National Cerebral and Cardiovascular


Research Institute

James Pearson

Name James Pearson, Ph.D.
Department Name,
Job Title
Director Department of Cardiac Physiology
Tel +81-6-6170-1069 (ext.60036)
Building / Room Research Institute
Room 50206
Research Field Cardiac Physiology, Cardiovascular Physiology, Diabetes, Hypertension, Heart Failure, X-ray and Synchrotron Imaging, Respiration and Metabolism
Research Result
  1. Zohdi, V., J.T. Pearson, M. Kett, P. Lombardo, M. Schneider-Kolsky, and M.J. Black. When early life growth restriction in rats is followed by attenuated postnatal growth: effects on cardiac function in adulthood. Eur J Nutr 54(5):743-750, 2015.
  2. Ngo, J.P., S. Kar, M.M. Kett, B.S. Gardner, J.T. Pearson, D.W. Smith, J. Ludbrook, J.F. Bertram, and R.G. Evans. Vascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney. Am J Physiol Renal Physiol 207: F1111-F1122, 2015.
  3. Zohdi V., J. Lim, J.T. Pearson* and M.J. Black. Developmental programming of cardiovascular disease following intrauterine growth restriction: findings using a rat model of maternal protein restriction. Nutrients 7:119-152, 2015. *corresponding author
  4. Waddingham, M.T., A.J. Edgley, D.J. Kelly, H. Tsuchimochi, M. Shirai and J.T. Pearson. Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes. 6(7):943-960, 2015.
  5. Kainuma, S., S. Miyagawa, S. Fukushima, J. Pearson, Y-C. Chen, A. Harada, H. Watabe, G. Horitsugi, M. Ishibashi, H. Ikeda, H. Tsuchimochi, T. Sonobe, Y. Fujii, H. Naito, K. Umetani, T. Shimizu, T. Okano, E. Kobayashi, T. Daimon, A. Saito, T. Ueno, T. Kuratani, K. Toda, N. Takakura, J. Hatazawa, M. Shirai, Y. Sawa. Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart. Molecular Therapy 23(2):374-86, 2015.
  6. Higuchi T., S. Miyagawa, J.T. Pearson, S. Fukushima, A. Saito, H. Tsuchimochi, T. Sonobe, Y. Fujii, N. Yagi, A. Alberto, M. Shirai, Y. Sawa. Functional and electrical integration of induced pluripotent stem cell-derived cardiomyocytes in an acute myocardial infarction rat model. Cell Transplantation.24:2479-2489, 2015.
  7. Zohdi, V., D. Whelan, B. Wood, J.T. Pearson, M.J. Black, K. Bambery. Importance of Tissue Preparation Methods in FTIR Micro-Spectroscopical Analysis of Biological Tissues: Traps for New Users. PLoS One 10(2):e0116491, 2015.
  8. Sonobe, T., H. Tsuchimochi, D.O. Schwenke, J.T. Pearson, M. Shirai. Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography. Cardiovascular Diabetology 14(1):51, 2015.
  9. Nagai H., I. Kuwahira, D.O. Schwenke, H. Tsuchimochi, A. Nara, S. Ogura, T. Sonobe, Y. Fujii, R. Yamaguchi, L. Wingenfeld, K. Umetani, T. Shimosawa, J.T. Pearson, K. Yoshida, M. Shirai. Activation of β3-AR/iNOS pathway in pulmonary M1 macrophage prevents development of intermittent hypoxia-induced pulmonary arterial hypertension. PLoS One 10(7):e0131923, 2015.
  10. Waddingham, M.T., A.J. Edgley, A. Astolfo, T. Inagaki, Y. Fujii, C-K. Du, D-Y. H. Tsuchimochi, N. Yagi, D.J. Kelly, M. Shirai and J.T. Pearson. Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing cross-bridge myosin extension. Cardiovascular Diabetology 14:92, 2015.
  11. Pearson, J.T. Cardiac responses to hypoxia and reoxygenation in Drosophila. New insights into evolutionary conserved gene responses. Am J Physiol Reg Integr Comp Physiol. 309(11):R1344-R1346, 2015.
  12. Furtado, M.B., J.C. Wilmans, A. Chandran, M. Tonta, C. Biben, M. Eichenlaub, H.A. Coleman, S. Berger, R. Bouveret, R. Singh, R.P. Harvey, M. Ramialison, J.T. Pearson, H. Parkington, N.A. Rosenthal, M.W. Costa. A novel mouse model for the study of Nkx2-5 reveals transcriptional control of cardiac ion channels. Differentiation 91:29-41, 2016.
