不整脈科
研究活動の概要

不整脈科では、種々の頻脈性・致死性不整脈の病態及び機序の解明、並びに新たな診断・治療法の開発に加え、近年増加している心房細動に関連した抗凝固療法や新しいアブレーション法を臨床研究のテーマとし難治性の不整脈疾患において種々の研究活動を行っている。

隠れた心房細動を見つけ出すAIを用いた独自の心電図診断装置の開発を、新病院になってオープンイノベーションセンター（OIC）にてJSR社との共同研究で行い、成果を2020年日本循環器学会で発表した。

心臓サルコイドーシスに関して、2015年に行った全国実態調査を、新たに作成したEDCを用い、来年度中に施行予定である。

遺伝性不整脈疾患に関しては遺伝性不整脈外来創設による効果で、昨年も500名近い遺伝子診断紹介を受け、次世代シーケンサーを使った診断を随時行っている。これらの結果を元にQT延長症候群、Brugada症候群などの治療に関する報告を種々の国際学会・英文論文等でその成果を報告している。

治療に関しては、心房細動に対するカテーテルアブレーションの有効性・安全性に関して、低心機能症例、無症状例を多施設共同の前向き研究として、またアブレーション法の違いによる周術期脳梗塞発生に関して単施設で研究を一部実施あるいは本年度中に開始見込みである。

デバイス（植込み型除細動器、心室再同期機能付き除細動器、ペースメーカ）に関しては、再同期治療に関する国際共同治験に日本代表として引き続いて参加し、新たにアジアを対象としたMidQ Response試験を開始している。皮下植込み型除細動器（S-ICD）、リードレスペースメーカ、Hisペーシングが臨床に導入され負担の少ない治療が可能となってきている。中でも心房細動治療が可能な新しいアルゴリズムをもつデバイスの研究を引き続き行っている。

デバイス遠隔モニタリングは800名を超える除細動器患者を含んで2000名以上に行い、デバイス植込み数とともに単施設の遠隔モニタリング数としては日本最大である。当科だけで年間1500名以上の入院患者を受け入れ診断・治療を行っている。

不整脈心電学会と共同研究を進め、アブレーション全例登録事業（J-AB）、リード抜去全例登録事業（J-LEX）を引き続いて行っている。J-ABは月間6000例を超える登録が安定して行われており、登録数は20万件を超え世界一となっている。2020年10月からは新たに左心耳閉鎖デバイスの全例登録事業（J-LAAO）を日本循環器学会との共同研究で開始した。

今後もあらゆる方面から難治性心不全や不整脈の治療・管理・研究に取り組む予定である。

2020年の主な研究成果
  • 今年度はカテーテルアブレーションが726、デバイス植込み（リード抜去術を含む）が約750例、遺伝子検査数は400例を超え日本最大。
  • 国際多施設共同治験（日本PI）として、Adapt-Response試験に参加中。
  • 不整脈心電学会との共同研究でアブレーション全例登録レジストリー事業（J-AB）、リード抜去全例登録事業（J-LEX）を継続。
  • 心臓サルコイドーシスに対する抗菌薬の効果をみる探索研究（J-ACNES開始）を継続。
  • 日本循環器学会との共同研究で左心耳閉鎖デバイス全例登録事業（J-LAAO）の開始。
  • 低心機能例に対する心房細動カテーテルアブレーションの有効性をみる多施設前向き研究（CRABL-HF試験）の開始。
研究業績
  1. Birnie D, Beanlands RSB, Nery P, Aaron SD, Culver DA, DeKemp RA, Gula L, Ha A, Healey JS, Inoue Y, Judson MA, Juneau D, Kusano K, Quinn R, Rivard L, Toma M, Varnava A, Wells G, Wickremasinghe M, Kron J. Cardiac Sarcoidosis multi-center randomized controlled trial (CHASM CS- RCT). American Heart Journal. 220, 246-252, 2020.
