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  4. Department of Cardiac Physiology
  5. X-ray Crystallography of Cardiovascular Disease Related Proteins

Research Institute

X-ray Crystallography of Cardiovascular Disease Related Proteins

Recent publications

  1. Takeda S. "ADAM and ADAMTS family proteins and snake venom metalloproteinases: a structural overview (Review article)"Toxins, 8(5), 155 (2016)
  2. Matsuo T, Takeda S, Oda T, Fujiwara S "Structures of the Troponin Core Domain Containing the Cardiomyopathy-Causing Mutants Studied by Small-Angle X-ray Scattering"Biophys. Physicobiol. 12, 145-158 (2015)
  3. Takeda S. "Structure-function relationship of the modular domains of the P-III class snake venom metalloproteinases (SVMPs) (Book chapter)"In Handbook of Toxinology, Venom Genomics and Proteomics (Gopalakrishnakone P. (ed.)), SpringerReference, Springer, 1-22 (2014)
  4. Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T. "Crystal structure of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism"J. Thromb. Haemost. 11: 1399-1406 (2013)
  5. Takeda S "Russellysin (Book chapter)"In The 3rd edition of Handbook of Proteolytic Enzymes (Rawlings, N. and Salvesen, G. (ed.)), Elsevier, 1051-1053, (2013)
  6. Takeda S, Takeya H, Iwanaga S "Snake venom metalloproteinases: structure, function and relevance to the mammalian ADAM/ADAMTS family proteins (Review article)"Biochim Biophys Acta: Proteins and Proteomics 1824: 164-176, (2012)
  7. Kang TS, Georgieva D, Genov N, Murakami MT, Sinha M, Kumar RP, Kaur P, Kumar S, Dey S, Sharma S, Vrielink A, Betzel C, Takeda S, Arni RK, Singh TP, Kini RM. "Enzymatic Toxins from Snake Venom: Structural Characterization and Mechanism of Catalysis (Review article)"FEBS J, 278, 4544-4576, (2011)
  8. Nakayama D, Ben Ammar Y, Miyata T, Takeda S. "Structural basis of coagulation factor V recognition for cleavage by RVV-V"FEBS Lett, 585: 3020-3025 (2011)
  9. Takeda S. "Structural aspects of the factor X activator RVV-X from Russell's viper venom (Book chapter)"In Toxins and Hemostasis: From Bench to Bedside (Kini, RM, McLane, MA, Clemetson, K, Markland, FS and Morita, T (eds.)), 465-484., Springer+Business Media, (2010)
  10. Takeda S. "VAP1: snake venom homolog of mammalian ADAMs (Book chapter)"In Handbook of Metalloproteins (Messerschmidt, A (ed.)), Vol.5, 699-713, John Wiley & Sons, Inc., (2010)
  11. Takeda S. "Three-dimensional domain architecture of the ADAM family proteinases (Review article)"Semin Cell Dev Biol, 20, 146-152, (2009)
  12. Nakayama D, Ben Ammar, Takeda S. "Crystallization and preliminary X-ray crystallographic analysis of the blood coagulation factor V-activating proteinase (RVV-V) from Russell's viper venom"Acta Cryst: F65, 1306-1308, (2009)
  13. Akiyama, M, Takeda S, Kokame, K, Takagi, J, Miyata, T. "Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor"Proc Natl Acad Sci USA., 106: 19274-19279, (2009)
  14. Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T. "Production, crystallization and preliminary X-ray crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13"Acta Cryst., F65: 739-742, (2009)
  15. Takeda S, Igarashi T, Mori H. "Crystal structures of RVV-X: evolutionary gain of specificity by ADAM family proteinases"FEBS Lett, 581: 5859-64, (2007)
  16. Igarashi T, Araki S, Mori H, Takeda S. "Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins"FEBS Lett, 581, 2416-22, (2007)
  17. Takeda S. "Preparation of protein crystals for X-ray structural study (Book chapter)"Methods Mol Med: Cardiovascular Disease, 129:291-303, (2006)
  18. Takeda S, Igarashi T, Mori H, Araki S. "Crystal structures of VAP1 reveal ADAMs' MDC domain architecture and its unique C-shaped scaffold"EMBO J, 25(11): 2388-2396, (2006)
  19. Masuda M, Takeda S, Sone M, Ohki T, Mori H, Kamioka Y, Mochizuki N "Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms"EMBO J, 25(12): 2889-2897, (2006)
  20. Igarashi T, Oishi Y, Araki S, Mori H, Takeda S "Crystallization and preliminary X-ray crystallographic analysis of two vascular apoptosis-inducing proteins (VAPs) from Crotalus atrox venom"Acta Cryst, F62: 688-691, (2006)
  21. Ben Ammar Y, Takeda S, Hisamitsu T, Mori H, Wakabayashi S. "Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation"EMBO J, 25(11): 2315-2325, (2006)
  22. Ben Ammar Y, Takeda S, Sugawara M, Miyano M, Mori H, Wakabayashi S. "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1"Acta Cryst, F61: 956-958, (2005)
  23. Takeda S. "Crystal structure of troponin and the molecular mechanism of muscle regulation"J Electron Microsc, 54(suppl_1): i35-i41, (2005)
  24. Takeda S. "Structure of the core domain of human cardiac troponin in the Ca2+-saturated form"SPring-8 Research Frontier 2003, 12-13. (2004)
  25. Takeda S, Yamashita A, Maeda K, Maeda Y. "Structure of the core domain of human cardiac troponin in the Ca2+-saturated form"Nature, 424(6944): 35-41, (2003)

last updated：2021/10/01

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