循環器病統合情報センター
研究活動の概要

　循環器病の情報を統括的に収集し、研究、医療施策に活用する体制を整備することはナショナルセンターとしての責務である。循環器病統合情報センターは、日本循環器学会とJROAD、JROAD-DPCを行うとともに、脳卒中に関しても脳卒中協会が行っていた脳卒中データバンク事業を行っている。
また、日本不整脈学会や日本動脈硬化学会などとの共同研究事業も行っている。

研究業績
  1. Ohuchi H, Negishi J, Hayama Y, Miike H, Suzuki D, Nakajima K, Konagai N, Iwasa T, Sakaguchi H, Kurosaki K, Nakai M. Abnormal glucose metabolism in patients with Fontan circulation: Unique characteristics and associations with Fontan pathophysiology. American Heart Journal. 216, 125-135, 2019.
  2. Miyoshi T, Hosoda H, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N. Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias. American Journal of Obstetrics and Gynecology. 220, 104.e1-104.e15, 2019.
  3. Hori M, Ohta N, Takahashi A, Masuda H, Isoda R, Yamamoto S, Son C, Ogura M, Hosoda K, Miyamoto Y, Harada-Shiba M. Impact of LDLR and PCSK9 pathogenic variants in Japanese heterozygous familial hypercholesterolemia patients. Atherosclerosis. 289, 101-108, 2019.
  4. Kubo S, Nishida Y, Kubota Y, Higashiyama A, Sugiyama D, Hirata T, Miyamatsu N, Tanabe A, Hirata A, Tatsumi Y, Kadota A, Kuwabara K, Nishikawa T, Miyamoto Y, Okamura T. Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. BMC Nephrology. 20, 117, 2019.
  5. Kataoka Y, Hosoda K, Makino H, Matsubara M, Matsuo M, Ohata Y, Koezuka R, Tamanaha T, Tomita T, Honda-Kohmo K, Noguchi M, Son C, Nishimura K, Asaumi Y, Miyamoto Y, Noguchi T, Yasuda S. The efficacy of glycemic control with continuous glucose monitoring on atheroma progression: rationale and design of the Observation of Coronary Atheroma Progression under Continuous Glucose Monitoring Guidance in Patients with Type 2 Diabetes Mellitus (OPTIMAL). Cardiovascular Diagnosis and Therapy. 9, 431-438, 2019.
  6. Honda S, Nishihira K, Kojima S, Takegami M, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S; JAMIR investigators. Rationale, Design, and Baseline Characteristics of the Prospective Japan Acute Myocardial Infarction Registry (JAMIR). Cardiovascular Drugs and Therapy. 33, 97-103, 2019.
  7. Okami Y, Ueshima H, Nakamura Y, Kondo K, Kadota A, Okuda N, Okamura T, Miura K; NIPPON DATA80/90 and NIPPON DATA2010 Research Groups. Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan - NIPPON DATA80/90/2010 -. Circulation Journal. 83, 147-155, 2019.
  8. Nakano H, Omote K, Nagai T, Nakai M, Nishimura K, Honda Y, Honda S, Iwakami N, Sugano Y, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Chikamori T, Anzai T; NaDEF Investigators. Comparison of Mortality Prediction Models on Long-Term Mortality in Hospitalized Patients With Acute Heart Failure - The Importance of Accounting for Nutritional Status -. Circulation Journal. 83, 614-621, 2019.
  9. Kanaoka K, Okayama S, Nakai M, Sumita Y, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Hospitalization Costs for Patients With Acute Congestive Heart Failure in Japan. Circulation Journal. 83, 1025-1031, 2019.
  10. Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Admission Heart Rate Is a Determinant of Effectiveness of Beta-Blockers in Acute Myocardial Infarction Patients. Circulation Journal. 83, 1054-1063, 2019.
  11. Uemura S, Okamoto H, Nakai M, Nishimura K, Miyamoto Y, Yasuda S, Tanaka N, Kohsaka S, Kadota K, Saito Y, Tsutsui H, Komuro I, Ikari Y, Ogawa H, Nakamura M. Primary Percutaneous Coronary Intervention in Elderly Patients With Acute Myocardial Infarction - An Analysis From a Japanese Nationwide Claim-Based Database -. Circulation Journal. 83, 1229-1238, 2019.