  2. Iwakami N, Aiba T, Kamakura S, Takaki H, Furukawa TA, Sato T, Sun W, Shishido T, Nishimura K, Yamada-Inoue Y, Nagase S, Shimizu W, Yasuda S, Sugimachi M, Kusano K. Identification of malignant early repolarization pattern by late QRS activity in high-resolution magnetocardiography. Annals of Noninvasive Electrocardiology. 25, e12741, 2020.
  3. Tsuda E, Noda T, Noguchi T. Two females with coronary artery occlusion caused by presumed Kawasaki disease would have delivered without recognition of ischaemic heart disease. Cardiology in the Young. 30, 785-789, 2020.
  4. Ueda N, Noda T, Ishibashi K, Nakajima K, Kataoka N, Kamakura T, Wada M, Yamagata K, Inoue Y, Miyamoto K, Nagase S, Aiba T, Kanzaki H, Izumi C, Noguchi T, Yasuda S, Kusano K. Efficacy of a Device-Based Continuous Optimization Algorithm for Patients With Cardiac Resynchronization Therapy. Circulation Journal. 84, 18-25, 2020.
  5. Kanemaru K, Yoshimoto T, Inoue H, Yamashita T, Akao M, Atarashi H, Ikeda T, Okumura K, Koretsune Y, Shimizu W, Tsutsui H, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Kaburagi J, Takita A, Kusano K, Toyoda K; All Nippon Atrial Fibrillation in the Elderly (ANAFIE) Group. Baseline Characteristics of Elderly Japanese Patients Aged ≥75 Years With Non-Valvular Atrial Fibrillation and a History of Stroke - ANAFIE Registry -. Circulation Journal. 84, 516-523, 2020.
  6. Okumura K, Sasaki S, Kusano K, Mine T, Fujii K, Iwasa A, Sunagawa O, Yamabe H, Takahashi N, Ishii S, Takeishi Y, Tsuboi N, Shizuta S, Aonuma K, Shimane A, Tada H, Ishikawa T, Tsunoda R, Numata T, Mukai Y, Kihara Y, Koehler J, Hidaka K, Sharma V. Evaluation of an Integrated Device Diagnostics Algorithm to Risk Stratify Heart Failure Patients - Results From the SCAN-HF Study -. Circulation Journal. 84, 1118-1123, 2020.
  7. Aonuma K, Yamasaki H, Nakamura M, Matsumoto T, Takayama M, Ando K, Hirao K, Goya M, Morino Y, Hayashida K, Kusano K, Gomi Y, Main ML, Uchida T, Saito S. Efficacy and Safety of Left Atrial Appendage Closure With WATCHMAN in Japanese Nonvalvular Atrial Fibrillation Patients - Final 2-Year Follow-up Outcome Data From the SALUTE Trial -. Circulation Journal. 84, 1237-1243, 2020.
  8. Marume K, Noguchi T, Tateishi E, Morita Y, Miura H, Nishimura K, Ohta-Ogo K, Yamada N, Tsujita K, Izumi C, Kusano K, Ogawa H, Yasuda S. Prognosis and Clinical Characteristics of Dilated Cardiomyopathy With Family History via Pedigree Analysis. Circulation Journal. 84, 1284-1293, 2020.
  9. Fujiki S, Iijima K, Okabe M, Niwano S, Tsujita K, Naito S, Ando K, Kusano K, Kato R, Nitta J, Miura T, Mitsuhashi T, Kario K, Kondo Y, Ieda M, Hagiwara N, Murohara T, Takahashi K, Tomita H, Takeishi Y, Anzai T, Shimizu W, Watanabe M, Morino Y, Kato T, Tada H, Nakagawa Y, Yano M, Maemura K, Kimura T, Yoshida H, Ota K, Tanaka T, Kitamura N, Node K, Aizawa Y, Shimizu I, Izumi D, Ozaki K, Minamino T; EMPA-ICD investigators. Placebo-Controlled, Double-Blind Study of Empagliflozin (EMPA) and Implantable Cardioverter-Defibrillator (EMPA-ICD) in Patients with Type 2 Diabetes (T2DM): Rationale and Design. Diabetes Therapy. 11, 2739-2755, 2020.
