予防医学・疫学情報部
研究活動の概要

　予防医学・疫学情報部は、循環器に関する疫学研究や人工知能応用を中心とした情報科学研究を行うため、研究テーマとして以下のような研究テーマに取り組んでいる。

  1. 電子カルテ構造化データ（病名、検査、手技、処方、各科テンプレートなど）からの研究用データ抽出用API作成（情報統括部、予防医学）
  2. 電子カルテ非構造化データ（患者症状、身体所見、臨床スコア（NIHSSなど）POC検査、電子カルテ自由記載所見、退院サマリー、看護記録等）からの自然言語処理によるデータ抽出（東北大学での外部妥当性検証含む）（情報統括部、予防医学）
  3. 動脈瘤、ASL、もやもや病など脳画像を利用した診断用AIの開発および医療機器化（脳神経外科、脳神経内科、予防医学、フィリップス社）
  4. 吹田市の小児健診約80000例を利用した小児心電図の診断AI開発（小児科、予防医学）
  5. 病理部との共同で心筋炎病理画像の自動診断AIの開発（病理部、予防医学）
  6. 延岡市での約2000例の認知機能検査および当院認知症外来入院患者を対象とした米国 Canary Speech 社、SMK社との共同による３０秒程度で認知症、パーキンソン病、うつ病を診断するAI（米国版はFDAのFast truck申請中）（脳神経内科、予防医学）
  7. 次世代スマートメーター（5年後から全国に導入予定、最終的には国内全家庭に導入される（経産省、国内全地域電力会社）の電力器具使用パターンによる認知機能障害、および孤独死等検知によるAI見守りシステム（東京電力、大和ハウス工業、旭化成ヘーベルハウス、積水ハウス、NTT西日本、関西電力、中部電力、青森市、つくば市、那須塩原市、前橋市、延岡市、東京都）
  8. 冠動脈不安定プラークの自動診断AI（フィリップス社、冠疾患科、予防医学）
  9. 院外心停止、脳卒中、熱中症の気候条件による発症予測AIモデル（ウツタインデータ、救急搬送では論文化し、現在高知県全件データによる脳卒中、米国の院外心停止１００万件およびNASA気象データによりミシガン大学と米国版を作成中）（冠疾患科、予防医学、日本気象協会）
  10. 共同偏視、口角異常、上下肢筋力低下などに対する画像認識によるAI診断システム（脳神経内科、予防医学、ノエル社）
  11. 電話およびSNSでの問い合わせ等に対する循環器疾患特化型チャットボットの開発（ジーワン社）
  12. ポリファーマーシー状態に対する薬剤処方適正化AI（HUホールディングス、SRL社）
  13. 介護、医療、健診データに関するビックデータ解析用BIツールの開発（尼崎市、大津市、凸版印刷）
  14. 延岡市の全小学生（約6000人）を対象とした学校保健データと学童用ウエアラブルによるバイタル測定、PHRによる健康管理システム（延岡市、慶応SFC、東京学芸大学）
  15. 体液貯留およびHR等による心不全患者用ウエアラブルモニタリングデバイスの開発（テルモ社、心不全科、予防医学）
  16. UWB電波、ミリ波レーダーによる病室内遠隔バイタルモニタリングおよび転倒検知システム（SMK社）
  17. 政策モデル（IMPACTモデル循環器死亡、発症）による都道府県レベルでの疾病の将来動向予測（リバープル大学）および保険者努力支援制度による自治体の課題分析BIツール（ICIおよび凸版印刷）への組み込みによる社会実装
2021年の主な研究成果
  1. 環境省の環境総合推進費を受け、関西の主要自治体（京都、大阪、神戸、堺含む背景人工960万人）の熱中症発症の約2万5千件のデータにより熱中症の気候条件による発症件数を予測するモデルおよびIoTデバイスを使った個別アラートシステムを関西大学、国立環境研と共同で開発中である。
    発症予測に関してはAIを使用した世界初のモデルとして90％以上の予測精度を持つモデルを開発し、Nature Communicationsに掲載された。
    　Ogata S, Takegami M, Ozaki T, Nakashima T, Onozuka D, Murata S, Nakaoku Y, Suzuki K, Hagihara A, Noguchi T, Iihara K, Kitazume K, Morioka T, Yamazaki S, Yoshida T, Yamagata Y,* Nishimura K. Heatstroke predictions by machine learning, weather information, and an all-population registry for 12-hour heatstroke alerts.Nat Commun. 2021 Jul 28;12(1):4575. (IF= 14.919)
    またウツタインデータ約120万件をもとに冬季のヒートショックによる心停止を気候条件により予測するAIモデルを同様に開発した。
