ホーム > 各部のご紹介 > 分子生理部 > 業績

分子生理部

中川 修 (Osamu NAKAGAWA)

  1. Fujita M, Sakabe M, Ioka T, Watanabe Y, Kinugasa-Katayama Y, Tsuchihashi T, Utset MF, Yamagishi H, Nakagawa O. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev 139:65-73, 2016.
  2. Mizuta K, Sakabe M, Hashimoto A, Ioka T, Sakai C, Okumura K, Hattammaru M, Fujita M, Araki M, Somekawa S, Saito Y, Nakagawa O. Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos. Dev Dyn 244:31-42, 2015.
  3. Morioka T, Sakabe M, Ioka T, Iguchi T, Mizuta K, Hattammaru M, Sakai C, Itoh M, Sato GE, Hashimoto A, Fujita M, Okumura K, Araki M, Xin M, Pedersen RA, Utset MF, Kimura H, Nakagawa O. An important role of endothelial Hairy-related transcription factors in mouse vascular development. Genesis 52:897-906, 2014.
  4. Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K, Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y. Tmem100, an ALK1 signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Nat Acad Sci USA 109:12064-9, 2012.
  5. Xin M, Small EM, van Rooij E, Qi X, Richardson JA, Nakagawa O, Olson EN. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Nat Acad Sci USA 104:7975-80, 2007.
  6. Nakagawa O, Arnold M, Nakagawa M, Hamada H, Shelton JM, Kusano H, Harris TM, Childs G, Campbell KP, Richardson JA, Nishino I, Olson EN. Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev 19:2066-77, 2005.
  7. Murakami M, Nakagawa M, Olson EN, Nakagawa O. A WW domain protein TAZ is a critical co-activator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Nat Acad Sci USA 102:18034-9, 2005.
  8. Kathiriya IS, King IN, Murakami M, Nakagawa M, Astle JA, Gardner KA, Gerard RD, Olson EN, Srivastava D, Nakagawa O. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem 279:54937-43, 2004.
  9. Gottlieb PD, Pierce SA, Sims RJ III, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nature Genet 31:25-32, 2002.
  10. Nakagawa O, McFadden DG, Nakagawa M, Yanagisawa H, Hu T, Srivastava D, Olson EN. Members of the HRT family of bHLH proteins act as transcriptional repressors downstream of Notch signaling. Proc Nat Acad Sci USA 97:13655-60, 2000.

西谷(中村)友重 (Tomoe Y. NAKAMURA)

  1. Wakabayashi S, Hisamitsu T, Nakamura TY. Regulation of the cardiac Na+/H+ exchanger in health and disease. J Mol Cell Cardiol 61:68-76, 2013.
  2. Nakamura TY, Wakabayashi S. Role of neuronal calcium sensor-1 in the cardiovascular system. Trends Cardiovasc Med 22:12-7, 2012.
  3. Nakamura TY, Jeromin A, Mikoshiba K, Wakabayashi S. Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals. Circ Res 109:512-23, 2011.
  4. Nakamura TY*, Iwata Y*, Arai Y, Komamura K, Wakabayashi S (* Equal Contribution). Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Circ Res 103:891-9, 2008.
  5. Nakamura TY, Jeromin A, Smith G, Kurushima H, Koga H, Nakabeppu Y, Wakabayashi S, Nabekura J. Novel role of neuronal Ca2+ sensor-1 as a survival factor up-regulated in injured neurons. J Cell Biol 172:1081-91, 2006.
  6. Nakamura TY, Pountney DJ, Ozaita A, Nandi S, Ueda S, Rudy B, Coetzee WA. A role for frequenin, a Ca2+-binding protein, as a regulator of Kv4 K+-currents. Proc Natl Acad Sci USA 98:12808-13, 2001.
  7. Nakamura TY, Iwata Y, Sampaolesi M, Hanada H, Saito N, Artman M, Coetzee WA, Shigekawa M. Stretch-activated cation channels in skeletal muscle myotubes from sarcoglycan-deficient hamsters. Am J Physiol Cell Physiol 281:C690-9, 2001.
  8. Nakamura TY, Yamamoto I, Nishitani H, Matozaki T, Suzuki T, Wakabayashi S, Shigekawa M, Goshima K. Detachment of cultured cells from the substratum induced by the neutrophil-derived oxidant NH2Cl: Synergistic role of phosphotyrosine and intracellular Ca2+ concentration. J Cell Biol 131:509-24, 1995.
  9. Nakamura TY, Yamamoto I, Kanno Y, Shiba Y, Goshima K. Metabolic coupling of glutathione between mouse and quail cardiac myocytes and its protective role against oxidative stress. Circ Res 74:806-16, 1994.
  10. Nakamura TY, Goda K, Okamoto T, Kishi T, Nakamura T, Goshima K. Contractile and morphological impairment of cultured fetal mouse myocytes induced by oxygen radicals and oxidants. Correlation with intracellular Ca2+ concentration. Circ Res 73:758-70, 1993.

