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  5. Toshihisa Hatae

Research Institute

Toshihisa Hatae

Name Toshihisa Hatae
Department Name,
Job Title		 Laboratory of Drug Action and Metabolism, Departmentof Molecular Pharmacology, Laboratory Chief
Tel +81-6-6833-5012
Fax +81-6-6872-8090
E-Mail (Please refer to the correspondingsection in research result listed below)
Research Field Drug action and metabolism for humancell regulation
Research Result Key publication
  • Hayashi K, Ishizuka S, Yokoyama C, HataeT. Attenuation of interferon-gamma mRNA expressionin activated Jurkat T cells by exogenouszinc via down-regulation of the calcium-independentPKC-AP-1 signaling pathway. Life Sci 83(1-2),6-11, 2008
  • Piqueras L, Reynolds AR, Hodivala-DilkeKM, Alfranca A, Redondo JM, Hatae T, TanabeT, Warner TD, Bishop-Bailey D. Activationof PPARbeta/delta induces endothelial cellproliferation and angiogenesis. ArteriosclerThromb Vasc Biol 27(1), 63-69, 2007
  • Wada M, Yokoyama C, Hatae T, ShimonishiM, Nakamura M, Imai Y, Ullrich V, TanabeT. Purification and characterization of recombinanthuman prostacyclin synthase. J Biochem 135(4),455-463, 2004
  • Hatae T, Tanabe T. [PPARs and signal transductionof prostaglandins]. Seikagaku 74, 551-554,2002. Review. Japanese.
  • Hatae T, Wada M, Yokoyama C, ShimonishiM, Tanabe T. Prostacyclin-dependent apoptosismediated by PPAR delta. J Biol Chem276(49),46260-43267, 2001
  • Hatae T, Takimoto E, Murakami K, FukamizuA. Comparative studies on species-specificreactivity between renin and angiotensinogen.Mol Cell Biochem 131(1), 43-47, 1994
  • Hatae T, Murakami K. [Renin]. TanpakushitsuKakusan Koso 37 (11 Suppl), 1742-1746, 1992.Review. Japanese.
  • Hatae T, Takimoto E, Fukamizu A, MurakamiK. Kinetic studies on recombinant human reninwith recombinant human angiotensinogen derivedfrom Chinese hamster ovary cells. BiomedRes 13(5), 381-383, 1992
  • Hatae T, Takimoto E, Fukamizu A, HoriH, Kimoto K, Murakami K. Expression and purificationof human angiotensinogen in Chinese hamsterovary cells. Biochim Biophys Acta 1121(3),335-338, 1992
Academic Award Received  
Academic Degree Ph.D. in Biochemistry
Academic Society Affiliation Japanese Biochemical Society (JBS),Molecular Biology Society of Japan (MBSJ), PharmaceuticalSociety of Japan (PSJ) and Division of MedicinalChemistry, Japanese Peptide Society (JPS), JapanBranch of International Neuropeptide Society, AmericanSociety of Biochemistry and Molecular Biology (ASBMB)
Educational Activity Member of Society for Mind, Heartand Medical Genetics (Tsukuba, Japan)
Other Activities Member of the Teki-juku MemorialAssociation (Osaka, Japan)
Researcher Information Keywords for the research informationin this lab are human enzyme, human substrate,signaling, cell viability, proliferation, apoptosis,inflammation, human cardiovascular disease, andtherapeutic application.
Link Foundation for Advancement of InternationalScience
（http://www.fais.or.jp/index.html）

last updated：2021/10/01

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