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心臓生理機能部

2013年の業績

  1. Shirai M., D.O. Schwenke, H. Tsuchimochi, K. Umetani, N. Yagi, J.T. Pearson. Synchrotron radiation imaging for advancing our understanding of cardiovascular function. Circ Res 112(1): 209-221, 2013.
  2. Joshi, M.S, P. Berger, D.M. Kaye, J.T. Pearson, J.A. Bauer, and R. Ritchie. Functional relevance of genetic variations of endothelial nitric oxide synthase (NOS3) and vascular endothelial growth factor (VEGF) in diabetic coronary microvessel dysfunction. Clin Exper Pharmacol Physiol 40:253-261, 2013.
  3. Jenkins M.J., J.T. Pearson, D.O. Schwenke, A.J. Edgley, T. Sonobe, Y. Fujii, H. Ishibashi-Ueda, D.J. Kelly, N. Yagi, and M. Shirai. Myosin heads are displaced from actin filaments in the in situ beating rat heart in early diabetes. Biophys J. 104(5): 1065-1072, 2013.
  4. Pearson J.T., M.J. Jenkins, A. Edgley, T. Sonobe, M. Joshi, M.T. Waddingham, Y. Fujii, D.O. Schwenke, H. Tsuchimochi, M. Yoshimoto, K. Umetani, D.J. Kelly, and M. Shirai. Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation. Cardiovasc Diabetol 12:111, 2013.
  5. Shirai M., M. Beard, J.T. Pearson, T. Sonobe, H. Tsuchimochi, Y. Fujii, E. Gray, K. Umetani, and D.O. Schwenke. Impaired pulmonary blood flow distribution in congestive heart failure assessed using synchrotron radiation microangiography. J Synchrotron Radiat 20(3): 441-448, 2013.
  6. Gray E.A., H. Tsuchimochi, J.T. Pearson, T. Sonobe, Y. Fujii, M. Yoshimoto, K. Umetani, M. Shirai, and D.O. Schwenke. Assessment of the serotonin pathway as a therapeutic target for pulmonary hypertension. J Synchrotron Radiat 20(5): 756-764, 2013.
  7. Nakaoka H., Y. Nakagawa-Toyama, M. Nishida, T. Okada, R. Kawase, T. Yamashita, M. Yuasa-Kawase, K. Nakatani, D. Masuda, T. Ohama, T. Sonobe, M. Shirai, I. Komuro and S. Yamashita. Establishment of a novel murine model of ischemic cardiomyopathy with multiple diffuse coronary lesions. PLoS One 8(8): e70755, 2013.
  8. Ogura S., T. Shimosawa, S. Mu, T. Sonobe, F. Kawakami-Mori, H. Wang, Y. Uetake, K.I. Yoshida, Y. Yatomi, M. Shirai and T. Fujita. Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing oxidized LDL receptor. Am J Physiol Heart Circ Physiol 305(2): H155-H162, 2013.
  9. Maeda H., H. Nagai, G. Takemura, K. Shintani-Ishida, M. Komatsu, S. Ogura, T. Aki, M. Shirai, I. Kuwahira, K-I. Yoshida. Intermittent-hupoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart. Biochim Biophys Acta 1832(8): 1159-1166, 2013.
  10. Fujii Y., M. Shirai, S. Inamori, A. Shimouchi, T. Sonobe, H. Tsuchimochi, J.T. Pearson, Y. Takewa, E. Tatsumi and Y. Taenaka. Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model. Artif Organs 37(2): 136-141, 2013.
  11. Inamori S., M. Shirai, N. Yahagi, J.T. Pearson, Y. Fujii, K. Umetani, Y. Kobayashi, Y. Okura, M. Yakehiro and M. Minamiyama. A comparative study of cerebral microcirculation during pulsatile and nonpulsatile selective cerebral perfusion: Assessment by synchrotron radiation microangiography. ASAIO J 59(4): 374-379, 2013.
  12. Fujii Y., M. Shirai, H. Tsuchimochi, J.T. Pearson, Y. Takewa, E. Tatsumi and Y. Taenaka. Hyperoxic condition promotes an inflammatory responses during cardiopulmonary bypass in a rat model. Artif Organs 37:1034-1040, 2013.
  13. Komaki F., T. Akiyama, T. Yamazaki, H. Kitagawa, S. Nosaka and M. Shirai. Effects of intravenous magnesium infusion on in vivo release of acetylcholine and catecholamine in rat adrenal medulla. Auton Neurosci 177, 123-128, 2013.
  14. Kawada T., T. Akiyama, S. Shimizu, A. Kamiya, K. Uemura, M.J. Turner, M. Shirai and M. Sugimachi. Sympathetic afferent stimulation inhibits central vagal activation induced by intravenous medetomidine in rats. Acta Physiol 209, 55-61, 2013.
  15. Zhan D.Y., C.K. Du, T. Akiyama, T. Sonobe, H. Tsuchimochi, S. Shimizu, T. Kawada and M. Shirai. In vivo monitoring of acetylcholine release from cardiac vagal nerve endings in anesthetized mice. Auton Neurosci 176: 91-94, 2013.
  16. Sonobe T., T. Akiyama, C.K. Du, D.Y. Zhan and M. Shirai. Contribution of serotonin uptake and degradation to myocardial interstitial serotonin levels during ischemia-reperfusion in rabbits. Acta Physiol 207: 260-268, 2013.
  17. Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T. "Crystal structure of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism" J. Thromb. Haemost. 11: 1399-1406 (2013)
  18. Takeda S "Russellysin (Book chapter)" In The 3rd edition of Handbook of Proteolytic Enzymes (Rawlings, N. and Salvesen, G. (ed.)), Elsevier, 1051-1053, (2013)
  19. Zohdi, V., B.R. Wood, J.T. Pearson, K.R. Bambery, and M.J. Black. Evidence of altered biochemical composition in the hearts of adult intrauterine growth-restricted rats. European Journal of Nutrition, 52(2):749-758, 2013.