    　Nakashima T, Ogata S, Noguchi T, Tahara Y, Onozuka D, Kato S, Yamagata Y, Kojima S, Iwami T, Sakamoto T, Nagao K, Nonogi H, Yasuda S, Iihara K, Neumar R, *Nishimura K.Machine learning model for predicting out-of-hospital cardiac arrests using meteorological and chronological data. Heart. 2021 May 17;107(13):1084-91. (IF= 5.994)
    　こちらについては現在客員研究員として米国ミシガン大学に留学中の中島、および尾形室長を中心として米国全体の院外心停止データであるCaresとNASAの気象データにより米国版を作成中である。

  2. 藤田医科大学の長期間の畜尿フォローのビックデータから、適切な塩分制限とカリウム制限がCKDの進展予防に有効であり、過度な塩分制限およびカリウム制限が増悪因子であることを証明した。
    　Ogata S, Akashi Y, Sakusabe T, Yoshizaki S, Maeda Y, Nishimura K, Maeda K, Nakai S. A multiple 24-hour urine collection study indicates that kidney function decline is related to urinary sodium and potassium excretion in patients with chronic kidney disease. Kidney Int. 2022 Jan;101(1):164-173. (IF= 10.612)

  3. 東京電力とはAIを用いた電気機器の機器分離技術により高齢者特に認知症、心不全患者における見守り、生活行動変容に関しての24時間持続モニタリングを延岡市約100件、淡路島40件、愛知県50件の疾患患者を対象に検討を行い、世界で初めて家庭内の電力モニターをAI技術により周波数分離しモニタリングしたデータをもとに高齢者の認知機能異常を予測するモデルの開発に成功した。
    　Nakaoku Y, Ogata S, Murata S, Nishimori M, Ihara M, Iihara K, Takegami M, *Nishimura K. AI-Assisted In-House Power Monitoring for the Detection of Cognitive Impairment in Older Adults. Sensors (Basel). 2021 Sep 17;21(18):6249. (IF= 3.576)
    　現在東京電力とAMEDにおいて更なる精度向上を目指す研究を継続しており、次世代スマートメーターを活用した要介護者（脳卒中、心不全、認知症、フレイル）の見守りシステムの形成（青森市、那須塩原市、延岡市、東京電力、NTT西日本、中部電力、関西電力などの企業連合、大和ハウス工業、旭化成、積水ハウス等のハウスメーカー）の社会実装およびAIモデルの精度向上を行う予定である。特に青森市などの自治体では行政による要介護者見守り事業として2022-2023年に全市に導入予定であり、大和ハウス工業では同社の賃貸住宅などに全国導入、上市の予定である。将来的には日本国内の全家庭に取り付けられるスマートメーター上で分析が可能となる。

  4. フィリップス社のグロバールR&Dセンターとの提携等により、
    　１）不安定プラークのMRI画像による自動抽出プログラム
    　２）未破裂動脈瘤の位置および大きさ、blebの有無など破裂リスクを含む自動診断システム
    を構築中で２）については2022-2023年にプログラム医療機器の申請を予定している。

  5. AMED西村班で開発したロナ対策としてN95マスクを新規開発し、ニプロ、ダイキン工業、クロスエフェクト社と事業開発を進めている。開発品は、①フィルターカートリッジ部分が着脱交換可能であり本体部分は殺菌・滅菌等で繰り返し利用可能である（アルコール、次亜塩素水等により100回以上消毒後再利用が可能なことを実験的に証明）、②柔軟性のある素材を使用するとともに日本人の標準的な顔面形状を元に形状を設計することで口元に密着可能で長時間の連続装着にも耐えうるNIPRO LUFUKSマスクとして市販化した。

    またAIモデル関連は、随時日本循環器学会、日本脳卒中学会などで報告している。

研究業績
  1. Vyas CM, Ogata S, Reynolds CF, Mischoulon D, Chang G, Cook NR, Manson JE, Crous-Bou M, De Vivo I, Okereke OI. Telomere length and its relationships with lifestyle and behavioural factors:variations by sex and race/ethnicity. Age and Ageing. 50, 838-846, 2021.
