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James Pearson

Name James Pearson, Ph.D.
Department Name,
Job Title
Director Department of Cardiac Physiology
Tel +81-6-6833-5004 (ext.2350)
Fax +81-6-6835-5416
E-Mail jpearson@ncvc.go.jp
Research Field Cardiac Physiology, Cardiovascular Physiology, Diabetes, Hypertension, X-ray and Synchrotron Imaging, Respiration and Metabolism
Research Result
  1. Schwenke, D.O., J.T. Pearson, T. Sonobe, H. Ishibashi-Ueda, A. Shimouchi, K. Kangawa, K. Umetani and M. Shirai. Role of rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. Journal of Applied Physiology 110:901-908, 2011.
  2. Zohdi, V., Black M.J. and J.T. Pearson. Elevated vascular resistance and afterload reduce the cardiac output response to dobutamine in early growth restricted rats in adulthood. British Journal of Nutrition 106:1374-1382, 2011.
  3. Sonobe, T., Schwenke, D.O., J.T. Pearson, M. Yoshimoto, Y. Fujii, K. Umetani, M. Shirai. Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography. Journal of Applied Physiology 111:75-80, 2011.
  4. Masato Hoshino, Kentaro Uesugi, James Pearson, Takashi Sonobe, Mikiyasu Shirai and Naoto Yagi. Development of X-ray real-time stereo imaging technique using synchrotron radiation. J Synch Rad. 18:569-574, 2011
  5. Schwenke, D.O., E. Gray, J.T. Pearson, T. Sonobe, H. Ishibashi-Ueda, Campillo I, K. Kangawa, K. Umetani and M. Shirai. Exogenous ghrelin improves blood flow distribution in pulmonary hypertension - assessed using synchrotron microangiography. Pflugers Archiv - Eur J Physiol 462:397-406, 2011.
  6. Jenkins, M.J., A.J. Edgley, T. Sonobe, K. Umetani, D.O. Schwenke, Y. Fujii, R.D. Brown, D.J. Kelly, M. Shirai, J.T. Pearson. Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo. Arteriosclerosis Thrombosis and Vascular Biology 32:370-377, 2012.
  7. Zohdi, V., B.R. Wood, J.T. Pearson, K.R. Bambery, and M.J. Black. Evidence of altered biochemical composition in the hearts of adult intrauterine growth-restricted rats. European Journal of Nutrition, 52(2):749-758, 2013.
  8. Fujii, Y., M. Shirai, S. Inamori, A. Shimouchi, T. Sonobe, H. Tsuchimochi, J.T. Pearson, Y. Takewa, E. Tatsumi, and Y. Taenaka. Insufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat model. Artificial Organs 37:136-141, 2013.
  9. Jenkins, M.J.*, J.T. Pearson*, D.O. Schwenke, A.J. Edgley, T. Sonobe, Y. Fujii, H. Ishibashi-Ueda, D.J. Kelly, N. Yagi, M. Shirai. Myosin heads are displaced from actin filaments in the in situ beating rat heart in early diabetes. Biophysical Journal 104:1065-1072, 2013. *equal authors
  10. Shirai, M., M. Beard, J.T. Pearson, T. Sonobe, H. Tsuchimochi, Y. Fujii, E. Gray, K. Umetani, D.O. Schwenke. Impaired pulmonary blood flow distribution in congestive heart failure - assessed using synchrotron radiation microangiography. J Synchrotron Rad 20:441-448, 2013.
  11. Gray, E.A., H. Tsuchimochi, J.T. Pearson, T. Sonobe,Y. Fujii, K. Umetani, M. Shirai and D.O. Schwenke. Is the serotonin pathway a therapeutic target for pulmonary hypertension - assessing vascular function using Synchrotron Radiation Microangiography. J Synchrotron Rad 20(5):756-764, 2013.
  12. Fujii, Y., M. Shirai, H. Tsuchimochi, T. Sonobe, J.T. Pearson, Y. Takewa, E. Tatsumi, and Y. Taenaka. Hyperoxic condition promotes an inflammatory response during cardiopulmonary bypass in a rat model. Artificial Organs 37:1034-1040, 2013.
