冠疾患科・血管科
研究活動の概要

当科はCCUおよび冠疾患科、血管科からなり、研究内容として虚血性心疾患、循環器救急医療、動脈硬化、大血管、末梢血管を対象とした臨床研究ならびに臨床応用を目指した基礎研究を実施しています。

具体的には、以下のテーマで研究を行っています。

  1. 心臓MRIを用いた不安定プラークの検出と治療効果判定に関する研究
  2. 心臓MRIを用いた低心機能患者の左室内血栓と脳梗塞、抗凝固治療との相関に関する研究
  3. 冠動脈内イメージングモダリティと心臓MRIを用いた冠動脈プラーク・イメージング
  4. 急性非代償性心不全（ADHF）に関する研究
  5. 急性心筋梗塞多施設共同研究レジストリーからの同症予後規定因子の検証
  6. 血液中PCSK9と冠動脈硬化症の関係解明研究
  7. 家族性高コレステロール血症を有する冠動脈疾患症例の特徴、長期予後調査
  8. 血糖変動介入による糖尿病性動脈硬化進展抑制効果の検証(OPTIMAL研究)
  9. 結合織疾患症例の遺伝子解析、長期予後に関する研究
  10. 下肢閉塞性動脈硬化症の治療指針構築を目指した研究(CURE-PAD)

2020年の主な研究成果
  • 急性心筋梗塞後のスタチン投与に対する反応不良性が心不全発症リスクと関連することを、Cardiovascular Diagnosis and Therapy誌に発表した。
  • 家族歴を有する拡張型心筋症の予後と臨床的特徴について、Circulation Journal誌に発表した。
  • 下肢閉塞性動脈硬化症におけるDuplex超音波上のacceleration timeを用いた新規評価法の有用性について、Circulation Journal誌に発表した。
  • 急性心不全患者において、入院時の尿中N-acetyl-beta-D-glucosamidase濃度が長期予後と関連することをEuropean Heart Journal Acute Cardiovascular Care誌に発表した。
  • 急性心不全におけるbase excessの予後予測能について、European Heart Journal Acute Cardiovascular Care誌に発表した。
  • 非造影T1強調MRI画像における冠動脈高輝度プラークの3次元評価が、待機的経皮的冠動脈インターベンションにおける周術期心筋傷害の予測に有用であることを、Journal of Cardiovascular Magnetic Resonance誌に発表した。
  • 心原性ショック患者における体外式膜型人工肺の離脱可能性の予測因子について、ESC Heart Failure誌に発表した。
  • 石灰化結節による急性冠症候群の臨床転帰について、Atherosclerosis誌に発表した。
  • 生体吸収性スキャフォールド留置後に生じた遅発性圧着不全の光干渉断層画像による経時的評価について、European Heart Journal誌に発表した。
  • 本邦の急性心筋梗塞後ろ向き多施設共同レジストリーから、本邦の高齢者心筋梗塞の臨床像および、来院時 Killip分類 2-4に相当する80歳以上の高齢者においてST上昇型心筋梗塞の予後が不良であることを報告した。
研究業績
  1. Tsuda K, Kataoka Y, Ogata S, Nishimura K, Nishikawa R, Doi T, Nakashima T, Hosoda H, Honda S, Kawakami S, Fujino M, Nakao K, Yoneda S, Nishihira K, Otsuka F, Tahara Y, Asaumi Y, Hoshiga M, Noguchi T, Yasuda S. Diminished response to statins predicts the occurrence of heart failure after acute myocardial infarction. Cardiovascular Diagnosis and Therapy. 10, 705-716, 2020.
  2. Matsuzawa Y, Konishi M, Nakai M, Saigusa Y, Taguri M, Gohbara M, Ebina T, Kosuge M, Hibi K, Nishimura K, Miyamoto Y, Yasuda S, Ogawa H, Saito Y, Nakayama N, Takeuchi I, Tamura K, Kimura K. In-Hospital Mortality in Acute Myocardial Infarction According to Population Density and Primary Angioplasty Procedures Volume. Circulation Journal. 84, 1140-1146, 2020.
  3. Marume K, Noguchi T, Tateishi E, Morita Y, Miura H, Nishimura K, Ohta-Ogo K, Yamada N, Tsujita K, Izumi C, Kusano K, Ogawa H, Yasuda S. Prognosis and Clinical Characteristics of Dilated Cardiomyopathy With Family History via Pedigree Analysis. Circulation Journal. 84, 1284-1293, 2020.
