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心臓生理機能部

2015年の業績

  1. Waddingham M.T., A.J. Edgley, A. Astolfo, T. Inagaki, Y. Fujii, C-K. Du, D-Y. H. Tsuchimochi, N. Yagi, D.J. Kelly, M. Shirai and J.T. Pearson. Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing cross-bridge myosin extension. Cardiovascular Diabetology 14:92, 2015.
  2. Nagai H., I. Kuwahira, D.O. Schwenke, H. Tsuchimochi, A. Nara, S. Ogura, T. Sonobe, Y. Fujii, R. Yamaguchi, L. Wingenfeld, K. Umetani, T. Shimosawa, J.T. Pearson, K. Yoshida, and M. Shirai. Activation of β3-AR/iNOS pathway in pulmonary M1 macrophage prevents development of intermittent hypoxia-induced pulmonary arterial hypertension. PLoS One 10(7):e0131923, 2015.
  3. Sonobe T., H. Tsuchimochi, D.O. Schwenke, and M. Shirai. Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography. Cardiovascular Diabetology 14(1):51, 2015.
  4. Kainuma, S., S. Miyagawa, S. Fukushima, J. Pearson, Y-C. Chen, A. Harada, H. Watabe, G. Horitsugi, M. Ishibashi, H. Ikeda, H. Tsuchimochi, T. Sonobe, Y. Fujii, H. Naito, K. Umetani, T. Shimizu, T. Okano, E. Kobayashi, T. Daimon, A. Saito, T. Ueno, T. Kuratani, K. Toda, N. Takakura, J. Hatazawa, M. Shirai, Y. Sawa. Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart. Molecular Therapy 23(2):374-86, 2015.
  5. Higuchi T., S. Miyagawa, J.T. Pearson, S. Fukushima, A. Saito, H. Tsuchimochi, T. Sonobe, Y. Fujii, N. Yagi, A. Alberto, M. Shirai, Y. Sawa. Functional and electrical integration of induced pluripotent stem cell-derived cardiomyocytes in an acute myocardial infarction rat model. Cell Transplantation.24:2479-2489, 2015.
  6. Shirai M., N. Joe, H. Tsuchimochi, T. Sonobe, D.O. Schwenke. Ghrelin Supresses Sympathetic Hyperexcitation in Acute Heart Failure in Male Rats: Assessing Centrally and Peripherally Mediated Pathways. Endocrinology. 156:3309-3316, 2015.
  7. Jiao Q., Q. Ke, W. Li, M. Jin, Y. Luo, L. Zhang, D. Yang and X. Zhang. Effect of inflammatory factor-induced cyclo-oxygenase expression on the development of reperfusion-related no-reflow phenomenon in acute myocardial infarction. Clinical and Experimental Pharmacology and Physiology 42, 162-170, 2015.
  8. Larsimont J.C., K.K.Youssef, A. Sanchez-Danes, V. Sukumaran, M. Defrance, B. Delatte, M. Liagre, P. Baatsen, J.C. Marine, S. Lippens, C. Guerin, V. Del Marmol, J.M. Vanderwinden, F. Fuks and C. Blanpain. Sox9 Controls Self-Renewal of Oncogene Targeted Cells and Links Tumor Initiation and Invasion. Cell Stem Cell. 17(1): 60-73, 2015.
  9. 生理活性ペプチドを用いた拡張型心筋症の新規治療法の開発. 戦 冬雲, 杜 成坤, 秋山 剛, 白井 幹康. Medical Science Digest. 41(13):476-479, 2015