  13. Lang, J.A.R, J.T. Pearson, C. Binder-Heschl, M.J. Wallace, M.L. Siew, M.J. Kitchen, A.B. te Pas, A. Fouras, R.A. Lewis, G.R. Polglase, M. Shirai, S.B. Hooper. Increase in blood flow at birth; role of oxygen and lung aeration. J. Physiol. 594:1389-1398, 2016.
  14. Chen, Y.C., T. Inagaki, Y. Fujii, D.O. Schwenke, H. Tsuchimochi, A.J. Edgley, K. Umetani, Y. Zhang, D.J. Kelly, M. Yoshimoto, H. Nagai, R.G. Evans, I. Kuwahira, M. Shirai*, J.T. Pearson*. Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin resistant Goto-Kakizaki rats. Am J Physiol Reg Integr Comp Physiol. 311:R426-R439, 2016. *equal authors
  15. Ngo J., C.P.C. Ow, B.S. Gardiner, S. Kar, J.T. Pearson, D.W. Smith and R.G. Evans. Diffusive shunting of gases and other molecules in the renal vasculature: Physiological and evolutionary significance. Am. J. Physiol. Reg. Integr. Comp. Physiol. 311(5):R797-R810, 2016.
  16. Lew J.K.R., J.T. Pearson, D.O. Schwenke and R. Katare. Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways. Cardiovascular Diabetology 16(1):10, 2016
  17. Samarage, C.R., R. Carnibella, M. Preissner, H. Jones, J.T. Pearson, A. Fouras, S. Dubsky. Contrast free angiography of the pulmonary vasculature in live mice using a laboratory X-ray source. Medical Physics 43(11):6017, 2016.
  18. Neale J., J.T. Pearson, R. Katare, D.O. Schwenke. Ghrelin, microRNAs, and critical limb ischaemia: hungering for a novel treatment option. Frontiers in Endocrinology 8:350, 2017.
  19. Lang J.A., Pearson, J.T., Binder-Heschl, C., Wallace, M.J., Siew ML, Kitchen, M.J., te Pas, A.B., Fouras, A., Lewis, R.A., Polglase, G.R., Shirai, M. & Hooper, S.B. Vagal denervation inhibits the increase in pulmonary blood flow during partial aeration without oxygen at birth. J. Physiol. 595(5):1593-1606, 2017.
  20. Du, C.K., D.Y. Zhan, T. Akiyama, T. Inagaki, T. Shishido, M. Shirai, J.T. Pearson. Myocardial interstitial levels of serotonin and its major metabolite 5-hydroxyindole acetic acid during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 312(1):H60-H67, 2017.
  21. Furtado, M.B., J.C. Wilmanns, A. Chandran, J. Perera, O. Hon, C. Biben, T.J. Willow, H.T. Nim, G. Kaur, S. Simonds, Q. Wu, D. Willians, E. Salimova, N. Plachta, J.M. Denegre, S.A. Murray, D. Fatkin, M. Cowley, J.T. Pearson, D. Kaye, M. Ramialison, R.P. Harvey, N. A. Rosenthal, M.W. Costa. Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling. JCI Insight. 2(6):e88271, 2017.
  22. Alahmari, D.M., B. Skiold, S.K. Barton, I. Nitsos, C. McDonald, S.L. Miller, V. Zahra, R. Galinksy, Q. Wu, M. Farrell, T.J. Moss, S.B. Hooper, J.T. Pearson, G.R. Polglase. Diffusion tensor imaging colour mapping threshold for identification of ventilation-induced brain injury after intrauterine inflammation in preterm lambs. Frontiers Pediatr 5:70, 2017.
  23. Zhan, D.Y., C.K. Du, T. Akiyama, S. Morimoto, S. Shimizu, T. Kawada, M. Shirai. J.T. Pearson. Cardiac vagal control in a knock-in mouse model of dilated cardiomyopathy with a troponin mutation. Auton Neurosci pii:S1566-0702(16)30133-3, 2017.
  24. Gao, X.M., Q. Wu, H. Kiriazis, Y. Su, L.P. Han, J.T. Pearson, A. Taylor, X.J. Du. Microvascular leakage in acute myocardial infarction: characterization by histology, biochemistry and magnetic resonance imaging. Am J Physiol Heart Circ Physiol 312(5):H1068-H1075, 2017.