  4. Yagyu T, Funabashi S, Yoneda S, Noguchi T, Yasuda S. Novel Evaluation Method for Lower Extremity Peripheral Artery Disease With Duplex Ultrasound - Usefulness of Acceleration Time -. Circulation Journal. 84, 1990-1998, 2020.
  5. Funabashi S, Omote K, Nagai T, Honda Y, Nakano H, Honda S, Iwakami N, Hamatani Y, Nakai M, Nishimura K, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Anzai T. Elevated admission urinary N-acetyl-β-D-glucosamidase level is associated with worse long-term clinical outcomes in patients with acute heart failure. European Heart Journal: Acute Cardiovascular Care. 9, 429-436, 2020.
  6. Nakano H, Nagai T, Honda Y, Honda S, Iwakami N, Matsumoto C, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Ogawa H, Yasuda S, Chikamori T, Anzai T. Prognostic value of base excess as indicator of acid-base balance in acute heart failure. European Heart Journal: Acute Cardiovascular Care. 9, 399-405, 2020.
  7. Ishii M, Seki T, Kaikita K, Sakamoto K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Tsutsui H, Komuro I, Saito Y, Ogawa H, Tsujita K, Kawakami K; JROAD Investigators. Short-term exposure to desert dust and the risk of acute myocardial infarction in Japan: a time-stratified case-crossover study. European Journal of Epidemiology. 35, 455-464, 2020.
  8. Suzuki M, Nishihira K, Takegami M, Honda S, Kojima S, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S; JAMIR Investigators. Clinical profiles and outcomes in the treatment of acute myocardial infarction in Japan of aging society. Heart and Vessels. 35, 1681-1688, 2020.
  9. Suwa S, Ogita M, Ebina H, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Admission During Off-Hours Does Not Affect Long-Term Clinical Outcomes of Japanese Patients with Acute Myocardial Infarction: J-MINUET Substudy. International Heart Journal. 61, 215-222, 2020.
  10. Takahashi N, Ogita M, Suwa S, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Prognostic Impact of B-Type Natriuretic Peptide on Long-Term Clinical Outcomes in Patients with Non-ST-Segment Elevation Acute Myocardial Infarction Without Creatine Kinase Elevation A Japanese registry of acute Myocardial INfarction diagnosed by Universal dEfiniTion (J-MINUET) Substudy. International Heart Journal. 61, 888-895, 2020.
  11. Ishii M, Kaikita K, Sakamoto K, Seki T, Kawakami K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Tsutsui H, Komuro I, Saito Y, Ogawa H, Tsujita K; JROAD Investigators. Characteristics and in-hospital mortality of patients with myocardial infarction in the absence of obstructive coronary artery disease in super-aging society. International Journal of Cardiology. 301, 108-113, 2020.
  12. Brieger D, Pocock SJ, Blankenberg S, Chen JY, Cohen MG, Granger CB, Grieve R, Nicolau JC, Simon T, Westermann D, Yasuda S, Gregson J, Rennie KL, Hedman K, Sundell KA, Goodman SG. Two-year outcomes among stable high-risk patients following acute MI. Insights from a global registry in 25 countries. International Journal of Cardiology. 311, 7-14, 2020.
  13. Onuma Y, Honda Y, Asano T, Shiomi H, Kozuma K, Ozaki Y, Namiki A, Yasuda S, Ueno T, Ando K, Furuya J, Hanaoka KI, Tanabe K, Okada K, Kitahara H, Ono M, Kusano H, Rapoza R, Simonton C, Popma JJ, Stone GW, Fitzgerald PJ, Serruys PW, Kimura T. Randomized Comparison Between Everolimus-Eluting Bioresorbable Scaffold and Metallic Stent: Multimodality Imaging Through 3 Years. JACC: Cardiovascular Interventions. 13, 116-127, 2020.
  14. Akahori H, Masuyama T, Imanaka T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Impact of peripheral artery disease on prognosis after myocardial infarction: The J-MINUET study. Journal of Cardiology. 76, 402-406, 2020.
  15. Hosoda H, Asaumi Y, Noguchi T, Morita Y, Kataoka Y, Otsuka F, Nakao K, Fujino M, Nagai T, Nakai M, Nishimura K, Kono A, Komori Y, Hoshi T, Sato A, Kawasaki T, Izumi C, Kusano K, Fukuda T, Yasuda S. Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention. Journal of Cardiovascular Magnetic Resonance. 22, 5, 2020.