  10. Wilkoff BL, Birnie D, Gold MR, Hersi AS, Jacobs S, Gerritse B, Kusano K, Leclercq C, Mullens W, Filippatos G. Differences in clinical characteristics and reported quality of life of men and women undergoing cardiac resynchronization therapy. ESC Heart Failure. 7, 2972-2982, 2020.
  11. Asada S, Morita H, Watanabe A, Nakagawa K, Nagase S, Miyamoto M, Morimoto Y, Kawada S, Nishii N, Ito H. Indication and prognostic significance of programmed ventricular stimulation in asymptomatic patients with Brugada syndrome. Europace. 22, 972-979, 2020.
  12. Tanaka N, Inoue K, Kobori A, Kaitani K, Morimoto T, Kurotobi T, Morishima I, Yamaji H, Matsui Y, Nakazawa Y, Kusano K, Okada M, Tanaka K, Hirao Y, Oka T, Koyama Y, Okamura A, Iwakura K, Fujii K, Kimura T, Shizuta S. Sex differences in atrial fibrillation ablation outcomes: insights from a large-scale multicentre registry. Europace. 22, 1345-1357, 2020.
  13. Funabashi S, Omote K, Nagai T, Honda Y, Nakano H, Honda S, Iwakami N, Hamatani Y, Nakai M, Nishimura K, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Anzai T. Elevated admission urinary N-acetyl-β-D-glucosamidase level is associated with worse long-term clinical outcomes in patients with acute heart failure. European Heart Journal: Acute Cardiovascular Care. 9, 429-436, 2020.
  14. Nakano H, Nagai T, Honda Y, Honda S, Iwakami N, Matsumoto C, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Ogawa H, Yasuda S, Chikamori T, Anzai T. Prognostic value of base excess as indicator of acid-base balance in acute heart failure. European Heart Journal: Acute Cardiovascular Care. 9, 399-405, 2020.
  15. Nagashima K, Hiro T, Fukamachi D, Okumura Y, Watanabe I, Hirayama A, Tanaka M, Tanaka T, Takamisawa I, Taguchi I, Sato A, Aonuma K, Fukamizu S, Nakada A, Watanabe A, Amioka N, Suzuki Y, Matsumoto N, Koizumi J, Kumagai K, Naya M, Higuchi Y, Naito Y, Masuyama T, Kawamura M, Tsunoda R, Suzuki S, Ishii H, Murohara T, Shimizu T, Takeishi Y, Shiina K, Yamashita J, Imamura T, Sumitomo N, Noguchi T, Aso T, Furukawa K, Yamauchi Y, Okishige K, Sakata K, Yamagishi M, Shimizu S, Ohno M, Sugano T, Matsumura K, Matsumoto K, Ozaki K, Hayashidani S, Meno H, Iwata A, Higuma T, Tomita H, Yoshino H, Taniai S, Shishido K, Murakami M, Negishi K, Nii M, Wakatsuki D, Suzuki H, Motoike Y, Ozaki Y, Nakazato J, Hayashi H, Higuchi S, Shoda M. Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry). European Heart Journal: Cardiovascular Imaging. 21, 222-230, 2020.
  16. Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H. Identification of transmembrane protein 168 mutation in familial Brugada syndrome. The FASEB Journal. 34, 6399-6417, 2020.
  17. Kamakura T, Shinohara T, Yodogawa K, Murakoshi N, Morita H, Takahashi N, Inden Y, Shimizu W, Nogami A, Horie M, Aiba T, Kusano K. Long-term prognosis of patients with J-wave syndrome. Heart. 106, 299-306, 2020.
  18. Ueda N, Noda T, Nakajima I, Ishibashi K, Nakajima K, Kamakura T, Wada M, Yamagata K, Inoue Y, Miyamoto K, Nagase S, Aiba T, Kiso K, Kanzaki H, Izumi C, Noguchi T, Yasuda S, Kusano K. Clinical impact of left ventricular paced conduction disturbance in cardiac resynchronization therapy. Heart Rhythm. 17, 1870-1877, 2020.
