ホーム > 研究について > 2017年以前

2017年以前

  1. Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T, Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M, Kamatani Y. Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat Genet. 49, 1458-1467, 2017.
  2. Bae CR, Hino J, Hosoda H, Arai Y, Son C, Makino H, Tokudome T, Tomita T, Kimura T, Nojiri T, Hosoda K, Miyazato M, Kangawa K. Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity. Sci Rep. 7, 9807, 2017.
  3. Hachiya T, Kamatani Y, Takahashi A, Hata J, Furukawa R, Shiwa Y, Yamaji T, Hara M, Tanno K, Ohmomo H, Ono K, Takashima N, Matsuda K, Wakai K, Sawada N, Iwasaki M, Yamagishi K, Ago T, Ninomiya T, Fukushima A, Hozawa A, Minegishi N, Satoh M, Endo R, Sasaki M, Sakata K, Kobayashi S, Ogasawara K, Nakamura M, Hitomi J, Kita Y, Tanaka K, Iso H, Kitazono T, Kubo M, Tanaka H, Tsugane S, Kiyohara Y, Yamamoto M, Sobue K, Shimizu A. Genetic Predisposition to Ischemic Stroke: A Polygenic Risk Score. Stroke. 48, 253-258, 2017.
  4. Kim JJ, Yun SW, Yu JJ, Yoon KL, Lee KY, Kil HR, Kim GB, Han MK, Song MS, Lee HD, Ha KS, Sohn S, Johnson TA, Takahashi A, Kubo M, Tsunoda T, Ito K, Onouchi Y, Hong YM, Jang GY, Lee JK, Korean Kawasaki Dis Genetics C. A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease. J Hum Genet 62, 1023-1029, 2017.
  5. Nagai-Okatani C, Kangawa K, Minamino N. Three molecular forms of atrial natriuretic peptides: quantitative analysis and biological characterization. Journal of Peptide Science. 23, 486-495, 2017.
  6. Nakagawa Y, Nishikimi T, Kuwahara K, Fujishima A, Oka S, Tsutamoto T, Kinoshita H, Nakao K, Cho K, Inazumi H, Okamoto H, Nishida M, Kato T, Fukushima H, Yamashita JK, Wijnen WJ, Creemers EE, Kangawa K, Minamino N, Nakao K, Kimura T. MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts. J Am Heart Assoc. 6, e003601, 2017.
  7. Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N, Consortium E, Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. Ann Rheumat Dis. 76, 869-877, 2017.
  8. Shindo K, Asakura M, Min KD, Ito S, Fu HY, Yamazaki S, Takahashi A, Imazu M, Fukuda H, Nakajima Y, Asanuma H, Minamino T, Takashima S, Minamino N, Mochizuki N, Kitakaze M. Cartilage Intermediate Layer Protein 1 Suppresses TGF-β Signaling in Cardiac Fibroblasts. International J Gerontol. 11, 67-74, 2017.
  9. Takayama K, Mori K, Tanaka A, Nomura E, Sohma Y, Mori M, Taguchi A, Taniguchi A, Sakane T, Yamamoto A, Minamino N, Miyazato M, Kangawa K, Hayashi Y. Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability. J Med Chem. 60, 5228-5234, 2017.
  10. Takeda H, Ueda Y, Inuzuka T, Yamashita Y, Osaki Y, Nasu A, Umeda M, Takemura R, Seno H, Sekine A, Marusawa H. Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing. Sci Rep. 7, 45605, 2017.
  11. Xiao X, Wang L, Wang C, Yuan TF, Zhou D, Zheng F, Li L, Grigoroiu-Serbanescu M, Ikeda M, Iwata N, Takahashi A, Kamatani Y, Kubo M, Preisig M, Kutalik Z, Castelao E, Pistis G, Amin N, van Duijn CM, Forstner AJ, Strohmaier J, Hecker J, Schulze TG, Muller-Myhsok B, Reif A, Mitchell PB, Martin NG, Schofield PR, Cichon S, Nothen MM, Chang H, Luo XJ, Fang Y, Yao YG, Zhang C, Rietschel M, Li M; Advanced Collaborative Study of Mood Disorder (COSMO) Team, MooDS Bipolar Consortium. Common variants at 2q11.2, 8q21.3, and 11q13.2 are associated with major mood disorders. Transl Psychiat. 7, 1273, 2017.