  2. Murata S, Ono R, Sugimoto T, Toba K, Sakurai T. Functional Decline and Body Composition Change in Older Adults With Alzheimer Disease: A Retrospective Cohort Study at a Japanese Memory Clinic. Alzheimer Disease & Associated Disorders. 35, 36-43, 2021.
  3. Kimura T, Akahori H, Asakura M, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Wake M, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubara T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Impact of Age on Gender Difference in Long-term Outcome of Patients With Acute Myocardial Infarction (from J-MINUET). American Journal of Cardiology. 142, 44329, 2021.
  4. Sugane H, Kataoka Y, Otsuka F, Nakaoku Y, Nishimura K, Nakano H, Murai K, Honda S, Hosoda H, Matama H, Doi T, Nakashima T, Fujino M, Nakao K, Yoneda S, Tahara Y, Asaumi Y, Noguchi T, Kawai K, Yasuda S. Cardiac outcomes in patients with acute coronary syndrome attributable to calcified nodule. Atherosclerosis. 318, 70-75, 2021.
  5. Tanaka T, Fukuma K, Abe S, Matsubara S, Motoyama R, Mizobuchi M, Yoshimura H, Matsuki T, Manabe Y, Suzuki J, Ikeda S, Kamogawa N, Ishiyama H, Kobayashi K, Shimotake A, Nishimura K, Onozuka D, Koga M, Toyoda K, Murayama S, Matsumoto R, Takahashi R, Ikeda A, Ihara M. Antiseizure medications for post-stroke epilepsy: A real-world prospective cohort study. Brain and Behavior. 11, e2330, 2021.
  6. Murai K, Kataoka Y, Nakaoku Y, Nishimura K, Kitahara S, Iwai T, Nakamura H, Hosoda H, Hirayama A, Matama H, Doi T, Nakashima T, Honda S, Fujino M, Nakao K, Yoneda S, Nishihira K, Kanaya T, Otsuka F, Asaumi Y, Tsujita K, Noguchi T, Yasuda S. The association between the extent of lipidic burden and delta-fractional flow reserve: analysis from coronary physiological and near-infrared spectroscopic measures. Cardiovascular Diagnosis and Therapy. 11, 362-372, 2021.
  7. Ide T, Kaku H, Matsushima S, Tohyama T, Enzan N, Funakoshi K, Sumita Y, Nakai M, Nishimura K, Miyamoto Y, Tsuchihashi-Makaya M, Hatano M, Komuro I, Tsutsui H. Clinical Characteristics and Outcomes of Hospitalized Patients With Heart Failure From the Large-Scale Japanese Registry Of Acute Decompensated Heart Failure (JROADHF). Circulation Journal. 85, 1438-1450, 2021.
  8. Hashimoto Y, Ozaki Y, Kan S, Nakao K, Kimura K, Ako J, Noguchi T, Suwa S, Fujimoto K, Dai K, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Wake M, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Yasuda S, Ismail TF, Muramatsu T, Izawa H, Takahashi H, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Impact of Chronic Kidney Disease on In-Hospital and 3-Year Clinical Outcomes in Patients With Acute Myocardial Infarction Treated by Contemporary Percutaneous Coronary Intervention and Optimal Medical Therapy - Insights From the J-MINUET Study -. Circulation Journal. 85, 1710-1718, 2021.
  9. Ogata S, Marume K, Nakai M, Kaichi R, Ishii M, Ikebe S, Mori T, Komaki S, Kusaka H, Toida R, Kurogi K, Iwanaga Y, Yano T, Yamamoto N, Miyamoto Y. Incidence Rate of Acute Coronary Syndrome Including Acute Myocardial Infarction, Unstable Angina, and Sudden Cardiac Death in Nobeoka City for the Super-Aged Society of Japan. Circulation Journal. 85, 1722-1730, 2021.
