病理部 病理診断科
研究活動の概要

病理部門は、循環器疾患の診療に必要な組織病理診断情報を臨床に提供するために、病理解剖と外科手術検体や心筋などの生検材料の病理組織診断を主要な業務としている。これらの検体を活用した広い分野にわたる臨床研究を他科と協力して行っており、循環器系および病理系、一部呼吸器系の学会および学術誌に発表している。病理解剖は今日、世界的にその数は著明に減少している。NCVCにおいても剖検数は10数年前と比べると激減してきた。2020年1月～12月は剖検率が20％（年間総数37体）と少ないながらも、その件数は全国では常に上位にランクされている。組織診断件数は数年前から増加傾向にあり、特に心筋生検の数は2020年の1年間で546件と増加傾向を維持している。また、心・血管を専門とする病理部門は全国的に少なく、この特殊性を生かすため、これまで随時全国の医療機関から循環器系疾患の病理診断のコンサルテーションを受け入れてきた。2020年度上半期で275件と例年に比し著増している。外部施設からの病理検体の作製依頼および診断の有料のコンサルテーションの受け入れ体制を整え、ホームページに公開し、現在30施設以上と契約している。また2020年4月からはアミロイドーシスに関する調査研究に参加しており、心筋生検におけるアミロイド診断についてのコンサルテーション体制を構築している。病理解剖に関しては近隣施設からの病理解剖を受け入れるようにした。

研究については病理部門のスタッフの専門性を生かしつつ、他科と多数の共同研究を行っている。
現在進行中の主な研究テーマは、

  1. 慢性心筋炎の診断基準確立と予後予測因子の探索
  2. 肺高血圧症の病理
  3. 中性脂肪蓄積性心筋血管症の検討
  4. 抗ガン剤投与後の心筋障害に関する病理学的検討
  5. 血栓症の病理
  6. 粥状動脈硬化症の病理

などである。また、他科のレジデントの学術発表や論文の指導も行っている。定期的な心筋生検や病理解剖（全剖検例でCPCを施行）のカンファレンスでは臨床科とのディスカッションが活発に行われている。

その他、NCVCバイオバンク保存のため、病理部門はバイオバンクと協力し病理解剖、周産期検体、移植摘出心などの組織の収集保存を行っている。

研究業績
  1. Higashi M, Yamada N, Imakita S, Yutani C, Ishibashi-Ueda H, Iihara K, Naito H. CT-pathologic correlation of non-calcified atherosclerotic arterial plaques: a study using carotid endarterectomy specimens. British Journal of Radiology. 93, 20190901, 2020.
  2. Obikane H, Fujiyoshi T, Takahashi S, Ogino H, Matsubayashi J, Nagao T, Ishibashi-Ueda H. Giant cell arteritis in a patient with aortic dissection: a case report. Cardiovascular Pathology. 46, 107206, 2020.
  3. Kitagawa K, Toyoda K, Kitazono T, Nishikawa M, Nanto S, Ikeda Y, Abe K, Ogawa A. Safety and Efficacy of Prasugrel in Elderly/Low Body Weight Japanese Patients with Ischemic Stroke: Randomized PRASTRO-II. Cerebrovascular Diseases. 49, 152-159, 2020.
  4. Yanase M, Iwasaki K, Watanabe T, Seguchi O, Nakajima S, Kuroda K, Mochizuki H, Matsuda S, Takenaka H, Ikura M, Tadokoro N, Fukushima S, Fujita T, Ishibashi-Ueda H, Nakatani T, Kitamura S, Kobayashi J, Tsujita K, Ogawa H, Fukushima N. Effect of Therapeutic Modification on Outcomes in Heart Transplantation Over the Past Two Decades - A Single-Center Experience in Japan -. Circulation Journal. 84, 965-974, 2020.