  12. Nagai-Okatani C, Minamino N. Aberrant Glycosylation in the Left Ventricle and Plasma of Rats with Cardiac Hypertrophy and Heart Failure. PLoS One. 11, e0150210, 2016.
  13. Choi SG, Wang Q, Jia JJ, Chikina M, Pincas H, Dolios G, Sasaki K, Wang R, Minamino N, Salton SRJ, Sealfon SC. Characterization of Gonadotrope Secretoproteome Identifies Neurosecretory Protein VGF-derived Peptide Suppression of Follicle-stimulating Hormone Gene Expression. J Biol Chem. 291, 21322-21331, 2016
  14. Koyama H, Iwakura H, Dote K, Bando M, Hosoda H, Ariyasu H, Kusakabe T, Son C, Hosoda K, Akamizu T, Kangawa K, Nakao K. Comprehensive Profiling of GPCR Expression in Ghrelin-Producing Cells. Endocrinology, 157, 692-704, 2016
  15. Nishigori M, Yagi H, Mochiduki A, Minamino N. Multiomics approach to identify novel biomarkers for dilated cardiomyopathy: Proteome and transcriptome analyses of 4C30 dilated cardiomyopathy mouse model. Biopolymers, 106, 491-502, 2016
  16. Nagai-Okatani C, Kangawa K, Takashio S, Takahama H, Hayashi T, Anzai T, Minamino N. Novel chemiluminescent enzyme immunoassays for individual quantification of three endogenous molecular forms of atrial natriuretic peptide in human plasma. J Applied Lab Med. 1, 47-59, 2016
  17. Aotani D, Son C, Shimizu Y, Nomura H, Hikida T, Kusakabe T, Tanaka T, Miyazawa T, Hosoda K, Nakao K. Reevaluation of anti-obesity action of mazindol and elucidation of its effect on the reward system. Neuroscie lett 28, 141-145, 2016.
  18. Kawase , K., Kondo, K., Saito, T., Shimasaki, A., Takahashi, A., Kamatani, Y., Kawabe, N., Hashimoto, S., Ikeda, M., Kubo, M., Yoshioka, K., Iwata, N. Risk factors and clinical characteristics of the depressive state induced by pegylated interferon therapy in patients with hepatitis C virus infection: A prospective study. Psychiatry Clin Neurosci 70, 489-497 2016.
  19. Saito, T., Ikeda, M., Mushiroda, T., Ozeki, T., Kondo, K., Shimasaki, A., Kawase, K., Hashimoto, S., Yamamori, H., Yasuda, Y., Fujimoto, M., Ohi, K., Takeda, M., Kamatani, Y., Numata, S., Ohmori, T., Ueno, S., Makinodan, M., Nishihata, Y., Kubota, M., Kimura, T., Kanahara, N., Hashimoto, N., Fujita, K., Nemoto, K., Fukao, T., Suwa, T., Noda, T., Yada, Y., Takaki, M., Kida, N., Otsuru, T., Murakami, M., Takahashi, A., Kubo, M., Hashimoto, R., Iwata, N. Pharmacogenomic Study of Clozapine-Induced Agranulocytosis/Granulocytopenia in a Japanese Population. Biol Psychiatry 80, 636-42, 2016.