  10. Matoba T, Sakamoto K, Nakai M, Ichimura K, Mohri M, Tsujita Y, Yamasaki M, Ueki Y, Tanaka N, Hokama Y, Fukutomi M, Hashiba K, Fukuhara R, Suwa S, Matsuura H, Hosoda H, Nakashima T, Tahara Y, Sumita Y, Nishimura K, Miyamoto Y, Yonemoto N, Yagi T, Tachibana E, Nagao K, Ikeda T, Sato N, Tsutsui H. Institutional Characteristics and Prognosis of Acute Myocardial Infarction With Cardiogenic Shock in Japan - Analysis From the JROAD/JROAD-DPC Database -. Circulation Journal. 85, 1797-1805, 2021.
  11. Fujimoto W, Toh R, Takegami M, Hayashi T, Kuroda K, Hatani Y, Yamashita S, Imanishi J, Iwasaki M, Inoue T, Okamoto H, Okuda M, Konishi A, Shinohara M, Murata S, Ogata S, Nishimura K, Hirata K. Estimating Incidence of Acute Heart Failure Syndromes in Japan - An Analysis From the KUNIUMI Registry -. Circulation Journal. 85, 1860-1868, 2021.
  12. Nishimura K, Ogasawara K, Kitazono T, Iihara K. Impact of Physician Volume and Specialty on In-Hospital Mortality of Ischemic and Hemorrhagic Stroke. Circulation Journal. 85, 1876-1884, 2021.
  13. Ren N, Nishimura A, Kurogi A, Nishimura K, Matsuo R, Ogasawara K, Hashimoto Y, Higashi T, Sakai N, Toyoda K, Shiokawa Y, Tominaga T, Miyachi S, Kada A, Abe K, Ono K, Matsumizu K, Arimura K, Kitazono T, Miyamoto S, Minematsu K, Iihara K. Measuring Quality of Care for Ischemic Stroke Treated With Acute Reperfusion Therapy in Japan - The Close The Gap-Stroke -. Circulation Journal. 85, 201-209, 2021.
  14. Anzai T, Sato T, Fukumoto Y, Izumi C, Kizawa Y, Koga M, Nishimura K, Ohishi M, Sakashita A, Sakata Y, Shiga T, Takeishi Y, Yasuda S, Yamamoto K, Abe T, Akaho R, Hamatani Y, Hosoda H, Ishimori N, Kato M, Kinugasa Y, Kubozono T, Nagai T, Oishi S, Okada K, Shibata T, Suzuki A, Suzuki T, Takagi M, Takada Y, Tsuruga K, Yoshihisa A, Yumino D, Fukuda K, Kihara Y, Saito Y, Sawa Y, Tsutsui H, Kimura T. JCS/JHFS 2021 Statement on Palliative Care in Cardiovascular Diseases. Circulation Journal. 85, 695-757, 2021.
  15. Son C, Makino H, Kasahara M, Tanaka T, Nishimura K, Taneda S, Nishimura T, Kasama S, Ogawa Y, Miyamoto Y, Hosoda K. Comparison of efficacy between dipeptidyl peptidase-4 inhibitor and sodium-glucose cotransporter 2 inhibitor on metabolic risk factors in Japanese patients with type 2 diabetes mellitus: Results from the CANTABILE study. Diabetes Research and Clinical Practice. 180, 109037, 2021.
  16. Onozuka D, Nakamura Y, Tsuji G, Furue M. Cancer- and noncancer-specific cumulative incidence of death after exposure to polychlorinated biphenyls and dioxins: A competing risk analysis among Yusho patients. Environment International. 147, 106320, 2021.
  17. Hayashi C, Toyoda H, Ogata S, Okano T, Mashino S. Long-term participation in community-based group resistance exercises delays the transition from robustness to frailty in older adults: a retrospective cohort study. Environmental Health and Preventive Medicine. 26, 105, 2021.
  18. Marume K, Noguchi T, Kamakura T, Tateishi E, Morita Y, Miura H, Nakaoku Y, Nishimura K, Yamada N, Tsujita K, Izumi C, Kusano K, Ogawa H, Yasuda S. Prognostic impact of multiple fragmented QRS on cardiac events in idiopathic dilated cardiomyopathy. EP Europace. 23, 287-297, 2021.