  25. Flemmer, A.W., M. Thio, M.J. Wallace, K. Lee, M.J. Kitchen, L. Kerr, C.C. Roehr, A. Fouras, R. Carnibella, J. Jani, P. DeKoninck, A.B. te Pas, J.T. Pearson, S.B. Hooper. Lung hypoplasia in newborn rabbits with a diaphragmatic hernia affects pulmonary ventilation but not perfusion. Pediatric Res 82(3):536-543, 2017.
  26. Torii, M., T. Fukui, M. Inoue, S. Kanao, K. Umetani, M. Shirai, T. Inagaki, H. Tsuchimochi, J.T. Pearson, M. Toi. Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography. J Synchrotron Rad 24(5):1039-1047, 2017.
  27. Alahmari, D.M., S.K. Barton, R. Galinsky, I. Nitsos, A. Atik, M. Farrell, J.T. Pearson*, G.R. Polglase*. Correlation between diffusion tensor imaging and histological brain injury in ventilated preterm lambs. Imaging Med 9(3):67-76, 2017.
  28. Sukumaran, V., H. Tsuchimochi, E. Tatsumi, M. Shirai, J.T. Pearson. Azilsartan ameliorates diabetic cardiomyopathy in young db/db mice through the modulation of ACE-2/ANG 1-7/Mas receptor cascade. Biochem. Pharmacol. 144:90-99, 2017.
  29. Ngo, J., B. Le, Z. Khan, M.M. Kett, B.S. Gardner, D.W. Smith, M.M. Melhem, A. Maksimenko, J.T. Pearson*, R.G. Evans*. Micro-computed tomographic analysis of the radial geometry of intrarenal artery-vein pairs in rats and rabbits: comparison with light microscopy. Clin Exper Pharmacol Physiol, 44(12):1241-1253, 2017.
  30. Kainuma, S., S. Miyagawa, S Fukushima, H. Tsuchimochi, T. Sonobe, Y. Fujii, J.T. Pearson, A. Saito, A. Harada, K. Toda, M. Shirai, Y. Sawa. Influence of coronary architecture on the variability in myocardial infarction induced by coronary ligation in rats. PLoS One 12(8):e0183323, 2017.
  31. Khan, Z., J.P. Ngo, B. Le, R.G. Evans, J.T. Pearson, B. Gardiner, D.Smith. Three-dimensional morphometric analysis of the renal vasculature. Am J Physiol Renal Physiol 314(5):F715-F725, 2017.
  32. Alahmari, D.M.*, K.Y.Y. Chan, V. Stojanovska, D. LaRosa, S.K. Barton, I. Nitsos, V. Zahra, J. Barbuto, M. Farrell, S. Yamaoka, S.B. Hooper, J.T. Pearson*, G.R. Polglase*. Diffusion tensor imaging detects ventilation-induced brain injury in preterm lambs. PLoS One 12(12):e0188737, 2017. *equal
  33. Pearson, J.T., M. Yoshimoto, Y.C. Chen, R. Sultani, A.J. Edgley, H. Nakaoka, M. Nishida, K. Umetani, M.T. Waddingham, H.L. Jin, Y. Zhang, D.J. Kelly, D.O. Schwenke, T. Inagaki, H. Tsuchimochi, I. Komuro, S. Yamashita, M. Shirai. Widespread coronary dysfunction in the absence of HDL Receptor SR-B1 in an ischemic cardiomyopathy mouse model. Sci. Rep. 7(1):18108, 2017.
  34. Mochizuki, N., J.T. Pearson, S. Kitamura. Beyond proof of concepts for ideal cardiac regenerative therapy. J Thorac Cardiovasc Surg pii:S0022-5223(17)30915-7, 2017.
  35. Pearson, J.T., N. Collie, R.R. Lamberts, T. Inagaki, M. Yoshimoto, K. Umetani, P. Davis, G. Wilkins, P.P. Jones, M. Shirai, D.O. Schwenke. Ghrelin preserves ischemia-induced vasodilation of male rat coronary vessels following beta-adrenergic receptor blockade. Endocrinology 159(4):1763-1773, 2018.
  36. Katayama, K., T. Sakamoto, K. Saito, H. Tsuchimochi, H. Kaiya, T. Watanabe, J.T. Pearson, Y. Takei. Drinking by amphibious fish: convergent evolution of thirst mechanisms during vertebrate terrestrialization. Sci. Rep. 8(1):625, 2018.
