予防医学・疫学情報部
研究活動の概要

　予防医学・疫学情報部は、循環器に関する疫学研究や人工知能応用を中心とした情報科学研究を行うため、研究テーマとして以下のような研究テーマに取り組んでいる。

  • IBMワトソンなど電子カルテに対する自然言語処理などを利用したデータマインニング
    （内閣府AIホスピタル事業に参画）
  • 機械学習、深層学習などの手法による循環器病の予後予測、動脈瘤、不安定プラークなどの画像診断に関するAI応用（フィリプスNCVCプロジェクトなど）
  • J-ASPECT研究、JROAD研究、ウツタイン研究など全国規模の循環器データベースを用いた研究
  • 関西エリア1千万人のデータによる熱中症発症の予測モデル（環境研究総合推進費）
  • AIによる機器分離技術を用いた認知症患者の見守り技術開発（東京電力）

　院内各科（心臓内科、心臓外科、脳内科、麻酔科、周産期科など）および研究所の主として観察研究の統計解析を行い、2019-2020年にはLancet, Annals of surgery, Circulationなどで70本の英語論文が出版されており、15本の英語論文が受理されている。また現在、Circulationなどでreviseおよび投稿準備中のもの30本程度、作業進行中である。

　また電子カルテData Ware Houseからの自動症例抽出システムを継続して開発しており、さらに心臓カテーテル検査レポート、超音波検査レポート、分娩台帳といった電子カルテとは直接関係ない部門システムからの情報もData Ware Houseからデータが抽出できる仕組みを開発した。特にIBM社ワトソンなどの人工知能を応用する先進的取り組みを行い、米国心臓病学会（AHA/ACC）の包括的循環器疾患レジストリーPINNACLに準拠した項目約400項目中95％の項目を自動抽出することができるようになった。
さらに心エコー、心臓カテール所見に関しては別途抽出ロジックを構築し、フリーテキストとして入力された50項目程度が抽出可能となり、予後についても電子カルテに関して記録のあるものについては抽出可能となった。同研究については阪大が主管施設となっている内閣府のAIホスピタル事業に参加している。

　OIC入居予定のフィリップス社のグロバールR&Dセンターとの提携などにより、

  1. 不安定プラークのMRI画像による自動抽出プログラム
  2. 未破裂動脈瘤の位置および大きさ、blebの有無など破裂リスクを含む自動診断システム
  3. 心不全科と共同で心エコーの10年間におよぶ長期フォロー画像の集積およびリスク予測モデル

　を構築中である。

2019年の主な研究成果

主要な取り組みの成果として

  1. Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study.
    Nakashima T, Noguchi T, Tahara Y, Nishimura K, Yasuda S, Onozuka D, Iwami T, Yonemoto N, Nagao K, Nonogi H, Ikeda T, Sato N, Tsutsui H; Japanese Circulation Society with Resuscitation Science Study Group.
    Lancet. 2020 Dec 21;394(10216):2255-2262

AEDのバイスタンダーによる取り組みを評価したもの

  1. Explaining the decline in coronary heart disease mortality rates in Japan: Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012.
    Ogata S, Nishimura K, Guzman-Castillo M, Sumita Y, Nakai M, Nakao YM, Nishi N, Noguchi T, Sekikawa A, Saito Y, Watanabe T, Kobayashi Y, Okamura T, Ogawa H, Yasuda S, Miyamoto Y, Capewell S, O'Flaherty M.
    Int J Cardiol. 2019 Sep 15;291:183-188

