National Cerebral and Cardiovascular

Menu

  1. National Cerebral and Cardiovascular Center TOP
  2. Hospital
  3. The Group of Treatment
  4. Lifestyle disease department - Department of Preventive Cardiology
  5. More details

Department of Preventive Cardiology

More details

The Department of Preventive Cardiology aims for our health and longevity through epidemiological research on cardiovascular disease. Until now, it was an urgent task to take measures against stroke and ischemic heart disease. But recently, the aging rate has become the highest in the world, and it has become necessary to take measures against diseases of organ terminal images. However, there are few studies on heart failure and dementia in Japan, and studies that track both are not in Japan. We are a hospital with specialists in the brain and heart, and we are confident that we will be able to obtain precious follow-up research results by closely tracking both.

Recent research results

Relationship between masticatory function and the onset of cardiovascular disease in urban residents (April 21, 2021)
Hashimoto S, Kosaka T, Nakai M, Kida M, Suita S, Kokubo Y, et al. A lower maximum bite force is a risk factor for developing cardiovascular disease: The Suita Study.

Relationship between continuous regular dental consultations and masticatory efficiency in urban residents (March 6, 2020)
Fujii K, Kosaka T, Hasegawa Y, Kida M, Hashimoto S, Suita S, et al. Periodical utilization of dental services is an effective breakthrough for declining masticatory performance: The Suita Study. Odontology. 2020; 108: 715-22

Development of predictive score for coronary artery disease and stroke in urban residents (February 28, 2020)
Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, et al. Development of a cardiovascular disease risk prediction model using the Suita study, a population-based prospective cohort study in Japan. J Atheroscler Thromb. 2020; 27: 1160 -75

Suggesting the relationship between long-term changes in fasting blood glucose levels in Japan and the risk of developing cardiovascular disease after middle age (February 20, 2019)
Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, et al. Longitudinal trajectories of fasting plasma glucose and risks of cardiovascular diseases in middle age to elderly people within the general Japanese population: The Suita Study. J Am Heart Assoc. 2019; 8: e010628

Carotid plaque progression is associated with subsequent risk of developing cardiovascular disease (June 1, 2018)
Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, Miyamoto Y. Impact of intima-media thickness progression in the common carotid arteries on the risk of incident cardiovascular disease in the Suita study. J Am Heart Assoc. 2018; 7: e007720.

Research content

Suita Study NEXT (Sep 2021- )
A follow-up study of heart failure and dementia in urban areas, including sensory (visual, auditory, and olfactory) dysfunctions that are risk factors.

Co-creation place formation support program
Intractable cardiovascular disease / cancer, dementia, emerging revival viral infectious disease Research aimed at forming a community-based bio-community in order to realize a resilient society that can overcome

Heart Failure Severity Prevention Measures Project (October 2020-)
A project to work on a joint project to prevent heart failure in Suita citizens, to engage in non-drug intervention research while providing new health guidance to citizens, and to engage in long-term follow-up research on prognostic factors (medical costs, long-term care, cause of death) of heart failure.

