Home > Research Institute > Departments > Department of Vascular Physiology > Makoto Okazawa

Makoto Okazawa

Name Makoto Okazawa
Department Name,
Job Title
Department of Vascular Physiology, Laboratory chief
Tel +81 6 6833 5012 ex. 2518
Fax +81 6 6835 5329
E-Mail okazawa@ncvc.go.jp
Research Field Pharmacology, Vascular Medicine, Neuroscience
Research Result
  • Ohtani, T., Ninomiya, H., Okazawa, M., Imamura, S. and Masaki, T.: Bromodeoxyuridine-induced expression of endothelin A in A375 human melanoma cells. Biochem Biophys Res Commun, 234:526-530, 1997.
  • Okazawa, M., Shiraki, T., Ninomiya, H., Kobayashi, S. and Masaki, T.: Endothelin-induced apoptosis of A375 human melanoma cells. J Biol Chem, 273(20):12584-12592, 1998.
  • Iwamuro, Y., Miwa, S., Zhang, XF., Minowa, T., Enoki, T., Okamoto, Y., Hasegawa, H., Furutani, H., Okazawa, M., Ishikawa, M., Hashimoto, N. and Masaki, T.: Activation of three types of voltage-independent Ca2+ channel in A7r5 cells by endothelin-1 as revealed by a novel Ca2+ channel blocker LOE 908. Br J Pharmacol, 126:1107-1114, 1999
  • Miwa, S., Iwamuro, Y., Zhang, X.F., Inoki, T., Okamoto, Y., Okazawa, M. and Masaki, T.: Ca2+ entry channels in rat thoracic aortic smooth muscle cells activated by endothelin-1. Jpn J Pharmacol, 80:281-288, 1999
  • Zhang, X.F., Iwamuro, Y., Enoki, T., Okazawa, M., Lee, K., Komuro, T., Minowa, T., Okamoto, Y., Hasegawa, H., Furutani, H., Miwa, S. and Masaki, T.: Pharmacological characterization of Ca2+ entry channels in endothelin-1-induced contraction of rat aorta using LOE 908 and SK&F 96365. Br J Pharmacol, 127:1388-1398, 1999
  • Okazawa, M., Terauchi, T., Shiraki, T., Matsumura, K. and Kobayashi, S.: l-Menthol-induced [Ca2+]i increase and impulses in cultured sensory neurons. Neuroreport, 11:2151-2155, 2000
  • Okazawa, M., Takao, K., Hori, A., Shiraki, T., Matsumura, K. and Kobayashi, S.: Ionic basis of cold receptors acting as thermostats. J Neurosci, 22:3994-4001, 2002
  • Abe, J., Okazawa, M., Adachi, R., Matsumura, K. and Kobayashi, S.: Primary cold-sensitive neurons in acutely dissociated cells of rat hypothalamus. Neurosci Lett, 342:29-32, 2003
  • Okazawa, M., Inoue, W., Hori, A., Hosokawa, H., Matsumura, K. and Kobayashi, S.: Noxious heat receptors present in cold-sensory cells in rats. Neurosci Lett, 359:33-36, 2004
  • Abe, J., Hosokawa, H., Okazawa, M., Kandachi, M., Sawada, Y., Yamanaka, K., Matsumura, K. and Kobayashi, S.: TRPM8 protein localization in trigeminal ganglion and taste papillae. Brain Res Mol Brain Res, 136:91-98, 2005
  • Kobayashi, S., Okazawa, M., Hori, A., Matsumura, K. and Hosokawa, H.: Paradigm shift in sensory system - Animals do not have sensors. J Thermal Biol, 31:19-23, 2006
  • Nakanishi, S. and Okazawa, M.: Membrane potential-regulated Ca2+ signalling in development and maturation of mammalian cerebellar granule cells. J Physiol, 575:389-395, 2006
  • Iijima, K., Abe, H., Okazawa, M., Moriyoshi, K. and Nakanishi, S.: Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures. Proc Natl Acad Sci USA, 105:12010-12015, 2008
  • Nakatani,J.,Tamada, K., Hatanaka, F., Ise, S., Ohta, H., Inoue, K., Tomonaga, S., Watanabe, Y., Chung, Y.J., Banerjee, R., Okazawa, M., Yamauchi, K., Tanda, T., Takao, T., Miyakawa, T., Bradley, A. and Takumi, T.: Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell, 137:1235-1246, 2009.
  • Okazawa, M., Abe, H., Katsukawa, M., Iijima, K., Kiwada, T. and Nakanishi, S.: Role of calcineurin signaling in membrane potential-regulated maturation of cerebellar granule cells. J Neurosci, 29:2938-2947, 2009
  • Toyoda, H., Saito, M., Okazawa, M., Hirao, K., Sato, H., Abe, H., Takada, K., Funabiki, K., Takada, M., Kaneko, T. and Kang, Y.: Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain. J Neurosci, 30:5677-5689, 2010
  • Abe, H., Okazawa, M. and Nakanishi, S.: The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Proc Natl Acad Sci USA, 108:12497-12502, 2011
  • Abe, H., Okazawa, M., and Nakanishi, S.: Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells. Proc Natl Acad Sci USA, 109:8734-8739, 2012
Academic Award Received
  • Yasu Kuno Memorial Award (Physiological Society of Japan)(2004)
Academic Degree Ph.D.
Academic Society Affiliation The Japan Neuroscience Society, The Molecular Biology Society of Japan, Society for Neuroscience
Educational Activity
Other Activities
Researcher Information
Link
Page Top