National Cerebral and Cardiovascular


Research Institute

Department of Biostatistics


DirectorKunihiro Nishimura
Staff ScientistKanako Teramoto
Yusuke Yoshikawa

Research Theme

The development of "Evidence-Based Medicine (EBM)"is essential to elucidate cardiovascular diseases and establish methods for their treatment and prevention. This is a concept that seeks to integrate the best evidence, the experience of healthcare professionals, and the values of healthcare recipients in order to achieve better healthcare or diagnosis for patients. To this end, the latest data science approaches are becoming indispensable. The Department of Biostatistics conducts research in statistical science (data science) for this purpose, and aims to accomplish innovative medical care by applying state-of-the-art statistical methods.


  • Dynamic treatment regimen estimation problem applying ideas from statistical causal inference and reinforcement learning
  • Research to develop predictive models of disease progression and treatment efficacy
  • Research on clinical research design for efficient derivation of medical evidence
  • Research on statistical methods for evaluation and decision making in drug and medical device development
  • Research aimed at solving statistical problems related to survival time analysis
  • Research to progress EBM using big dataset such as Diagnosis Procedure Combination dataset or receipt dataset such as National Database of Health Insurance Claims and Specific Health Checkups of Japan
  • Performing statistical consulting in clinical research (especially observational and epidemiological studies)


