メニュー

心臓再生制御部

スタッフ
渡邉 裕介

スタッフ紹介 [渡邉 裕介]

氏名 渡邉 裕介
よみ わたなべ ゆうすけ
所属・職務 心臓再生制御部 室長
内線番号  
FAX番号  
Eメール ywatanabe(at)ncvc.go.jp
※ (at)を@に変換してください。
棟/部屋番号 研究所4F
専門 心臓形態形成、心筋分化、心臓再生、発生工学
主要論文・著書

<代表的論文>

  1. Watanabe Y*, Wang Y, Tanaka Y, Iwase A, Kawamura T, Saga Y, Yashiro K, Kurihara H, Nakagawa O* (*Co-corresponding authors). Hey2 enhancer activity defines unipotent progenitors for left ventricular cardiomyocytes in juxta-cardiac field of early mouse embryo. Proc Natl Acad Sci U S A. 120(37):e2307658120 (2023)
  2. Yoshida Y, Uchida K, Kodo K, Ishizaki-Asami R, Maeda J, Katsumata Y, Yuasa S, Fukuda K, Kosaki K, Watanabe Y, Nakagawa O, Yamagishi H. A genetic and developmental biological approach for a family with complex congenital heart diseases-evidence of digenic inheritance. Front Cardiovasc Med. 10:1135141 (2023)
  3. Harada Y, Tanaka T, Arai Y, Isomoto Y, Nakano A, Nakao S, Urasaki A, Watanabe Y, Kawamura T, Nakagawa O. ETS-dependent enhancers for endothelial-specific expression of serum/glucocorticoid-regulated kinase 1 during mouse embryo development. Genes Cells. 26(8):611-626 (2021)
  4. Kinugasa-Katayama Y, Watanabe Y, Hisamitsu T, Arima Y, Liu NM, Tomimatsu A, Harada Y, Arai Y, Urasaki A, Kawamura T, Saito Y, Nakagawa O. Tmem100-BAC-EGFP mice to selectively mark and purify embryonic endothelial cells of large caliber arteries in mid-gestational vascular formation. Genesis. 59(4):e23416 (2021)
  5. Seya D, Ihara D, Shirai M, Kawamura T, Watanabe Y *, Nakagawa O * (*Co-corresponding authors). A role of Hey2 transcription factor for right ventricle development through regulation of Tbx2-Mycn pathway during cardiac morphogenesis. Dev Growth Differ. 63(1):82-92 (2021)
  6. Watanabe Y *, Seya D, Ihara D, Ishii S, Uemoto T, Kubo A, Arai Y, Isomoto Y, Nakano A, Abe T, Shigeta M, Kawamura T, Saito Y, Ogura T, Nakagawa O*. (*Co-corresponding authors). Importance of endothelial Hey1 expression for thoracic great vessel development and its distal enhancer for Notch-dependent endothelial transcription. J Biol Chem. 295(51):17632-17645 (2020)
  7. Ihara D, Watanabe Y *, Seya D, Arai Y, Isomoto Y, Nakano A, Kubo A, Ogura T, Kawamura T, Nakagawa O*. (*Co-corresponding authors). Expression of Hey2 transcription factor in the early embryonic ventricles is controlled through a distal enhancer by Tbx20 and Gata transcription factors. Dev Biol. 461(2):124-131 (2020)
  8. Miyoshi T, Hisamitsu T, Ishibashi-Ueda H, Ikemura K, Ikeda T, Miyazato M, Kangawa K, Watanabe Y, Nakagawa O, Hosoda H. Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure. Int J Cardiol. 302:110-116. (2020)
  9. Araki M, Hisamitsu T, Kinugasa-Katayama Y, Tanaka T, Harada Y, Nakao S, Hanada S, Ishii S, Fujita M, Kawamura T, Saito Y, Nishiyama K, Watanabe Y, Nakagawa O. Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis. 21(2):415-423 (2018)
  10. Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, Ogura T. Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 7:46135. doi: 10.1038/srep46135 (2017)
  11. Fujita M, Sakabe M, Ioka T, Watanabe Y, Kinugasa-Katayama Y, Tsuchihashi T, Utset MF, Yamagishi H, Nakagawa O. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev. 139:65-73 (2016)