国内外の学会参加・発表者

  1. Increases in Breath Carbon Oxide during Night Sleep are associated with Deterioration of Mental Health Conditions.,2013年3月, 横浜. Akito Shimouchi, 日本生理学会
  2. Alterations of hydrogen exhalation and carbon monoxide production in monocrotaline-induced pulmonary hypertension rats.  Tomoe Mizukami, 日本生理学会、Breath Analysis Summit (ドイツ)
  3. 拡張型心筋症ノックインマウスに対するグレリンの治療効果 杜成坤, 日本生理学会、第86回日本薬理学会年会、第17回日本心血管内分泌代謝学会学術総会
  4. マウス心臓交感神経終末におけるノルエピネフリン動態の解析-マイクロダイアリシス法を用いて-戦冬雲, 日本生理学会
  5. 麻酔下マウスにおける心臓迷走神経終末からのアセチルコリン分泌モニタリング-マイクロダイアリシス法を用いて- 戦冬雲, 日本生理学会、第86回日本薬理学会年会
  6. Hyperoxic air insufflation aggravates the systemic inflammatory response during cardiopulmonary bypass  Yutaka Fujii, 第90回日本生理学会大会
  7. Abnormal cross-bridge dynamics in the in situ beating rat heart in early diabetes.  白井幹康, 第90回日本生理学会大会
  8. Changes in renal sympathetic nerve activity during development of renovascular hypertension in rats.  吉本光佐, 日本生理学会大会
  9. 慢性低酸素により生じる右心室肥大におけるNCS-1の働き 稲垣薫克 日本生理学会
  10. Stimulation of subthalamic locomotor region stimulates myocardial perfusion in anesthetized rats 土持裕胤, 第90回 日本生理学会大会
  11. 血管造影法を用いた小動物血管網の可視的機能評価 曽野部崇, 第67回日本体力医学会大会
  12. 水素付加による体外循環時の炎症反応および臓器障害の抑制効果 藤井豊, 第50回日本人工臓器学会大会
  13. A small animal extracorporeal circulation model for studying pathophysiology of cardiopulmonary bypass Yutaka Fujii, 20th Congress of the International Society for Rotary Blood Pump
  14. A novel miniature CPB model using rat for pathophysiological examination Yutaka Fujii, ASAIO 58th Annual Conference
  15. 環デバイス評価につながる小動物体外循環モデルの構築 藤井豊, 第35回日本バイオレオロジー学会
  16. 先端放射光画像による心血管機能のin vivo解析 白井幹康, 第4回 Molecular Cardiovascular Conference II
  17. Hydrogen Consumption in the Human Body during the Inhalation of Hydrogen Gas  Akito Shimouchi, 日本呼吸器学会
  18. Possible clinical significance of breath hydrogen monitoring as an anti-oxidative biomarker Shimouchi A, Breath Analysis Summit(ドイツ)
  19. Direct detection of hydroxyl radicals emanating from human skin using laser-induced fluorescence technique Che DC, Breath Analysis Summit(ドイツ)
  20. Sympathetic nerve activity during the development of hypertension in Dahl salt-sensitive rats 吉本光佐, International Union of Physiological Science(UK)
  21. 水素水飲水ならびに低濃度水素ガス吸入に伴う水素消費の定量 下内章人, 分子状水素医学シンポジウム
  22. 水素水および難消化性糖類を摂取したときの呼気ガス中水素濃度の検討 青木実怜, 分子状水素医学シンポジウム
  23. ヒト糞便中から放出される硫黄化合物の動態 下内章人, 第73回分析化学討論会
  24. ヒトとラットにおける水素水飲水に伴う水素分子の呼気動態の解析と対比 水上智恵,第73回分析化学討論会
  25. Contributions of central command and exercise pressor reflex on myocardial perfusion during exercise in rats Tsuchimochi,H, Experimental Biology 2013 (Boston, USA)
  26. うっ血性心不全の病態生理学における脳セロトニン機能障害の役割 李蕾, 第86回日本薬理学会年会、第17回日本心血管内分泌代謝学会学術総会
  27. In vivo imaging of intracellular Ca2+ after muscle contraction and direct calcium injection in diabetic rat skeletal muscle. Hiroaki Eshima Experimental Biology 2013
  28. Hyperoxia condition Promotes an inflammatory response during extracorporeal circulation in rat model. Yutaka Fujii, 51st Annual Meeting of Japanese Society of Artificial Organs(Yokohama)
  29. Hydrogen gas suppresses systemic inflammatory response during cardiopulmonary bypass in a rat mode. Yutaka Fujii, l ASAIO 59th Annual Conference(Chicago)
  30. 低侵襲体外循環を目指した低充填量回路の作製 -ラット体外循環モデルを用いた評価-藤井豊, 第36回日本バイオレオロジー学会 (福岡)

最終更新日 2016年07月01日

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