ホーム > 各部のご紹介 > 分子生理部 > 業績

分子生理部

分子生理部では現在心血管系の発生・形態形成・成熟機能獲得の分子機構研究、特に転写調節因子・シグナル伝達分子に関する研究を行っています。

研究テーマ関連業績(前所属における業績を含む)

  • Araki M, et al., Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells. Angiogenesis 2018.
  • Fujita M, et al. Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor. Mech Dev 2016.
  • Mizuta K, et al. Impairment of endothelial-mesenchymal transformation during atrioventricular cushion formation in Tmem100 null embryos. Dev Dyn 2015.
  • Morioka T, et al. An important role of endothelial Hairy-related transcription factors in mouse vascular development. genesis 2014.
  • Somekawa S, et al. Tmem100, an ALK1 signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Nat Acad Sci USA 2012.
  • Watanabe Y, et al. Fgf10 regulation in the second heart field by Tbx1, Nkx2-5 and Islet1 reveals a genetic switch for down-regulation of transcription in the myocardium. Proc Natl Acad Sci U S A 2012.
  • Watanabe Y, et al. Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res 2010.
  • Park EJ*, Watanabe Y*, et al. (* Equal contribution) An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. Development 2008.
  • Xin M, et al. Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Nat Acad Sci USA 2007.
  • Watanabe Y, et al. Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse. Development 2006.
  • Murakami M, et al. A WW domain protein TAZ is a critical co-activator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Nat Acad Sci USA 2005.
  • Kathiriya IS, et al. Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem 2004.
  • Gottlieb PD, et al. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nature Genet 2002.
  • Nakagawa O, et al. Members of the HRT family of bHLH proteins act as transcriptional repressors downstream of Notch signaling. Proc Nat Acad Sci USA 2000.

これまでの部の業績

分子生理部ロゴ

最終更新日 2018年11月30日

ページ上部へ