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Naoto Minamino

Name Naoto MINAMINO
Department Name,
Job Title
Director, Department of Molecular Pharmacology
Tel +81-6-6833-5012 (ext. 2507)
Fax +81-6-6835-5349
E-Mail
Research Field Biochemistry, Pharmacology, Peptide Chemistry, Peptidomics, Proteomics
Research Result
  • C. Nagai and N. Minamino: Direct chemiluminescent enzyme immunoassay for atrial natriuretic peptide in mammalian plasma using a PEGylated antibody. Anal. Biochem., 2014 in press.
  • K. Toshinai, T. Saito, H. Yamaguchi, K. Sasaki, W. Tsuchimochi, N. Minamino, Y. Ueta, and M. Nakazato: Neuroendocrine regulatory peptide-1 and -2 (NERPs) inhibit the excitability of magnocellular neurosecretory cells in the hypothalamus. Brain Res. 1563, 52-60 (2014)
  • K. Maekawa, A. Hirayama, Y. Iwata, Y. Tajima, T. Nishimaki-Mogami, S. Sugawara, N. Ueno, H. Abe, M. Ishikawa, M. Murayama, Y. Matsuzawa, H. Nakanishi, K. Ikeda, M. Arita, R. Taguchi, N. Minamino, S. Wakabayashi, T. Soga, and Y. Saito: Global metabolomic analysis of heart tissue in a hamster model for dilated cardiomyopathy. J. Mol. Cell. Cardiol., 59, 76-85 (2013)
  • K. Tokizane, H. Konishi, M. Yasui, T. Ogawa, K. Sasaki, N. Minamino, and H. Kiyama: Continuous stress promotes expression of VGF in melanotroph via suppression of dopamine. Mol. Cell. Endocrinol., 372, 49-56 (2013)
  • K. Sasaki, T. Osaki, and N. Minamino: Large-scale identification of endogenous secretory peptides using electron transfer dissociation mass spectrometry. Mol. Cell. Proteomics, 12, 700-709 (2013)
  • T. Nishikimi, H. Okamoto, M. Nakamura, N. Ogawa, K. Horii, K. Nagata, Y. Nakagawa, H. Kinoshita, C. Yamada, K. Nakao, T. Minami, Y. Kuwabara, K. Kuwahara, K. Kangawa, N. Minamino, and K. Nakao: Direct immunochemiluminescent assay for proBNP and total BNP in human plasma: proBNP and total BNP levels in healthy individuals and heart failure patients. Plos One, 8, e53233 (2013)
  • H. Fujihara, K. Sasaki, E. Mishiro-Sato, T. Ohbuchi, G. Dayanithi, M. Yamasaki, Y. Ueta, and N. Minamino: Molecular characterization and biological function of neuroendocrine regulatory peptide-3 in the rat. Endocrinology, 153, 1377-1386 (2012)
  • T. Osaki, K. Sasaki, and N. Minamino: Peptidomics-based discovery of an antimicrobial peptide derived from insulin-like growth factor-binding protein 5. J. Proteome Res., 10, 1870-1880 (2011)
  • K. Sasaki, N. Takahashi, M. Satoh, M. Yamasaki, and N. Minamino: A peptidomics strategy for discovering endogenous bioactive peptides. J. Proteome Res.,9, 5047-5052 (2010)
  • E. Mishiro-Satoh, K. Sasaki, T. Matsuo, H. Kageyama, H. Yamaguchi, Y. Date, M. Matsubara, T. Ishizu, K. Yoshizawa-Kumagaye, Y. Satomi, T. Takao, S. Shioda, M. Nakazato, and N. Minamino: Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat. J. Neurochem., 114, 1097-1106 (2010)
  • T. Nishikimi, N. Minamino, M. Ikeda, Y. Takeda, K. Tadokoro, I. Shibasaki, H. Fukuda, Y. Horiuchi, S. Oikawa, T. Ieiri, M. Matsubara, H. Matsuoka: Diversity of molecular forms of plasma brain natriuretic peptide in heart failure: different proBNP-108 to BNP-32 ratios in atrial and ventricular overload. Heart, 96, 432-439 (2010)
  • K. Sasaki, Y. Satomi, T. Takao and N. Minamino: Snapshot peptidomics of the regulated secretory pathway. Mol. Cell. Proteomics, 8, 1638-1647 (2009)
  • T. Katafuchi, T. Osaki, H.Yasue and N. Minamino: Calcitonin receptor- stimulating peptide: Its evolutionary and functional relationship with calcitonin gene-related peptide based on gene structure. Peptides, 30, 1753-1762 (2009)
  • H. Yamaguchi, K. Sasaki, Y. Satomi, T. Shimbara, H. Kageyama, M.S. Mondal, K. Toshinai, Y. Date, L.J. Gonzalez, S. Shioda, T. Takao, M, Nakazato, and N. Minamino: Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2. J. Biol. Chem., 282, 26354-26360 (2007)
