予防医学・疫学情報部
研究活動の概要

　予防医学・疫学情報部は、循環器に関する疫学研究や人工知能応用を中心とした情報科学研究を行うため、研究テーマとして以下のような研究テーマに取り組んでいる。

  • IBMワトソンなど電子カルテに対する自然言語処理などを利用したデータマインニング
    （内閣府AIホスピタル事業に参画）
  • 機械学習、深層学習などの手法による循環器病の予後予測、動脈瘤、不安定プラークなどの画像診断に関するAI応用（フィリプスNCVCプロジェクトなど）
  • J-ASPECT研究、JROAD研究、ウツタイン研究など全国規模の循環器データベースを用いた研究
  • 関西エリア1千万人のデータによる熱中症発症の予測モデル（環境研究総合推進費）
  • AIによる機器分離技術を用いた認知症患者の見守り技術開発（東京電力）（延岡市100家庭、東京都大田区での東京都スマートシティ事業で、現在認知症独居家庭20件（2021年度中に100家庭）でデータ取得中）
  • コロナに対する院内の感染防御対策として新型のN95マスク開発を行い、AMEDから1億700万円の助成により事業化、ニプロ社ダイキン工業社とOIC入居中のクロスエフェクトと共同で2021年6月より市販を開始予定
  • パナソニック社と経済産業省電動車椅子普及により衝突防止センサーを備えた電動車いすの病院内での実証実験を行い、2023年度まで同社の搬送用ロボット技術の建物内でGPSセンサーによる完全自動運転型の電動車いすを共同開発し製品化する予定である
2020年の主な研究成果

　主要な取り組みの成果として

　院内各科（心臓内科、心臓外科、脳内科、麻酔科、周産期科など各科）および研究所の主として観察研究の統計解析を行いLancet, Annals of surgery, Circulationなどで英語論文が受理されている。また現在Circulation等でreviseおよび投稿準備中のものが作業進行中である。

　また電子カルテData Ware Houseからの自動症例抽出システムを継続して開発しており、さらに、心臓カテーテル検査レポート、超音波検査レポート、分娩台帳といった電子カルテとは直接関係ない部門システムからの情報もData Ware Houseからデータが抽出できる仕組みを開発した。特にIBM社ワトソンなどの人工知能を応用する先進的取り組みを行い、米国心臓病学会（AHA/ACC）の包括的循環器疾患レジストリーPINNACLに準拠した項目約400項目中95％の項目を自動抽出することができるようになった。また心エコー、心臓カテール所見に関しては別途抽出ロジックを構築し、フリーテキストとして入力された50項目程度が抽出可能となり、予後についても電子カルテに関して記録のあるものについては抽出可能となった。同研究については阪大が主管施設となっている内閣府のAIホスピタル事業に参加している。

　現在、情報統括部 平松部長と共同で、以下をすすめている。

  1. 研究所研究者および外部研究者に対してもデータを直接ダウンロードさせずにかつ匿名性を保ってアクセス可能な仮想端末（VDIシステム）
  2. 上記自然言語処理について従来数か月を要していた辞書構築を1か月以内におわらせるための自動NLPシステム
  3. 画像情報の自動集積およびAI活用行うための画像特徴量の自動抽出
  4. その他構造化データによる患者予後を含めた縦断的な脳卒中、循環器疾患患者のレジストリー化
    を1-3と同時に行い、病院のみならず研究所研究者にもデータ利用を可能とするシステムの構築

　OIC入居予定のフィリップス社のグロバールR&Dセンターとの提携等により、

  1. 未破裂動脈瘤の位置および大きさ、blebの有無など破裂リスクを含む自動診断システムについては約360例の未破裂脳動脈瘤に対して、新規に自動的に頭蓋内の血管を同定するプログラムを開発し、さらに動脈瘤の存在に関しては99％の精度で診断可能なプログラムを開発した。本プログラムはさらに脳動脈瘤の大きさに対しての計測システムを現在開発中であり、2021年度に医療機器申請を行う予定としている。
  2. 心不全科と共同で心エコーの10年間におよぶ長期フォロー画像の集積およびリスク予測モデルを開発中である。ベースとなる臨床データはBNPなど約15個の臨床指標を約100項目の臨床データ変数からAIにより選択したモデルにより1年後の心不全予後を86％の精度で予測可能なモデルを開発し、論文を投稿中である。本モデルにさらに画像所見（心エコー動画データ）を合わせて更なる精度向上をはかる予定である。
  3. 不安定プラークのMRI画像による自動抽出プログラムを構築中である。

　またAIモデル関連は、日本循環器学会、日本脳卒中学会などで報告し、心不全の予後予測に関しては論文を投稿中である。

研究業績
  1. Iwakami N, Aiba T, Kamakura S, Takaki H, Furukawa TA, Sato T, Sun W, Shishido T, Nishimura K, Yamada-Inoue Y, Nagase S, Shimizu W, Yasuda S, Sugimachi M, Kusano K. Identification of malignant early repolarization pattern by late QRS activity in high-resolution magnetocardiography. Annals of Noninvasive Electrocardiology. 25, e12741, 2020.
