National Cerebral and Cardiovascular


Research Institute

Department of Preventive Medicine and Epidemiology



DirectorKunihiro Nishimura
Laboratory ChiefSoshiro Ogata
Staff ScientistEri Kiyoshige
Postdoctoral FellowShogo Watanabe
Kiyomasa Nakatsuka
Graduate StudentMondal Rajib



In our department, we aim to conduct epidemiological research using big data and information science research on artificial intelligence for CVD to accumulate knowledge that contributes to the improvement of healthy life expectancy. We are currently working on the following projects:
・Data mining by using natural language processing for electronic medical records with 98% accuracy (participating in projects for AI Hospital, supported by the Cabinet Office)
・Predicting outcomes for CVD by using machine learning and deep learning, and applying AI to diagnostic imaging of cerebral aneurysm over 95% accuracy
・Research using nationwide CVD database (500K to 1 million study, JROAD study, and All Japan Utstein Registry (published in Lancet)
・Development of the AI prediction model for heat stroke based on data for the 10 million population in the Kansai area (Environment Research and Technology Development Fund of the Ministry of the Environment) (published in Nature Communications and Heart)
・Development of monitoring technology for patients with dementia using AI-powered disaggregation technology with 85% accuracy (Funded by Tokyo Electric Power Company)
・Automated AI diagnostic systems for HCM and other congenital heart disease using 80K cases of Suita city elementary school health check records.
・Developing reusable N95 respirator for prevention of COVID-19 collaborating with Nipro and Daikin



1) Ogata T, Takegami M, Ozaki T, Nakashima T, Onozuka T, Murata T, Nakaoku Y, Kitazume K, Morioka T, Yamazaki S, Yoshida T, Yamagata Y, Nishimura K Heatstroke predictions by machine learning, weather information, and an all-population registry for 12-hour heatstroke alerts Nat Commun. 2021 Jul 28;12(1):4575.

2)Nakashima T, Noguchi T, Tahara Y, Nishimura K, Yasuda S, Onozuka D, Iwami T, Yonemoto N, Nagao K, Nonogi H, Ikeda T, Sato N, Tsutsui H; Japanese Circulation Society with Resuscitation Science Study Group. Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study. Lancet. 2019 Dec 21;394(10216):2255-2262.

3)Ogata S, Akashi Y, Sakusabe T, Yoshizaki S, Maeda Y, Nishimura K, Maeda K, Nakai S. A multiple 24-hour urine collection study indicates that kidney function decline is related to urinary sodium and potassium excretion in patients with chronic kidney disease. Kidney Int. 2022 Jan;101(1):164-173.

4)Nakaoku Y, Ogata S, Murata S, Nishimori M, Ihara M, Iihara K, Takegami M, Nishimura K. AI-Assisted In-House Power Monitoring for the Detection of Cognitive Impairment in Older Adults. Sensors (Basel). 2021 Sep 17;21(18):6249.

5)Ogata S, Nishimura K, Guzman-Castillo M, Capewell S, O'Flaherty et al. Explaining the decline in coronary heart disease mortality rates in Japan: Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. Int J Cardiol. 2019 Sep 15;291:183-188

6)Kurogi R, Nishimura K, T, Hagihara A, Iihara K et al; J-ASPECT Study Collaborators. Comparing intracerebral hemorrhages associated with direct oral anticoagulants or warfarin. Neurology. 2018 ;27;90(13):e1143-e1149

7)Shiraishi I, Nishimura K, Kagisaki K, Ichikawa H et al. Acute rupture of chordae tendineae of the mitral valve in infants: a nationwide survey in Japan exploring a new syndrome. Circulation. 2014 Sep 23;130(13):1053-61

8) Yokoyama Y,Nishimura K, Barnard ND, Takegami M, Watanabe M, Sekikawa A, Okamura T, Miyamoto Y. Vegetarian diets and blood pressure: a meta-analysis. JAMA Intern Med. 2014 Apr;174(4):577-87

last updated : 2024/04/22

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