メニュー

  1. 国立循環器病研究センター 研究所 TOP
  2. 各部のご紹介
  3. 心血管老化制御部
  4. スタッフ - 清水 逸平

心血管老化制御部

スタッフ
清水 逸平

スタッフ紹介 [清水 逸平]

氏名清水 逸平
よみしみず　いっぺい
所属・職務心血管老化制御部　部長、心不全・移植部門　特任部長
内線番号60037
Eメールshimizu.ippei[at]ncvc.go.jp　（atを@に変換ください）
棟/部屋番号研究棟6階60110
専門循環器内科学（循環器専門医、総合内科専門医）、心不全・老化研究
主要論文・著書
  1. Furuuchi R*, Shimizu I*,**, Yoshida Y, Katsuumi G, Suda M, Kubota Y, Walsh K, Minamino T. Endothelial SIRT-1 has critical role for the maintenance of capillarization in brown adipose tissue. iScience. 2022 Nov18, 25, 105424. *Co-first author, **Co-corresponding author
  2. Yoshida Y*, Shimizu I*,**, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C, Yamamoto H, Ishikawa T, Kano K, Aoki J, Hayashi Y, Ikegami R, Katsuumi G, Suda M, Ozaki K, Kashimura T, Izumi D, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T** and Minamino T**. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Sci Rep. 2022 Sep 1;12(1):14883. *Co-first author, **Co-corresponding author
  3. Hayashi Y*, Shimizu I*,**, Yoshida Y*, Ikegami R, Suda M, Katsuumi G, Nakao M, Fujiki S, Abe M, Sakimura K, Okuda S, Hayano T, Walsh K, Jespersen NJ, Nielsen S, Scheele C, Minamino T**. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience. 2022 Jun 7;25(7):104547. *Co-first author, **Co-corresponding
  4. Suda M*, Shimizu I*, Katsuumi G, Yoshida Y, Matsumoto N, Yoshida Y, Katayama A, Wada J, Seki M, Suzuki Y, Okuda S, Ozaki K, Matsui M, Minamino T. Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells. Sci Rep. 2022, April 20, 6522. *Co-first author.
  5. Yoshida Y*, Shimizu I*, Yung Ting Hsiao*, Hayashi Y, Suda M, Katsuumi G, Ikegami R, Nakao M, Sakai R, Seki M, Suzuki Y, Okuda S, Soga T, Minamino T. Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue. iScience. 2022 *Co-first author
  6. Park N, Marquez J, Pham T, Ko TH, Youm JB, Kim M, Choi SH, Moon J, Flores J, Ko K, Rhee BD, Shimizu I, Minamino T, Ha JD, Hwang JY, Yang SJ, Park CS, Kim HK and Han J. Cereblon contributes to cardiac dysfunction by degrading Cav1.2α. European Heart Journal. 2022, Feb; 22.
  7. Suda M*, Shimizu I*, Katsuumi G, Yoshida Y, Hayashi Y, Ikegami R, Matsumoto N, Yoshida Y, Mikawa R, Katayama A, Wada J, Seki M, Suzuki Y, Iwama A, Nakagami H, Nagasawa A, Morishita R, Sugimoto M, Okuda S, Tsuchida M, Ozaki K, Matsui M, Minamino T. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nature aging. 2021, Dec; 10. *Co-first author
  8. Yung Ting Hsiao*, Shimizu I*,**, Yoshida Y, Tohru Minamino**. Role of circulating molecules in age-related cardiovascular and metabolic disorders. Inflammation and regeneration. (in press) *Co-first author, **Co-corresponding author
  9. Cho K, Ushiki T, Ishiguro H Tamura S, Araki M, Suwabe T, Katagiri T, Ohashi R, Ajioka Y, Shimizu I, Okuda S, Masuko M, Nakagawa Y, Hirai H, Alexander W, Shimano H, Sone H. Altered Microbiota by a High-Fat Diet Accelerates Lethal Myeloid Hematopoiesis Associated with Systemic Socs3 Deficiency. iScience. 2021, Oct; 24(10), 103117.
  10. Nakao M, Shimizu I*,**, Katsuumi G, Yoshida Y, Suda M, Hayashi Y, Ikegami R, Hsiao Yung Ting, Okuda S, Soga T, Minamino T**. Empagliflozin Maintains Capillarization and Improves Cardiac Function in a Murine Model of Left Ventricular Pressure Overload. Sci Rep. 11, Article number: 18384 (2021). *Co-first author, **Co-corresponding
