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Research Institute

Department of Cardiovascular Dynamics

 

Member

DirectorTomohiro Nishinaka (concurrent director)
Laboratory ChiefKazunori Uemura
Keita Saku
Staff ScientistMasafumi Fukumitsu
ScientistToru Kawada
Meihua Li
Takuya Nishikawa (Dept. of Research Promotion and Management)
Hidetaka Morita (Research fellow)
Kei Sato (Research fellow)
Nana Hiraki (Research fellow)
Norihiro Honda
Yusuke Hirakawa
Daisuke Nose
Midori Kakuuchi (Osaka University Hospital)
Graduate StudentHiroki Matsushita (Research fellow)
Yuki Yoshida
Masahiro Otake
Kenta Oba
Visiting ScientistTadayoshi Miyamoto (Osaka Sangyo University)
Kazumasu Sasaki (Akita Cerebrospinal and Cardiovascular Center)
Taro Kariya (Tokyo University)
Takaaki Maruhashi (Kitasato University)
Mitsuru Iida (Tokyo Rinkai Hospital)
Takashi Unoki (Saiseikai Kumamoto Hospital)
Naoshi Hotta (Yokohama City University)
Sho Fukuzumi (Dolphin Animal Hospital)
Shohei Yokota (Osaka University PhD student)
Mika Nishikawa（Tokushima University）
Yuta Nakamura（Shonan Kamakura General Hospital）
Sota Nakamoto（Osaka Institute of Technology）
Research AssistantHitomi Ito
Kenji Kibayashi 
Fuyuko Kunisawa
Haruka Yamauchi
Kana Sakamoto
Visiting DirectorKenji Sunagawa (Circulatory System Research Foundation)

 

Research

The Department of Cardiovascular Dynamics is working to understand the circulatory mechanism and develop strategies/devices that utilize the function and intrinsic regulation of the circulatory system.
Circulation refers to the entire mechanism by which the heart, as a pump, stably delivers oxygenated blood. We are trying to understand the mechanism of the circulatory system as simply as possible through mathematical modeling and to find the optimal control method based on the model. In addition, we are conducting joint research and development with many companies for the development of medical device.
The Department of Cardiovascular Dynamics is always looking for new researchers and collaborators. If you are interested in the department of cardiovascular dynamics, don't hesitate to get in touch with Dr. Keita Saku at saku.keita@ncvc.go.jp.