  13. Inamori S, Shirai M, Yahagi N, Pearson JT, Fujii Y, Umetani K, Kobayashi Y, Okura Y, Yakehiro M, Minamiyama M. A Comparative Study of Cerebral Microcirculation During Pulsatile and Nonpulsatile Selective Cerebral Perfusion: Assessment by Synchrotron Radiation Microangiography. American Society for Artificial Internal Organs Journal 59(4):374-379, 2013.
  14. Pearson, J.T. *, Jenkins, M.J.*, A.J. Edgley, T. Sonobe, M. Joshi, M.T. Waddingham, Y. Fujii, D.O. Schwenke, M. Yoshimoto, K. Umetani, D.J. Kelly, M. Shirai. Acute rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculation. Cardiovascular Diabetology 12:e111, 2013.
  15. Shirai, M., D.O. Schwenke, H. Tsuchimochi, N. Yagi, K. Umetani, and J.T. Pearson. Synchrotron radiation imaging for advancing our understanding of cardiovascular function. Circ Res 112:209-221, 2013.
  16. Furtado MB, Costa MW, Adi Pranoto EM, Salimova E, Pinto AR, Lam NT, Park A, Snider P, Chandran A, Harvey RP, Boyd R, Conway SJ, Pearson JT, Kaye DM, Rosenthal N. Cardiogenic Genes Expressed in Cardiac Fibroblasts Contribute to Heart Development and Repair. Circ Res 114:1422-1434, 2014.
  17. Lang J., J.T. Pearson, A.B. te Pas, M. Wallace, M. Siew, M. Kitchen, A. Fouras, R. Lewis, K. Wheeler, G. Polglase, M. Shirai, T. Sonobe, S.B. Hooper. Ventilation / perfusion mismatch during lung aeration at birth. J Appl Physiol 117(5):535-43, 2014.
  18. Shirai M, H. Nagai, E. Gray, J.T. Pearson, H. Tsuchimochi, T. Sonobe, S. Ogura, T. Inagaki, Y. Fujii, I. Kuwahira, Y. Yoshida, D.O. Schwenke. Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia. Basic Research in Cardiology, 109(5):432, 2014.
  19. Skiold B., Q. Wu, S.B. Hooper, P.G. Davis, M. Tolcos, J. Pearson, R. Vreys, G. Egan, S.K. Barton, J.L-Y. Cheong, G.R. Polglase. Early detection of ventilation induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: an in vivo study in preterm lambs. PLoS One 9(4):e95804, 2014.
  20. Nagai H., I. Kuwahira, D.O. Schwenke, H. Tsuchimochi, A. Nara, T. Inagaki, S. Ogura, Y. Fujii, K. Umetani, T. Shimosawa, K. Yoshida, J.T. Pearson, K. Uemura, M. Shirai. β2-adrenergic receptor dependent attenuation of hypoxic pulmonary vasoconstriction prevents a progression of pulmonary arterial hypertension in intermittent hypoxic rats. PLoS One 9(10):e110693, 2014.
  21. Zohdi, V., J.T. Pearson, M. Kett, P. Lombardo, M. Schneider-Kolsky, and M.J. Black. When early life growth restriction in rats is followed by attenuated postnatal growth: effects on cardiac function in adulthood. Eur J Nutr 54(5):743-750, 2015.
  22. Ngo, J.P., S. Kar, M.M. Kett, B.S. Gardner, J.T. Pearson, D.W. Smith, J. Ludbrook, J.F. Bertram, and R.G. Evans. Vascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney. Am J Physiol Renal Physiol 207: F1111-F1122, 2015.
  23. Zohdi V., J. Lim, J.T. Pearson* and M.J. Black. Developmental programming of cardiovascular disease following intrauterine growth restriction: findings using a rat model of maternal protein restriction. Nutrients 7:119-152, 2015. *corresponding author
  24. Waddingham, M.T., A.J. Edgley, D.J. Kelly, H. Tsuchimochi, M. Shirai and J.T. Pearson. Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes. 6(7):943-960, 2015.
  25. Kainuma, S., S. Miyagawa, S. Fukushima, J. Pearson, Y-C. Chen, A. Harada, H. Watabe, G. Horitsugi, M. Ishibashi, H. Ikeda, H. Tsuchimochi, T. Sonobe, Y. Fujii, H. Naito, K. Umetani, T. Shimizu, T. Okano, E. Kobayashi, T. Daimon, A. Saito, T. Ueno, T. Kuratani, K. Toda, N. Takakura, J. Hatazawa, M. Shirai, Y. Sawa. Cell-sheet therapy with omentopexy promotes arteriogenesis and improves coronary circulation physiology in failing heart. Molecular Therapy 23(2):374-86, 2015.
