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心臓生理機能部

スタッフ紹介 [土持 裕胤]

氏名 土持 裕胤
土持 裕胤 写真
よみ つちもち ひろつぐ
所属・職務 心臓生理機能部 統合生理研究室 室長
内線番号 2381
FAX番号 06-6835-5416
Eメール tsuchimo@ncvc.go.jp
棟/部屋番号 研究所本館 6階622室
専門

運動生理学、循環生理学、自律神経生理学、感覚神経生理学
【安静時や運動時の呼吸・循環機能が自律神経系によってどのように調節されているのかについて、中枢性制御および末梢由来反射性制御の両面から研究を行っています。】

主要論文・著書 主要論文
  • Shirai M, Tsuchimochi H, Nagai H, Gray E, Pearson JT, Sonobe T, Yoshimoto M, Inagaki T, Fujii Y, Umetani K, Kuwahira I, Schwenke DO. Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia. Basic Res Cardiol. 109: 432, 2014.
  • Yamauchi K, Tsuchimochi H, Stone AJ, Stocker SD, Kaufman MP. Increased dietary salt intake enhances the exercise pressor reflex. Am J Physiol Heart Circ Physiol. 306: H450-H454, 2014.
  • Pearson JT, Jenkins MJ, Edgley AJ, Sonobe T, Joshi M, Waddingham MT, Fujii Y, Schwenke DO, Tsuchimochi H, Yoshimoto M, Umetani K, Kelly DJ, Shirai M. Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation. Cardiovasc Diabetol. 12: 111, 2013.
  • Gray EA, Tsuchimochi H, Pearson JT, Sonobe T, Fujii Y, Yoshimoto M, Umetani K, Shirai M, Schwenke DO. Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension. J Synchrotron Radiat. 20: 756-764, 2013.
  • Endo K, Matsukawa K, Liang N, Nakatsuka C, Tsuchimochi H, Okamura H, Hamaoka T. Dynamic exercise improves cognitive function in association with increased prefrontal oxygenation. J Physiol Sci. 63: 287-298, 2013.
  • Shirai M, Beard M, Pearson JT, Sonobe T, Tsuchimochi H, Fujii Y, Gray E, Umetani K, Schwenke DO. Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography. J Synchrotron Radiat. 20: 441-448, 2013.
  • Shirai M, Schwenke DO, Tsuchimochi H, Umetani K, Yagi N, Pearson JT. Synchrotron radiation imaging for advancing our understanding of cardiovascular function. Circ Res. 112: 209-221, 2013.
  • Murata J, Matsukawa K, Komine H, and Tsuchimochi H. Modulation of radial blood flow during Braille character discrimination task. Acta physiologica Hungarica, 99: 25-32, 2012.
  • Tsuchimochi H, Yamauchi K, McCord JL, and Kaufman MP. Blockade of acid sensing ion channels attenuates the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. The Journal of Physiology, 589: 6173-6189, 2011.
  • Leal AK, McCord JL, Tsuchimochi H, and Kaufman MP. Blockade of the TP receptor attenuates the exercise pressor reflex in decerebrated rats with chronic femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology, 301 (5): H2140-2146, 2011.
  • McCord JL, Tsuchimochi H, Yamauchi K, Leal AK, and Kaufman MP. Tempol attenuates the exercise pressor reflex independently of neutralizing reactive oxygen species in femoral arterial ligated rats. Journal of Applied Physiology, 111: 971-979, 2011.
  • Tsuchimochi H, McCord JL, Leal AK, and Kaufman MP. Dorsal root tetrodotoxin-resistant sodium channels do not contribute to the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology 300 (2): H652-663, 2011.
  • McCord JL, Tsuchimochi H and Kaufman MP. P2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex in decerebrated cats. Journal of Applied Physiology 109 (5): 1416-1423, 2010.
  • Tsuchimochi H, McCord JL and Kaufman MP. Peripheral μ-opioid receptors attenuate the augmented exercise pressor reflex in rats with chronic femoral artery occlusion. American Journal of Physiology-Heart and Circulatory Physiology 299 (2): H557-565, 2010.
  • Tsuchimochi H, McCord JL and Kaufman MP. Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats. American Journal of Physiology-Heart and Circulatory Physiology 299 (1): H106-113, 2010.
  • Tsuchimochi H, Nakamoto T and Matsukawa K. Centrally evoked increase in adrenal sympathetic outflow elicits immediate secretion of adrenaline in anaesthetized rats. Experimental Physiology 95: 93-106, 2010.
  • McCord JL, Tsuchimochi H and Kaufman MP. Acid-sensing ion channels contribute to the metaboreceptor component of the exercise pressor reflex. American Journal of Physiology-Heart and Circulatory Physiology 297: H443-H449, 2009.
  • Tsuchimochi H, Hayes SG, McCord JL and Kaufman MP. Both central command and exercise pressor reflex activate cardiac sympathetic nerve activity in decerebrate cats. American Journal of Physiology-Heart and Circulatory Physiology 296: H1157-H1163, 2009.
  • Tsuchimochi H, Matsukawa K, Komine H and Murata J. Direct measurement of cardiac sympathetic efferent nerve activity during dynamic exercise. American Journal of Physiology-Heart and Circulatory Physiology 283: H1896-H1906, 2002.
  • Tsuchimochi H, Inashima S, and Wada M. Effect of dithiothreitol on Ca2+-ATPase activity of sarcoplasmic reticulum in rat skeletal muscle after high-intensity exercise. Japanese Journal of Physical Fitness and Sports Medicine 50: 325-332, 2001 (Article in Japanese).
  • Wada M, and Tsuchimochi H. Dysfunction of Sarcoplasmic Reticulum by Exercise. Japanese Journal of SPORTS SCIENCES 15: 279-285, 1996 (Article in Japanese).

著書

  • 土持 裕胤 (2012). 「12 運動昇圧反射」 宮村実晴(編) 身体運動と呼吸・循環機能,真興交易㈱医書出版部 pp. 283-291 (分担執筆).
  • 松川 寛二,中本 智子,高橋 真,小峰 秀彦,土持 裕胤 (2007). 「VI. 加齢と循環調節」 斎藤 満(編著) 循環II-運動時の調節と適応,NAP,pp. 207-224 (分担執筆).
受賞
学位 博士(保健学)
所属学会 日本生理学会、日本体力医学会
American Physiological Society
教育活動
その他の活動
研究者情報 J-GLOBALResearcherID
リンク

最終更新日 2015年04月01日

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