リバプール大学とのIMPACTモデルを用いた日本人の循環器死亡に関するリスク寄与度の評価について出版した。

またAIモデル関連は、本年の日本循環器学会、日本脳卒中学会などで報告し、心不全の予後予測に関しては論文を投稿中である。

研究業績
  1. Hishikawa T, Sugiu K, Murai S, Takahashi Y, Kidani N, Nishihiro S, Hiramatsu M, Date I, Satow T, Iihara K, Sakai N; JR-NET2 and JR-NET3 study groups. A comparison of the prevalence and risk factors of complications in intracranial tumor embolization between the Japanese Registry of NeuroEndovascular Therapy 2 (JR-NET2) and JR-NET3. Acta Neurochirurgica. 161, 1675-1682, 2019.
  2. Izumi C, Kitai T, Kume T, Onishi T, Yuda S, Hirata K, Yamashita E, Kawata T, Nishimura K, Takeuchi M, Nakatani S. Effect of Left Ventricular Reverse Remodeling on Long-term Outcomes After Aortic Valve Replacement. American Journal of Cardiology. 124, 105-112, 2019.
  3. Miyoshi T, Hosoda H, Nakai M, Nishimura K, Miyazato M, Kangawa K, Ikeda T, Yoshimatsu J, Minamino N. Maternal biomarkers for fetal heart failure in fetuses with congenital heart defects or arrhythmias. American Journal of Obstetrics and Gynecology. 220, 104.e1-104.e15, 2019.
  4. Kataoka Y, Hosoda K, Makino H, Matsubara M, Matsuo M, Ohata Y, Koezuka R, Tamanaha T, Tomita T, Honda-Kohmo K, Noguchi M, Son C, Nishimura K, Asaumi Y, Miyamoto Y, Noguchi T, Yasuda S. The efficacy of glycemic control with continuous glucose monitoring on atheroma progression: rationale and design of the Observation of Coronary Atheroma Progression under Continuous Glucose Monitoring Guidance in Patients with Type 2 Diabetes Mellitus (OPTIMAL). Cardiovascular Diagnosis and Therapy. 9, 431-438, 2019.
  5. Nakano H, Omote K, Nagai T, Nakai M, Nishimura K, Honda Y, Honda S, Iwakami N, Sugano Y, Asaumi Y, Aiba T, Noguchi T, Kusano K, Yokoyama H, Yasuda S, Ogawa H, Chikamori T, Anzai T; NaDEF Investigators. Comparison of Mortality Prediction Models on Long-Term Mortality in Hospitalized Patients With Acute Heart Failure - The Importance of Accounting for Nutritional Status -. Circulation Journal. 83, 614-621, 2019.
  6. Nakashima T, Noguchi T, Tahara Y, Nishimura K, Ogata S, Yasuda S, Onozuka D, Morimura N, Nagao K, Gaieski DF, Asai Y, Yokota H, Nara S, Hase M, Atsumi T, Sakamoto T; SAVE-J Group. Patients With Refractory Out-of-Cardiac Arrest and Sustained Ventricular Fibrillation as Candidates for Extracorporeal Cardiopulmonary Resuscitation - Prospective Multi-Center Observational Study. Circulation Journal. 83, 1011-1018, 2019.
  7. Kanaoka K, Okayama S, Nakai M, Sumita Y, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Hospitalization Costs for Patients With Acute Congestive Heart Failure in Japan. Circulation Journal. 83, 1025-1031, 2019.
  8. Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Admission Heart Rate Is a Determinant of Effectiveness of Beta-Blockers in Acute Myocardial Infarction Patients. Circulation Journal. 83, 1054-1063, 2019.
  9. Uemura S, Okamoto H, Nakai M, Nishimura K, Miyamoto Y, Yasuda S, Tanaka N, Kohsaka S, Kadota K, Saito Y, Tsutsui H, Komuro I, Ikari Y, Ogawa H, Nakamura M. Primary Percutaneous Coronary Intervention in Elderly Patients With Acute Myocardial Infarction - An Analysis From a Japanese Nationwide Claim-Based Database -. Circulation Journal. 83, 1229-1238, 2019.
  10. Nishimura A, Nishimura K, Onozuka D, Matsuo R, Kada A, Kamitani S, Higashi T, Ogasawara K, Shimodozono M, Harada M, Hashimoto Y, Hirano T, Hoshino H, Itabashi R, Itoh Y, Iwama T, Kohriyama T, Matsumaru Y, Osato T, Sasaki M, Shiokawa Y, Shimizu H, Takekawa H, Nishi T, Uno M, Yagita Y, Ido K, Kurogi A, Kurogi R, Arimura K, Ren N, Hagihara A, Takizawa S, Arai H, Kitazono T, Miyamoto S, Minematsu K, Iihara K; J-ASPECT study collaborators. Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan - J-ASPECT Study -. Circulation Journal. 83, 2292-2302, 2019.
