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Development of surface modified porous scaffold for alveolar bone regeneration

Periodontal disease is a chronic inflammatory disorder and potentially leads to loss of teeth, because the alveolar bone surrounding the teeth gets week due to bone degradation. Guided bone regeneration is an oral therapeutic method to regenerate bone tissue using porous ceramic scaffolds-e.g. tricalcium phosphate or hydroxyapatite. However, improvements in regenerating speed remains to be solved. In our previous study, heparin-supported basic fibroblast growth factor immobilization on porous scaffold strongly enhanced tissue integration speed. We are engaged in realization of bone tissue regenerative scaffold with high tissue integration property using this heparin intermediating strategy.

Fig.1 Heparin mediated surface modification for growth factor immobilization.

Publications

  1. PCT/JP2014/061771, 13849269.9
  2. Kakinoki S, Sakai Y, Fujisato T and Yamaoka T. Journal of Biomedical Materials Research, 103, 3790-3797 (2015)
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