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心臓再生制御部

スタッフ
菊地 和

スタッフ紹介 [菊地 和]

氏名 菊地 和 NoPhoto
よみ きくち かず
所属・職務 再生医療部・部長
内線番号
FAX番号
Eメール kikuchi*ncvc.go.jp *が@
棟/部屋番号 研究所4F
専門 発生生物学、再生医学
主要論文・著書
  1. New function of zebrafish regulatory T cells in organ regeneration.
    Kikuchi K.
    Current Opinion in Immunology 63:7-13 (2019).
  2. Pharmacological Enhancement of Regeneration-Dependent Regulatory T Cell Recruitment in Zebrafish.
    Zwi S, Choron C, Zheng D, Nguyen D, Zhang Y, Roshal C, Kikuchi K*, Hesselson D*. (*Co-corresponding authors)
    International Journal of Molecular Sciences 20:5189 (2019).
  3. Comparative regenerative mechanisms across different mammalian tissues.
    Iismaa SE, Kaidonis X, Nicks AM, Bogush B, Kikuchi K, Naqvi N, Harvey RP, Husain A, Graham RM.
    npj Regenerative Medicine 3:6 (2018).
  4. Zebrafish regulatory T cells mediate organ-specific regenerative programs.
    Hui SP, Sheng DZ, Sugimoto K, Gonzalez-Rajal A, Nakagawa S, Hesselson D, Kikuchi K.
    Developmental Cell 43:659-672 (2017).
    • Awarded ZDMS Junior Faculty Award for Excellence
    • Previews: Regulatory T Cells Know What Is Needed to Regenerate.
      Jahn, C, Weidinger G. Developmental Cell 43:651-652 (2017).
    • Selected for Cover Art
  5. Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch.
    Sugimoto K, Hui SP, Sheng DZ, Kikuchi K.
    eLIFE 6: e24635 (2017).
  6. NAD Deficiency, Congenital Malformations, and Niacin Supplementation.
    Shi H, Enriquez A, Rapadas M, Martin EMMA, Wang R, Moreau J, Lim CK, Szot JO, Ip E, Hughes JN, Sugimoto K, Humphreys DT, McInerney-Leo AM, Leo PJ, Maghzal GJ, Halliday J, Smith J, Colley A, Mark PR, Collins F, Sillence DO, Winlaw DS, Ho JWK, Guillemin GJ, Brown MA, Kikuchi K, Thomas PQ, Stocker R, Giannoulatou E, Chapman G, Duncan EL, Sparrow DB, Dunwoodie SL.
    New England Journal of Medicine 377:544-552 (2017).
  7. Zebrafish FOXP3 is required for the maintenance of immune tolerance.
    Sugimoto K, Hui SP, Sheng DZ, Gonzalez-Rajal A, Nakayama M, Kikuchi K.
    Developmental and Comparative Immunology 73:156-62 (2017).
  8. Endogenous mechanisms of cardiac regeneration.
    Xiang MSW, Kikuchi K.
    International Review of Cell and Molecular Biology 326:67-131 (2016).
  9. Myocardial NF-κB activation is essential for zebrafish heart regeneration.
    Karra K, Knecht A, Kikuchi K, Poss KD.
    Proceedings of the National Academy of Sciences of USA 112:13255-13260 (2015).
  10. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration.
    Nachtrab G, Kikuchi K, Tornini VA, and Poss KD.
    Development 140:3754-3764 (2013).
  11. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration.
    Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD.
    Proceedings of the National Academy of Sciences of USA 110:13416-13421 (2013).
  12. Dedifferentiation, transdifferentiation, and proliferation: mechanisms underlying cardiac regeneration in zebrafish.
    Kikuchi K.
    Current Pathobiology Reports 3:81-88 (2015).
  13. Advances in understanding the mechanism of zebrafish heart regeneration.
    Kikuchi K.
    Stem Cell Research 13:542-555 (2014).
  14. Zebrafish second heart field development relies on ALPM progenitor specification and nkx2.5 function.
    Guner-Ataman B, Paffett-Lugassy N, Adams MS, Nevis KR, Jahangiri L, Obregon P, Kikuchi K, Poss KD, Burns CE, Burns CG.
    Development 140:1353-1363 (2013).
  15. Cardiac regenerative capacity and mechanisms.
    Kikuchi K*, Poss KD*. (*Co-corresponding authors)
    Annual Review of Cell and Developmental Biology 28:719-741 (2012).
  16. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion.