  2. Shigemura H, Sakatsume E, Sekizuka T, Yokoyama H, Hamada K, Etoh Y, Carle Y, Mizumoto S, Hirai S, Matsui M, Kimura H, Suzuki M, Onozuka D, Kuroda M, Inoshima Y, Murakami K. Food Workers as a Reservoir of Extended-Spectrum-Cephalosporin-Resistant Salmonella Strains in Japan. Applied and Environmental Microbiology. 86, e00072-20, 2020.
  3. Kitagaki K, Murata S, Tsuboi Y, Isa T, Ono R. Relationship between exercise capacity and depressive symptoms in community-dwelling older adults. Archives of Gerontology and Geriatrics. 89, 104084, 2020.
  4. Kubomura A, Sekizuka T, Onozuka D, Murakami K, Kimura H, Sakaguchi M, Oishi K, Hirai S, Kuroda M, Okabe N. Truncated Class 1 Integron Gene Cassette Arrays Contribute to Antimicrobial Resistance of Diarrheagenic Escherichia coli. BioMed Research International. 2020, 4908189, 2020.
  5. Kurogi A, Nishimura A, Nishimura K, Kada A, Onozuka D, Hagihara A, Ogasawara K, Shiokawa Y, Kitazono T, Arimura K, Iihara K; J-ASPECT Study Collaborators. Temporal trends and geographical disparities in comprehensive stroke centre capabilities in Japan from 2010 to 2018. BMJ Open. 10, e033055, 2020.
  6. Tsuda K, Kataoka Y, Ogata S, Nishimura K, Nishikawa R, Doi T, Nakashima T, Hosoda H, Honda S, Kawakami S, Fujino M, Nakao K, Yoneda S, Nishihira K, Otsuka F, Tahara Y, Asaumi Y, Hoshiga M, Noguchi T, Yasuda S. Diminished response to statins predicts the occurrence of heart failure after acute myocardial infarction. Cardiovascular Diagnosis and Therapy. 10, 705-716, 2020.
  7. Furukawa Y, Miyake M, Fujita T, Koyama T, Takegami M, Kimura T, Sugio K, Takita A, Nishimura K, Izumi C; BPV-AF Registry group. Rationale, Design, and Baseline Characteristics of the BioProsthetic Valves with Atrial Fibrillation (BPV-AF) Study. Cardiovascular Drugs and Therapy. 34, 689-696, 2020.
  8. Otani K, Tokudome T, Kamiya CA, Mao Y, Nishimura H, Hasegawa T, Arai Y, Kaneko M, Shioi G, Ishida J, Fukamizu A, Osaki T, Nagai-Okatani C, Minamino N, Ensho T, Hino J, Murata S, Takegami M, Nishimura K, Kishimoto I, Miyazato M, Harada-Shiba M, Yoshimatsu J, Nakao K, Ikeda T, Kangawa K. Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Circulation. 141, 571-588, 2020.