  • Fukuma K, Ikeda S, Tanaka T, Kamogawa N, Ishiyama H, Abe S, Tojima M, Kobayashi K, Shimotake A, Nakaoku Y, Nishimura K, Koga M, Toyoda K, Matsumoto R, Ikeda A, Ihara M. Clinical and imaging features of nonmotor onset seizure in poststroke epilepsy. Epilepsia 2022 May 20. Online ahead of print.
  • Tokudome T, Otani K, Mao Y, Jensen LJ, Arai Y, Miyazaki T, Sonobe T, Pearson JT, Osaki T, Minamino N, Ishida J, Fukamizu A, Kawakami H, Onozuka D, Nishimura K, Miyazato M, Nishimura H. Endothelial Natriuretic Peptide Receptor 1 Play Crucial Role for Acute and Chronic Blood Pressure Regulation by Atrial Natriuretic Peptide. Hypertension. doi = 10.1161/ HYPERTENSIONAHA. 121.18114.
  • Yoshimura H, Tanaka T, Fukuma K, Matsubara S, Motoyama R, Mizobuchi M, Matsuki T, Manabe Y, Suzuki J, Kobayashi K, Shimotake A, Nishimura K, Onozuka D, Kawamoto M, Koga M, Toyoda K, Murayama S, Matsumoto R, Takahashi R, Ikeda A, Ihara M; and the PROPOSE Study Investigators. Impact of Seizure Recurrence on 1-Year Functional Outcome and Mortality in Patients With Poststroke Epilepsy. Neurology. 2022 May 4:10.1212/WNL.0000000000200609.
  • Murata S, Takegami M, Ogata S, Ono R, Nakatsuka K, Nakaoku Y, Iihara K, Hagihara A, Nishimura K. Joint effect of cognitive decline and walking ability on incidence of wandering behavior in older adults with dementia: A cohort study. Int J Geriatr Psychiatry. 2022 May;37(5).
  • Nakai M, Iwanaga Y, Sumita Y, Wada S, Hiramatsu H, Iihara K, Kohro T, Komuro I, Kuroda T, Matoba T, Nakayama M, Nishimura K, Noguchi T, Takemura T, Tominaga T, Toyoda K, Tsujita K, Yasuda S, Miyamoto Y, Ogawa H. Associations among cardiovascular and cerebrovascular diseases: Analysis of the nationwide claims-based JROAD-DPC dataset. PLoS One. 2022 Mar 11;17(3):e0264390.
  • Ohta-Ogo K, Sugano Y, Ogata S, Nakayama T, Komori T, Eguchi K, Dohi K, Yokokawa T, Kanamori H, Nishimura S, Nakamura K, Ikeda Y, Nishimura K, Takemura G, Anzai T, Hiroe M, Hatakeyama K, Ishibashi-Ueda H, Imanaka-Yoshida K. Myocardial T-Lymphocytes as a Prognostic Risk-Stratifying Marker of Dilated Cardiomyopathy - Results of the Multicenter Registry to Investigate Inflammatory Cell Infiltration in Dilated Cardiomyopathy in Tissues of Endomyocardial Biopsy (INDICATE Study). Circ J. 2022 Mar 10.
  • Fukuma K, Yamagami H, Ihara M, Tanaka T, Miyata T, Miyata S, Kokame K, Nishimura K, Nakaoku Y, Yamamoto H, Hayakawa M, Kamiyama K, Enomoto Y, Itabashi R, Furui E, Manabe Y, Ezura M, Todo K, Hashikawa K, Uchiyama S, Toyoda K, Nagatsuka K; PRAISE Study Investigators. P2Y12 Reaction Units and Clinical Outcomes in Acute Large Artery Atherosclerotic Stroke: A Multicenter Prospective Study. J Atheroscler Thromb. 2022.
  • Kurogi A, Onozuka D, Hagihara A, Nishimura K, Kada A, Hasegawa M, Higashi T, Kitazono T, Ohta T, Sakai N, Arai H, Miyamoto S, Sakamoto T, Iihara K; J-ASPECT Study Collaborators. Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016.Sci Rep. 2022 Feb 28;12(1):3252.
  • Kato Y, Okada A, Amaki M, Nishimura K, Kanzaki H, Kataoka Y, Miyamoto K, Hamatani Y, Amano M, Takahama H, Hasegawa T, Kusano K, Fujita T, Kobayashi J, Yasuda S, Izumi C. Three-dimensional echocardiography for predicting mitral stenosis after MitraClip for functional mitral regurgitation. J Echocardiogr. 2022 Jan 27. doi: 10.1007/s12574-022-00564-x. Online ahead of print.
  • Arai M, Asaumi Y, Murata S, Matama H, Honda S, Otsuka F, Tahara Y, Kataoka Y, Nishimura K, Noguchi T.Thyroid Storm Patients With Elevated Brain Natriuretic Peptide Levels and Associated Left Ventricular Dilatation May Require Percutaneous Mechanical Support. Crit Care Explor. 2021 Dec 16;3(12):e0599.
  • Amano M, Miyake M, Kitai T, Obayashi Y, Takegami M, Nishimura K, Furukawa Y, Izumi C. Additional Effects of Antiplatelet Therapy on Anticoagulant Agents in Patients With Bioprosthetic Valves and Atrial Fibrillation.Circ J. 2022 Feb 25;86(3):415-424.
  • Ogata S, Akashi Y, Sakusabe T, Yoshizaki S, Maeda Y, Nishimura K, Maeda K, Nakai S. A multiple 24-hour urine collection study indicates that kidney function decline is related to urinary sodium and potassium excretion in patients with chronic kidney disease. Kidney Int. 2022 Jan;101(1):164-173.
  • Takeishi R, Yoshihisa A, Hotsuki Y, Anzai F, Sato Y, Sumita Y, Nakai M, Misaka T, Takeishi Y. Temporal Trends in the Practice Pattern for Sleep-Disordered Breathing in Patients With Cardiovascular Diseases in Japan - Insights From the Japanese Registry of All Cardiac and Vascular Diseases - Diagnosis Procedure Combination. Circ J. 2022 Apr 27. Online ahead of print.
  • Kanaoka K, Iwanaga Y, Nakai M, Nishioka Y, Myojin T, Kubo S, Okada K, Soeda T, Noda T, Sakata Y, Miyamoto Y, Saito Y, Imamura T. Outpatient cardiac rehabilitation dose after acute coronary syndrome in a nationwide cohort. Heart. 2022 Mar 3. Online ahead of print.
  • Nishi T, Ishii M, Tsujita K, Okamoto H, Koto S, Nakai M, Sumita Y, Iwanaga Y, Matoba S, Kobayashi Y, Hirata KI, Hikichi Y, Yokoi H, Ikari Y, Uemura S. Outcomes of Venoarterial Extracorporeal Membrane Oxygenation Plus Intra-Aortic Balloon Pumping for Treatment of Acute Myocardial Infarction Complicated by Cardiogenic Shock. J Am Heart Assoc. 2022 Apr 5;11(7):e023713.
  • Sundaram V, Nagai T, Chiang CE, Reddy YNV, Chao TF, Zakeri R, Bloom C, Nakai M, Nishimura K, Hung CL, Miyamoto Y, Yasuda S, Banerjee A, Anzai T, Simon DI, Rajagopalan S, Cleland JGF, Sahadevan J, Quint JK. Hospitalization for Heart Failure in the United States, UK, Taiwan, and Japan: An International Comparison of Administrative Health Records on 413,385 Individual Patients. J Card Fail. 2022 Mar;28(3):353-366.
  • Tonegawa-Kuji R, Inoue YY, Nakai M, Kanaoka K, Sumita Y, Miyazaki Y, Wakamiya A, Shimamoto K, Ueda N, Wada M, Yamagata K, Ishibashi K, Miyamoto K, Nagase S, Aiba T, Iwanaga Y, Miyamoto Y, Kusano K. Current clinical practice of subcutaneous implantable cardioverter-defibrillator: Analysis using the JROAD-DPC database. Heart Rhythm. 2022 Feb 12:S1547-5271(22)00129-1.

last updated : 2023/08/02

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