  19. Mikami T, Ishii M, Yamamoto N, Marume K, Nakai M, Ogata S, Kaichi R, Ikebe S, Mori T, Komaki S, Kusaka H, Toida R, Kurogi K, Iwanaga Y, Ogawa H, Miyamoto Y, Tsujita K. Association of early administration of furosemide with improved oxygenation in patients with acute heart failure. ESC Heart Failure. 8, 3354-3359, 2021.
  20. Ishikawa T, Kimoto H, Mishima H, Yamagata K, Ogata S, Aizawa Y, Hayashi K, Morita H, Nakajima T, Nakano Y, Nagase S, Murakoshi N, Kowase S, Ohkubo K, Aiba T, Morimoto S, Ohno S, Kamakura S, Nogami A, Takagi M, Karakachoff M, Dina C, Schott JJ, Yoshiura KI, Horie M, Shimizu W, Nishimura K, Kusano K, Makita N. Functionally validated SCN5A variants allow interpretation of pathogenicity and prediction of lethal events in Brugada syndrome. European Heart Journal. 42, 2854-2863, 2021.
  21. Nishihira K, Honda S, Takegami M, Kojima S, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S; JAMIR investigators. Impact of bleeding on mortality in patients with acute myocardial infarction complicated by cardiogenic shock. European Heart Journal: Acute Cardiovascular Care. 10, 388-396, 2021.
  22. Hayashi C, Ogata S, Okano T, Toyoda H, Mashino S. Long-term participation in community group exercise improves lower extremity muscle strength and delays age-related declines in walking speed and physical function in older adults. European Review of Aging and Physical Activity. 18, 6, 2021.
  23. Horibe K, Isa T, Matsuda N, Murata S, Tsuboi Y, Okumura M, Kawaharada R, Kogaki M, Uchida K, Nakatsuka K, Ono R. Association between sleep disturbance and low back and pelvic pain in 4-month postpartum women: A cross-sectional study. European Spine Journal. 30, 2983-2988, 2021.
  24. Eto F, Yoshimoto T, Okazaki S, Nishimura K, Ogura S, Yamaguchi E, Fukuma K, Saito S, Washida K, Koga M, Toyoda K, Morimoto T, Maruyama H, Koizumi A, Ihara M. RNF213 p.R4810K (c.14429G > A) Variant Determines Anatomical Variations of the Circle of Willis in Cerebrovascular Disease. Frontiers in Aging Neuroscience. 13, 681743, 2021.
  25. Ono R, Murata S, Uchida K, Endo T, Otani K. Reciprocal relationship between locomotive syndrome and social frailty in older adults. Geriatrics & Gerontology International. 21, 981-984, 2021.
  26. Nakashima T, Ogata S, Noguchi T, Tahara Y, Onozuka D, Kato S, Yamagata Y, Kojima S, Iwami T, Sakamoto T, Nagao K, Nonogi H, Yasuda S, Iihara K, Neumar R, Nishimura K. Machine learning model for predicting out-of-hospital cardiac arrests using meteorological and chronological data. Heart. 107, 1084-1091, 2021.
  27. Hashimoto T, Minami Y, Ako J, Nakao K, Ozaki Y, Kimura K, Noguchi T, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Validation of the atherothrombotic risk score for secondary prevention in patients with acute myocardial infarction: the J-MINUET study. Heart and Vessels. 36, 1506-1513, 2021.
  28. Wada H, Ogita M, Suwa S, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Wake M, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Long-Term Clinical Impact of Cardiogenic Shock and Heart Failure on Admission for Acute Myocardial Infarction A Landmark Sub-Analysis from J-MINUET Registry. International Heart Journal. 62, 520-527, 2021.
  29. Hayashi C, Ogata S, Tanaka H, Hayakawa K. The Differential Heritability of Social Adjustment by Sex. International Journal of Environmental Research and Public Health. 18, 621, 2021.
  30. Nakaoku Y, Takahashi Y, Tominari S, Nakayama T. Predictors of New Dementia Diagnoses in Elderly Individuals: A Retrospective Cohort Study Based on Prefecture-Wide Claims Data in Japan. International Journal of Environmental Research and Public Health. 18, 629, 2021.
  31. Honda S, Nishihira K, Kojima S, Takegami M, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S. Characteristics and clinical outcomes of patients with de-escalation from prasugrel to clopidogrel after acute myocardial infarction - Insights from the prospective Japan Acute Myocardial Infarction Registry (JAMIR) -. Journal of Cardiology. 78, 99-106, 2021.