  12. Kondo K, Miura K, Tanaka-Mizuno S, Kadota A, Arima H, Okuda N, Fujiyoshi A, Miyagawa N, Yoshita K, Okamura T, Okayama A, Ueshima H, Ueshima H, Okayama A, Ueshima H, Okamura T, Saitoh S, Sakata K, Hozawa A, Hayakawa T, Nakamura Y, Nishi N, Okuda N, Ohkubo T, Kasagi F, Murakami Y, Izumi T, Matsumura Y, Ojima T, Tamakoshi K, Nakagawa H, Kita Y, Miura K, Kadota A, Fujiyoshi A, Miyamatsu N, Nakamura Y, Yoshita K, Miyamoto Y, Kodama K, Kiyohara Y. Cardiovascular Risk Assessment Chart by Dietary Factors in Japan - NIPPON DATA80 -. Circulation Journal. 83, 1254-1260, 2019.
  13. Makino H, Tanaka A, Asakura K, Koezuka R, Tochiya M, Ohata Y, Tamanaha T, Son C, Shimabara Y, Fujita T, Miyamoto Y, Kobayashi J, Hosoda K. Addition of low-dose liraglutide to insulin therapy is useful for glycaemic control during the peri-operative period: effect of glucagon-like peptide-1 receptor agonist therapy on glycaemic control in patients undergoing cardiac surgery (GLOLIA study). Diabetic Medicine. 36, 1621-1628, 2019.
  14. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Tazaki J, Kyuragi R, Kinoshita O, Miyamoto T, Sakata Y, Nozato T, Ogino H. Editor's Choice - Endovascular Repair Versus Surgical Repair for Japanese Patients With Ruptured Thoracic and Abdominal Aortic Aneurysms: A Nationwide Study. European Journal of Vascular and Endovascular Surgery. 57, 779-786, 2019.
  15. Okura H, Saito Y, Soeda T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET investigators. Frequency and prognostic impact of intravascular imaging-guided urgent percutaneous coronary intervention in patients with acute myocardial infarction: results from J-MINUET. Heart and Vessels. 34, 564-571, 2019.
  16. Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy. Heart and Vessels. 34, 1899-1908, 2019.
  17. Satoh M, Ohkubo T, Asayama K, Murakami Y, Sugiyama D, Yamada M, Saitoh S, Sakata K, Irie F, Sairenchi T, Ishikawa S, Kiyama M, Ohnishi H, Miura K, Imai Y, Ueshima H, Okamura T; EPOCH-JAPAN Research Group. Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan). Hypertension. 73, 52-59, 2019.
  18. Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T. Risk of developing type 2 diabetes according to blood pressure levels and presence or absence of hypertensive treatment: the Saku study. Hypertension Research. 42, 105-113, 2019.
  19. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Miyamoto T, Sakata Y, Nozato T, Ogino H. The impact of institutional case volume on the prognosis of ruptured aortic aneurysms: a Japanese nationwide study. Interactive Cardiovascular and Thoracic Surgery. 29, 109-116, 2019.
  20. Matoba T, Kohro T, Fujita H, Nakayama M, Kiyosue A, Miyamoto Y, Nishimura K, Hashimoto H, Antoku Y, Nakashima N, Ohe K, Ogawa H, Tsutsui H, Nagai R. Architecture of the Japan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT) System. International Heart Journal. 60, 264-270, 2019.
  21. Nakamura K, Kanzaki H, Okada A, Amaki M, Takahama H, Hasegawa T, Sugano Y, Yasuda S, Anzai T. Independent Prognostic Value of Pulmonary Diffusing Capacity in Nonsmoking Patients with Chronic Heart Failure. International Heart Journal. 60, 366-373, 2019.
  22. Ohuchi H, Negishi J, Miike H, Toyoshima Y, Morimoto H, Fukuyama M, Iwasa T, Sakaguchi H, Miyazaki A, Shiraishi I, Kurosaki K, Nakai M. Positive pediatric exercise capacity trajectory predicts better adult Fontan physiology rationale for early establishment of exercise habits. International Journal of Cardiology. 274, 80-87, 2019.