久光 隆 (Takashi HISAMITSU)

  1. Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Hirayama N, Wakabayashi S. Na+/H+ exchanger 1 is regulated via its lipid-interacting domain which functions as a molecular switch: A pharmacological approach using indolocarbazole compounds. Mol Pharmacol 85:18-28, 2014.
  2. Wakabayashi S, Hisamitsu T, Nakamura TY. Regulation of the cardiac Na+/H+ exchanger in health and disease. J Mol Cell Cardiol 61:68-76, 2013.
  3. Shimada-Shimizu N, Hisamitsu T, Nakamura TY, Wakabayashi S. Evidence that Na+/H+ exchanger 1 is an ATP-binding protein. FEBS J 280:1430-42, 2013.
  4. Hisamitsu T, Nakamura TY, Wakabayashi S. Na+/H+ exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy. Mol Cell Biol 32:3265-80, 2012.
  5. Wakabayashi S, Nakamura TY, Kobayashi S, Hisamitsu T. Novel phorbol ester-binding motif mediates hormonal activation of Na+/H+ exchanger. J Biol Chem 285:26652-61, 2010.
  6. Iwata Y, Katanosaka Y, Hisamitsu T, Wakabayashi S. Enhanced Na+/H+ exchange activity contributes to the pathogenesis of muscular dystrophy via involvement of P2 receptors. Am J Pathol 171:1576-87, 2007.
  7. Hisamitsu T*, Yamada K*, Nakamura TY, Wakabayashi S (* Equal Contribution). Functional importance of charged residues within the putative intracellular loops in pH regulation by Na+/H+ exchanger NHE1. FEBS J 274:4326-35, 2007.
  8. Hisamitsu T, BenAmmar Y, Nakamura TY, Wakabayashi S. Dimerization is crucial for function of the Na+/H+ exchanger NHE1. Biochemistry 45:13346-55, 2006.
  9. BenAmmar Y, Takeda S, Hisamitsu T, Mori H, Wakabayashi S. Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. EMBO J 25:2315-25, 2006.
  10. Hisamitsu T, Pang T, Shigekawa M, Wakabayashi S. Dimeric interaction between the cytoplasmic domains of the Na+/H+ exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation. Biochemistry 31:11135-43, 2004.

渡邉 裕介 (Yusuke WATANABE)

  1. Inoue SI, Moriya M, Watanabe Y, Miyagawa-Tomita S, Niihori T, Oba D, Ono M, Kure S, Ogura T, Matsubara Y, Aoki Y. New BRAF knock-in mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet 23:6553-66, 2014.
  2. Vincent SD, Mayeuf-Louchart A, Watanabe Y, Brzezinski JA 4th, Miyagawa-Tomita S, Kelly RG, Buckingham M. Prdm1 functions in the mesoderm of the second heart field, where it interacts genetically with Tbx1, during outflow tract morphogenesis in the mouse embryo. Hum Mol Genet 23:5087-101, 2014.
  3. Huynen L, Suzuki T, Ogura T, Watanabe Y, Millar CD, Hofreiter M, Smith C, Mirmoeini S, Lambert DM. Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes). BMC Evol Biol 14:75, 2014.
  4. Aoki Y, Niihori T, Banjo T, Okamoto N, Mizuno S, Kurosawa K, Ogata T, Takada F, Yano M, Ando T, Hoshika T, Barnett C, Ohashi H, Kawame H, Hasegawa T, Okutani T, Nagashima T, Hasegawa S, Funayama R, Nagashima T, Nakayama K, Inoue S, Watanabe Y, Ogura T, Matsubara Y. Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome. Am J Hum Genet 93:173-80, 2013.
  5. Watanabe Y, Zaffran S, Kuroiwa A, Higuchi H, Ogura T, Harvey RP, Kelly RG, Buckingham M. Fgf10 regulation in the second heart field by Tbx1, Nkx2-5 and Islet1 reveals a genetic switch for down-regulation of transcription in the myocardium. Proc Natl Acad Sci U S A 109:18273-80, 2012.
  6. Watanabe Y, Buckingham M. The formation of the embryonic mouse heart: heart fields and myocardial cell lineages. Ann N Y Acad Sci 1188:15-24, 2010.
  7. Watanabe Y, Miyagawa-Tomita S, Stephane VD, Kelly RG, Moon AM, Buckingham M. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries.
    Circ Res 106:495-503, 2010.
  8. Park EJ*, Watanabe Y*, Smyth G, Miyagawa-Tomita S, Meyers E, Klingensmith J, Camenisch T, Buckingham M, Moon AM (* Equal Contribution). An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development 135:3599-610, 2008.
  9. Prall OW, Menon MK, Solloway MJ, Watanabe Y, Zaffran S, Bajolle F, Biben C, McBride JJ, Robertson BR, Chaulet H, Stennard FA, Wise N, Schaft D, Wolstein O, Furtado MB, Shiratori H, Chien KR, Hamada H, Black BL, Saga Y, Robertson EJ, Buckingham ME, Harvey RP. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 128:947-59, 2007.
  10. Watanabe Y, Kokubo H, Miyagawa-Tomita S, Endo M, Igarashi K, Aisaki K, Kanno J, Saga Y. Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development 133:1625-34, 2006.

過去の業績

分子生理部ロゴ

最終更新日 2017年05月08日

ページ上部へ