  37. Katare, R., J.T. Pearson, J.K.S. Lew, M. Wei, H. Tsuchimochi, C.K. Du, D.Y. Zhan, K. Umetani, M. Shirai, D.O. Schwenke. Progressive decrease in coronary vascular function associated with type 2 diabetic heart disease. Front. Physiol. 9:696, 2018.
  38. Sukumaran, V., H. Tsuchimochi, Y. Fujii, H. Hosoda, K. Kangawa, T. Akiyama, M. Shirai, J.T. Pearson. Ghrelin pre-treatment attenuates local oxidative stress and end-organ damage during cardiopulmonary bypass in anesthetized rats. Front. Physiol. 9:196, 2018.
  39. Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Central activation of cardiac vagal nerve by α2-adrenergic stimulation in impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci 216:39-45, 2019.
  40. Wilmanns, J.C., R. Pandey, O. Hon, A. Chandran, J.M. Schilling, E. Forte, Q. Wu, G. Cagnone, P. Bais, V. Phillip, D. Coleman, H. Kocalis, S.K. Archer, J.T. Pearson, M. Ramialison, J. Heineke, H.H. Patel, N.A. Rosenthal, M.B. Furtado, M.W. Costa. Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Molecular Metabolism. pii: S2212-8778(18)30836-6, 2019.
  41. Sonobe T, CK Du, T Akiyama, JT Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo. Physiological Reports 7(22):e14297, 2019.
  42. Kawada T, T Akiyama, T Sonobe, S Shimizu, Y Hayama, JT Pearson, T Shishido, M Sugimachi. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci.218:25-30, 2019.
  43. Sukumaran, V., H. Tsuchimochi, T. Sonobe, M. Shirai, J.T. Pearson. Liraglutide improves renal endothelial function in obese Zucker rats on a high salt diet. J Pharmacol Exp Ther 369(3):375-388, 2019.
  44. Bui CB, M Kolodziej, E Lamanna, K Elgass, A Sehgal, I Rudloff, DO Schwenke, H Tsuchimochi, MAGM Kroon, SX Cho, A Maksimenko, M Cholewa, PJ Berger, MJ Young, JE Bourke, JT Pearson, MF Nold, CA Nold-Petry. Interleukin-1 receptor antagonist protects newborn mice against pulmonary hypertension. Front Immunol 10:1480, 2019.
  45. Nagano K, C Kwon, J Ishida, T Hashimoto, JD Kim, N Kisikawa, M Murao, K Kimura, Y Kasuya, S Kimura, YC Chen, H Tsuchimochi, M Shirai, JT Pearson, A Fukamizu. Cooperative action of APJ and α1A-adrenergic receptor in vascular smooth muscle cells induces vasoconstriction. J Biochem 166(5):283-392, 2019.
  46. Waddingham MT, T. Sonobe, H. Tsuchimochi, A.J. Edgley, V. Sukumaran, Y-C Chen, S.S. Hansra, D.O. Schwenke, K. Umetani, K. Aoyama, N. Yagi, D.J. Kelly, S. Gaderi, M. Herwig, D. Kolijn, A. Mugge, W.J. Paulus, T. Ogo, M. Shirai, N. Hamdani, J.T. Pearson. Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model. J. Mole. Cell Cardiol. 137:119-131, 2019.
  47. Pearson JT, M Shirai, V Sukumaran, CK Du, H Tsuchimochi, T Sonobe, MT Waddingham, R Katare, DO Schwenke. Ghrelin and vascular protection. Vascular Biology 1:H97-H102, 2019.
  48. Sukumaran V, H Tsuchimochi, T Sonobe, MT Waddingham, M Shirai, JT Pearson. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 19:24, 2020.
  49. Kawada T, Y Sata, T Akiyama, S Shimizu, T Sonobe, JT Pearson, M Sugimachi. Threshold and saturation pressures of baroreflex-mediated myocardial interstitial acetylcholine release in rats. Auton Neurosci. 225:102657, 2020.
Award Foreign Young Investigator Award, International Union of Physiological Sciences, Kyoto 2009
Academic Degree PhD, Physiology
Academic Society Affiliation American Physiological Society, High Blood Pressure Research Council of Australia, Physiological Society of Japan, European Society of Cardiology, International Society for Hypertension, International Society of Heart Research
Educational Activity Formerly, Lecturers at Monash University, Department of Physiology
Researcher Information

last updated:2021/10/01

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