  12. Inoue S, Moriya M, Watanabe Y, Miyagawa-Tomita S, Niihori T, Oba D, Ono M, Kure S, Ogura T, Matsubara Y, Aoki Y. New BRAF knock-in mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 23(24):6553-66 (2014)
  13. Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA 4th, Miyagawa-Tomita S, Kelly RG, Buckingham M. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet. 23(19):5087-101 (2014)
  14. Huynen L, Suzuki T, Ogura T, Watanabe Y, Millar CD, Hofreiter M, Smith C, Mirmoeini S, Lambert DM. Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes). BMC Evol Biol. 14:75 (2014)
  15. Aoki Y, Niihori T, Banjo T, Okamoto N, Mizuno S, Kurosawa K, Ogata T, Takada F, Yano M, Ando T, Hoshika T, Barnett C, Ohashi H, Kawame H, Hasegawa T, Okutani T, Nagashima T, Hasegawa S, Funayama R, Nagashima T, Nakayama K, Inoue S, Watanabe Y, Ogura T, Matsubara Y. Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. Am J Hum Genet. 93(1):173-80 (2013)
  16. Watanabe Y, Zaffran S, Kuroiwa A, Higuchi H, Ogura T, Harvey RP, Kelly RG, Buckingham M. Fgf10 regulation in the second heart field by Tbx1, Nkx2-5 and Islet1 reveals a genetic switch for down-regulation of transcription in the myocardium. Proc Natl Acad Sci U S A. 109(45):18273-80 (2012)
  17. Watanabe Y, Miyagawa-Tomita S, Vincent SD, Kelly RG, Moon AM, Buckingham M. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res. 106(3):495-503 (2010)
  18. Suzuki K, Machiyama F, Nishino S, Watanabe Y, Kashiwagi K, Kashiwagi A, Yoshizato K. Molecular features of thyroid hormone-regulated skin remodeling in Xenopus laevis during metamorphosis. Dev Growth Differ. 51(4):411-27 (2009)
  19. Park EJ*, Watanabe Y *, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM. (*Co-first authors). An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development. 135(21):3599-610 (2008)
  20. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell. 128(5):947-59 (2007)
  21. Watanabe Y *, Kokubo H*, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki K, Kanno J, Saga Y. (*Co-first authors). Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development. 133(9):1625-34 (2006)
  22. Utoh R, Shigenaga S, Watanabe Y, Yoshizato K. Platelet-derived growth factor signaling as a cue of the epithelial-mesenchymal interaction required for anuran skin metamorphosis. Dev Dyn. 227(2):157-69 (2003)
  23. Watanabe Y, Tanaka R, Kobayashi H, Utoh R, Suzuki K, Obara M, Yoshizato K. Metamorphosis-dependent transcriptional regulation of xak-c, a novel Xenopus type I keratin gene. Dev Dyn. 225(4):561-70 (2002)
  24. Oofusa K, Tooi O, Kashiwagi A, Kashiwagi K, Kondo Y, Watanabe Y, Sawada T, Fujikawa K, Yoshizato K. Expression of thyroid hormone receptor beta A gene assayed by transgenic Xenopus laevis carrying its promoter sequences. Mol Cell Endocrinol. 181(1-2):97-110 (2001)
  25. Watanabe Y*, Kobayashi H*, Suzuki K, Kotani K, Yoshizato K. (*Co-first authors). New epidermal keratin genes from Xenopus laevis: hormonal and regional regulation of their expression during anuran skin metamorphosis. Biochim Biophys Acta. 1517(3):339-50 (2001)
受賞  
学位 博士(理学)
所属学会 日本分子生物学会、日本発生生物学会
教育活動 奈良県立医科大学 連携大学院 招聘准教授
大阪大学大学院医学研究科 招聘准教授
その他の活動  
研究者情報 Research map https://researchmap.jp/yrwatanabe
リンク  

最終更新日:2024年03月21日

各部の紹介About

設定メニュー