国立循環器病研究センター研究所

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  • 組織・各部の紹介
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組織・各部の紹介　分子生理部

最近の論文

  1. Hisamitsu, T., Ben Ammar, Y. Nakamura, T.Y., Wakabayashi, S.: Dimerization is crucial for the function of the Na+/H+ Exchanger NHE1. (2006) Biochemistry (in press).
  2. Mishima, M., Wakabayashi, S., Kojima, C.: Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. (2006) J. Biol. Chem. (in press).
  3. Kobayashi, Y., Katanosaka, Y., Iwata, Y., Shigekawa, M, Wakabayashi, S.: Identification and characterization of GSRP-56, a novel Golgi-localized spectrin-repeat containing protein. (2006) Exp. Cell Res. 312: 3152-3164
  4. Ben Ammar, Y., Takeda, S., Hisamitsu, T., Mori. H., Wakabayashi,S.: Crystal structure of CHP2 in complex with its binding region in NHE1 and insights into the mechanism of pH regulation. (2006) EMBO J. 25(11): 2315-2325
  5. Nakamura, T.Y., Jeromin, A., Smith, G., Kurushima, H., Koga, H., Nakabeppu, Y., Wakabayashi, S., Nabekura, J.: Novel Role of Neuronal Ca2+ Sensor-1 as a Survival Factor Up-Refulated in Injured Neurons. (2006) J. Cell Biol. 172(7): 1081-1091
  6. Ben Ammar, Y., Takeda, S., Sugawara, M., Miyano, M., Mori, H., Wakabayashi, S.: Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1. (2005) Acta Crystallographica Section F 61(10): 956-958
  7. Iwata, Y., Katanosaka, Y., Zhu, S., Kobayashi, Y., Hanada, H., Shigekawa, M., Wakabayashi, S.: Protective effects of Ca2+ handling drugs against abnormal Ca2+ homeostasis and cell damage in myopathic skeletal muscle cells. (2005) Biochem. Pharmacol. 70: 740-751
  8. Hamahata, K., Adachi, S., Matsubara, H., Okada, M., Imai, T., Watanabe, K., Toyokuni, S., Ueno, M., Wakabayashi, S., Katanosaka, Y., Akiba, S., Kubota, M., Nakahata, T.: Mitochondrial dysfunction is related to necrosis-like programmed cell death induced by A23187 in CEM cells. (2005) Eur. J. Pharmacol. 516: 187-196
  9. Katanosaka, Y., Iwata, Y., Kobayashi, Y., Shibasaki, F., Wakabayashi, S., Shigekawa, M.: Calcineurin Inhibits Na+/Ca2+ Exchange in Phenylephrine-treated Hypertrophic Cardiomyocytes. (2005) J. Biol. Chem. 280(7): 5764-5772
  10. Iwata, Y., Shigekawa, M., Wakabayashi, S.: Cardiac Syntrophin Isoforms: Species-Dependent Expression, Association with Dystrophin Complex and Subcellular Localization. (2005) Mol. Cell. Biochem. 268: 59-66
  11. Iwata, Y., Sampaolesi, M., Shigekawa, M., Wakabayashi, S.: Syntrophin is an actin-binding protein the cellular localization of which is regulated through cytoskeletal reorganization in skeletal muscle cells. (2004) Eur. J. Cell Biol. 83: 555-565
  12. Hisamitsu, T., Pang, T., Shigekawa, M., Wakabayashi, S.: Dimeric Interaction between the Cytoplasmic Domains of the Na+/H+ Exchanger NHE1 Revealed by Symmetrical Intermolecular Cross-Linking and Selective Co-Immunoprecipitation. (2004) Biochemistry 43(34): 11135-11143
  13. Kokubo, Y., Inamoto, N., Tomoike, H., Kamide, K., Takiuchi, S., Kawano, Y., Tanaka, C., Katanosaka, Y., Wakabayashi, S., Shigekawa, M., Hishikawa, O., Miyata, T.: Association of Genetic Polymorphisms of Sodium-Calcium Exchanger 1 Gene, NCX1, with Hypertension in a Japanese General Population. (2004) Hypertension Res. 27(10): 697-702
  14. Pang, T., Hisamitsu, T., Mori, H., Shigekawa, M., Wakabayashi, S.: Role of Calcineurin B Homologous Protein in pH Regulation by the Na+/H+ Exchanger 1: Tightly Bound Ca2+ Ions as Important Structural Elements. (2004) Biochemistry 43(12): 3628-3636
  15. Muraki, K., Iwata, Y., Katanosaka, Y., Ito, T., Ohya, S., Shigekawa, M., Imaizumi, Y.: TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes. (2003) Circ. Res. 93: 829-838