  5. Mori H, Ishibashi T, Inagaki T, Okazawa M, Masaki T, Asano R, Manabe Y, Ohta-Ogo K, Narazaki M, Ishibashi-Ueda H, Kumanogoh A, Nakaoka Y. Pristane/Hypoxia (PriHx) Mouse as a Novel Model of Pulmonary Hypertension Reflecting Inflammation and Fibrosis. Circulation Journal. 84, 1163-1172, 2020.
  6. Marume K, Noguchi T, Tateishi E, Morita Y, Miura H, Nishimura K, Ohta-Ogo K, Yamada N, Tsujita K, Izumi C, Kusano K, Ogawa H, Yasuda S. Prognosis and Clinical Characteristics of Dilated Cardiomyopathy With Family History via Pedigree Analysis. Circulation Journal. 84, 1284-1293, 2020.
  7. Koyama T, Yamamoto H, Matsumoto M, Isogai J, Isomura T, Tanaka S. Late-Stage Löffler's Endocarditis Mimicking Cardiac Tumor: A Case Report. Frontiers in Cardiovascular Medicine. 7, 589212, 2020.
  8. Miyoshi T, Hisamitsu T, Ishibashi-Ueda H, Ikemura K, Ikeda T, Miyazato M, Kangawa K, Watanabe Y, Nakagawa O, Hosoda H. Maternal administration of tadalafil improves fetal ventricular systolic function in a Hey2 knockout mouse model of fetal heart failure. International Journal of Cardiology. 302, 110-116, 2020.
  9. Amemiya K, Mousseaux E, Ishibashi-Ueda H, Achouh P, Ochiai M, Bruneval P. Impact of histopathological changes in ascending aortic diseases. International Journal of Cardiology. 311, 91-96, 2020.
  10. Komoriyama H, Omote K, Nagai T, Kato Y, Nagano N, Koyanagawa K, Kamiya K, Konishi T, Sato T, Kobayashi Y, Tsujinaga S, Iwano H, Kusano K, Yasuda S, Ogawa H, Ishibashi-Ueda H, Anzai T. Lower left ventricular ejection fraction and higher serum angiotensin-converting enzyme activity are associated with histopathological diagnosis by endomyocardial biopsy in patients with cardiac sarcoidosis. International Journal of Cardiology. 321, 113-117, 2020.
  11. Hattori H, Hirata A, Kubo S, Nishida Y, Nozawa M, Kawamura K, Hirata T, Kubota Y, Sata M, Kuwabara K, Higashiyama A, Kadota A, Sugiyama D, Miyamatsu N, Miyamoto Y, Okamura T. Estimated 24 h Urinary Sodium-to-Potassium Ratio Is Related to Renal Function Decline: A 6-Year Cohort Study of Japanese Urban Residents. International Journal of Environmental Research and Public Health. 17, 5811, 2020.
  12. Kitano T, Sakaguchi M, Yamagami H, Ishikawa T, Ishibashi-Ueda H, Tanaka K, Okazaki S, Sasaki T, Kadono Y, Takagaki M, Nishida T, Nakamura H, Yanase M, Fukushima N, Shiozawa M, Toyoda K, Takahashi JC, Funatsu T, Ryu B, Yoshioka D, Toda K, Murayama S, Kawamata T, Kishima H, Sawa Y, Mochizuki H, Todo K. Mechanical thrombectomy in acute ischemic stroke patients with left ventricular assist device. Journal of the Neurological Sciences. 418, 117142, 2020.
  13. Seike Y, Minatoya K, Matsuda H, Ishibashi-Ueda H, Morisaki H, Morisaki T, Kobayashi J. Histologic differences between the ascending and descending aortas in young adults with fibrillin-1 mutations. The Journal of Thoracic and Cardiovascular Surgery. 159, 1214-1220.e1, 2020.
  14. Sakai K, Fujimura Y, Nagata Y, Higasa S, Moriyama M, Isonishi A, Konno M, Kajiwara M, Ogawa Y, Kaburagi S, Hara T, Kokame K, Miyata T, Hatakeyama K, Matsumoto M. Success and limitations of plasma treatment in pregnant women with congenital thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis. 18, 2929-2941, 2020.