Suita Study (April 1989-)
Cardiovascular cohort study of urban residents

  1. Higashiyama A, Wakabayashi I, Okamura T, Kokubo Y, Watanabe M, et al. The risk of fasting triglycerides and its related indices for ischemic cardiovascular diseases in Japanese community dwellers: The Suita study. J Atheroscler Thromb. 2021 (in press)
  2. Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, et al. Development of a cardiovascular disease risk prediction model using the Suita study, a population-based prospective cohort study in Japan. J Atheroscler Thromb. 2020;27:1160-1175
  3. Higashiyama A, Kokubo Y, Watanabe M, Nakao YM, Okamura T, et al. Echocardiographic parameters and the risk of incident atrial fibrillation: The Suita study. J Epidemiol. 2020;30:183-187
  4. Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, et al. Longitudinal trajectories of fasting plasma glucose and risks of cardiovascular diseases in middle age to elderly people within the general Japanese population: The Suita study. J Am Heart Assoc. 2019;8:e010628
  5. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, et al. Impact of Intima-Media Thickness Progression in the Common Carotid Arteries on the Risk of Incident Cardiovascular Disease in the Suita Study. J Am Heart Assoc. 2018;7(11). pii: e007720
  6. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kusano K, et al. Development of a Basic Risk Score for Incident Atrial Fibrillation in a Japanese General Population - The Suita Study. Circ J. 2017; 81:1580-1588.
  7. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, et al. Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. Am J Hypertens. 2015;28:1355-61.
  8. Tsukinoki R, Okamura T, Watanabe M, Kokubo Y, Higashiyama A, et al. Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in japanese: The Suita study. Am J Hypertens. 2014;27:1362-1369
  9. Nishimura K, Okamura T, Watanabe M, Nakai M, Takegami M, et al. Predicting coronary heart disease using risk factor categories for a Japanese urban population, and comparison with the Framingham risk score: The Suita study. J Atheroscler Thromb. 2014;21:784-798
  10. Tatsumi Y, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Okamura T, et al. Effect of age on the association between waist-to-height ratio and incidence of cardiovascular disease: The Suita study. J Epidemiol. 2013;23:351-359
  11. Higashiyama A, Okamura T, Watanabe M, Kokubo Y, Wakabayashi I, Okayama A, et al. Alcohol consumption and cardiovascular disease incidence in men with and without hypertension: The Suita study. Hypertens Res. 2013;36:58-64
  12. Arai H, Kokubo Y, Watanabe M, Sawamura T, Ito Y, Minagawa A, et al. Small dense low-density lipoproteins cholesterol can predict incident cardiovascular disease in an urban Japanese cohort: The Suita Study. J Atheroscler Thromb. 2013;20:195-203
  13. Watanabe M, Kokubo Y, Higashiyama A, Ono Y, Miyamoto Y, et al. Serum 1,5-anhydro-d-glucitol levels predict first-ever cardiovascular disease: An 11-year population-based cohort study in Japan, the Suita study. Atherosclerosis. 2011;216:477-483
  14. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, et al. A revised definition of the metabolic syndrome predicts coronary artery disease and ischemic stroke after adjusting for low density lipoprotein cholesterol in a 13-year cohort study of Japanese: The Suita study. Atherosclerosis. 2011;217:201-206
  15. Higashiyama A, Wakabayashi I, Ono Y, Watanabe M, Kokubo Y, et al. Association with serum gamma-glutamyltransferase levels and alcohol consumption on stroke and coronary artery disease: The Suita study. Stroke. 2011;42:1764-1767
  16. Kokubo Y, Okamura T, Watanabe M, Higashiyama A, Ono Y, et al. The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study. Hypertens Res. 2010;33:1238-43.
  17. Watanabe M, Kokubo Y, Higashiyama A, Ono Y, Okayama A, et al. New diagnosis criteria for diabetes with hemoglobin a1c and risks of macro-vascular complications in an urban Japanese cohort: The Suita study. Diabetes Res Clin Pract. 2010;88:e20-23
  18. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ono Y, et al. Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort: The Suita study. Atherosclerosis. 2010;209:290-294
  19. Furukawa Y, Kokubo Y, Okamura T, Watanabe M, Higashiyama A, et al. The relationship between waist circumference and the risk of stroke and myocardial infarction in a Japanese urban cohort: The Suita study. Stroke. 2010;41:550-553
  20. Kokubo Y, Nakamura S, Okamura T, Yoshimasa Y, et al. Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study. Stroke. 2009;40:2674-9.
  21. Higashiyama A, Okamura T, Ono Y, Watanabe M, Kokubo Y, et al. Risk of smoking and metabolic syndrome for incidence of cardiovascular disease--comparison of relative contribution in urban Japanese population: The Suita study. Circ J. 2009;73:2258-2263.
  22. Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Miyamoto Y, et al. Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study. Atherosclerosis. 2008
  23. Kokubo Y, Okamura T, Yoshimasa Y, Miyamoto Y, Kawanishi K, et al. Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the suita study. Hypertens Res. 2008;31:2027-35.
  24. Kokubo Y, Kamide K, Okamura T, Watanabe M, Higashiyama A, et al. Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort: the Suita study. Hypertension. 2008;52:652-9

Suita Research: Dentistry
A study in which a dental examination was conducted in a cardiovascular cohort study targeting urban residents

