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Name Mika HORI
Department Name,
Job Title
Laboratory chief,
Department of Molecular Innovation in Lipidolpogy
Tel +81-6-6833-5004 (ext. 2909)
FAX +81-6-6872-8415
E-Mail Mihori☆ri.ncvc.go.jp        ☆=@
Research Field Molecular biology
Research Result
  • M. Hori, T. Kitahashi, T. Imai, R. Ishigamori, S. Takasu, M. Mutoh, T. Sugimura, K. Wakabayashi and M. Takahashi: Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl) amine-treated hamsters by high fat diet. Pancreas in press.
  • M. Hori, T. Suzuki, N. Minakawa, A. Matsuda, H. Harashima and H. Kamiya: Mutagenicity of secondary oxidation products of 8-oxo-7,8-dihydro-2'- deoxyguanosine 5'-triphosphate (8-hydroxy-2'-deoxyguanosine 5'-triphosphate). Mutat Res, 2011; 714: 11-16.
  • M. Hori, K. Satou, H. Harashima and H. Kamiya: Suppression of mutagenesis by 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (7,8-dihydro-8-oxo -2'-deoxyguanosine 5'-triphosphate) by human MTH1, MTH2, and NUDT5. Free Radic Biol Med, 2010; 48: 1197-1201.
  • H. Kamiya, M. Hori, T. Arimori, M. Sekiguchi, Y. Yamagat and H. Harashima: NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity. DNA Repair 2009; 8: 1250-1254.
  • K. Satou*, M. Hori*, H. Harashima and H. Kamiya (*equal contribution): Involvement of specialized DNA polymerases in mutagenesis by 8-hydroxy-dGTP in human cells. DNA Repair, 2009; 8: 637-642.
  • M. Hori, C. Ishiguro, T. Suzuki, N. Nakagawa, T. Nunoshiba, S. Kuramitsu, K. Yamamoto, H. Kasai, H. Harashima and H. Kamiya: UvrA and UvrB enhance mutations induced by oxidized deoxyribonucleotides. DNA Repair, 2007; 6:1786-1793.
  • M. Hori, T. Asanuma, O. Inanami, M. Kuwabara, H. Harashima and H. Kamiya: Effects of overexpression and antisense RNA expression of Orf17, a MutT- type enzyme. Biol Pharm Bull, 2006; 29: 1087-1091.
  • M. Hori, C. Ishiguro, H. Harashima and H. Kamiya: In vivo mutagenecities of damaged nucleotides produced by nitric oxide and ionizing radiation. Biol Pharm Bull, 2005; 28: 520-522.
  • M. Hori, K. Fujikawa, H. Kasai, H. Harashima and H. Kamiya: Dual hydrolysis of diphosphate and triphosphate derivatives of oxidized deoxyadenosine by Orf17 (NtpA), a MutT-type enzyme. DNA Repair, 2005; 4: 33-39.
Academic Award Received
  • The Environmental Mutagen Society Student Travel Award (The 9th International Conference on Environmental Mutagens 2005 San Francisco)
  • 2009 Otsuka Award in Hokkaido University
  • The 18th Pancreas Research Foundation Research Award
Academic Degree Ph.D.
Academic Society Affiliation Japanese Cancer Association, Japanese Association for Cancer Prevention, The Molecular Biology Society of Japan, The Japan Radiation Research Society
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