  20. Shiraishi, K., Okada, Y., Takahashi, A., Kamatani, Y., Momozawa, Y., Ashikawa, K., Kunitoh, H., Matsumoto, S., Takano, A., Shimizu, K., Goto, A., Tsuta, K., Watanabe, S., Ohe, Y., Watanabe, Y., Goto, Y., Nokihara, H., Furuta, K., Yoshida, A., Goto, K., Hishida, T., Tsuboi, M., Tsuchihara, K., Miyagi, Y., Nakayama, H., Yokose, T., Tanaka, K., Nagashima, T., Ohtaki, Y., Maeda, D., Imai, K., Minamiya, Y., Sakamoto, H., Saito, A., Shimada, Y., Sunami, K., Saito, M., Inazawa, J., Nakamura, Y., Yoshida, T., Yokota, J., Matsuda, F., Matsuo, K., Daigo, Y., Kubo, M., Kohno, T. Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. Nat Commun 7, 12451, 2016.
  21. Ikeda, M., Shimasaki, A., Takahashi, A., Kondo, K., Saito, T., Kawase, K., Esaki, K., Otsuka, Y., Mano, K., Kubo, M., Iwata, N. Genome-wide environment interaction between depressive state and stressful life events. J Clin Psychiatry 77, e29-30, 2016.
  22. Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., Zhao, W., Wang, X., Huerta-Chagoya, A., Hu, C., Moon, S., Long, J., Kwak, S.H., Rasheed, A., Saxena, R., Ma, R.C., Okada, Y., Iwata, M., Hosoe, J., Shojima, N., Iwasaki, M., Fujita, H., Suzuki, K., Danesh, J., Jorgensen, T., Jorgensen, M.E., Witte, D.R., Brandslund, I., Christensen, C., Hansen, T., Mercader, J.M., Flannick, J., Moreno-Macias, H., Burtt, N.P., Zhang, R., Kim, Y.J., Zheng, W., Singh, J.R., Tam, C.H., Hirose, H., Maegawa, H., Ito, C., Kaku, K., Watada, H., Tanaka, Y., Tobe, K., Kawamori, R., Kubo, M., Cho, Y.S., Chan, J.C., Sanghera, D., Frossard, P., Park, K.S., Shu, X.O., Kim, B.J., Florez, J.C., Tusie-Luna, T., Jia, W., Tai, E.S., Pedersen, O., Saleheen, D., Maeda, S., Kadowaki, T. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 7, 10531, 2016.
  23. Tsuchiya T, Osaki T, Minamino N, Sasaki K. Peptidomics for Studying Limited Proteolysis. J Proteome Res. 14, 4921-4931, 2015.
  24. Pereira CD, Minamino N, Takao T. Free Thiol of Transthyretin in Human Plasma Most Accessible to Modification/Oxidation. Analyt Chem. 87, 10785-10791, 2015.
  25. Nishikimi T, Nakagawa Y, Minamino N, Ikeda M, Tabei K, Fujishima A, Takayama K, Akimoto K, Yamada C, Nakao K, Minami T, Kuwabara Y, Kinoshita H, Tsutamoto T, Ishimitsu T, Kangawa K, Kuwahara K, Nakao K. Pro-B-type natriuretic peptide is cleaved intracellularly: impact of distance between O-glycosylation and cleavage sites. American Journal of Physiology-Regulatory, Integr Comp Physiol. 309, R639-R649, 2015.
  26. Takashio S, Sugiyama S, Yamamuro M, Takahama H, Hayashi T, Sugano Y, Izumiya Y, Hokimoto S, Minamino N, Yasuda S, Anzai T, Ogawa H. Significance of low plasma levels of brain-derived neurotrophic factor in patients with heart failure. Am J Cardiol. 116, 243-249, 2015.
  27. Takayama K, Mori K, Sohma Y, Taketa K, Taguchi A, Yakushiji F, Minamino N, Miyazato M, Kangawa K, Hayashi Y. Discovery of potent hexapeptide agonists to human neuromedin u receptor 1 and identification of their serum metabolites. ACS Med Chem Lett. 6, 302-307, 2015.
  28. Kim JW, Rhee M, Park JH, Yamaguchi H, Sasaki K, Minamino N, Nakazato M, Song DK, Yoon KH. Chronic effects of neuroendocrine regulatory peptide (NERP-1 and -2) on insulin secretion and gene expression in pancreatic β-cells. Biochem Biophys Res Commun. 457:148-53,2015

最終更新日 2019年09月19日

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