  16. Toyoda S, Sakuma M, Abe S, Inoue T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Okamura A, Mano T, Wake M, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Toubaru T, Saku K, Ohshima S, Miyamoto Y, Ogawa H, Ishihara M. Prediction of Long-Term Outcomes in ST-Elevation Myocardial Infarction and Non-ST Elevation Myocardial Infarction with and without Creatinine Kinase Elevation-Post-Hoc Analysis of the J-MINUET Study. Journal of Clinical Medicine. 9, 2667, 2020.
  17. Sato R, Sakamoto K, Kaikita K, Tsujita K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Long-Term Prognosis of Patients with Myocardial Infarction Type 1 and Type 2 with and without Involvement of Coronary Vasospasm. Journal of Clinical Medicine. 9, 1686, 2020.
  18. Tada A, Omote K, Nagai T, Honda Y, Nakano H, Honda S, Iwakami N, Hamatani Y, Nakai M, Nishimura K, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Anzai T. Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure. Journal of Clinical Medicine. 9, 2219, 2020.
  19. Mori M, Sakata K, Yokawa J, Nakanishi C, Murai K, Okada H, Shimojima M, Yoshida S, Yoshioka K, Takuwa Y, Hayashi K, Yamagishi M, Kawashiri MA. Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model. Journal of Interventional Cardiology. 2020, 1956015, 2020.
  20. Fujino M, Otsuka F, Noguchi T, Yasuda S. Fate of late-acquired bioresorbable scaffold malapposition: insights from serial optical coherence tomography. European Heart Journal. 41, 4446, 2020.
  21. Shishikura D, Kataoka Y, Di Giovanni G, Takata K, Scherer DJ, Andrews J, Psaltis PJ, Puri R, Wolski K, Nissen SE, Nicholls SJ. Progression of ultrasound plaque attenuation and low echogenicity associates with major adverse cardiovascular events. European Heart Journal. 41, 2965-2973, 2020.
  22. Nakano H, Kataoka Y, Otsuka F, Nakashima T, Asaumi Y, Noguchi T, Yasuda S. Refractory In-Stent Restenosis Attributable to Eruptive Calcified Nodule. JACC: Case Reports. 2, 1872-1878, 2020.
  23. Kitahara S, Kataoka Y, Sugane H, Otsuka F, Asaumi Y, Noguchi T, Yasuda S. In vivo imaging of vulnerable plaque with intravascular modalities: its advantages and limitations. Cardiovascular Diagnosis and Therapy. 10, 1461-1479, 2020.
  24. Yokoi K, Otsuka F, Mizote I, Shiraki T, Tsukamoto Y, Nakamura D, Ohtani T, Hikoso S, Ikeda Y, Hatakeyama K, Sakata Y. In Vivo Intracoronary Imaging Assessment of Cardiac Allograft Vasculopathy With Histopathologic Confirmation. JACC: Cardiovascular Interventions. 13, 2305-2307, 2020.
  25. Jinnouchi H, Otsuka F, Sato Y, Bhoite RR, Sakamoto A, Torii S, Yahagi K, Cornelissen A, Mori M, Kawakami R, Kolodgie FD, Virmani R, Finn AV. Healthy Strut Coverage After Coronary Stent Implantation: An Ex Vivo Human Autopsy Study. Circulation: Cardiovascular Interventions. 13, e008869, 2020.
  26. Nakamura M, Kimura K, Kimura T, Ishihara M, Otsuka F, Kozuma K, Kosuge M, Shinke T, Nakagawa Y, Natsuaki M, Yasuda S, Akasaka T, Kohsaka S, Haze K, Hirayama A. JCS 2020 Guideline Focused Update on Antithrombotic Therapy in Patients With Coronary Artery Disease. Circulation Journal. 84, 831-865, 2020.
  27. Shintani Y, Takahama H, Hamatani Y, Nishimura K, Kanzaki H, Kusano K, Noguchi T, Toyoda K, Yasuda S, Izumi C. Ischemic stroke risk during post-discharge phases of heart failure: association of left ventricular concentric geometry. Heart and Vessels. 35, 564-575, 2020.
