メニュー

分子生物学部

スタッフ
Dimitar Petrov Zankov

スタッフ紹介 [Dimitar Petrov Zankov]

氏名 Dimitar Petrov Zankov
よみ ディミトル・ペトロフ・ツァンコフ
所属・職務 分子生物学部・遺伝子機能研究室長
内線番号 31019/60011
FAX番号 +81-6-6170-1659
Eメール zankov.dimitar@ncvc.go.jp
棟/部屋番号
専門 心臓電気生理・Translational research
主要論文・著書
  • Shimizu A*, Zankov DP*, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M and Ogita H. Identification of transmembrane protein 168 mutation in familial Brugada syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020. In press (*contributed equally to this work)
  • Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, Miura K, Ueshima H, Komuro I, Yamagishi M, Horie M, Kawakami K, Furukawa T, Koizumi A, Kurachi Y, Sakata Y, Minamino T, Kitakaze M, Takashima S. Mutant KCNJ3 and KCNJ5 Potassium Channels as Novel Molecular Targets in Bradyarrhythmias and Atrial Fibrillation. Circulation. 2019;139(18):2157-2169.
  • Zankov DP, Salloum FN, Jiang M, Tseng GN. Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes. Heart Rhythm. 2019;16(1):108-116.
  • Shimizu A, Zankov DP, Kurokawa-Seo M, Ogita H. Vascular endothelial growth factor-A exerts diverse cellular effects via small G proteins, Rho and Rap. Int J Mol Sci. 2018;19:E1203.
  • Zankov DP, Sato A, Shimizu A, Ogita H. Differential effects of myocardial afadin on pressure overload-induced compensated cardiac hypertrophy. Circ J. 2017;81:1862-1870(Circulation Journal Award 2017)
  • Zankov DP, Shimizu A, Tanaka-Okamoto M, Miyoshi J, Ogita H. Protective effects of intercalated disk protein afadin on chronic pressure overload-induced myocardial damage. Sci Rep. 2017;7:39335.
  • Pang X, Shimizu A, Kurita S,Zankov DP, Takeuchi K, Yasuda-Yamahara M, Kume S, Ishida T, Ogita H. Novel therapeutic role for dipeptidyl peptidase III in the treatment of hypertension. Hypertension. 2016;68:630-641.
  • Zankov DP, Ogita H. Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. Biomed Res Int. 2015; Article ID 314178.
  • Majima T, Takeuchi K, Sano K, Hirashima M, Zankov DP, Tanaka-Okamoto M, Ishizaki H, Miyoshi J, Ogita H. An adaptor molecule afadin regulates lymphangiogenesis by modulating RhoA activity in the developing mouse embryo. PLoS One. 2013; 8: e68134.
  • Zankov DP, Ogita H. ACTN4 (actinin, alpha 4). Atlas Genet Cytogenet Oncol Haematol. 2013;17: 663-669.
  • Wang Y, Zankov DP, Jiang M, Zhang M, Henderson SC, Tseng GN. [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes. J Biol Chem. 2013; 288: 35358-35371.
  • Zhang M, Wang Y, Jiang M, Zankov DP, Chowdhury S, Kasirajan V, Tseng GN. KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner. Am J Physiol Heart Circ Physiol. 2012; 302: H910-H922.
  • Wang Y, Zhang M, Xu Y, Jiang M, Zankov DP, Cui M, Tseng GN. Probing the structural basis for differential KCNQ1 modulation by KCNE1 and KCNE2. J Gen Physiol. 2012;140(6):653-69.
  • Ohno S, Zankov DP, Ding W-G, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H, Horie M. KCNE5 (KCNE1L) Variants are novel modulators of Brugada syndrome and idiopathic ventricular fibrilation. Circ Arrythm Electrophysiol. 2011;4:352-361.
  • Toyoda F, Ding W-G, Zankov DP, Omatsu-Kanbe M, Isono T, Horie M, Matsuura H. Characterization of the rapidly activating delayed rectifier potassium current, I (Kr), in HL-1 mouse atrial myocytes. J Membr Biol. 2010;235(2):73-87
  • Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T, Horie M. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Hum Mutat. 2009;30(4):557-63.
  • Zankov DP, Toyoda F, Omatsu-Kanbe M, Matsuura H, Horie M. Angiotensin II type 1 receptor mediates partially hyposmotic-induced increase of IKs current in guinea pig atrium. Pflügers Archiv. 2009;458(5):837-49.
  • Zankov DP, Yoshida H, Tsuji K, Toyoda F, Matsuura H, Horie M. Adrenergic regulation of the rapid component of delayed rectifier K+ current: Implications for arrhythmogenesis in LQT2 patients. Heart Rhythm. 2009;6(7):1038-46.
  • Ohno S, Zankov DP, Yoshida H, Tsuji K, Makiyama T, Itoh H, Akao M, Hancox JC, Kita T, Horie M. N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm. 2007;4(3):332-40.
  • Zankov DP, Omatsu-Kanbe M, Isono T, Toyoda F, Ding W-G, Matsuura H, Horie M. Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes. Circulation. 2006;113:1278-1286.
  • Zankov DP, Ding W-G, Matsuura H, Horie M. Open-state unblock characterizes acute inhibition of IKs potassium current by amiodarone in guinea-pig ventricular myocytes. J Cardiovasc Electrophysiol. 2005;16:314-322.
  • Aiba T, Shimizu W, Inagaki M, Noda T, Miyoshi S, Ding W-G, Zankov DP, Toyoda F, Matsuura H, Horie M, Sunagawa K. Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil. J Am Coll Cardiol. 2005; 45(2):300-307.
受賞
  • Circulation Journal Award for the year 2017, Experimental Investigation Section, Second Place; article "Differential Effects of Myocardial Afadin on Pressure Overload-Induced Compensated Cardiac Hypertrophy", Circ J 2017; 81: 1862-1870;
  • Certificate of Merit from the President of Shiga University of Medical Science, Shiga, Japan (acknowledgement of PhD thesis, 2007).
学位 博士(医学)
所属学会 日本循環器学会、Biophysical Society of the USA.
教育活動 滋賀医科大学客員准教授
その他の活動
研究者情報
リンク https://researchmap.jp/dpz

最終更新日:2021年10月22日

各部の紹介About

設定メニュー