  32. Tsukinaga A, Yoshitani K, Kubota Y, Kanemaru E, Nishimura K, Ogata S, Nakai M, Tsukinaga R, Kamiya CA, Yoshimatsu J, Ohnishi Y. Anesthesia for Cesarean Section and Postpartum Cardiovascular Events in Congenital Heart Disease: A Retrospective Cohort Study. Journal of Cardiothoracic and Vascular Anesthesia. 35, 2108-2114, 2021.
  33. Shimokawa A, Hayashi H, Yoshitani K, Kakuta T, Kawamoto N, Kanzaki H, Fukushima S, Fujita T, Ogata S, Ohnishi Y. Impact of Balloon Postdilation on Six-Year Mortality After Transcatheter Aortic Valve Replacement. Journal of Cardiothoracic and Vascular Anesthesia. 35, 2626-2630, 2021.
  34. Murata S, Takegami M, Onozuka D, Nakaoku Y, Hagihara A, Nishimura K. Incidence and Mortality of Dementia-Related Missing and Their Associated Factors: An Ecological Study in Japan. Journal of Epidemiology. 31, 361-368, 2021.
  35. Kurogi R, Kada A, Ogasawara K, Kitazono T, Sakai N, Hashimoto Y, Shiokawa Y, Miyachi S, Matsumaru Y, Iwama T, Tominaga T, Onozuka D, Nishimura A, Arimura K, Kurogi A, Ren N, Hagihara A, Nakaoku Y, Arai H, Miyamoto S, Nishimura K, Iihara K. Effects of case volume and comprehensive stroke center capabilities on patient outcomes of clipping and coiling for subarachnoid hemorrhage. Journal of Neurosurgery. 134, 929-939, 2021.
  36. Nakatsuka K, Tsuboi Y, Okumura M, Murata S, Isa T, Kawaharada R, Matsuda N, Uchida K, Horibe K, Kogaki M, Ono R. Association between comprehensive workstation and neck and upper-limb pain among office worker. Journal of Occupational Health. 63, e12194, 2021.
  37. Doi T, Hori M, Harada-Shiba M, Kataoka Y, Onozuka D, Nishimura K, Nishikawa R, Tsuda K, Ogura M, Son C, Miyamoto Y, Noguchi T, Shimokawa H, Yasuda S. Patients With LDLR and PCSK9 Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia. Journal of the American Heart Association. 10, e018263, 2021.
  38. Kuyama N, Kataoka Y, Takegami M, Nishimura K, Harada-Shiba M, Hori M, Ogura M, Otsuka F, Asaumi Y, Noguchi T, Tsujita K, Yasuda S. Circulating Mature PCSK9 Level Predicts Diminished Response to Statin Therapy. Journal of the American Heart Association. 10, e019525, 2021.
  39. Ogata S, Takegami M, Ozaki T, Nakashima T, Onozuka D, Murata S, Nakaoku Y, Suzuki K, Hagihara A, Noguchi T, Iihara K, Kitazume K, Morioka T, Yamazaki S, Yoshida T, Yamagata Y, Nishimura K. Heatstroke predictions by machine learning, weather information, and an all-population registry for 12-hour heatstroke alerts. Nature Communications. 12, 4575, 2021.
  40. Eto F, Washida K, Matsubara M, Makino H, Takahashi A, Noda K, Hattori Y, Nakaoku Y, Nishimura K, Hosoda K, Ihara M. Glucose Fluctuation and Severe Internal Carotid Artery Siphon Stenosis in Type 2 Diabetes Patients. Nutrients. 13, 2379, 2021.
  41. Nakano H, Hamatani Y, Nagai T, Nakai M, Nishimura K, Sumita Y, Ogawa H, Anzai T. Current practice and effects of intravenous anticoagulant therapy in hospitalized acute heart failure patients with sinus rhythm. Scientific Reports. 11, 1202, 2021.