  19. Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, Dagres N, Di Toro D, Eckhardt LL, Ellenbogen K, Hardy C, Ikeda T, Jaswal A, Kaufman E, Krahn A, Kusano K, Kutyifa V, Lim HS, Lip GYH, Nava-Townsend S, Pak HN, Diez GR, Sauer W, Saxena A, Svendsen JH, Vanegas D, Vaseghi M, Wilde A, Bunch TJ; ESC Scientific Document Group: Buxton AE, Calvimontes G, Chao TF, Eckardt L, Estner H, Gillis AM, Isa R, Kautzner J, Maury P, Moss JD, Nam GB, Olshansky B, Pava Molano LF, Pimentel M, Prabhu M, Tzou WS, Sommer P, Swampillal J, Vidal A, Deneke T, Hindricks G, Leclercq C. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Heart Rhythm. 17, e269-e316, 2020.
  20. Kakehashi S, Kamakura T, Aiba T, Kusano K. Two Forms of Monomorphic Ventricular Tachycardia in a Patient with Brugada Syndrome. Internal Medicine. 59, 1287-1290, 2020.
  21. Otsuki S, Aiba T, Tahara Y, Nakajima K, Kataoka N, Kamakura T, Wada M, Ishibashi K, Yamagata K, Inoue Y, Miyamoto K, Nagase S, Noda T, Izumi C, Noguchi T, Nishimura K, Yonemoto N, Nonogi H, Nagao K, Ikeda T, Sato N, Tsutsui H, Yasuda S, Kusano K; Japanese Circulation Society With Resuscitation Science Study (JCS-ReSS) Group. Intra-day change in occurrence of out-of-hospital ventricular fibrillation in Japan: The JCS-ReSS study. International Journal of Cardiology. 318, 54-60, 2020.
  22. Komoriyama H, Omote K, Nagai T, Kato Y, Nagano N, Koyanagawa K, Kamiya K, Konishi T, Sato T, Kobayashi Y, Tsujinaga S, Iwano H, Kusano K, Yasuda S, Ogawa H, Ishibashi-Ueda H, Anzai T. Lower left ventricular ejection fraction and higher serum angiotensin-converting enzyme activity are associated with histopathological diagnosis by endomyocardial biopsy in patients with cardiac sarcoidosis. International Journal of Cardiology. 321, 113-117, 2020.
  23. Onuma Y, Honda Y, Asano T, Shiomi H, Kozuma K, Ozaki Y, Namiki A, Yasuda S, Ueno T, Ando K, Furuya J, Hanaoka KI, Tanabe K, Okada K, Kitahara H, Ono M, Kusano H, Rapoza R, Simonton C, Popma JJ, Stone GW, Fitzgerald PJ, Serruys PW, Kimura T. Randomized Comparison Between Everolimus-Eluting Bioresorbable Scaffold and Metallic Stent: Multimodality Imaging Through 3 Years. JACC: Cardiovascular Interventions. 13, 116-127, 2020.
  24. Ueda N, Kamakura T, Noda T, Nakajima K, Kataoka N, Wada M, Yamagata K, Ishibashi K, Inoue Y, Miyamoto K, Nagase S, Aiba T, Izumi C, Noguchi T, Yasuda S, Kusano K. Efficacy and safety of new-generation atrial antitachycardia pacing for atrial tachyarrhythmias in patients implanted with cardiac resynchronization therapy devices. Journal of Cardiology. 75, 559-566, 2020.
  25. Yamamoto K, Mori S, Fukuzawa K, Miyamoto K, Toba T, Izawa Y, Tanaka H, Kono AK, Hirata KI. Revisiting the prevalence and diversity of localized thinning of the left ventricular apex. Journal of Cardiovascular Electrophysiology. 31, 915-920, 2020.