  23. Ohuchi H, Inai K, Nakamura M, Park IS, Watanabe M, Hiroshi O, Kim KS, Sakazaki H, Waki K, Yamagishi H, Yamamura K, Kuraishi K, Miura M, Nakai M, Nishimura K, Niwa K. Mode of death and predictors of mortality in adult Fontan survivors: A Japanese multicenter observational study. International Journal of Cardiology. 276, 74-80, 2019.
  24. Nagai T, Iwakami N, Nakai M, Nishimura K, Sumita Y, Mizuno A, Tsutsui H, Ogawa H, Anzai T. Effect of intravenous carperitide versus nitrates as first-line vasodilators on in-hospital outcomes in hospitalized patients with acute heart failure: Insight from a nationwide claim-based database. International Journal of Cardiology. 280, 104-109, 2019.
  25. Ogata S, Nishimura K, Guzman-Castillo M, Sumita Y, Nakai M, Nakao YM, Nishi N, Noguchi T, Sekikawa A, Saito Y, Watanabe T, Kobayashi Y, Okamura T, Ogawa H, Yasuda S, Miyamoto Y, Capewell S, O'Flaherty M. Explaining the decline in coronary heart disease mortality rates in Japan: Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. International Journal of Cardiology. 291, 183-188, 2019.
  26. Miyoshi T, Oku H, Asahara S, Okamoto A, Kokame K, Nakai M, Nishimura K, Otsuka F, Higashiyama A, Yoshimatsu J, Miyata T. Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study. International Journal of Hematology. 109, 641-649, 2019.
  27. Shimizu W, Makimoto H, Yamagata K, Kamakura T, Wada M, Miyamoto K, Inoue-Yamada Y, Okamura H, Ishibashi K, Noda T, Nagase S, Miyazaki A, Sakaguchi H, Shiraishi I, Makiyama T, Ohno S, Itoh H, Watanabe H, Hayashi K, Yamagishi M, Morita H, Yoshinaga M, Aizawa Y, Kusano K, Miyamoto Y, Kamakura S, Yasuda S, Ogawa H, Tanaka T, Sumitomo N, Hagiwara N, Fukuda K, Ogawa S, Aizawa Y, Makita N, Ohe T, Horie M, Aiba T. Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients. JAMA Cardiology. 4, 246-254, 2019.
  28. Shibata Y, Ojima T, Nakamura M, Kuwabara K, Miyagawa N, Saito Y, Nakamura Y, Kiyohara Y, Nakagawa H, Fujiyoshi A, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010. Journal of Epidemiology. 29, 133-138, 2019.
  29. Miyoshi T, Katsuragi S, Neki R, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Yoshimatsu J, Ikeda T. Cardiovascular profile and biophysical profile scores predict short-term prognosis in infants with congenital heart defect. Journal of Obstetrics and Gynaecology Research. 45, 1268-1276, 2019.
  30. Nakao K, Yasuda S, Nishimura K, Noguchi T, Nakai M, Miyamoto Y, Sumita Y, Shishido T, Anzai T, Ito H, Tsutsui H, Saito Y, Komuro I, Ogawa H. Prescription Rates of Guideline-Directed Medications Are Associated With In-Hospital Mortality Among Japanese Patients With Acute Myocardial Infarction: A Report From JROAD-DPC Study. Journal of the American Heart Association. 8, e009692, 2019.
  31. Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, Takegami M, Nishimura K, Nakai M, Kiyoshige E, Hosoda K, Okamura T, Miyamoto Y. Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population: The Suita Study. Journal of the American Heart Association. 8, e010628, 2019.
  32. Kanaoka K, Okayama S, Nakai M, Sumita Y, Onoue K, Soeda T, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan. Journal of the American Heart Association. 8, e012282, 2019.
  33. Yokota C, Yamamoto Y, Kamada M, Nakai M, Nishimura K, Ando D, Sato T, Kog M, Ihara M, Toyoda K, Fujimoto Y, Odani H, Minematsu K, Nakajima T. Acute stroke rehabilitation for gait training with cyborg type robot Hybrid Assistive Limb: A pilot study. Journal of the Neurological Sciences. 404, 11-15, 2019.
