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心臓再生制御部

スタッフ
菊地 和

スタッフ紹介 [菊地 和]

氏名 菊地 和 NoPhoto
よみ きくち かず
所属・職務 心臓再生制御部・部長
内線番号
FAX番号
Eメール kikuchi*ncvc.go.jp *が@
棟/部屋番号 研究所4F
専門 発生生物学、再生医学
主要論文・著書
  1. Rough and smooth variant Mycobacterium abscessus infections are differentially controlled by host immunity during chronic infection. Julia Y. Kam, Elinor Hortle, Elizabeth Krogman, Sherridan E. Warner, Kathryn Wright, Kaiming Luo, Tina Cheng, Pradeep Manuneedhi Cholan, Kazu Kikuchi, James A. Triccas, Warwick J. Britton, Matt D. Johansen, Laurent Kremer, Stefan H. Oehlers. Nat Commun 13:952 (2022)
  2. Zebrafish heme oxygenase 1a is necessary for normal development and macrophage migration. Kaiming Luo, Masahito Ogawa, Anita Ayer, Warwick J. Britton, Roland Stocker, Kazu Kikuchi, Stefan H. Oehlers. Zebrafish 19:7-17 (2022)
  3. Haeme oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish. Kaiming Luo, Roland Stocker, Warwick J. Britton, Kazu Kikuchi, Stefan H. Oehlers. FEBS Lett 289:671-81 (2022)
  4. Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain. Percival P. D’Gama, Tao Qiu, Mehmet I. Cosacak, Dheeraj Rayamajhi, Ahsen Konac, Jan N. Hansen, Christa Ringers, Francisca Acuña-Hinrichsen, Subhra P. Hui, Emilie W. Olstad, Yan L. Chong, Charlton K. A. Lim, Astha Gupta, Chee P. Ng, Benedikt Nilges, Nachiket D. Kashikar, Dagmar Wachten, David Liebl, Kazu Kikuchi, Caghan Kizil, Emre Yaksi, Sudipto Roy*, Nathalie Jurisch-Yaksi*. (*Contributed equally) Cell Rep 37:109775 (2021)
  5. Krüppel-like factor 1 is a core cardiomyogenic trigger in zebrafish. Masahito Ogawa, Fan-Suo Geng, David T. Humphreys, Esther Kristianto, Delicia Z. Sheng, Subhra P. Hui, Yuxi Zhang, Kotaro Sugimoto, Maki Nakayama, Dawei Zheng, Daniel Hesselson, Mark P. Hodson, Ozren Bogdanovic, Kazu Kikuchi. Science 372:201-5 (2021)
  6. Cardiac resection injury in zebrafish. Delicia Z. Sheng, Dawei Zheng, Kazu Kikuchi. Methods Mol Biol 2158:63-9 (2021)
  7. A zebrafish functional genomics model to investigate the role of human A20 variants in vivo. Daniele Cultrone, Nathan W. Zammit, Eleanor Self, Benno Postert, Jeremy Z. R. Han, Jacqueline Bailey, Joanna Warren, David R. Croucher, Kazu Kikuchi, Ozren Bogdanovic, Tatyana Chtanova, Daniel Hesselson, Shane T. Grey. Sci Rep 10:19085 (2020)
  8. Deep conservation of the enhancer regulatory code in animals. Emily S. Wong*, Dawei Zheng†, Siew Z. Tan†, Neil L. Bower, Victoria Garside, Gilles Vanwalleghem, Federico Gaiti, Ethan Scott, Benjamin M. Hogan, Kazu Kikuchi, Edwina McGlinn, Mathias Francois*‡, Bernard M. Degnan*‡. (*Corresponding author; †, ‡Contributed equally) Science 370:eaax8137 (2020)
  9. Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling. Catherine R. Cochrane, Vijesh Vaghjiani, Anette Szczepny, W. Samantha N. Jayasekara, Alvaro Gonzalez-Rajal, Kazu Kikuchi, Geoffrey W. McCaughan, Andrew Burgess, Daniel J. Gough, D. Neil Watkins, Jason E. Cain. J Clin Invest 130:4006-18 (2020)
  10. New function of zebrafish regulatory T cells in organ regeneration. Kazu Kikuchi. Curr Opin Immunol 63:7-13 (2020)
  11. Pharmacological enhancement of regeneration-dependent regulatory T cell recruitment in zebrafish. Stephanie F. Zwi, Clarisse Choron, Dawei Zheng, David Nguyen, Yuxi Zhang, Camilla Roshal, Kazu Kikuchi*, Daniel Hesselson*. (*Corresponding author) Int J Mol Sci 20:5189 (2019)
