betrie, RG Evans, CN May, YR Lankadeva. Targeting oxidative stress in septic acute kidney injury: from theory to practice. J Clin Med. 10(17);3798, 2021.
13. Matsumura T, H Hashimoto, M Sekimizu, AM Saito, Y Iwata, M Asakura, K Kimura, T Tamura, M Funato, K Segawa, K Ogata, T Nakajima. Study protocol for a multicenter, open-label, single-arm study of tranilast for cardiomyopathy of muscular dystrophy. Kurume Med J. 66;121-126, 2021.

2019～2020年の業績

1. Sukumaran V, H Tsuchimochi, T Sonobe, MT Waddingham, M Shirai, JT Pearson. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 19:24, 2020.
2. Kawada T, Y Sata, T Akiyama, S Shimizu, T Sonobe, JT Pearson, M Sugimachi. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 225:102657, 2020.
3. Sonobe T, CK Du, T Akiyama, JT Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological Reports 7(22):e14297, 2019.
4. Kakehi K, Y Iwanaga, H Watanabe, T Sonobe, T Akiyama, S Shimizu, H Yamamoto, S Miyazaki. Modulation of sympathetic activity and innervation with chronic ivabradine and β-blocker therapies: Analysis of hypertensive rats with heart failure. J Cardiovasc Pharmacol Ther. 24(4):387-396, 2019.
5. Yoshimoto M, Y Onishi, N Mineyama, S Ikegame, M Shirai, JW Osborn, K Miki. Renal and lumbar sympathetic nerve activity during development of hypertension in Dahl salt-sensitive rats. Hypertension 74:888-895, 2019.
6. Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Central activation of cardiac vagal nerve by α₂-adrenergic stimulation in impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci 216:39-45, 2019.
7. Wilmanns JC, R Pandey, O Hon, A Chandran, JM Schilling, E Forte, Q Wu, G Cagnone, P Bais, V Phillip, D Coleman, H Kocalis, SK Archer, JT Pearson, M Ramialison, J Heineke, HH Patel, NA Rosenthal, MB Furtado, MW Costa. Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism. 20:102-114, 2019.
8. Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci.218:25-30, 2019.
9. Sukumaran V, H Tsuchimochi, T Sonobe, M Shirai, JT Pearson. Liraglutide improves renal endothelial function in obese Zucker rats on a high salt diet. J Pharmacol Exp Ther 369(3):375-388, 2019.
10. Bui CB, M Kolodziej, E Lamanna, K Elgass, A Sehgal, I Rudloff, DO Schwenke, H Tsuchimochi, MAGM Kroon, SX Cho, A Maksimenko, M Cholewa, PJ Berger, MJ Young, JE Bourke, JT Pearson, MF Nold, CA Nold-Petry. Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension. Front Immunol 10:1480, 2019.
11. Nagano K, C Kwon, J Ishida, T Hashimoto, JD Kim, N Kisikawa, M Murao, K Kimura, Y Kasuya, S Kimura, YC Chen, H Tsuchimochi, M Shirai, JT Pearson, A Fukamizu. Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem 166(5):283-392, 2019.
12. Waddingham MT, T. Sonobe, H. Tsuchimochi, A.J. Edgley, V. Sukumaran, Y-C Chen, S.S. Hansra, D.O. Schwenke, K. Umetani, K. Aoyama, N. Yagi, D.J. Kelly, S. Gaderi, M. Herwig, D. Kolijn, A. Mügge, W.J. Paulus, T. Ogo, M. Shirai, N. Hamdani, J.T. Pearson. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J. Mole. Cell Cardiol. 137:119-131, 2019.
13. Pearson JT, M Shirai, V Sukumaran, CK Du, H Tsuchimochi, T Sonobe, MT Waddingham, R Katare, DO Schwenke. Ghrelin and vascular protection. Vascular Biology 1:H97-H102, 2019.
14. Honda M, H Tsuchimochi, K Hitachi, S Ohno. Transcriptional cofactor Vgll2 is required for functional adaptations of skeletal muscle induced by chronic overload. J Cell Physiol. 234(9):15809-15824, 2019.

2018年の業績

1. Pearson, J.T., N. Collie, R.R. Lamberts, T. Inagaki, M. Yoshimoto, K. Umetani, P. Davis, G. Wilkins, P.P. Jones, M. Shirai, D.O. Schwenke. Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology 159(4):1763-1773, 2018.
2. Khan, Z., J.P. Ngo, B. Le, R.G. Evans, J.T. Pearson, B. Gardiner, D.Smith. Three-dimensional morphometric analysis of the renal vasculature. Am J Physiol Renal Physiol 314(5):F715-F725, 2018.
3. Katayama, K., T. Sakamoto, K. Saito, H. Tsuchimochi, H. Kaiya, T. Watanabe, J.T. Pearson, Y. Takei. Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization. Sci. Rep. 8(1):625, 2018.
4. Katare, R., J.T. Pearson, J.K.S. Lew, M. Wei, H. Tsuchimochi, C.K. Du, D.Y. Zhan, K. Umetani, M. Shirai, D.O. Schwenke. Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Front. Physiol. 9:696, 2018.
5. Sukumaran, V., H. Tsuchimochi, Y. Fujii, H. Hosoda, K. Kangawa, T. Akiyama, M. Shirai, J.T. Pearson. Ghrelin pre-treatment attenuates local oxidative stress and end-organ damage during cardiopulmonary bypass in anesthetized rats. Front. Physiol. 9:196, 2018.
6. Takeshita H, K. Yamamoto, S Nozato, M Takeda, SI Fukada, T Inagaki, H Tsuchimochi, M Shirai, Y Nozato, T Fujimoto, Y Imaizumi, S Yokoyama, M Nagasawa, G Hamano, K Hongyo, T Kawai, H Hanasaki-Yamamoto, S Takeda, T Takahashi, H Akasaka, N Itoh, Y Takami, Y Takeya, K Sugimoto, H Nakagami, H Rakugi. Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice. J Cachexia Sarcopenia Muscle 9:975-986, 2018.

過去の業績

• 2017年の業績
• 2016年の業績
• 2015年の業績
• 2014年の業績
• 2013年の業績
• 2012年の業績
• 2011年以前の業績については業績年報よりご覧ください。