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心不全病態制御部

業績

主要な業績

心不全病態研究

  1. Akazawa Y, Taneike M, Ueda H, Kitazume-Taneike R, Murakawa T, Sugihara R, Yorifuji H, Nishida H, Mine K, Hioki A, Omiya S, Nakayama H, Yamaguchi O, Yoshimori T, Sakata Y, Otsu K. Rubicon-regulated beta-1 adrenergic receptor recycling protects the heart from pressure overload. Sci. Rep. 2022;12(41). PMID: 34996972
  2. Abe H, Tanada Y, Omiya S, Podaru M-N, Murakawa T, Ito J, Shah AM, Conway SJ, Ono M, Otsu K. NF-kB activation in cardiac fibroblasts results in the recruitment of inflammatory
    Ly6Chi monocytes in pressure-overloaded hearts. Sci. Signal. 2021;14(704):eabe4932. PMID: 34637330
  3. Ito J, Omiya S, Rusu M-C, Ueda H, Murakawa T, Tanada Y, Abe H, Nakahara K, Asahi M, Taneike M, Nishida K, Shah AM, Otsu K. Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice. eLife. 2021;10:e62174:1- 23. PMID: 33526170
  4. Omiya S, Omori Y, Taneike M, Murakawa T, Ito J, Tanada Y, Nishida K, Yamaguchi O, Satoh T, Shah AM, Akira S, Otsu K. Cytokine mRNA Degradation in Cardiomyocytes Restrains Sterile Inflammation in Pressure-Overloaded Hearts. Circulation. 2020;141(8):667- 677. PMID: 31931613
  5. Ueda H, Yamaguchi O, Taneike M, Akazawa Y, Wada-Kobayashi H, Sugihara R, Yorifuji H, Nakayama H, Omiya S, Murakawa T, Sakata Y, Otsu K. Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice. JACC: Basic Transl. Sci. 2019;4(3):348-363. PMID: 31312759
  6. Kitazume-Taneike R, Taneike M, Omiya S, Misaka T, Nishida K, Yamaguchi O, Akira S, Shattock MJ, Sakata S, Otsu K. Ablation of Toll-like receptor 9 attenuates myocardial ischemia/reperfusion injury in mice. Biochem Biophys Res Commun. 2019;515(3), 442-447. PMID: 31160091 
  7. Murakawa T, Okamoto K, Omiya S, Taneike M, Yamaguchi O, Otsu A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy. Cell reports. 2019;26(2):338-345. PMID: 30625316
  8. Omiya S, Omori Y, Taneike M, Protti A, Yamaguchi O, Akira S, Shah AM, Nishida K, Otsu K. Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. Am J Physiol Heart Circ Physiol. 2016;311(6):H1485-H1497. PMID: 27769998
  9. Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K. Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation. Nat Commun. 2015;6:7527 . PMID: 26146385
  10. Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu T, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature. 2012;10;485(7397):251-5. PMID: 22535248
  11. Hikoso S, Yamaguchi O, Nakano Y, Takeda T, Omiya S, Mizote I, Taneike M, Oka T, Tamai T, Oyabu J, Uno Y, Matsumura Y, Nishida K, Suzuki K, Kogo M, Hori M, Otsu K.  The IkB kinase b/nuclear factor kB signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression. Circ Res. 2009;105(1):70-9. PMID: 19478205
  12. Omiya S, Hikoso S, Imanishi Y, Saito A, Yamaguchi O, Takeda T, Mizote I, Oka T, Taneike M, Nakano Y, Matsumura Y, Nishida K, Sawa Y, Hori M, Otsu K. Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes. J Mol Cell Cardiol. 2009;46(1):59-66. PMID: 18992754
  13. Watanabe T, Takeda T, Omiya S (Co-first author), Hikoso S, Yamaguchi O, Nakano Y, Higuchi Y, Nakai A, Abe Y, Aki-Jin Y, Taniike M, Mizote I, Matsumura Y, Shimizu T, Nishida K, Imai K, Hori M, Shirasawa T, Otsu K. Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure. J Am Coll Cardiol. 2008;52(9):779-86. PMID: 18718428
  14. Nakai A, Yamaguchi O (Co-first author), Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, Mizote I, Matsumura Y, Asahi M, Nishida K, Hori M, Mizushima N, and Otsu K. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nature Med. 2007;13(5):619-624. PMID: 17450150
  15. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T, Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 2005;434(7033):652-8. PMID: 15800626
  16. Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, Shungo H, Takeda T, Watanabe T, Asahi M, Taniike M, Matsumura Y, Tsujimoto I, Hongo K, Kusakari Y, Kurihara S, Nishida K, Ichijo H, Hori M, Otsu K. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci U S A. 2003; 100(26):15883-8. PMID: 14665690

ペプチドホルモン研究

  1. Tokudome T, Otani K, Mao Y, Jensen LJ, Arai Y, Miyazaki T, Sonobe T, Pearson JT, Osaki T, Minamino N, Ishida J, Fukamizu A, Kawakami H, Onozuka D, Nishimura K, Miyazato M, Nishimura H. Endothelial natriuretic peptide receptor 1 play crucial role for acute and chronic blood pressure regulation by atrial natriuretic peptide. Hypertension. 2022;0:10.1161/HYPERTENSIONAHA.121.18114. PMID: 35534926
  2. Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K.  Deficiency of cardiac natriuretic peptide signaling promotes peripartum cardiomyopathy-like remodeling in the mouse heart. Circulation. 2020;141(7):571-588. PMID: 31665900
  3. 最終更新日:2022年06月01日

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