  12. Comparative regenerative mechanisms across different mammalian tissues. Siiri E. Iismaa, Xenia Kaidonis, Amy M. Nicks, Nikolay Bogush, Kazu Kikuchi, Nawazish Naqvi, Richard P. Harvey, Ahsan Husain, Robert M. Graham. NPJ Regen Med 3:6 (2018)
  13. Zebrafish regulatory T cells mediate organ-specific regenerative programs. Subhra P. Hui, Delicia Z. Sheng, Kotaro Sugimoto, Alvaro Gonzalez-Rajal, Shinichi Nakagawa, Daniel Hesselson, Kazu Kikuchi. Dev Cell 43:659-672 (2017)
  14. Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch. Kotaro Sugimoto, Subhra P. Hui, Delicia Z. Sheng, Kazu Kikuchi. eLife 6: e24635 (2017)
  15. NAD deficiency, congenital malformations, and niacin supplementation. Hongjun Shi, Annabelle Enriquez, Melissa Rapadas, Ella M. M. A. Martin, Roni Wang, Julie Moreau, Chai K. Lim, Justin O. Szot, Eddie Ip, James N. Hughes, Kotaro Sugimoto, David T. Humphreys, Aideen M. McInerney-Leo, Paul J. Leo, Ghassan J. Maghzal, Jake Halliday, Janine Smith, Alison Colley, Paul R. Mark, Felicity Collins, David O. Sillence, David S. Winlaw, Joshua W. K. Ho, Gilles J. Guillemin, Matthew A. Brown, Kazu Kikuchi, Paul Q. Thomas, Roland Stocker, Eleni Giannoulatou, Gavin Chapman, Emma L. Duncan, Duncan B. Sparrow, Sally L. Dunwoodie. N Engl J Med 377:544-552 (2017)
  16. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Kotaro Sugimoto, Subhra P. Hui, Delicia Z. Sheng, Alvaro Gonzalez-Rajal, Maki Nakayama, Kazu Kikuchi. Dev Comp Immunol 73:156-62 (2017)
  17. Endogenous mechanisms of cardiac regeneration. Michelle S. W. Xiang, Kazu Kikuchi. Int Rev Cell Mol Biol 326:67-131 (2016)
  18. Myocardial NF-kB activation is essential for zebrafish heart regeneration. Ravi Karra, Anne K. Knecht, Kazu Kikuchi, Kenneth D. Poss. Proc Natl Acad Sci USA 112:13255-13260 (2015)
  19. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Gregory Nachtrab, Kazu Kikuchi, Valerie A. Tornini, Kenneth D. Poss. Development 140:3754-3764 (2013)
  20. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Yi Fang, Vikas Gupta, Ravi Karra, Jennifer E. Holdway, Kazu Kikuchi, Kenneth D. Poss. Proc Natl Acad Sci USA 110:13416-13421 (2013)
  21. Dedifferentiation, transdifferentiation, and proliferation: mechanisms underlying cardiac regeneration in zebrafish. Kazu Kikuchi. Curr Pathobiol Rep 3:81-88 (2015)
  22. Advances in understanding the mechanism of zebrafish heart regeneration. Kazu Kikuchi. Stem Cell Res 13:542-555 (2014)
  23. Zebrafish second heart field development relies on ALPM progenitor specification and nkx2.5 function. Burcu Guner-Ataman, Noelle Paffett-Lugassy, Meghan S. Adams, Kathleen R. Nevis, Leila Jahangiri, Pablo Obregon, Kazu Kikuchi, Kenneth D. Poss, Caroline E. Burns, C. Geoffrey Burns. Development 140:1353-1363 (2013)
  24. Cardiac regenerative capacity and mechanisms. Kazu Kikuchi, Kenneth D. Poss. Annu Rev Cell Dev Biol 28:719-741 (2012)
  25. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Jinhu Wang, Daniela Panáková, Kazu Kikuchi, Jennifer E. Holdway, Matthew Gemberling, James S. Burris, Sumeet Pal Singh, Amy L. Dickson, Yi-Fan Lin, M. Khaled Sabeh, Andreas A. Werdich, Deborah Yelon, Calum A. Macrae, Kenneth D. Poss. Development 138:3421-3430 (2011)
  26. tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration. Kazu Kikuchi, Vikas Gupta, Jinhu Wang, Jennifer E. Holdway, Airon A. Wills, Yi Fang, Kenneth D. Poss. Development 138:2895-2902 (2011)
  27. Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration. Kazu Kikuchi, Jennifer E. Holdway, Robert J. Major, Nicola Blum, Randall D. Dahn, Gerrit Begemann, Kenneth D. Poss. Dev Cell 20:397-404 (2011)