  28. Otsuki S, Aiba T, Tahara Y, Nakajima K, Kataoka N, Kamakura T, Wada M, Ishibashi K, Yamagata K, Inoue Y, Miyamoto K, Nagase S, Noda T, Izumi C, Noguchi T, Nishimura K, Yonemoto N, Nonogi H, Nagao K, Ikeda T, Sato N, Tsutsui H, Yasuda S, Kusano K; Japanese Circulation Society With Resuscitation Science Study (JCS-ReSS) Group. Intra-day change in occurrence of out-of-hospital ventricular fibrillation in Japan: The JCS-ReSS study. International Journal of Cardiology. 318, 54-60, 2020.
  29. Wada H, Ogita M, Suwa S, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M; J-MINUET investigators. Guideline adherence and long-term clinical outcomes in patients with acute myocardial infarction: a Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) substudy. European Heart Journal: Acute Cardiovascular Care. 9, 939-947, 2020.
  30. Ueda N, Kamakura T, Noda T, Nakajima K, Kataoka N, Wada M, Yamagata K, Ishibashi K, Inoue Y, Miyamoto K, Nagase S, Aiba T, Izumi C, Noguchi T, Yasuda S, Kusano K. Efficacy and safety of new-generation atrial antitachycardia pacing for atrial tachyarrhythmias in patients implanted with cardiac resynchronization therapy devices. Journal of Cardiology. 75, 559-566, 2020.
  31. Yagyu T, Ito S, Kawarada O, Mizuseki M, Yamamoto H, Asakura M, Funabashi S, Onda K, Ohshima K, Fukuda-Doi M, Asakura K, Kitakaze M, Noguchi T, Yasuda S. Rationale and Design of a Prospective, Multicenter, Single-Arm Clinical Trial to Investigate the Safety and Effectiveness of Rotablator Atherectomy System as an Adjunctive Device for Endovascular Treatment of Occlusive Atherosclerotic Lesions in Below-the-Knee Arteries With Critical Limb Ischemia (RESCUE-BTK). Circulation Reports. 2, 449-454, 2020.
  32. Matsuoka Y, Goto R, Atsumi T, Morimura N, Nagao K, Tahara Y, Asai Y, Yokota H, Ariyoshi K, Yamamoto Y, Sakamoto T; SAVE-J Study Group. Cost-effectiveness of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A multi-centre prospective cohort study. Resuscitation. 157, 32-38, 2020.
  33. Lin A, Nerlekar N, Munnur RK, Kataoka Y, Andrews J, Dey D, Nicholls SJ, Wong DT. Cholesterol crystal-induced coronary inflammation: Insights from optical coherence tomography and pericoronary adipose tissue computed tomography attenuation. Journal of Cardiovascular Computed Tomography. 14, 277-278, 2020.
  34. 片岡 有, 岩井 雄大, 北原 慧, 邑井 洸太, 野口 暉夫, 安田 聡. 脂質性プラークに対する新しい生体内イメージング 近赤外線スペクトロスコピー(NIRS)の可能性. 循環器病研究の進歩. 41, 18-26, 2020.
  35. 庵地 雄太, 中西 道郎, 三浦 弘之, 森内 健史, 髙濱 博幸, 泉 知里, 安田 聡. 公認心理師にとっての心臓リハビリという臨床 回復期心臓リハビリにおける心理的アプローチの実際. 心臓リハビリテーション. 26, 35-40, 2020.
  36. 三浦 弘之. 心拍数に基づく運動処方の心不全患者における有用性. 心臓リハビリテーション. 26, 68-71, 2020.
  37. 三浦 弘之, 野口 暉夫. PCIのためのMRA. 非侵襲的虚血評価スタンダードマニュアル. 151-159, 2020.
  38. 藤野 雅史. 心内(左室内・左房内)血栓に対する抗血栓療法の注意点は? 循環器ジャーナル. 68, 720-727, 2020.
  39. 田原 良雄. 2018年大阪府北部地震時のライフラインパニックと病院避難の経験. 救急医学. 44, 1050-1056, 2020.
  40. 田原 良雄. 病態を踏まえた治療をどうするか 疾患別薬物療法 ショック. 救急・集中治療. 32, 1171-1178, 2020.
  41. 田原 良雄, 野口暉夫. 国立循環器病研究センターを中心とした健都Heart safe cityプロジェクト 市民によるAED(自動体外式除細動器)を用いた心肺蘇生率の向上を目指して. 循環器病研究の進歩. 41, 4-10, 2020.
  42. 真玉 英生, 浅海 泰栄. 経皮的補助循環. 重症心不全治療プラクティス. 65-68, 2020.