  1. Kosaka T, Ono T, Kida M, Fushida S, Nokubi T, Kokubo Y, et al. Deterioration of periodontal status affects declines in masticatory performance: the Suita study. J Clin Periodontol. 2021 (in press)
  2. Kosaka T, Ono T, Kida M, Fushida S, Nokubi T, Kokubo Y, et al. Association between declines in objective masticatory performance and salivary stress markers: The Suita study. J Oral Rehabil. 2021;48:575-81
  3. Kosaka T, Ono T, Kida M, Fushida S, Nokubi T, Kokubo Y, et al. A prediction model of masticatory performance change in 50- to 70-year-old Japanese: The Suita study. J Dent. 2021;104:103535
  4. Hashimoto S, Kosaka T, Nakai M, Kida M, Fushida S, Kokubo Y, et al. A lower maximum bite force is a risk factor for developing cardiovascular disease: the Suita study. Sci Rep. 2021;11:7671
  5. Fushida S, Kosaka T, Kida M, Kokubo Y, Watanabe M, Higashiyama A, et al. Decrease in posterior occlusal support area can accelerate tooth loss: The Suita study. J Prosthodont Res. 2021 (in press)
  6. Kida M, Ono T, Kokubo Y, Yoshimuta Y, Kosaka T, Kikui M, et al. Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study. J Prosthodont Res. 2020;64:346-53
  7. Fujii K, Kosaka T, Hasegawa Y, Kida M, Hashimoto S, Fushida S, et al. Periodical utilization of dental services is an effective breakthrough for declining masticatory performance: the Suita study. Odontology. 2020;108:715-22
  8. Kosaka T, Kida M, Kikui M, Hashimoto S, Fujii K, Yamamoto M, et al. Factors Influencing the Changes in Masticatory Performance: The Suita Study. JDR Clin Trans Res. 2018;3:405-12
  9. Choi YH, Kosaka T, Ojima M, Sekine S, Kokubo Y, Watanabe M, et al. Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study. BMC Oral Health. 2018;18:77
  10. Kikui M, Ono T, Kokubo Y, Kida M, Kosaka T, Yamamoto M, et al. Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population: The Suita study. J Dent. 2017;56:53-7
  11. Kikui M, Kokubo Y, Ono T, Kida M, Kosaka T, Yamamoto M, et al. Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study. J Atheroscler Thromb. 2017;24:495-507
  12. Kosaka T, Ono T, Kida M, Kikui M, Yamamoto M, Yasui S, et al. A multifactorial model of masticatory performance: the Suita study. J Oral Rehabil. 2016;43:340-7
  13. Kikui M, Ono T, Kida M, Kosaka T, Yamamoto M, Yoshimuta Y, et al. Does the utilization of dental services associate with masticatory performance in a Japanese urban population?: the Suita study. Clin Exp Dent Res. 2015;1:57-62.
  14. Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, et al. Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study. Atherosclerosis. 2014;237:123-8.
  15. Kosaka T, Ono T, Yoshimuta Y, Kida M, Kikui M, Nokubi T, et al. The effect of periodontal status and occlusal support on masticatory performance: the Suita study. J Clin Periodontol. 2014;41:497-503.

Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD study: April 2015-)
A study to identify risk factors and defense factors for dementia and elucidate their pathophysiology in 10,000 people in 8 districts nationwide

1. Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y; JPSFC-AD Study Group. Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). Environ Health Prev Med. 2020 Oct 31;25(1):64

The Japan Publish Health Cohort study (JPHC study, April 1989-)
A cohort study of various diseases such as cancer, cardiovascular disease, and diabetes, targeting local residents in 11 health districts nationwide, gathering information on lifestyle-related diseases and tracking the onset of diseases for a long period of 20 years or more. This study is being conducted to clarify what lifestyles are associated with the development of diseases.

  1. Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Clin Nutr. 2017. pii: S0261-5614(17)30274-1.
  2. Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, Inoue M, Tsugane S. The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population. Stroke. 2013;44:1369-74.
  3. Kokubo Y, Iso H, Saito I, Yamagishi K, Ishihara J, Inoue M, Tsugane S; JPHC Study Group. Dietary fiber intake and risk of cardiovascular disease in the Japanese population. Eur J Clin Nutr. 2011;65:1233-41.
  4. Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S; JPHC Study Group. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations. Circulation. 2007;116:2553-62.
  5. Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, Kokubo Y, Tsugane S. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: the Japan Public Health Center-Based (JPHC) Study Cohort I. Circulation. 2006;113:195-202.

Cross-disease cohort research information infrastructure development project utilizing electronic medical information
This research infrastructure project promotes cohort studies across diseases by integrating epidemiological data held by six national highly specialized medical research centers (National Centers: NC) in Japan. The expected outcome is as follows:
1) Strengthening the cross-disease research implementation system
2) Cooperation in creating evidence for cross-disease prevention
3) Coordination of efforts for cross-disease prevention

last updated : 2021/10/01

Site setting