  28. A dual role for ErbB2 signaling in cardiac trabeculation. Jiandong Liu, Michael Bressan, David Hassel, Jan Huisken, David Staudt, Kazu Kikuchi, Kenneth D. Poss, Takashi Mikawa, Didier Y. R. Stainier. Development 137:3867-3875 (2010)
  29. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Chunyue Yin, Kazu Kikuchi, Tatiana Hochgreb, Kenneth D. Poss, Didier Y. R. Stainier. Dev Cell 18:973-984 (2010)
  30. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Kazu Kikuchi, Jennifer E. Holdway, Andreas A. Werdich, Ryan M. Anderson, Yi Fang, Gregory F. Egnaczyk, Todd Evans, Calum A. Macrae, Didier Y. R. Stainier, Kenneth D Poss. Nature 464:601-605 (2010)
  31. IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression. Kazu Kikuchi, Hirotake Kasai, Akiko Watanabe, Anne Y. Lai, Motonari Kondo. J Immunol 181:383-392 (2008)
  32. Activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway is involved in myeloid lineage commitment. Chia-Lin Hsu, Kazu Kikuchi, Motonari Kondo. Blood 110:1420-1428 (2007)
  33. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Alexandra Lepilina*, Ashley N. Coon*, Kazu Kikuchi, Jennifer E. Holdway, Richard W. Roberts, C. Geoffrey Burns, Kenneth D. Poss (*Contributed equally) Cell 127:607-619 (2006)
  34. Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth. Kazu Kikuchi, Motonari Kondo. Proc Natl Acad Sci USA 103:17852-17857 (2006)
  35. AMSH, an ESCRT-III associated enzyme, deubiquitinates cargo on MVB/late endosomes. Masanao Kyuuma*, Kazu Kikuchi*, Katsuhiko Kojima, Yuriko Sugawara, Mariko Sato, Nariyasu Mano, Junichi Goto, Toshikazu Takeshita, Akitsugu Yamamoto, Kazuo Sugamura, Nobuyuki Tanaka. (*Contributed equally) Cell Struct Funct 31:159-172 (2006)
  36. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. Kazu Kikuchi, Anne Y Lai, Chia-Lin Hsu, Motonari Kondo. J Exp Med 201: 1197-1203 (2005)
  37. Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif. Kazu Kikuchi, Naoto Ishii, Hironobu Asao, Kazuo Sugamura. Biochem Biophys Res Commun 306:637-643 (2003)
  38. Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice. Takayuki Sato, Naoto Ishii, Kazuko Murata, Kazu Kikuchi, Satoshi Nakagawa, Lishomwa C. Ndhlovu, Kazuo Sugamura. Eur J Immunol 32:3326-3335 (2002)
  39. Suppression of thymic development by the dominant-negative form of Gads. Kazu Kikuchi, Yoshitada Kawasaki, Naoto Ishii, Yoshiteru Sasaki, Hironobu Asao, Toshikazu Takeshita, Ichiro Miyoshi, Noriyuki Kasai, Kazuo Sugamura. Int Immunol 13:777-783 (2001)
  40. STAM2, a new member of the STAM family, binding to the Janus kinases. Kazuhiro Endo, Toshikazu Takeshita, Hirotake Kasai, Yoshiteru Sasaki, Nobuyuki Tanaka, Hironobu Asao, Kazu Kikuchi, Mitsuhiro Yamada, Min Chen, John J O'Shea, Kazuo Sugamura. FEBS Lett 477:55-61 (2000)
受賞 Zebrafish Disease Models Society (ZDMS) Junior Faculty Award for Excellence (2018)
Australian Research Council (ARC) Future Fellowship (2011)
学位 医学博士
所属学会 Zebrafish Disease Models Society (ZDMS)
Stem Cells Australia Affiliates
Australian Network of Cardiac and Vascular Developmental Biologists
Australia and New Zealand Society for Cell and Developmental Biology
教育活動 Guest Lecturer (2016-2018), University of Sydney (PHSI3010: Reproduction, Development and Disease)
その他の活動
研究者情報 https://researchmap.jp/Kazu_kikuchi
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最終更新日:2022年05月31日

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