  15. Yagi H, Nishigori M, Murakami Y, Osaki T, Muto S, Iba Y, Minatoya K, Ikeda Y, Ishibashi-Ueda H, Morisaki T, Ogino H, Tanaka H, Sasaki H, Matsuda H, Minamino N. Discovery of novel biomarkers for atherosclerotic aortic aneurysm through proteomics-based assessment of disease progression. Scientific Reports. 10, 6429, 2020.
  16. Kotsugi M, Nakagawa I, Hatakeyama K, Park H, Sato F, Furuta T, Nishimura F, Yamada S, Motoyama Y, Park YS, Nakase H. Lipid Core Plaque Distribution Using Near-infrared Spectroscopy Is Consistent with Pathological Evaluation in Carotid Artery Plaques. Neurologia medico-chirurgica. 60, 499-506, 2020.
  17. Itami H, Hara S, Samejima K, Tsushima H, Morimoto K, Okamoto K, Kosugi T, Kawano T, Fujiki K, Kitada H, Hatakeyama K, Tsuruya K, Ohbayashi C. Complement activation is associated with crescent formation in IgA nephropathy. Virchows Archiv. 477, 565-572 , 2020.
  18. Fujii T, Uchiyama T, Matsuoka M, Myojin T, Sugimoto S, Nitta Y, Okabe F, Sugimoto A, Sekita-Hatakeyama Y, Morita K, Itami H, Hatakeyama K, Ohbayashi C. Evaluation of DNA and RNA quality from archival formalin-fixed paraffin-embedded tissue for next-generation sequencing - Retrospective study in Japanese single institution. Pathology International. 70, 602-611, 2020.
  19. Nishikawa T, Fujii T, Tatsumi S, Sugimoto A, Sekita-Hatakeyama Y, Shimada K, Yamazaki M, Hatakeyama K, Ohbayashi C. Molecular Analysis of Liquid-Based Cytological Specimen Using Virtually Positive Sputum with Adenocarcinoma Cells. Diagnostics (Basel). 10, 84, 2020.
  20. Fujii T, Itami H, Uchiyama T, Morita K, Nakai T, Hatakeyama K, Sugimoto A, Shimada K, Tsuji S, Ohbayashi C. HEG1-responsive microRNA-23b regulates cell proliferation in malignant mesothelioma cells. Biochemical and Biophysical Research Communications. 526, 927-933, 2020.
  21. Miyake M, Oda Y, Nishimura N, Morizawa Y, Ohnishi S, Hatakeyama K, Fujii T, Hori S, Gotoh D, Nakai Y, Anai S, Torimoto K, Tsukamoto S, Fujii H, Kido A, Honoki K, Matsumura Y, Okajima E, Tanaka N, Fujimoto K. Integrative assessment of clinicopathological parameters and the expression of PD-L1, PD-L2 and PD-1 in tumor cells of retroperitoneal sarcoma. Oncology Letters. 20, 190, 2020.
  22. Asada Y, Yamashita A, Sato Y, Hatakeyama K. Pathophysiology of atherothrombosis: Mechanisms of thrombus formation on disrupted atherosclerotic plaques. Pathology International. 70, 309-322, 2020.
  23. Yoshizawa H, Kobayashi K, Kataoka M, Sogabe S, Maeda H, Sakurai K, Ohta-Ogo K, Hatakeyama K, Yoshida K. A sudden death of middle-aged woman with congenital heart diseased presented pulmonary artery macroscopic and microscopic aneurysm and dissection with thrombosis. Human Pathology: Case Reports. 22, 200455, 2020.
  24. Tanaka T, Ueda T, Yokoyama T, Harada S, Hatakeyama K, Yoshimura A. Pseudosarcomatous myofibroblastic proliferation of the appendix with an abdominal abscess due to diverticulum perforation: a case report. Surgical Case Reports. 6, 144, 2020.