  11. Hsiao YT*, Shimizu I*,**, Wakasugi T, Jiao S, Watanabe T, Yoshida Y, Ikegami R, Hayashi Y, Suda M, Katsuumi G, Nakao M, Ozawa T, Kashimura T, Ozaki K, Hanawa H, Minamino T**. Cardiac Mitofusin-1 is Reduced in Non-responding Patients with Idiopathic Dilated Cardiomyopathy. *Co-first author, **Co-corresponding author Sci Rep. Mar24; 11(1):6722, 2021. *Co-first author, **Co-corresponding author
  12. Kim HK, Ko T, Song I, Jeong Y, Heo HJ, Jeong S, Kim M, Park NM, Seo DY, Kha PT, Kim SW, Lee SR, Cho SW, Won JC, Youm JB, Ko K, Rhee B, Kim N, Cho KI, Shimizu I, Minamino T, Ha NC, Park Y, Nilius B, Han J. BH4 activates CaMKK2 and rescues the cardiomyopathic phenotype in rodent models of diabetes. Life Science Alliance. 2020 Jul 22;3(9):e201900619.
  13. Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J. Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis. S0925-4439(19)30241-8, 2019.
  14. Yoshida Y*, Shimizu I*, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Nakagmi H, Morishita R, Minamino T. Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity. Sci Rep 2019 Mar7; 9(1)3858 *Co-first author
  15. Ikegami R*, Shimizu I*,**, Sato T*, Yoshida Y, Hayashi Y, Suda M, Katsuumi G, Li J, Wakasugi T, Minokoshi Y, Okamoto S, Hinoi E, Nielsen S, Jespersen N, Scheele C, Soga T, Minamino T**. Gamma-aminobutyric acid signaling in brown adipose tissue promotes systemic metabolic dysfunction in obesity. *Co-first author, **Co-corresponding author Cell Rep. 24(11):2827-2837 2018
  16. Furuuchi R*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Suda M, Katsuumi G, Wakasugi T, Nakao M, Minamino T. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLOS One. 13(8):e0202051, 2018. *Co-first author
  17. Katsuumi G*, Shimizu I*, Yoshida Y, Minamino T. Vascular senescence in cardiovascular and metabolic diseases. Front Cardiovasc Med 05 March 2018 https://doi.org/10.3389/fcvm.2018.00018. *Co-first author
  18. Ikegami R*, Shimizu I*, Yoshida Y, Minamino T. Metabolomic analysis in heart failure. Circ J 2017 ;82(1):10-16 *Co-first author
  19. Suda M*, Shimizu I*, Yoshida Y, Hayashi Y, Ikegami R, Katsuumi G, Wakasugi T, Yoshida Y, Okuda S, Soga T, Minamino T. Inhibition of Dipeptidyl peptidase-4 ameliorates cardiac ischemia and systolic dysfunction by up-regulating the FGF-2/EGR-1 pathway. *Co-first author PLOS One 2017 Aug 3; 12(8), e0182422.
  20. Shimizu I*, Minamino T*. Physiological and pathological cardiac hypertrophy. J Mol Cell Cardiol. 2016 Jun 2;97:245-262 *Co-corresponding author
  21. Shimizu I, Yoshida Y, Minamino T. Hypertens Res 2016 Feb 18, A role for circadian clock in metabolic disease.
  22. Shimizu I, Yoshida Y, Minamino T. Diabetes. 2015 (Commentary) Dec;64(12):3984-6. Maintenance of subcutaneous fat homeostasis improves systemic metabolic dysfunction in obesity.
  23. Yoshida Y*, Shimizu I*, Katsuumi G*, Suda M, Hayashi Y, Minamino T. J Mol Cell Cardiol. 2015 June 85:183-198. p53-induced inflammation exacerbates cardiac dysfunction during pressure overload. *Co-first author
  24. Shimizu I, Yoshida Y, Suda M, Minamino T. Cell Metab. 2014 Dec 2;20(6):967-977. DNA damage response and metabolic disease.
  25. Kikuchi R, Nakamura K, Maclauchlan S, Ngo D, Shimizu I, Fuster J, Katanasaka Y, Yoshida S, Qiu Y, Yamaguchi T, Matsushita T, Murohara T, Gokce N, Bates D, Hamburg N, Walsh K. Nat Med. 2014 Dec;20(12):1464-71. An anti-angiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease.