  9. Kaku H, Funakoshi K, Ide T, Fujino T, Matsushima S, Ohtani K, Higo T, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Anzai T, Tsutsui H. Impact of Hospital Practice Factors on Mortality in Patients Hospitalized for Heart Failure in Japan -An Analysis of a Large Number of Health Records From a Nationwide Claims-Based Database, the JROAD-DPC-. Circulation Journal. 84, 742-753, 2020.
  10. Iwasaki K, Seguchi O, Murata S, Nishimura K, Yoshitake K, Yagi N, Sujino Y, Anegawa E, Mochizuki H, Kuroda K, Nakajima S, Watanabe T, Yanase M, Fukushima S, Fujita T, Kobayashi J, Ito H, Fukushima N. Effect of the Creatinine Excretion Rate Index, a Marker of Sarcopenia, on Prediction of Intracranial Hemorrhage in Patients With Advanced Heart Failure and a Continuous-Flow Left Ventricular Assist Device. Circulation Journal. 84, 949-957, 2020.
  11. Matsuzawa Y, Konishi M, Nakai M, Saigusa Y, Taguri M, Gohbara M, Ebina T, Kosuge M, Hibi K, Nishimura K, Miyamoto Y, Yasuda S, Ogawa H, Saito Y, Nakayama N, Takeuchi I, Tamura K, Kimura K. In-Hospital Mortality in Acute Myocardial Infarction According to Population Density and Primary Angioplasty Procedures Volume. Circulation Journal. 84, 1140-1146, 2020.
  12. Marume K, Noguchi T, Tateishi E, Morita Y, Miura H, Nishimura K, Ohta-Ogo K, Yamada N, Tsujita K, Izumi C, Kusano K, Ogawa H, Yasuda S. Prognosis and Clinical Characteristics of Dilated Cardiomyopathy With Family History via Pedigree Analysis. Circulation Journal. 84, 1284-1293, 2020.
  13. Matsubara M, Makino H, Washida K, Matsuo M, Koezuka R, Ohata Y, Tamanaha T, Honda-Kohmo K, Noguchi M, Tomita T, Son C, Nakai M, Nishimura K, Miyamoto Y, Ihara M, Hosoda K. A Prospective Longitudinal Study on the Relationship Between Glucose Fluctuation and Cognitive Function in Type 2 Diabetes: PROPOSAL Study Protocol. Diabetes Therapy. 11, 2729-2737, 2020.
  14. Kanaoka K, Okayama S, Terasaki S, Nakano T, Ishii M, Nakai M, Onoue K, Nishimura K, Yasuda S, Tsujita K, Kawakami R, Miyamoto Y, Tsutsui H, Komuro I, Ogawa H, Saito Y. Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016. ESC Heart Failure. 7, 2629-2636, 2020.
  15. Funabashi S, Omote K, Nagai T, Honda Y, Nakano H, Honda S, Iwakami N, Hamatani Y, Nakai M, Nishimura K, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Anzai T. Elevated admission urinary N-acetyl-β-D-glucosamidase level is associated with worse long-term clinical outcomes in patients with acute heart failure. European Heart Journal: Acute Cardiovascular Care. 9, 429-436, 2020.
  16. Ishii M, Seki T, Kaikita K, Sakamoto K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Tsutsui H, Komuro I, Saito Y, Ogawa H, Tsujita K, Kawakami K; JROAD Investigators. Short-term exposure to desert dust and the risk of acute myocardial infarction in Japan: a time-stratified case-crossover study. European Journal of Epidemiology. 35, 455-464, 2020.
  17. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Nagai T, Anzai T, Sakata Y, Ogino H. Impact of Endovascular Repair on the Outcomes of Octogenarians with Ruptured Abdominal Aortic Aneurysms: A Nationwide Japanese Study. European Journal of Vascular and Endovascular Surgery. 59, 219-225, 2020.