  • H. Sawada, H. Yamaguchi, T. Shimbara, K. Toshinai, M.S. Mondal, Y. Date, N. Murakami, T. Katafuchi, N. Minamino, H. Nunoi and M. Nakazato: Central effects of calcitonin receptor-stimulating peptide-1 on energy homeostasis in rats. Endocrinology, 147, 2043-2050 (2006)
  • T. Katafuchi, K. Kikumoto, K. Hamano, K. Kangawa, H. Matsuo and N. Minamino: Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. J. Biol. Chem., 278, 12046-12054 (2003)
  • N. Minamino, J. Tanaka, H. Kuwahara, T. Kihara, Y. Satomi, M. Matsubae and T. Takao: Determination of endogenous peptides in the porcine brain: Possible construction of Peptidome, a fact database for endogenous peptides. J. Chromatogr. B, 792, 33-48 (2003)
  • Y. Tomoda, K. Kikumoto, Y. Isumi, T. Katafuchi, A. Tanaka, K. Kangawa, K. Dohi and N. Minamino: Cardiac fibroblasts are major production and target cells of adrenomedullin in the heart in vitro. Cardiovasc. Res., 49, 721-730 (2001)
  • S. Ueda, K. Nishio, N. Minamino, A. Kubo, Y. Akai, K. Kangawa, H. Matsuo, Y. Fujimura, A. Yoshioka, K. Masui, N. Doi, Y. Murao and S. Miyamoto: Increased plasma levels of adrenomedullin in patients with systemic inflammatory response syndrome. Am. J. Resp. Crit. Care Med., 160, 132-136 (1999)
  • Y. Isumi, A. Kubo, T. Katafuchi, K. Kangawa and N. Minamino: Adrenomedullin suppresses interleukin-1beta-induced tumor necrosis factor-alpha production in Swiss 3T3 cells. FEBS Lett., 463, 110-114 (1999)
  • Y. Isumi, H. Shoji, S. Sugo, T. Tochimoto, M. Yoshioka, K. Kangawa, H. Matsuo and N. Minamino: Regulation of adrenomedullin production in rat endothelial cells. Endocrinology, 139, 838-846 (1998)
  • S. Sugo, N. Minamino, K. Kangawa, K. Miyamoto, K. Kitamura, J. Sakata, T. Eto and H. Matsuo: Endothelial cells actively synthesize and secrete adrenomedullin. Biochem. Biophys. Res. Commun., 201, 1160-1166 (1994)
  • A. Tanaka, K. Miyamoto, N. Minamino, M. Takeda, B. Sato, H. Matsuo and K. Matsumoto: Cloning and characterization of an androgen-induced growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Proc. Natl. Acad. Sci. USA, 89, 8928-8932 (1992)
  • K.J. Koller, D.G. Lowe, G.L. Bennett, N. Minamino, K. Kangawa, H. Matsuo, D.V. Goeddel: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science, 252, 120-123 (1991)
  • T. Sudoh, N. Minamino, K. Kangawa and H. Matsuo: C-type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain. Biochem. Biophys. Res. Commun., 168, 863-870 (1990)
  • A. Miyata, A. Arimura, R.D. Dahl, N. Minamino, L. Jiang, A. Uehara, M.D. Culler and D.H. Coy: Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem. Biophys. Res. Commun., 164, 567-574 (1989)
  • T. Sudoh, K. Kangawa, N. Minamino and H. Matsuo: A new natriuretic peptide in porcine brain. Nature, 332, 78-81 (1988)
  • N. Minamino, K. Kangawa and H. Matsuo: Neuromedin U-8 and U-25: Novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem. Biophys. Res. Commun., 130, 1078-1085 (1985)
  • N. Minamino, K. Kangawa and H. Matsuo: Neuromedin B: A novel bombesin-like peptide identified in porcine spinal cord. Biochem. Biophys. Res. Commun., 114, 541-548 (1983)
Academic Award Received Young Investigator Award of the Japanese Biochemical Society (1989)
Academic Degree Ph.D. (Osaka University, Graduate School of Science)
Academic Society Affiliation The Japanese Biochemical Society, the Japan Endocrine Society, the Japanese Peptide Society, the Cardiovascular Endocrine Society, the Japanese Circulation Society, the Endocrine Society
Educational Activity Fukui University Faculty of Medical Sciences
Other Activities

Peptides, Advisory board.
American Journal of Physiology - Regulatory, Integrative, and Comparative Physiology, Editorial board

Researcher Information J-GLOBAL
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last updated:2021/10/01

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