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分子生物学部

スタッフ
大野 聖子

スタッフ紹介 [大野 聖子]

氏名 大野 聖子
NoPhoto
よみ おおの せいこ
所属・職務 分子生物学部 部長
内線番号 31019
FAX番号 06-6170-1659
Eメール sohno[at]ncvc.go.jp (atを@に変更してください)
専門 遺伝学・循環器内科学
主要論文・著書 論文
  • Fukuyama M, Ohno S, Ozawa J, Kato K, Makiyama T, Nakagawa Y and Horie M. High Prevalence of Late-Appearing T-Wave in Patients With Long QT Syndrome Type 8. Circ J. 2020;84:559-568.
  • Takayama K, Ohno S, Ding WG, Ashihara T, Fukumoto D, Wada Y, Makiyama T, Kise H, Hoshiai M, Matsuura H and Horie M. A de novo gain-of-function KCND3 mutation in early repolarization syndrome. Heart Rhythm. 2019;16:1698-1706.
  • Sonoda K, Ohno S, Ozawa J, Hayano M, Hattori T, Kobori A, Yahata M, Aburadani I, Watanabe S, Matsumoto Y, Makiyama T and Horie M. Copy number variations of SCN5A in Brugada syndrome. Heart Rhythm. 2018;15:1179-1188.
  • Wu J, Mizusawa Y, Ohno S, Ding WG, Higaki T, Wang Q, Kohjitani H, Makiyama T, Itoh H, Toyoda F, James AF, Hancox JC, Matsuura H and Horie M. A hERG mutation E1039X produced a synergistic lesion on IKs together with KCNQ1-R174C mutation in a LQTS family with three compound mutations. Scientific reports. 2018;8:3129.
  • Wada Y, Ohno S, Aiba T and Horie M. Unique genetic background and outcome of non-Caucasian Japanese probands with arrhythmogenic right ventricular dysplasia/cardiomyopathy. Molecular Genetics & Genomic Medicine. 2017;5:639-651.
  • Sonoda K, Ohno S, Otuki S, Kato K, Yagihara N, Watanabe H, Makiyama T, Minamino T and Horie M. Quantitative analysis of PKP2 and neighbouring genes in a patient with arrhythmogenic right ventricular cardiomyopathy caused by heterozygous PKP2 deletion. Europace. 2017;19:644-650.
  • Fujii Y, Itoh H, Ohno S, Murayama T, Kurebayashi N, Aoki H, Blancard M, Nakagawa Y, Yamamoto S, Matsui Y, Ichikawa M, Sonoda K, Ozawa T, Ohkubo K, Watanabe I, Guicheney P and Horie M. A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia. Heart Rhythm. 2017;14:98-107.
  • Ohno S. The genetic background of arrhythmogenic right ventricular cardiomyopathy. J Arrhythmia. 2016;32:398-403.
  • Fukuyama M, Ohno S, Makiyama T and Horie M. Novel SCN10A variants associated with Brugada syndrome. Europace. 2016;18:905-11.
  • Itoh H, Crotti L, Aiba T, Spazzolini C, Denjoy I, Fressart V, Hayashi K, Nakajima T, Ohno S, Makiyama T, Wu J, Hasegawa K, Mastantuono E, Dagradi F, Pedrazzini M, Yamagishi M, Berthet M, Murakami Y, Shimizu W, Guicheney P, Schwartz PJ and Horie M. The genetics underlying acquired long QT syndrome: impact for genetic screening. Eur Heart J. 2016;37:1456-1464.
  • Ohno S, Hasegawa K and Horie M. Gender Differences in the Inheritance Mode of RYR2 Mutations in Catecholaminergic Polymorphic Ventricular Tachycardia Patients. PLoS ONE. 2015;10:e0131517.
  • Hasegawa K, Ohno S, Kimura H, Itoh H, Makiyama T, Yoshida Y and Horie M. Mosaic KCNJ2 mutation in Andersen-Tawil syndrome: targeted deep sequencing is useful for the detection of mosaicism. Clin Genet. 2015;87:279-83.
