National Cerebral and Cardiovascular


Open Innovation Center

Omics Research Center (ORC)


DirectorNaomasa Makita
Deputy DirectorAtsushi Takahashi
Laboratory chiefManabu Shirai, Masaki Wakabayashi

Research Focus - To Decipher Unexplored Molecular Basis of Cardiovascular Diseases by Means of Multi-Omics Approaches

Identification of novel biological, genetic, and clinical markers is essential for the "Precision Medicine"that achieves early diagnosis and prevention of patients at risk. By implementing multi-omics approaches including comprehensive genetic, genomic, proteomic, transcriptomic, and even physiomic analyses, and taking advantage of international collaborations, we aim at interrogating unexplored molecular mechanisms underlying several cardiovascular diseases, such as inherited lethal arrhythmia, common arrhythmia, cardiomyopathy, heart failure, and aneurysm.

    • Global collaboration of the comprehensive genetic and genomic studies for arrhythmias
    • Genetic and proteomic studies of aortic and intracranial aneurysm
    • Multi-omics study of dilated cardiomyopathy
    • Development of high throughput screening technology to functionally validate ion channel VUSs responsible for lethal arrhythmia (AMED project 2019)
    • Epigenetic study of congestive heart failure

last updated:2021/10/02

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