    Wang J, Panakova D, Kikuchi K, Holdway JE, Gemberling M, Burris J, Singh SP, Dickson A, Lin YF, Sabeh K, Werdich A, Yelon D, MacRae C, Poss KD.
    Development 138:3421-3430 (2011).
  17. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration.
    Kikuchi K, Gupta V, Wang J, Holdway JE, Wills AA, Fang Y, and Poss KD.
    Development 138:2895-2902 (2011).
  18. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration.
    Kikuchi K, Holdway JE, Major RJ, Blum N, Dahn RD, Begemann G, Poss KD.
    Developmental Cell 20:397-404 (2011).
  19. A dual role for ErbB2 signaling in cardiac trabeculation.
    Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, Stainier DYR.
    Development 137:3867-3875 (2010).
  20. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
    Yin C, Kikuchi K, Hochgreb T, Poss KD, Stainier DYR.
    Developmental Cell 18:973-984 (2010).
  21. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes.
    Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, MacRae CA, Stainier DYR, Poss KD.
    Nature 464:601-605 (2010).
    • Highly cited paper placed it in the top 1% of the academic field of Molecular Biology & Genetics (Web of Science, July/August 2018).
    • News & Views: Thanks be to Zebrafish. Williams, R. Circulation Research 107:570-572 (2010).
  22. IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression.
    Kikuchi K, Kasai H, Watanabe A, Lai AY, Kondo M.
    The Journal of Immunology 181:383-392 (2008).
  23. Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment.
    Hsu CL, Kikuchi K, Kondo M.
    Blood 110:1420-1428 (2007).
  24. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.
    Lepilina A*, Coon AN*, Kikuchi K, Holdway JE, Roberts RW, Burns CG, Poss KD. (*Co-first authors)
    Cell 127:607-619 (2006).
  25. Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth.
    Kikuchi K, Kondo M.
    Proceedings of the National Academy of Sciences of USA 103:17852-17857 (2006).
  26. AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes.
    Kyuuma M*, Kikuchi K*, Kojima K, Sugawara Y, Sato M, Mano N, Goto J, Takeshita T, Yamamoto A, Sugamura K, Tanaka N. (*Co-first authors)
    Cell Structure and Function 31:159-172 (2006).
  27. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF.
    Kikuchi K, Lai AY, Hsu CL, Kondo M.
    The Journal of Experimental Medicine 201: 1197-1203 (2005).
  28. Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif.
    Kikuchi K, Ishii N, Asao H, Sugamura K.
    Biochemical Biophysical Research Communications 306:637-643 (2003).
  29. Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice.
    Sato T, Ishii N, Murata K, Kikuchi K, Nakagawa S, Ndhlovu LC, Sugamura K.
    European Journal of Immunology 32:3326-3335 (2002).
  30. Suppression of thymic development by the dominant-negative form of Gads.
    Kikuchi K, Kawasaki Y, Ishii N, Sasaki Y, Asao H, Takeshita T, Miyoshi I, Kasai N, Sugamura K.
    International Immunology 13:777-783 (2001).
  31. STAM2, a new member of the STAM family, binding to the Janus kinases.
    Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K.
    FEBS Letters 477:55-61 (2000).
受賞 Zebrafish Disease Models Society (ZDMS) Junior Faculty Award for Excellence (2018)
Australian Research Council (ARC) Future Fellowship (2011)
学位 医学博士
所属学会 Zebrafish Disease Models Society (ZDMS)
Stem Cells Australia Affiliates
Australian Network of Cardiac and Vascular Developmental Biologists
Australia and New Zealand Society for Cell and Developmental Biology
教育活動 Guest Lecturer (2016-2018), University of Sydney (PHSI3010: Reproduction, Development and Disease)
その他の活動
研究者情報 https://researchmap.jp/Kazu_kikuchi
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最終更新日:2022年05月20日

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