  26. Shimizu I, Tamar A, Kikuchi R, Shimizu A, Papanicolaou K, Maclauchlan S, Maruyama S, Walsh K. J Clin Invest. 2014; May;124(5):2099-112. Vascular rarefaction mediates whitening of brown fat in obesity.
  27. Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. Cell Metab. 2013 Oct1;18(4):491-504. Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity. (Featured article)
  28. Shimizu I, Walsh K. J Mol Cell Cardiol. 2013 Jun;59:176-8. Vascular remodeling mediated by Angptl2 produced from perivascular adipose tissue.
  29. Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I. 2012; 149: 1298-313. Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes.
  30. Shimizu I, Yoshida Y, Katsuno T, Tateno K, Okada S, Moriya J, Yokoyama M, Nojima A, Ito T, Zechner R, Komuro I, Kobayashi Y, Minamino T. Cell Metab. 2012; 15:51-64. p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. (Featured article)
  31. Shimizu I, Minamino T, Toko H, Okada S, Ikeda H, Yasuda N, Tateno K, Moriya J, Yokoyama M, Nojima A, Koh G, Akazawa H, Shiojima I, Kahn C, Abel E, & Komuro I. J Clin Invest. 2010;120:1506-1514. Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents.
  32. Minamino T*, Orimo M*, Shimizu I*, Kunieda T, Yokoyama M, Ito T, Nojima A, Nabetani A, Oike Y, Matsubara H, Ishikawa F, Komuro I. Nat Med. 2009; 15:1082-7. A crucial role for adipose tissue p53 in the regulation of insulin resistance. *Co-first author
  33. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I. Nature. 2007; 446:444-8. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.
受賞・ 第48回日本心臓財団「佐藤賞」、2023年
・ Catalyst Award、U.S. National Academy of Medicine（全米医学アカデミー）、2020年
・ 第20回高峰譲吉研究奨励賞、第20回日本心血管内分泌代謝学会、2016年
・ 最優秀賞Young Investigator Competition、第58回韓国循環器学会2014年
・ 新潟大学学長賞、2014年
・ 最優秀賞 Melvin L. Marcus Young Investigator Award in Cardiovascular Sciences. American Heart Association、Scientific Sessions (AHA)、2012年
・ 学術奨励賞　第49回日本臨床分子医学会学術集会、2012年
・ 第三回千葉医学会　奨励賞、2011年
・ 最優秀賞、Young Investigator Award、第27回日本心臓研究会(ISHR)日本部会、2010年
・ 受賞、Young Investigator Award, 第14回日本心血管内分泌代謝学会、2010年
・ 千葉大学学長賞、2010年
・ 千葉大学医学薬学府長表彰、2010年
学位医学博士（千葉大学2010年）
所属学会日本内科学会、日本循環器学会、日本心不全学会、日本高血圧学会、日本心臓病学会
日本腫瘍循環器学会、日本血管生物医学会、日本動脈硬化学会、日本心脈管作動物質学会、日本老年医学会、日本抗加齢医学会、日本肥満学会、日本心血管内分泌代謝学会、日本分子生物学会、国際心臓研究会（ISHR）、脳心血管抗加齢研究会、日本基礎老化学会、American Heart Association、Fellow (FAHA)、European Society of Cardiology、Fellow (FESC)
Korean Society of Cardiology、名誉会員
その他の活動1. Associate Editorial board member; Frontiers in Cardiovascular Medicine
2. Editorial board member; J Mol Cell Cardiol
3. Editorial board member; Scientific Reports
4. Editorial board member; Frontiers in Physiology
5. Chair；Mid Career Investigator Network (MCI) Global Member、ISHR
6. JST（科学技術振興機構） 創発的研究支援事業研究者
7. 脳心血管抗加齢研究会　評議員
8. 日本血管生物医学会　評議員
9. 日本心血管内分泌代謝学会　評議員
10. 日本腫瘍循環器学会　評議員
11. 日本NO学会　評議員
12. 日本循環器学会関東甲信越地方会　評議員
13. 国際心臓研究会（ISHR）日本部会　評議員
14. 日本抗加齢医学会　評議員
15. 日本血管不全学会　監事
研究者情報Research map ID; https://researchmap.jp/ippeishimizu
リンクJapanese Circulation Society (JCS); http://j-circ.or.jp/english/
International Society for Heart Research (ISHR) Japanese Section; http://square.umin.ac.jp/ishr/
International Society for Heart Research (ISHR); https://ishrworld.org/
Frontiers in Cardiovascular Medicine；https://www.frontiersin.org/journals/cardiovascular-medicine
JMCC (Journal of Molecular and Cellular Cardiology); https://www.jmcc-online.com/
JMCC-PLUS; https://www.sciencedirect.com/journal/journal-of-molecular-and-cellular-cardiology-plus

戻る

最終更新日：2023年04月26日

各部の紹介About

設定メニュー