  10. Yamakoshi K., K. Yagishita, H. Tsuchimochi, T. Inagaki, M. Shirai, D.C. Poole, Y. Kano. Microvascular oxygen partial pressure during hyperbaric oxygen in diabetic rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 309:R1512-1520, 2015.
  11. Kidoya H., H. Naito, F. Muramatsu, D. Yamakawa, W. Jia, M. Ikawa, T. Sonobe, H. Tsuchimochi, M. Shirai, R.H. Adams, A. Fukamizu, N. Takakura. APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Dev Cell.33:247-259, 2015.
  12. Zohdi, V., J.T. Pearson, M. Kett, P. Lombardo, M. Schneider-Kolsky, and M.J. Black. When early life growth restriction in rats is followed by attenuated postnatal growth: effects on cardiac function in adulthood. Eur J Nutr 54(5):743-750, 2015.
  13. Abe C., Y. Nagai, S. Shimizu, T. Akiyama, T. Kawada, M. Sugimachi and H. Morita. Reduced carotid baroreceptor distensibility-induced baroreflex resetting contributes to impairment of sodium regulation in rats fed a high-fat diet. Am J Physiol Heart Circ Physiol 308, H942-950, 2015.
  14. Sata Y., T. Kawada, S. Shimizu, A. Kamiya, T. Akiyama and M. Sugimachi. Predominant role of neural arc in sympathetic baroreflex resetting of spontaneously hypertensive rats. Circ J 79, 592-599, 2015.
  15. Shimizu S., T. Kawada, T. Akiyama, M.J. Turner, T. Shishido, A. Kamiya, M. Shirai and M. Sugimachi. Guanfacine enhances cardiac acetylcholine release with little effect on norepinephrine release in anesthetized rabbits. Auton Neurosci 187, 84-87, 2015.
  16. Matsuo T, Takeda S, Oda T, Fujiwara S "Structures of the Troponin Core Domain Containing the Cardiomyopathy-Causing Mutants Studied by Small-Angle X-ray Scattering" Biophys. Physicobiol. 12, 145-158 (2015)
  17. Ngo, J.P., S. Kar, M.M. Kett, B.S. Gardner, J.T. Pearson, D.W. Smith, J. Ludbrook, J.F. Bertram, and R.G. Evans. Vascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney. Am J Physiol Renal Physiol 207: F1111-F1122, 2015.
  18. Zohdi V., J. Lim, J.T. Pearson* and M.J. Black. Developmental programming of cardiovascular disease following intrauterine growth restriction: findings using a rat model of maternal protein restriction. Nutrients 7:119-152, 2015. *corresponding author
  19. Waddingham, M.T., A.J. Edgley, D.J. Kelly, H. Tsuchimochi, M. Shirai and J.T. Pearson. Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes. 6(7):943-960, 2015.
  20. Zohdi, V., D. Whelan, B. Wood, J.T. Pearson, M.J. Black, K. Bambery. Importance of Tissue Preparation Methods in FTIR Micro-Spectroscopical Analysis of Biological Tissues: Traps for New Users. PLoS One 10(2):e0116491, 2015.
  21. Pearson, J.T. Cardiac responses to hypoxia and reoxygenation in Drosophila. New insights into evolutionary conserved gene responses. Am J Physiol Reg Integr Comp Physiol. 309(11):R1344-R1346, 2015.