  26. Hosoda H, Asaumi Y, Noguchi T, Morita Y, Kataoka Y, Otsuka F, Nakao K, Fujino M, Nagai T, Nakai M, Nishimura K, Kono A, Komori Y, Hoshi T, Sato A, Kawasaki T, Izumi C, Kusano K, Fukuda T, Yasuda S. Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention. Journal of Cardiovascular Magnetic Resonance. 22, 5, 2020.
  27. Tada A, Omote K, Nagai T, Honda Y, Nakano H, Honda S, Iwakami N, Hamatani Y, Nakai M, Nishimura K, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Anzai T. Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure. Journal of Clinical Medicine. 9, 2219, 2020.
  28. Chinushi M, Furushima H, Saitoh O, Noda T, Nitta T, Aizawa Y, Ohe T, Kurita T. Patient-by-patient basis anti-tachycardia pacing for fast ventricular tachycardia with structural heart diseases. PACE-Pacing and Clinical Electrophysiology. 43, 983-991, 2020.
  29. Hosonuma M, Yajima N, Takahashi R, Yanai R, Matsuyama T, Toyosaki E, Saito J, Kusano K, Morita H. Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity. PLOS ONE. 15, e0227022, 2020.
  30. Fujihara Y, Lu Y, Noda T, Oji A, Larasati T, Kojima-Kita K, Yu Z, Matzuk RM, Matzuk MM, Ikawa M. Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice. Proceedings of the National Academy of Sciences of the United States of America. 117, 9393-9400, 2020.
  31. Noda T, Lu Y, Fujihara Y, Oura S, Koyano T, Kobayashi S, Matzuk MM, Ikawa M. Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proceedings of the National Academy of Sciences of the United States of America. 117, 11493-11502, 2020.
  32. Shintani Y, Takahama H, Hamatani Y, Nishimura K, Kanzaki H, Kusano K, Noguchi T, Toyoda K, Yasuda S, Izumi C. Ischemic stroke risk during post-discharge phases of heart failure: association of left ventricular concentric geometry. Heart and Vessels. 35, 564-575, 2020.
  33. Tian C, An N, Yuan M, Wang L, Zhang H, Li X, Yang X, Li Y, Kusano KF, Gao Y, Xing Y. A Pooled Analysis of the Prognostic Significance of Brugada Syndrome with Atrial Fibrillation. Current Pharmaceutical Design. 26, 129-137, 2020.
  34. Roberts JD, Asaki SY, Mazzanti A, Bos JM, Tuleta I, Muir AR, Crotti L, Krahn AD, Kutyifa V, Shoemaker MB, Johnsrude CL, Aiba T, Marcondes L, Baban A, Udupa S, Dechert B, Fischbach P, Knight LM, Vittinghoff E, Kukavica D, Stallmeyer B, Giudicessi JR, Spazzolini C, Shimamoto K, Tadros R, Cadrin-Tourigny J, Duff HJ, Simpson CS, Roston TM, Wijeyeratne YD, El Hajjaji I, Yousif MD, Gula LJ, Leong-Sit P, Chavali N, Landstrom AP, Marcus GM, Dittmann S, Wilde AAM, Behr ER, Tfelt-Hansen J, Scheinman MM, Perez MV, Kaski JP, Gow RM, Drago F, Aziz PF, Abrams DJ, Gollob MH, Skinner JR, Shimizu W, Kaufman ES, Roden DM, Zareba W, Schwartz PJ, Schulze-Bahr E, Etheridge SP, Priori SG, Ackerman MJ. An International Multicenter Evaluation of Type 5 Long QT Syndrome: A Low Penetrant Primary Arrhythmic Condition. Circulation. 141, 429-439, 2020.
  35. Miyamoto K, Hasegawa K, Takahashi H, Masue Y, Kataoka N, Fukuzawa K, Ashikaga K, Noda T, Satomi K, Tada H, Takagi M, Yasuda S, Kusano K. A multicenter study comparing the outcome of catheter ablation of atrial fibrillation between cryoballoon and radiofrequency ablation in patients with heart failure (CRABL-HF): Study design. Journal of Arrhythmia. 36, 449-455, 2020.