  • Wu J, Naiki N, Ding WG, Ohno S, Kato K, Zang WJ, Delisle BP, Matsuura H and Horie M. A Molecular Mechanism for Adrenergic-Induced Long QT Syndrome. J Am Coll Cardiol. 2014;63:819-27.
  • Wang Q, Ohno S, Ding WG, Fukuyama M, Miyamoto A, Itoh H, Makiyama T, Wu J, Bai J, Hasegawa K, Shinohara T, Takahashi N, Shimizu A, Matsuura H and Horie M. Gain-of-function KCNH2 mutations in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2014;25:522-30.
  • Ohno S, Omura M, Kawamura M, Kimura H, Itoh H, Makiyama T, Ushinohama H, Makita N and Horie M. Exon 3 deletion of RYR2 encoding cardiac ryanodine receptor is associated with left ventricular non-compaction. Europace. 2014;16:1646-54.
  • Hasegawa K, Ohno S, Ashihara T, Itoh H, Ding WG, Toyoda F, Makiyama T, Aoki H, Nakamura Y, Delisle BP, Matsuura H and Horie M. A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels. Heart Rhythm. 2014;11:67-75.
  • Fukuyama M, Ohno S, Wang Q, Shirayama T, Itoh H and Horie M. Nonsense-mediated mRNA decay due to a CACNA1C splicing mutation in a patient with Brugada syndrome. Heart Rhythm. 2014;11:629-34.
  • Ohno S, Nagaoka I, Fukuyama M, Kimura H, Itoh H, Makiyama T, Shimizu A and Horie M. Age-dependent clinical and genetic characteristics in Japanese patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia. Circ J. 2013;77:1534-42.
  • Kawamura M, Ohno S, Naiki N, Nagaoka I, Dochi K, Wang Q, Hasegawa K, Kimura H, Miyamoto A, Mizusawa Y, Itoh H, Makiyama T, Sumitomo N, Ushinohama H, Oyama K, Murakoshi N, Aonuma K, Horigome H, Honda T, Yoshinaga M, Ito M and Horie M. Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan. Circ J. 2013;77:1705-13.
  • Ohno S, Zankov DP, Ding WG, Itoh H, Makiyama T, Doi T, Shizuta S, Hattori T, Miyamoto A, Naiki N, Hancox JC, Matsuura H and Horie M. KCNE5 (KCNE1L) Variants Are Novel Modulators of Brugada Syndrome and Idiopathic Ventricular Fibrillation. Circ Arrhythm Electrophysiol. 2011;4:352-61.
  • Ohno S, Toyoda F, Zankov DP, Yoshida H, Makiyama T, Tsuji K, Honda T, Obayashi K, Ueyama H, Shimizu W, Miyamoto Y, Kamakura S, Matsuura H, Kita T and Horie M. Novel KCNE3 mutation reduces repolarizing potassium current and associated with long QT syndrome. Hum Mutat. 2009;30:557-63.
  • Ohno S, Kubota T, Yoshida H, Tsuji K, Makiyama T, Yamada S, Kuga K, Yamaguchi I, Kita T and Horie M. A novel mutation associated with Jervell and Lange-Nielsen syndrome in a Japanese family. Circ J. 2008;72:687-93.
  • Ohno S, Zankov DP, Yoshida H, Tsuji K, Makiyama T, Itoh H, Akao M, Hancox JC, Kita T and Horie M. N- and C-terminal KCNE1 mutations cause distinct phenotypes of long QT syndrome. Heart Rhythm. 2007;4:332-40.
受賞
  • 2017年 滋賀医科大学 女性研究者賞
  • 2014年 井村臨床研究奨励賞
  • 2011年 4th Asia Pacific Heart Rhythm Society Scientific Session, Young Investigator Award
  • 2009年 第14回日本心電学会学術奨励賞
  • 2009年Cardio Rhythm 2009 Hong Kong, Young Investigator Award
学位 博士(医学)
所属学会 日本循環器病学会、日本人類遺伝学会、日本内科学会、日本不整脈心電学会(評議員)、ISHR日本部会(評議員)、日本小児心電学会
教育活動 滋賀医科大学客員教授
その他の活動
研究者情報 https://researchmap.jp/7000011790

最終更新日:2021年10月22日

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