  26. Higuchi T., S. Miyagawa, J.T. Pearson, S. Fukushima, A. Saito, H. Tsuchimochi, T. Sonobe, Y. Fujii, N. Yagi, A. Alberto, M. Shirai, Y. Sawa. Functional and electrical integration of induced pluripotent stem cell-derived cardiomyocytes in an acute myocardial infarction rat model. Cell Transplantation.24:2479-2489, 2015.
  27. Zohdi, V., D. Whelan, B. Wood, J.T. Pearson, M.J. Black, K. Bambery. Importance of Tissue Preparation Methods in FTIR Micro-Spectroscopical Analysis of Biological Tissues: Traps for New Users. PLoS One 10(2):e0116491, 2015.
  28. Sonobe, T., H. Tsuchimochi, D.O. Schwenke, J.T. Pearson, M. Shirai. Treadmill running improves hindlimb arteriolar endothelial function in type 1 diabetic mice as visualized by X-ray microangiography. Cardiovascular Diabetology 14(1):51, 2015.
  29. Nagai H., I. Kuwahira, D.O. Schwenke, H. Tsuchimochi, A. Nara, S. Ogura, T. Sonobe, Y. Fujii, R. Yamaguchi, L. Wingenfeld, K. Umetani, T. Shimosawa, J.T. Pearson, K. Yoshida, M. Shirai. Activation of β3-AR/iNOS pathway in pulmonary M1 macrophage prevents development of intermittent hypoxia-induced pulmonary arterial hypertension. PLoS One 10(7):e0131923, 2015.
  30. Waddingham, M.T., A.J. Edgley, A. Astolfo, T. Inagaki, Y. Fujii, C-K. Du, D-Y. H. Tsuchimochi, N. Yagi, D.J. Kelly, M. Shirai and J.T. Pearson. Chronic Rho-kinase inhibition improves left ventricular contractile dysfunction in early type-1 diabetes by increasing cross-bridge myosin extension. Cardiovascular Diabetology 14:92, 2015.
  31. Pearson, J.T. Cardiac responses to hypoxia and reoxygenation in Drosophila. New insights into evolutionary conserved gene responses. Am J Physiol Reg Integr Comp Physiol. 309(11):R1344-R1346, 2015.
  32. Furtado, M.B., J.C. Wilmans, A. Chandran, M. Tonta, C. Biben, M. Eichenlaub, H.A. Coleman, S. Berger, R. Bouveret, R. Singh, R.P. Harvey, M. Ramialison, J.T. Pearson, H. Parkington, N.A. Rosenthal, M.W. Costa. A novel mouse model for the study of Nkx2-5 reveals transcriptional control of cardiac ion channels. Differentiation 91:29-41, 2016.
  33. Lang, J.A.R, J.T. Pearson, C. Binder-Heschl, M.J. Wallace, M.L. Siew, M.J. Kitchen, A.B. te Pas, A. Fouras, R.A. Lewis, G.R. Polglase, M. Shirai, S.B. Hooper. Increase in blood flow at birth; role of oxygen and lung aeration. J. Physiol. 594:1389-1398, 2016.
  34. Chen, Y.C., T. Inagaki, Y. Fujii, D.O. Schwenke, H. Tsuchimochi, A.J. Edgley, K. Umetani, Y. Zhang, D.J. Kelly, M. Yoshimoto, H. Nagai, R.G. Evans, I. Kuwahira, M. Shirai*, J.T. Pearson*. Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin resistant Goto-Kakizaki rats. Am J Physiol Reg Integr Comp Physiol. (accepted 31 May, 2016) *equal authors
Award Foreign Young Investigator Award, International Union of Physiological Sciences, Kyoto 2009
Academic Degree PhD, Physiology
Academic Society Affiliation American Physiological Society, High Blood Pressure Research Council of Australia, Physiological Society of Japan
Educational Activity Formerly, Lecturers at Monash University, Department of Physiology
Researcher Information ResearcherID
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