  36. Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, Dagres N, Di Toro D, Eckhardt LL, Ellenbogen K, Hardy C, Ikeda T, Jaswal A, Kaufman E, Krahn A, Kusano K, Kutyifa V, Lim HS, Lip GYH, Nava-Townsend S, Pak HN, Rodriguez Diez G, Sauer W, Saxena A, Svendsen JH, Vanegas D, Vaseghi M, Wilde A, Bunch TJ, ESC Scientific Document Group: Buxton AE, Calvimontes G, Chao TF, Eckardt L, Estner H, Gillis AM, Isa R, Kautzner J, Maury P, Moss JD, Nam GB, Olshansky B, Pava Molano LF, Pimentel M, Prabhu M, Tzou WS, Sommer P, Swampillai J, Vidal A, Deneke T, Hindricks G, Leclercq C. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Europace. 22, 1147-1148, 2020.
  37. Nielsen JC, Lin YJ, de Oliveira Figueiredo MJ, Sepehri Shamloo A, Alfie A, Boveda S, Dagres N, Di Toro D, Eckhardt LL, Ellenbogen K, Hardy C, Ikeda T, Jaswal A, Kaufman E, Krahn A, Kusano K, Kutyifa V, S Lim H, Lip GYH, Nava-Townsend S, Pak HN, Rodriguez Diez G, Sauer W, Saxena A, Svendsen JH, Vanegas D, Vaseghi M, Wilde A, Bunch TJ, Buxton AE, Calvimontes G, Chao TF, Eckardt L, Estner H, Gillis AM, Isa R, Kautzner J, Maury P, Moss JD, Nam GB, Olshansky B, Molano LFP, Pimentel M, Prabhu M, Tzou WS, Sommer P, Swampillai J, Vidal A, Deneke T, Hindricks G, Leclercq C. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population. Journal of Arrhythmia. 36, 553-607, 2020.
  38. Kashiwa A, Aiba T, Makimoto H, Shimamoto K, Yamagata K, Kamakura T, Wada M, Miyamoto K, Inoue-Yamada Y, Ishibashi K, Noda T, Nagase S, Miyazaki A, Sakaguchi H, Shiraishi I, Yagihara N, Watanabe H, Aizawa Y, Makiyama T, Itoh H, Hayashi K, Yamagishi M, Sumitomo N, Yoshinaga M, Morita H, Ohe T, Miyamoto Y, Makita N, Yasuda S, Kusano K, Ohno S, Horie M, Shimizu W. Systematic Evaluation of KCNQ1 Variant Using ACMG/AMP Guidelines and Risk Stratification in Long QT Syndrome Type 1. Circulation: Genomic and Precision Medicine. Epub, 2020.
  39. Shoda M, Kusano K, Goya M, Nishii N, Imai K, Okamoto Y, Takegami M, Nakao YM, Miyamoto Y, Nogami A; J-LEX registry investigators. Study Design of the Nationwide Japanese Lead Extraction (J-LEX) Registry: Protocol for a Prospective, Multicenter, Open Registry. Journal of Arrhythmia. 36, 849-853, 2020.
  40. Filippatos G, Lu X, Tsintzos SI, Gold MR, Mullens W, Birnie D, Hersi AS, Kusano K, Leclercq C, Fagan DH, Wilkoff BL. Economic implications of adding a novel algorithm to optimize cardiac resynchronization therapy: rationale and design of economic analysis for the AdaptResponse trial. Journal of Medical Economics. 23, 1401-1408, 2020.
  41. Wakamiya A, Kamakura T, Shinohara T, Yodogawa K, Murakoshi N, Morita H, Takahashi N, Inden Y, Shimizu W, Nogami A, Horie M, Nakajima K, Kataoka N, Wada M, Yamagata K, Ishibashi K, Inoue Y, Miyamoto K, Nagase S, Noda T, Aiba T, Yasuda S, Ieda M, Kusano K. Improved Risk Stratification of Patients With Brugada Syndrome by the New Japanese Circulation Society Guideline - A Multicenter Validation Study. Circulation Journal. 84, 2158-2165, 2020.
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