  18. Shindo A, Tabei KI, Taniguchi A, Nozaki H, Onodera O, Ueda A, Ando Y, Urabe T, Kimura K, Kitagawa K, Hanyu H, Hirano T, Wakita H, Fukuyama H, Kagimura T, Miyamoto Y, Takegami M, Saito S, Watanabe-Hosomi A, Mizuta I, Ihara M, Mizuno T, Tomimoto H. A Nationwide Survey and Multicenter Registry-Based Database of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy in Japan. Frontiers in Aging Neuroscience. 12, 216, 2020.
  19. Suzuki M, Nishihira K, Takegami M, Honda S, Kojima S, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S; JAMIR Investigators. Clinical profiles and outcomes in the treatment of acute myocardial infarction in Japan of aging society. Heart and Vessels. 35, 1681-1688, 2020.
  20. Suwa S, Ogita M, Ebina H, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Admission During Off-Hours Does Not Affect Long-Term Clinical Outcomes of Japanese Patients with Acute Myocardial Infarction: J-MINUET Substudy. International Heart Journal. 61, 215-222, 2020.
  21. Takahashi N, Ogita M, Suwa S, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Prognostic Impact of B-Type Natriuretic Peptide on Long-Term Clinical Outcomes in Patients with Non-ST-Segment Elevation Acute Myocardial Infarction Without Creatine Kinase Elevation A Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) Substudy. International Heart Journal. 61, 888-895, 2020.
  22. Ishii M, Kaikita K, Sakamoto K, Seki T, Kawakami K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Tsutsui H, Komuro I, Saito Y, Ogawa H, Tsujita K; JROAD Investigators. Characteristics and in-hospital mortality of patients with myocardial infarction in the absence of obstructive coronary artery disease in super-aging society. International Journal of Cardiology. 301, 108-113, 2020.
  23. Otsuki S, Aiba T, Tahara Y, Nakajima K, Kataoka N, Kamakura T, Wada M, Ishibashi K, Yamagata K, Inoue Y, Miyamoto K, Nagase S, Noda T, Izumi C, Noguchi T, Nishimura K, Yonemoto N, Nonogi H, Nagao K, Ikeda T, Sato N, Tsutsui H, Yasuda S, Kusano K; Japanese Circulation Society With Resuscitation Science Study (JCS-ReSS) Group. Intra-day change in occurrence of out-of-hospital ventricular fibrillation in Japan: The JCS-ReSS study. International Journal of Cardiology. 318, 54-60, 2020.
  24. Sugiyama D, Turin TC, Yeasmin F, Rumana N, Watanabe M, Higashiyama A, Takegami M, Kokubo Y, Okamura T, Miyamoto Y. Hypercholesterolemia and Lifetime Risk of Coronary Heart Disease in the General Japanese Population: Results from the Suita Cohort Study. Journal of Atherosclerosis and Thrombosis. 27, 60-70, 2020.
  25. Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Takegami M, Nakao YM, Okamura T, Miyamoto Y. Development of a Cardiovascular Disease Risk Prediction Model Using the Suita Study, a Population-Based Prospective Cohort Study in Japan. Journal of Atherosclerosis and Thrombosis. 27, 1160-1175, 2020.
  26. Mizuno A, Niwa K, Ochiai R, Shiraishi I, Sumita Y, Daida H, Fukuda T, Miyamoto Y, Nishimura K, Ogawa H, Yasuda S. Impact of facilities accredited by both adult and pediatric cardiology societies on the outcome of patients with adult congenital heart disease. Journal of Cardiology. 75, 105-109, 2020.
  27. Konishi M, Matsuzawa Y, Ebina T, Kosuge M, Gohbara M, Nishimura K, Nakai M, Miyamoto Y, Saito Y, Tsutsui H, Komuro I, Ogawa H, Tamura K, Kimura K. Impact of population density on mortality in patients hospitalized for heart failure - JROAD-DPC Registry Analysis -. Journal of Cardiology. 75, 447-453, 2020.