  42. Nishimori M, Kiuchi K, Nishimura K, Kusano K, Yoshida A, Adachi K, Hirayama Y, Miyazaki Y, Fujiwara R, Sommer P, El Hamriti M, Imada H, Takemoto M, Takami M, Shinohara M, Toh R, Fukuzawa K, Hirata KI. Accessory pathway analysis using a multimodal deep learning model. Scientific Reports. 11, 8045, 2021.
  43. Nakaoku Y, Ogata S, Murata S, Nishimori M, Ihara M, Iihara K, Takegami M, Nishimura K. AI-Assisted In-House Power Monitoring for the Detection of Cognitive Impairment in Older Adults. Sensors. 21, 6249, 2021.
  44. Nakao K, Yasuda S, Noguchi T, Sumita Y, Nakao YM, Nishimura K, Nakai M, Miyamoto Y, Tsutsui H, Saito Y, Komuro I, Gale CP, Ogawa H. Association of hospital performance measures with readmissions for patients with heart failure: A report from JROAD-DPC study. International Journal of Cardiology. 340, 48-54, 2021.
  45. Ishii M, Seki T, Kaikita K, Sakamoto K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Kanaoka K, Terasaki S, Saito Y, Tsutsui H, Komuro I, Ogawa H, Tsujita K, Kawakami K; JROAD Investigators. Association of short-term exposure to air pollution with myocardial infarction with and without obstructive coronary artery disease. European Journal of Preventive Cardiology. 28, 1435-1444, 2021.
  46. Suzuki S, Tone A, Murata T, Nishimura K, Miyamoto Y, Sakane N, Satoh-Asahara N, Toyoda M, Hirota Y, Matsuhisa M, Kuroda A, Kato K, Kouyama R, Miura J, Suganuma A, Tomita T, Noguchi M, Son C, Kasahara M, Ito Y, Kasama S, Hosoda K. Protocol for a Randomized, Crossover Trial to Decrease Time in Hypoglycemia by Combined Intervention of the Usage of Intermittent-Scanning Continuous Glucose Monitoring Device and the Structured Education Regarding its Usage: Effect of Intermittent-Scanning Continuous Glucose Monitoring to Glycemic Control Including Hypoglycemia and Quality of Life of Patients with Type 1 Diabetes Mellitus Study (ISCHIA Study). The Tokai Journal of Experimental and Clinical Medicine. 46, 59-68, 2021.
  47. Kayamori Y, Nakamura M, Kishi K, Miida T, Nishimura K, Okamura T, Hirayama S, Ohmura H, Yoshida H, Ai M, Tanaka A, Sumino H, Murakami M, Inoue I, Teramoto T, Yokoyama S. Comparison of the Japan Society of Clinical Chemistry reference method and CDC method for HDL and LDL cholesterol measurements using fresh sera. Practical Laboratory Medicine. 25, e00228, 2021.
  48. Anegawa E, Takahama H, Nishimura K, Onozuka D, Irie Y, Moriuchi K, Amano M, Okada A, Amaki M, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Izumi C. Improvements of predictive power of B-type natriuretic peptide on admission by mathematically estimating its discharge levels in hospitalised patients with acute heart failure. Open Heart. 8, e001603, 2021.
  49. Nakai M, Iwanaga Y, Sumita Y, Kanaoka K, Kawakami R, Ishii M, Uchida K, Nagano N, Nakayama T, Nishimura K, Tsuchihashi K, Kimura K, Saito Y, Tsujita K, Ogawa H, Miyamoto Y, Yasuda S; on the behalf of the JROAD Investigators. Validation of Acute Myocardial Infarction and Heart Failure Diagnoses in Hospitalized Patients With the Nationwide Claim-Based JROAD-DPC Database. Circulation Reports. 3, 131-136, 2021.
  50. Kitahara S, Kataoka Y, Miura H, Nishii T, Nishimura K, Murai K, Iwai T, Nakamura H, Hosoda H, Matama H, Doi T, Nakashima T, Honda S, Fujino M, Nakao K, Yoneda S, Nishihira K, Kanaya T, Otsuka F, Asaumi Y, Tsujita K, Noguchi T, Yasuda S. The feasibility and limitation of coronary computed tomographic angiography imaging to identify coronary lipid-rich atheroma in vivo: Findings from near-infrared spectroscopy analysis. Atherosclerosis. 322, 1-7, 2021.