Publication

Original article

  1. Kawada T, Miyamoto T, Fukumitsu M, Saku K. Input-size dependence of the baroreflex neural arc transfer characteristics during Gaussian white noise inputs. Am J Physiol Regul Integr Comp Physiol. 2024, 326: R121–R133.
  2. Kawada T, Matsushita H, Yokota S, Yoshida Y, Fukumitsu, M, Alexander Jr J, Saku K. Short-term dynamic characteristics of diuresis during exogenous pressure perturbations with and without arterial baroreflex control. Am J Physiol Regul Integr Comp Physiol. 2024, 236(3): R230-R241.
  3. Matsushita H, Saku K, Nishikawa T, Yokota S, Sato K, Morita H, Yoshida Y, Fukumitsu M, Uemura K,Kawada T ,Tyamaura T. The impact of ECPELLA on haemodynamics and global oxygen delivery: a comprehensive simulation of biventricular failure. Intensive Care Medicine Experimental. 2023, 12: 13
  4. Li M, Zheng C, Kawada T, Uemura K, Yokota S, Matsushita H, Saku K. Donepezil Attenuates Progression of Cardiovascular Remodeling and Improves Prognosis in Spontaneously Hypertensive Rats with Chronic Myocardial Infarction. Hypertension Research. 2024, 47(5): 1298-1308.
  5. Tadokoro N, Koyamoto T, Tonai K, Yoshida Y, Hirahsima K, Kainuma S, Kawamoto N, Minami K, Nishioka H, Yasumasa T, Fujita T, Fukushima S. The outcomes of a standardized protocol for extracorporeal mechanical circulatory support selection-left ventricular challenge protocol. J Artif Organs. 2024, Online ahead of print.
  6. Unoki T, Konami Y, Nakayama T, Suzuyama H, Horio E, Taguchi E, Saku K, Sawamura T, Nakao K, Sakamoto T. Efficacy and safety of post-closure technique using Perclose ProGlide/ProStyle device for large-bore mechanical circulatory support access sites. Cardiovasc Revasc Med. 2023, S1553-8389(23)00970-3.　
  7. Kawada T, Yamamoto H, Yokoi A, Nishiura A, Kakuuchi M, Yokota S, Matsushita H, Alexander J, Saku K. Acute effects of empagliflozin on open-loop baroreflex function and urine glucose excretion in Goto-Kakizaki diabetic rats. J Physiol Sci. 2023, 73(1): 7.
  8. Yoshida K, Axelsen J, Saku K, Andersen A, S. de Man F, Sunagawa K, Noordegraaf A, Bogaard H. How to Incorporate Tricuspid Regurgitation in Right Ventricular-Pulmonary Arterial Coupling. J Appl Physiol. 2023, 135: 53-59.
  9. Unoki T, Saku K, Kametani M, Yufu T, Yamamuro M, Taguchi E, Sawamura T, Nakao K, Sakamoto T. Three Cases of STEMI-AMI with Cardiogenic Shock Under ECPELLA Support with Different Levels of Left Ventricular Unloading. Journal of Coronary Artery Disease 2023, 29(2):43-48.
  10. Yokoi A, Kawada T, Yokoi A, Yokota S, Kakuuchi M, Matsushita H, Nishiura A, Li M, Uemura K, Andersen A, Tanaka R, Saku K. Impact of vericiguat on baroreflex-mediated sympathetic circulatory regulation: an open-loop analysis. PLoS One. 2023, 18(8): e0286767.
  11. Kawada T, Li M, Nishiura A, Yoshida Y, Yokota S, Matsushita H, Fukumitsu M, Uemura K, Alexander J, Saku K. Acute effects of empaglifozin on open-loop barorefex function and urinary glucose excretion in rats with chronic myocardial infarction. The Journal of Physiological Sciences. 2023, 73: 20.
  12. Kataoka Y, Fukuda Y, Peterson J, Yokota S, Uemura K, Saku K, Alexander J, Sunagawa K. Analytical Representation of Four-dimensional Hemodynamics for Drug Therapy Simulation in Acute Heart Failure Treatment. Annu Int Conf IEEE Eng Med Biol Soc. 2023, Jul: 1-6.
  13. Kataoka Y, Fukuda Y, Shelly I, Peterson J, Yokota S, Uemura K, Saku K, Alexander J, Sunagawa K. Inverse ESPVR Estimation with Singularity Avoidance via Constrained EDPVR Parameter Optimization. Annu Int Conf IEEE Eng Med Biol Soc. 2023, Jul: 1-6.
  14. 此内 緑, 横田 翔平, 横井 愛美, 松下 裕貴, 西浦 照二, 李 梅花, 上村 和紀, 川田 徹, 朔 啓太.　犬リポポリサッカライド誘発性ショックモデルにおける血管収縮薬の心血管特性解析. 循環制御医学会機関誌「循環制御」2023, 44巻1号:18-28.

 

Review/Editorial

  1. Fukumitsu M, Saku K. Reconsidering coronary circulation in the era of LV unloading - the underlying physiology in the non-physiological setting. J Physiol. 2024, 602 (8): 1661-1662.
  2. Nakata J, Yamamoto T, Saku K, Ikeda Y, Unoki T, Asai K. Mechanical circulatory support in cardiogenic shock. J Intensive Care. 2023, 19; 11(1): 64.
  3. 森田 英剛, 朔 啓太. 心臓集中治療デバイスの今後. ICUと 医学図書出版. 2024, 48 (1): 61-69.
  4. 松下　裕貴, 朔　啓太. 心力学的視点で考える心不全における至適血圧. 循環器ジャーナル. 2023, 71(1): 220-226.
  5. 上村 和紀. 循環管理のロボット化：コンピュータ制御による自動循環管理システム. 医学図書出版. 2023, 47(5): 323-329.
  6. 森田　英剛, 朔　啓太.　臨床におけるPV loopの要点. Heart View. 2023, 27(9): 36-43.
  7. 佐藤 啓, 朔 啓太. 血行動態的理解を深める. ICUと 医学図書出版. 2023, 47 (12): 773.
  8. 田伏 真理, 月村 英利子, 朔 啓太, 西川 拓也, 金川 武司, 吉松 淳. 心力学で紐解く妊娠の循環動態 ～正常妊娠と左心機能障害合併妊娠～. 循環制御.　2023，44（2）: 87-94.

Book

  1. 松下 裕貴. モニタリング総論. 心原性ショック 最強の教科書. 2024, p34-42.
  2. 佐藤 啓. 心臓・末梢超音波スクリーニング. 心原性ショック 最強の教科書. 2024, p82-92.
  3. 森田 英剛. 新しいデバイス医療. 心原性ショック 最強の教科書. 2024, p281-291.

last updated : 2025/01/14

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