  25. Yokoi K, Otsuka F, Mizote I, Shiraki T, Tsukamoto Y, Nakamura D, Ohtani T, Hikoso S, Ikeda Y, Hatakeyama K, Sakata Y. In Vivo Intracoronary Imaging Assessment of Cardiac Allograft Vasculopathy With Histopathologic Confirmation. JACC: Cardiovascular Interventions. 13, 2305-2307, 2020.
  26. Matsui Y, Hamada M, Sumiyama F, Kobayashi T, Matsumi Y, Miki H, Ishida M, Kurokawa H, Sekimoto M, Sekita-Hatakeyama Y, Hatakeyama K, Ohbayashi C. Two cases of primary solitary fibrous tumor in the pelvis resected using laparoscopic surgery. International Journal of Surgery Case Reports. 71, 58-65, 2020.
  27. Tanaka M, Ikeda Y, Li M, Zaima N, Kawahara Y, Watanabe K, Inaba T, Kobayashi K, Noguchi H, Yamada S, Hao H, Hirano KI. A historical case of primary triglyceride deposit cardiomyovasculopathy. Pathology International. 70, 58-61, 2020.
  28. Ikeda Y, Kitamura S. Commentary: Complete surgery necessary for optimal outcome in aortic neoplasm forming malignant cartilage. The Journal of Thoracic and Cardiovascular Surgery. 159, e289-e290, 2020.
  29. Saito S, Ikeda Y, Ando D, Carare RO, Ishibashi-Ueda H, Ihara M. Cerebral Amyloid Angiopathy Presenting as Massive Subarachnoid Haemorrhage: A Case Study and Review of Literature. Frontiers in Aging Neuroscience. 12, 538456, 2020.
  30. Inoue T, Sera F, Nishimura S, Nakamoto K, Tsukamoto Y, Mizote I, Ohtani T, Hikoso S, Ikeda Y, Hori Y, Ishibashi-Ueda H, Morii E, Minamino T, Sakata Y. A Case of Lymphocytic Myocarditis with Eosinophilic Degranulation Successfully Treated with Steroid Therapy. Case Reports in Cardiology. 2020, 8887726, 2020.
  31. Omori T, Nakamori S, Ohta-Ogo K, Matsuda A, Ogihara Y, Yamada N, Imanaka-Yoshida K, Ito M, Dohi K. Autopsy study of pulmonary capillary hemangiomatosis with inflammatory cell infiltration into the myocardium. Pulmonary Circulation. 10, 2020.
  32. Yamamoto H, Ohta-Ogo K, Isogai J, Ishibashi-Ueda H, Nakamura Y. Epicardial Nodules as the Initial Manifestation of Immunoglobulin G4–Related Pericarditis. JACC: Case Reports. 2, 1505-1509, 2020.
  33. Yamamoto H, Ito Y, Isogai J, Ishibashi-Ueda H, Nakamura Y. Immunoglobulin G4-Related Multiple Giant Coronary Artery Aneurysms and a Single Left Gastric Artery Aneurysm. JACC: Case Reports. 2, 769-774, 2020.
  34. 伊達 恵美, 畠山 金太, 北岡 文, 平山 寛, 高橋 憲一, 飯塚 徳重. 胸腺腫合併肺癌に免疫チェックポイント阻害薬を投与し、筋炎・心筋炎を発症した1剖検例. 病理と臨床. 38, 1169-1175, 2020.
  35. 畠山 金太, 植田 初江. 病理画像からみた大動脈疾患. 医学と薬学. 77, 1605-1613, 2020.
  36. 大郷 恵子. 病理学および病理生物学. 呼吸器内科. 37, 220-226, 2020.
  37. 大郷 恵子, 植田 初江, 大郷 剛. 肺高血圧症の病理. Heart View. 24, 213-220, 2020.