  28. Kawaguchi J, Hamatani Y, Hirayama A, Nishimura K, Nakai E, Nakamura E, Miyata M, Kawano Y, Takada Y, Anchi Y, Funabashi S, Kuroda K, Azechi M, Takahama H, Anzai T, Yasuda S, Kitaoka H, Izumi C. Experience of morphine therapy for refractory dyspnea as palliative care in advanced heart failure patients. Journal of Cardiology. 75, 682-688, 2020.
  29. Akahori H, Masuyama T, Imanaka T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Impact of peripheral artery disease on prognosis after myocardial infarction: The J-MINUET study. Journal of Cardiology. 76, 402-406, 2020.
  30. Hosoda H, Asaumi Y, Noguchi T, Morita Y, Kataoka Y, Otsuka F, Nakao K, Fujino M, Nagai T, Nakai M, Nishimura K, Kono A, Komori Y, Hoshi T, Sato A, Kawasaki T, Izumi C, Kusano K, Fukuda T, Yasuda S. Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention. Journal of Cardiovascular Magnetic Resonance. 22, 5, 2020.
  31. Iwakami N, Nagai T, Furukawa TA, Tajika A, Onishi A, Nishimura K, Ogata S, Nakai M, Takegami M, Nakano H, Kawasaki Y, Alba AC, Guyatt GH, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Mizuno A, Yoshikawa T, Anzai T; investigators for the WET-NaDEF Collaboration Project. Optimal sampling in derivation studies was associated with improved discrimination in external validation for heart failure prognostic models. Journal of Clinical Epidemiology. 121, 71-80, 2020.
  32. Tada A, Omote K, Nagai T, Honda Y, Nakano H, Honda S, Iwakami N, Hamatani Y, Nakai M, Nishimura K, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Anzai T. Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure. Journal of Clinical Medicine. 9, 2219, 2020.
  33. Sato R, Sakamoto K, Kaikita K, Tsujita K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm. Journal of Clinical Medicine. 9, 1686, 2020.
  34. Sawada M, Yoshimatsuj J, Nakai M, Tsukinaga R, Yokouchi-Konishi T, Shionoiri T, Nakanishi A, Horiuchi C, Tsuritani M, Kamiya CA, Iwanaga N, Miyamoto Y, Nishimura K, Ohnishi Y. Appropriate delivery method for cardiac disease pregnancy based on noninvasive cardiac monitoring. Journal of Perinatal Medicine. 48, 376-383, 2020.
  35. Kida M, Ono T, Kokubo Y, Yoshimuta Y, Kosaka T, Kikui M, Yamamoto MA, Ikebe K, Maeda Y, Nokubi T, Nishimura K, Watanabe M, Higashiyama A, Miyamoto Y. Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study. Journal of Prosthodontic Research. 64, 346-353, 2020.
  36. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Nozato T, Ashikaga T, Nagai T, Anzai T, Sakata Y, Ogino H. Sex differences in Japanese patients with ruptured aortic aneurysms. Journal of Vascular Surgery. 71, 1907-1912.e3, 2020.
  37. Nakahara T, Izuhara K, Onozuka D, Nunomura S, Tamagawa-Mineoka R, Masuda K, Ichiyama S, Saeki H, Kabata Y, Abe R, Ohtsuki M, Kamiya K, Okano T, Miyagaki T, Ishiuji Y, Asahina A, Kawasaki H, Tanese K, Mitsui H, Kawamura T, Takeichi T, Akiyama M, Nishida E, Morita A, Tonomura K, Nakagawa Y, Sugawara K, Tateishi C, Kataoka Y, Fujimoto R, Kaneko S, Morita E, Tanaka A, Hide M, Aoki N, Sano S, Matsuda-Hirose H, Hatano Y, Takenaka M, Murota H, Katoh N, Furue M. Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab A study protocol. Medicine. 99, e22043, 2020.