国内外の学会参加・発表者

  1. Exhaled H2 molecules may be an anti-oxidative biomarker Akito Shimouchi, 日本呼吸器学会
  2. 牛乳乳製品摂取による呼気水素ならびに健康効果への影響 下内章人, 日本酸化ストレス学会
  3. 皮膚ガス中ヒドロキシルラジカル計測法の開発 神野直哉, 日本質量分析学会
  4. Hydrogen and oxygen consumption during moderate exercise with the inhalation of hydrogen gas Norio Hotta, International Association of Breath Research
  5. Basic consideration of exogenous H2 consumption in the biological system Akito Shimouchi, International Association of Breath Research
  6. Effects of Hydrogen Gas on Emanation of Hydroxyl Radical from Human Skin N.Jinno, International Association of Breath Research
  7. Effects of Epac-specific inhibitor, ESI-09 on Therapy of Heart Failure MeiHua Jin, Physiological Society of Japan
  8. Cardioprotective Role of Neuronal Ca2+-Sensor -1 during Stress. Nakamura,T, Biophysical Society 59th Annual Meeting
  9. 癌悪液質筋委縮は筋ジスとは異なりCa2+透過チャネルTRPV2非依存的な機構で筋変性を起す 岩田裕子, 第88回日本薬理学会年会
  10. カルシウムセンサーNCS-1はマウスの空間学習・記録に寄与する 中尾周, 第92回日本生理学会
  11. Calcineurin B homologous protein (CHP3) regulates phosphorylation of GSK3beta Kobayashi S, 第92回日本生理学会
  12. Effects of Epac-specific inhibitor, ESI-09 on heart failure model mice Jin M, 第92回日本生理学会
  13. 細胞内Ca2+シグナルによる代謝調節 中村-西谷友重, 第92回日本生理学会
  14. Aerobic treadmill training prevents the obesity caused by gene disruption of Ca2+-sensor protein in mice Wakabayashi S, 第92回日本生理学会
  15. Calcineurin homologous protein 1 interferes with calcineurin-dependent regulation of the renal Na-K-2Cl-cotransporter. Boldt C, Experimental Biology meeting 2015
  16. Absence of TRPV2 impaired BAT thermogenesis in mice. Sun,W, The 5th International Ion Channel Conference
  17. 癌悪液質における筋傷害にCa2+透過チャネルは関与するか? 岩田裕子, 第1回日本筋学会学術集会
  18. 細胞内Ca2+センサー蛋白質を介した心筋内ストレス防御機構 西谷(中村)友重, 第108回 近畿生理談話会
  19. 細胞内カルシウムセンサーによる心筋ストレス防御機構 西谷(中村)友重, 心血管膜輸送研究会2015
  20. Na+/H+交換輸送体NHE1とカルシニューリンとの結合に対するGタンパク質共役型受容体刺激の効果 久光隆, BMB2015 第38回日本分子生物学会年会第88回日本生化学会合同大会
  21. 継続的な有酸素運動はCa2+センサー蛋白質欠損で起こるマウスの肥満を解消できる 若林繁夫, BMB2015 第38回日本分子生物学会年会および第88回日本生化学会大会 合同大会
  22. 拡張型心筋症ノックインマウス生命予後に対するグレリンの治療効果 戦 冬雲, 第92回日本生理学会大会
  23. 心筋トロポニンT突然変異による肥大型心筋症ノックインマウスモデル 杜成坤, 第92回日本生理学会大会、第88回日本薬理学会年会
  24. モノアミンオキシダーゼによる心筋虚血再灌流時のヒドロキシラジカル産生 稲垣薫克, 第92回日本生理学会大会
  25. 中枢を介した迷走神経活性化による拡張型心筋症治療薬 戦冬雲, 第88回日本薬理学会年会
  26. 麻酔下マウス心機能評価における体温調節の重要性 土持裕胤, 第92回日本生理学会大会
  27. The role of TRPV1-expressing neurons in the control of heart rate during dynamic exercise in rats Tsuchimochi H, Experimental Biology 2015 (Boston, USA)
  28. Even small changes in body temperature can affect the cardiac function in anesthetized mice Tsuchimochi H, Experimental Biology 2015 (Boston, USA)
  29. Rho Kinase Inhibition Improves Cardiac Cross-Bridge Dynamics in Early Diabetic Cardiomyopathy Waddingham MT, Experimental Biology 2015 (Boston, USA)
  30. ヘビ毒由来プロテアーゼの立体構造と作用機構 武田壮一, 第15回日本蛋白質科学会年会
  31. 心臓間質におけるヒドロキシルラジカル測定法の開発 稲垣薫克, 第70回日本体力医学会大会
  32. Demonstrating the benefits of beta-blockers in hypertensive diabetic heart disease with synchrotron microangiography. Pearson JT, Medical Applications in Synchrotron Radiation 2015 Conference, ESRF Grenoble, France
  33. Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in young insulin resistant Goto-Kakizaki rats. Chen Y-C, Medical Applications in Synchrotron Radiation 2015 Conference, ESRF Grenoble, France
  34. In Vivo Microvascular Imaging Capability at the Australian Synchrotron. Pearson JT, Australian Society of Molecular Imaging Annual Meeting, Baker-IDI, Melbourne

最終更新日 2016年07月01日

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