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Makoto Okazawa

Name Makoto Okazawa
Department Name,
Job Title
Department of Vascular Physiology, Laboratory chief
Tel +81 6 6833 5012 ex. 2518
Fax +81 6 6835 5329
E-Mail okazawa@ncvc.go.jp
Research Field Pharmacology, Vascular Medicine, Neuroscience
Research Result
  • Ohtani, T., Ninomiya, H., Okazawa, M., Imamura, S. and Masaki, T.: Bromodeoxyuridine-induced expression of endothelin A in A375 human melanoma cells. Biochem Biophys Res Commun, 234:526-530, 1997.
  • Okazawa, M., Shiraki, T., Ninomiya, H., Kobayashi, S. and Masaki, T.: Endothelin-induced apoptosis of A375 human melanoma cells. J Biol Chem, 273(20):12584-12592, 1998.
  • Iwamuro, Y., Miwa, S., Zhang, XF., Minowa, T., Enoki, T., Okamoto, Y., Hasegawa, H., Furutani, H., Okazawa, M., Ishikawa, M., Hashimoto, N. and Masaki, T.: Activation of three types of voltage-independent Ca2+ channel in A7r5 cells by endothelin-1 as revealed by a novel Ca2+ channel blocker LOE 908. Br J Pharmacol, 126:1107-1114, 1999
  • Miwa, S., Iwamuro, Y., Zhang, X.F., Inoki, T., Okamoto, Y., Okazawa, M. and Masaki, T.: Ca2+ entry channels in rat thoracic aortic smooth muscle cells activated by endothelin-1. Jpn J Pharmacol, 80:281-288, 1999
  • Zhang, X.F., Iwamuro, Y., Enoki, T., Okazawa, M., Lee, K., Komuro, T., Minowa, T., Okamoto, Y., Hasegawa, H., Furutani, H., Miwa, S. and Masaki, T.: Pharmacological characterization of Ca2+ entry channels in endothelin-1-induced contraction of rat aorta using LOE 908 and SK&F 96365. Br J Pharmacol, 127:1388-1398, 1999
  • Okazawa, M., Terauchi, T., Shiraki, T., Matsumura, K. and Kobayashi, S.: l-Menthol-induced [Ca2+]i increase and impulses in cultured sensory neurons. Neuroreport, 11:2151-2155, 2000
  • Okazawa, M., Takao, K., Hori, A., Shiraki, T., Matsumura, K. and Kobayashi, S.: Ionic basis of cold receptors acting as thermostats. J Neurosci, 22:3994-4001, 2002
  • Abe, J., Okazawa, M., Adachi, R., Matsumura, K. and Kobayashi, S.: Primary cold-sensitive neurons in acutely dissociated cells of rat hypothalamus. Neurosci Lett, 342:29-32, 2003
  • Okazawa, M., Inoue, W., Hori, A., Hosokawa, H., Matsumura, K. and Kobayashi, S.: Noxious heat receptors present in cold-sensory cells in rats. Neurosci Lett, 359:33-36, 2004
  • Abe, J., Hosokawa, H., Okazawa, M., Kandachi, M., Sawada, Y., Yamanaka, K., Matsumura, K. and Kobayashi, S.: TRPM8 protein localization in trigeminal ganglion and taste papillae. Brain Res Mol Brain Res, 136:91-98, 2005
  • Kobayashi, S., Okazawa, M., Hori, A., Matsumura, K. and Hosokawa, H.: Paradigm shift in sensory system - Animals do not have sensors. J Thermal Biol, 31:19-23, 2006
  • Nakanishi, S. and Okazawa, M.: Membrane potential-regulated Ca2+ signalling in development and maturation of mammalian cerebellar granule cells. J Physiol, 575:389-395, 2006
  • Iijima, K., Abe, H., Okazawa, M., Moriyoshi, K. and Nakanishi, S.: Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures. Proc Natl Acad Sci USA, 105:12010-12015, 2008
  • Nakatani,J.,Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S., Watanabe, Y., Chung, Y.J., Banerjee, R., Okazawa, M., Yamauchi, K., Tanda, T., Takao, T., Miyakawa, T., Bradley, A. and Takumi, T.: Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell, 137:1235-1246, 2009.
  • Okazawa, M., Abe, H., Katsukawa, M., Iijima, K., Kiwada, T. and Nakanishi, S.: Role of calcineurin signaling in membrane potential-regulated maturation of cerebellar granule cells. J Neurosci, 29:2938-2947, 2009
  • Toyoda, H., Saito, M., Okazawa, M., Hirao, K., Sato, H., Abe, H., Takada, K., Funabiki, K., Takada, M., Kaneko, T. and Kang, Y.: Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain. J Neurosci, 30:5677-5689, 2010
  • Abe, H., Okazawa, M. and Nakanishi, S.: The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Proc Natl Acad Sci USA, 108:12497-12502, 2011
  • Abe, H., Okazawa, M., and Nakanishi, S.: Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells. Proc Natl Acad Sci USA, 109:8734-8739, 2012
Academic Award Received
  • Yasu Kuno Memorial Award (Physiological Society of Japan)(2004)
Academic Degree Ph.D.
Academic Society Affiliation The Japan Neuroscience Society, The Molecular Biology Society of Japan, Society for Neuroscience
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