  38. Ido K, Kurogi R, Kurogi A, Nishimura K, Arimura K, Nishimura A, Ren N, Kada A, Matsuo R, Onozuka D, Hagihara A, Takagishi S, Yamagami K, Takegami M, Nohara Y, Nakashima N, Kamouchi M, Date I, Kitazono T, Iihara K; J-ASPECT Study Collaborators. Effect of treatment modality and cerebral vasospasm agent on patient outcomes after aneurysmal subarachnoid hemorrhage in the elderly aged 75 years and older. PLOS ONE. 15, e0230953, 2020.
  39. Matsubara S, Tanaka T, Tomari S, Fukuma K, Ishiyama H, Abe S, Arimizu T, Yamaguchi Y, Ogata S, Nishimura K, Koga M, Ando Y, Toyoda K, Ihara M. Statin treatment can reduce incidence of early seizure in acute ischemic stroke: A propensity score analysis. Scientific Reports. 10, 1968, 2020.
  40. Matsuda N, Kitagaki K, Perrein E, Tsuboi Y, Ebina A, Kondo Y, Murata S, Isa T, Okumura M, Kawaharada R, Horibe K, Ono R. Association Between Excessive Weight Gain During Pregnancy and Persistent Low Back and Pelvic Pain After Delivery. Spine. 45, 319-324, 2020.
  41. Kusano K, Yamane T, Inoue K, Takegami M, Nakao YM, Miyamoto Y, Shoda M, Nogami A; J-AB registry investigators. The Japanese Catheter Ablation Registry (J-AB): A prospective nationwide multicenter registry in Japan. Annual report in 2018. Journal of Arrhythmia. 36, 953-961, 2020.
  42. Hosoki S, Saito S, Tonomura S, Ishiyama H, Yoshimoto T, Ikeda S, Ikenouchi H, Yamamoto Y, Hattori Y, Miwa K, Friedland RP, Carare RO, Nakahara J, Suzuki N, Koga M, Toyoda K, Nomura R, Nakano K, Takegami M, Ihara M. Oral Carriage of Streptococcus mutans Harboring the cnm Gene Relates to an Increased Incidence of Cerebral Microbleeds. Stroke. 51, 3632-3639, 2020.
  43. Shoda M, Kusano K, Goya M, Nishii N, Imai K, Okamoto Y, Takegami M, Nakao YM, Miyamoto Y, Nogami A; J-LEX registry investigators. Study Design of the Nationwide Japanese Lead Extraction (J-LEX) Registry: Protocol for a Prospective, Multicenter, Open Registry. Journal of Arrhythmia. 36, 849-853, 2020.
  44. Mori H, Suzuki H, Nishihira K, Honda S, Kojima S, Takegami M, Takahashi J, Itoh T, Watanabe T, Takenaka T, Ito M, Takayama M, Kario K, Sumiyoshi T, Kimura K, Yasuda S; JAMIR Investigators. In-hospital morality associated with acute myocardial infarction was inversely related with the number of coronary risk factors in patients from a Japanese nation-wide real-world database. International Journal of Cardiology Hypertension. 6, 100039, 2020.
  45. Izumi C, Miyake M, Amano M, Kitai T, Obayashi Y, Takegami M, Kimura T, Sugio K, Matsumoto T, Nishimura K, Furukawa Y. Registry of antithrombotic therapy in atrial fibrillation patients with bioprosthetic valves: A retrospective observational study. Journal of Cardiology. 76, 44-50, 2020.
  46. Ebina A, Sawa R, Kondo Y, Murata S, Saito T, Isa T, Tsuboi Y, Torizawa K, Matsuda N, Ono R. Daily physical activity is associated with increased sonographically measured bone status during lactation. Women's Health. 16, 2020.
  47. Ebina A, Sawa R, Kondo Y, Murata S, Takada M, Fujii H, Okuyama Y, Tanikawa Y, Souke K, Ono R. Influence of kinesiophobia with pregnancy-related lumbopelvic pain at late pregnancy on postpartum depressive symptoms. Physical Therapy Research. 23, 92-98, 2020.