  51. Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Takegami M, M Nakao Y, Okamura T, Miyamoto Y. Development of a Cardiovascular Disease Risk Prediction Model Using the Suita Study, a Population-Based Prospective Cohort Study in Japan. Journal of Atherosclerosis and Thrombosis. 28, 304, 2021.
  52. Okamoto C, Okada A, Nishimura K, Moriuchi K, Amano M, Takahama H, Amaki M, Hasegawa T, Kanzaki H, Fujita T, Kobayashi J, Yasuda S, Izumi C. Prognostic comparison of atrial and ventricular functional mitral regurgitation. Open Heart. 8, e001574, 2021.
  53. Kitahara S, Fujino M, Honda S, Asaumi Y, Kataoka Y, Otsuka F, Nakanishi M, Tahara Y, Ogata S, Onozuka D, Nishimura K, Fujita T, Tsujita K, Ogawa H, Noguchi T. COVID-19 pandemic is associated with mechanical complications in patients with ST-elevation myocardial infarction. Open Heart. 8, e001497, 2021.
  54. Sawada K, Kawakami S, Murata S, Nishimura K, Tahara Y, Hosoda H, Nakashima T, Kataoka Y, Asaumi Y, Noguchi T, Sugimachi M, Fujita T, Kobayashi J, Yasuda S. Predicting Parameters for Successful Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock. ESC Heart Failure. 8, 471-480, 2021.
  55. Kusano K, Yamane T, Inoue K, Takegami M, Nakao YM, Nakai M, Kanaoka K, Miyamoto K, Iwasaki YK, Takatsuki S, Nakamura K, Miyamoto Y, Shoda M, Nogami A, Shimizu W; J-AB registry investigators. The Japanese Catheter Ablation Registry (J-AB): Annual report in 2019. Journal of Arrhythmia. 37, 1443-1447, 2021.
  56. Higashiyama A, Wakabayashi I, Okamura T, Kokubo Y, Watanabe M, Takegami M, Honda-Kohmo K, Okayama A, Miyamoto Y. The Risk of Fasting Triglycerides and its Related Indices for Ischemic Cardiovascular Diseases in Japanese Community Dwellers: the Suita Study. Journal of Atherosclerosis and Thrombosis. 28, 1275-1288, 2021.
  57. Hamasaki T, Hagihara A. Dentists’ Legal Liability and Duty of Explanation in Dental Malpractice Litigation in Japan. International Dental Journal. 71, 300-308, 2021.
  58. Sawa S, Hashizume K, Abe T, Kusaka Y, Fukazawa Y, Hiraku Y, Hagihara A. Pathway linking physical activity, sleep duration, and breakfast consumption with the physical/psychosocial health of schoolchildren. Journal of Child Health Care. 25, 5-17, 2021.
  59. Hamasaki T, Hagihara A. Medical malpractice litigation related to choking accidents in older people in Japan. Gerodontology. 38, 104-112, 2021.
  60. Toh Y, Hagihara A, Shiotani M, Onozuka D, Yamaki C, Shimizu N, Morita S, Takayama T. Employing multiple-attribute utility technology to evaluate publicity activities for cancer information and counseling programs in Japan. Journal of Cancer Policy. 27, 100261, 2021.
  61. Hagihara A, Murata S. Review of: “The effect of video-instructed versus audio-instructed dispatcher-assisted cardiopulmonary resuscitation on patient outcomes following out of hospital cardiac arrest in Seoul”. Qeios. U9LZAH, 2021.
  62. Hagihara A, Murata S. Burnout among physicians in Poland. Polish Archives of Internal Medicine. 131, 612-614, 2021.
  63. Nagata T, Hagihara A, Lefor AK, Matsuda R, Steffen M. FIGHTING COVID-19 IN JAPAN: A Success Story? Coronavirus Politics: The Comparative Politics and Policy of COVID-19. 146-162, 2021.
  64. Arai M, Asaumi Y, Murata S, Matama H, Honda S, Otsuka F, Tahara Y, Kataoka Y, Nishimura K, Noguchi T. Thyroid Storm Patients With Elevated Brain Natriuretic Peptide Levels and Associated Left Ventricular Dilatation May Require Percutaneous Mechanical Support. Critical Care Explorations. 3, e0599, 2021.
  65. 萩原 明人. 余命宣告のストラテジー. 2021.