  34. Sakai N, Uchida K, Iihara K, Satow T, Ezura M, Hyodo A, Miyachi S, Miyamoto S, Nagai Y, Nishimura K, Toyoda K, Yoshimura S, Imamura H, Sakai C, Matsumaru Y; Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators. Japanese Surveillance of Neuroendovascular Therapy in JR-NET - Part II. Japanese Registry of NeuroEndovascular Treatment 3. Main Report. Neurologia Medico-Chirurgica. 59, 106-115, 2019.
  35. Inoguchi T, Fukuhara S, Yamato M, Nakai M, Etoh T, Masakado M, Suehiro S, Umeda F, Yamauchi T. Serum bilirubin level is a strong predictor for disability in activities in daily living (ADL) in Japanese elderly patients with diabetes. Scientific Reports. 9, 7069, 2019.
  36. Nishikawa T, Miyamatsu N, Higashiyama A, Kubota Y, Nishida Y, Hirata T, Sugiyama D, Kuwabara K, Kubo S, Miyamoto Y, Okamura T. Being Conscious of Water Intake Positively Associated with Sufficient Non-Alcohol Drink Intake Regardless of Seasons and Reasons in Healthy Japanese; the KOBE Study: A Cross Sectional Study. International Journal of Environmental Research and Public Health. 16, 4151, 2019.
  37. Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T. Fasting Blood Glucose Predicts Incidence of Hypertension Independent of HbA1c Levels and Insulin Resistance in Middle-Aged Japanese: The Saku Study. American Journal of Hypertension. 32, 1178-1185, 2019.
  38. Yamane T, Inoue K, Kusano K, Takegami M, Nakao YM, Miyamoto Y, Goya M, Uno K, Shoda M, Murakawa Y, Hirao K, Nogami A; J-AB registry investigators. Study design of nationwide Japanese Catheter Ablation Registry: Protocol for a prospective, multicenter, open registry. Journal of Arrhythmia. 35, 167-170, 2019.
  39. Sekikawa A, Ihara M, Lopez O, Kakuta C, Lopresti B, Higashiyama A, Aizenstein H, Chang YF, Mathis C, Miyamoto Y, Kuller L, Cui C. Effect of S-equol and Soy Isoflavones on Heart and Brain. Current Cardiology Reviews. 15, 114-135, 2019.
  40. Yasuda S, Honda S, Takegami M, Nishihira K, Kojima S, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K; JAMIR Investigators. Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction - Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR) -. Circulation Journal. 83, 1633-1643, 2019.
  41. Kawarada O, Nakai M, Nishimura K, Miwa H, Iwasaki Y, Kanno D, Nakama T, Yamamoto Y, Ogata N, Nakamura M, Yasuda S. Antithrombotic therapy after femoropopliteal artery stenting: 12-month results from Japan Postmarketing Surveillance. Heart Asia. 11, e011114, 2019.
  42. Takada Y, Hamatani Y, Kawano Y, Anchi Y, Nakai M, Izumi C, Yasuda S, Ogawa H, Sugano Y, Anzai T, Shibata T, Suzuki A, Nishikawa M, Ito H, Kato M, Shiga T, Fukumoto Y. Development and validation of support tools for advance care planning in patients with chronic heart failure. International Journal of Palliative Nursing. 25, 494-502, 2019.
  43. Yoneyama K, Kanaoka K, Okayama S, Nishimura K, Nakai M, Matsushita K, Miyamoto Y, Kida K, Ishibashi Y, Izumo M, Watanabe M, Soeda T, Okura H, Harada T, Yasuda S, Murohara T, Ogawa H, Saito Y, Akashi YJ. Association between the number of board-certified cardiologists and the risk of in-hospital mortality: a nationwide study involving the Japanese registry of all cardiac and vascular diseases. BMJ Open. 9, e024657, 2019.
  44. 中尾 葉子, 宮本 恵宏. 循環器病研究のためのビッグデータ. Precision Medicine. 2, 748-753, 2019.