  48. Uchida K, Murata S, Kawaharada R, Tsuboi Y, Isa T, Okumura M, Matsuda N, Nakatsuka K, Horibe K, Kogaki M, Ono R. Association Between Kinesiophobia and Life Space Among Community-Dwelling Older People with Chronic Musculoskeletal Pain. Pain Medicine. 21, 3360-3365, 2020.
  49. Yoshida H, Inaguma D, Koshi-Ito E, Ogata S, Kitagawa A, Takahashi K, Koide S, Hayashi H, Hasegawa M, Yuzawa Y, Tsuboi N. Extreme hyperuricemia is a risk factor for infection-related deaths in incident dialysis patients: a multicenter prospective cohort study. Renal Failure. 42, 646–655, 2020.
  50. Taira K, Ogata S, Kamide K. Comparing the differences in three measures of healthy life expectancy among prefectures in Japan. BMC Research Notes. 13, 371, 2020.
  51. Umeda R, Ogata S, Hara S, Takahashi K, Inaguma D, Hasegawa M, Yasuoka H, Yuzawa Y, Hayashi H, Tsuboi N. Comparison of the 2018 and 2003 International Society of Nephrology/Renal Pathology Society classification in terms of renal prognosis in patients of lupus nephritis: a retrospective cohort study. Arthritis Research & Therapy. 22, 260, 2020.
  52. Arai H, Ogata S, Ozeki T, Takahashi K, Tsuboi N, Maruyama S, Inaguma D, Hasegawa M, Yuzawa Y, Hayashi H. Long-term changes in renal function after treatment initiation and the importance of early diagnosis in maintaining renal function among IgG4-related tubulointerstitial nephritis patients in Japan. Arthritis Research & Therapy. 22, 261, 2020.
  53. Hayashi C, Tanaka H, Ogata S. Assessing timewise changes over 15 months in life-space mobility among community-dwelling elderly persons. BMC Geriatrics. 20, 502, 2020.
  54. Toyama H, Matsumoto I, Mizumoto T, Fujita H, Tsuchida S, Kanbara Y, Kadowaki Y, Maeda H, Okano K, Fukuoka M, Takase S, Shirakawa S, Terai S, Mukubo H, Ishida J, Yamashita H, Ueno K, Tanaka M, Kido M, Ajiki T, Murakami S, Nishimura K, Fukumoto T. Influence of the Retrocolic Versus Antecolic Route for Alimentary Tract Reconstruction on Delayed Gastric Emptying After Pancreatoduodenectomy: A Multicenter, Noninferiority Randomized Controlled Trial. Annals of Surgery. Epub, 2020.
  55. Fujii T, Yoshitani K, Kanemaru E, Nakai M, Nishimura K, Ohnishi Y, Nishiwaki K. Sizing of mitral annuloplasty rings using real-time three-dimensional transesophageal echocardiography and the difference between patients with and without recurrent mitral regurgitation: retrospective cohort study. Journal of Echocardiography. 18, 169-174, 2020.
  56. Ishii M, Seki T, Kaikita K, Sakamoto K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Kanaoka K, Terasaki S, Saito Y, Tsutsui H, Komuro I, Ogawa H, Tsujita K, Kawakami K; on the behalf of the JROAD Investigators. Association of short-term exposure to air pollution with myocardial infarction with and without obstructive coronary artery disease. European Journal of Preventive Cardiology. Epub, 2020.
  57. Imamura H, Sakai N, Satow T, Iihara K; JR-NET3 Study Group. Factors related to adverse events during endovascular coil embolization for ruptured cerebral aneurysms. Journal of NeuroInterventional Surgery. 12, 605-609, 2020.
  58. Wada H, Ogita M, Suwa S, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy. European Heart Journal: Acute Cardiovascular Care. 9, 939-947, 2020.