  16. Wakabayashi, S., Hisamitsu, T., Pang, T., Shigekawa, M.: Kinetic dissection of two distinct proton binding sites in Na+/H+ exchangers by measurement of reverse mode reaction. (2003) J. Biol. Chem. 278(44): 43580-43585
  17. Iwata, Y., Katanosaka, Y., Arai, Y., Komamura, K., Miyatake, K., Shigekawa, M.: A novel mechanism of myocyte degeneration involving the Ca2+-permeable growth factor-regulated channel. (2003) J. Cell Biol. 161(5): 957-967
  18. Wakabayashi, S., Hisamitsu, T., Pang, T., Shigekawa, M.: Mutations of Arg440 and Gly455/Gly456 Oppositely Change pH-Sensing of Na+/H+ Exchanger NHE1. (2003) J. Biol. Chem. 278(14): 11828-11835
  19. Hirata, T., Kaneko, T., Ono, T., Nakazato, T., Furukawa, N., Hasegawa, S., Wakabayashi, S., Shigekawa, M., Chang, M.-H., Romero M., Hirose, S.: Mechanism of acid adaptation of a fish living in a pH 3.5 lake. (2003) Am J Physiol Regul Integr Comp Physiol. 284(5): R1199-R1212
  20. Su, X., Pang, T., Wakabayashi, S., Shigekawa, M.: Evidence for involvement of the putative first extracellular loop in differential volume-sensitivity of the Na+/H+ exchangers NHE1 and NHE2. (2003) Biochemistry 42(4): 1086-1094
  21. Pang, T., Wakabayashi, S., Shigekawa, M.: Expression of Calcineurin B Homologous Protein 2 Protects Serum Deprivation-Induced Cell Death by Serum-Independent Activation of Na+/H+ exchanger. (2002) J. Biol. Chem. 277(46): 43771-43777
  22. Miyazaki, E., Sakaguchi, M., Wakabayashi, S., Shigekawa, M., Mihara, K.: NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. (2001) J. Biol. Chem. 276(52): 49221-49227
  23. Pang, T., Su, X., Wakabayashi, S., Shigekawa, M.: Calcineurin-homologous protein as an essential cofactor for Na+/H+ exchangers. (2001) J. Biol. Chem. 276(20): 17367-17372
  24. Nakamura T.Y., Iwata Y., Sampaolesi, M., Hanada, H., Saito,N., Artman, M.,Coetzee, W.A., Shigekawa, M.: Stretch-activated cation channels in skeletal muscle myotubes from sarcoglycan-deficient hamsters. (2001) Am. J. Physiol. 281: C690-C699
  25. Hisamitsu, T., Ohata, H., Kawanishi, T., Iwamoto, T., Shigekawa, M., Amano, H., Yamada, S., Momose, K.: A mechanism of Ca2+ release from Ca2+ stores coupling to the Na+/Ca2+ exchanger in cultured smooth muscle cells. (2001) Life Sci. 69: 2775-2787
  26. Shigekawa, M., Iwamoto, T.: Cardiac Na+/Ca2+ Exchange. Molecular and Pharmacological Aspects. (2001) Circ. Res. 88: 864-876
  27. Wakabayashi, S., Pang, T., Su, X., Shigekawa, M.: Structure_Function of the Na+/H+ exchangers. Role of interacting proteins. (2001) Kidney Int. 60: 403-404
  28. Sampaolesi, M., Yoshida, T., Iwata, T., Hanada, H., Shigekawa, M.: Stretch-induced cell damage in sarcoglycan-deficient myotubes. (2001) Pflugers Arch. 442: 161-170
  29. Wakabayashi, S., Pang, T., Su, X., Shigekawa, M.: Second mutations rescue point mutant of the Na+/H+ exchanger NHE1 showing defective surface expression. (2000) FEBS Lett. 487: 257-261
  30. Iwamoto, T., Uehara, A., Imanaga, I., Shigekawa, M.: The Na+/Ca2+ exchanger NCX1 has oppositely oriented reentrant loop domains that contain conserved aspartic acids whose mutation alters its apparent Ca2+ affinity. (2000) J. Biol. Chem. 275: 38571-38580
  31. Wakabayashi, S., Pang, T., Su, X., Shigekawa, M.: A novel topology model of the human Na+/H+ exchanger isoform 1. (2000) J. Biol. Chem. 275: 7942-7949
  32. Kobayashi, Y., Pang, T., Iwamoto, T., Wakabayashi, S., Shigekawa, M.: Lithium activates the Na+/H+ exchanger: Isoform specificity and inhibition by genistein. (2000) Pflugers Arch. 439: 455-462

最終更新日 2011年03月07日

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国立循環器病研究センター研究所：〒565-8565 大阪府吹田市藤白台5丁目7番1号　電話：06-6833-5012（代）
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