  11. Kanaya T, Noguchi T, Otsuka F, Asaumi Y, Kataoka Y, Morita Y, Miura H, Nakao K, Fujino M, Kawasaki T, Nishimura K, Inoue T, Narula J, Yasuda S. Optical coherence tomography-verified morphological correlates of high-intensity coronary plaques on non-contrast T1-weighted magnetic resonance imaging in patients with stable coronary artery disease. European Heart Journal-Cardiovascular Imaging. 20, 75-83, 2019.
  12. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Tazaki J, Kyuragi R, Kinoshita O, Miyamoto T, Sakata Y, Nozato T, Ogino H. Editor's Choice - Endovascular Repair Versus Surgical Repair for Japanese Patients With Ruptured Thoracic and Abdominal Aortic Aneurysms: A Nationwide Study. European Journal of Vascular and Endovascular Surgery. 57, 779-786, 2019.
  13. Okamoto C, Okada A, Kanzaki H, Nishimura K, Hamatani Y, Amano M, Takahama H, Amaki M, Hasegawa T, Fujita T, Kobayashi J, Yasuda S, Izumi C. Prognostic impact of peak mitral inflow velocity in asymptomatic degenerative mitral regurgitation. Heart. 105, 609-615, 2019.
  14. Okura H, Saito Y, Soeda T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET investigators. Frequency and prognostic impact of intravascular imaging-guided urgent percutaneous coronary intervention in patients with acute myocardial infarction: results from J-MINUET. Heart and Vessels. 34, 564-571, 2019.
  15. Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy. Heart and Vessels. 34, 1899-1908, 2019.
  16. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Miyamoto T, Sakata Y, Nozato T, Ogino H. The impact of institutional case volume on the prognosis of ruptured aortic aneurysms: a Japanese nationwide study. Interactive Cardiovascular and Thoracic Surgery. 29, 109-116, 2019.
  17. Matoba T, Kohro T, Fujita H, Nakayama M, Kiyosue A, Miyamoto Y, Nishimura K, Hashimoto H, Antoku Y, Nakashima N, Ohe K, Ogawa H, Tsutsui H, Nagai R. Architecture of the Japan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT) System. International Heart Journal. 60, 264-270, 2019.
  18. Ohuchi H, Inai K, Nakamura M, Park IS, Watanabe M, Hiroshi O, Kim KS, Sakazaki H, Waki K, Yamagishi H, Yamamura K, Kuraishi K, Miura M, Nakai M, Nishimura K, Niwa K. Mode of death and predictors of mortality in adult Fontan survivors: A Japanese multicenter observational study. International Journal of Cardiology. 276, 74-80, 2019.
  19. Nagai T, Iwakami N, Nakai M, Nishimura K, Sumita Y, Mizuno A, Tsutsui H, Ogawa H, Anzai T. Effect of intravenous carperitide versus nitrates as first-line vasodilators on in-hospital outcomes in hospitalized patients with acute heart failure: Insight from a nationwide claim-based database. International Journal of Cardiology. 280, 104-109, 2019.
  20. Ogata S, Nishimura K, Guzman-Castillo M, Sumita Y, Nakai M, Nakao YM, Nishi N, Noguchi T, Sekikawa A, Saito Y, Watanabe T, Kobayashi Y, Okamura T, Ogawa H, Yasuda S, Miyamoto Y, Capewell S, O'Flaherty M. Explaining the decline in coronary heart disease mortality rates in Japan: Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. International Journal of Cardiology. 291, 183-188, 2019.
  21. Miyoshi T, Oku H, Asahara S, Okamoto A, Kokame K, Nakai M, Nishimura K, Otsuka F, Higashiyama A, Yoshimatsu J, Miyata T. Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study. International Journal of Hematology. 109, 641-649, 2019.
  22. Nakaoku Y, Saito S, Yamamoto Y, Maki T, Takahashi R, Ihara M. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Ameliorates High-fat Induced Cognitive Decline in Tauopathy Model Mice. International Journal of Molecular Sciences. 20, 2539, 2019.
  23. Miyoshi T, Katsuragi S, Neki R, Kurosaki KI, Shiraishi I, Nakai M, Nishimura K, Yoshimatsu J, Ikeda T. Cardiovascular profile and biophysical profile scores predict short-term prognosis in infants with congenital heart defect. Journal of Obstetrics and Gynaecology Research. 45, 1268-1276, 2019.
  24. Takahama H, Nishikimi T, Takashio S, Hayashi T, Nagai-Okatani C, Asada T, Fujiwara A, Nakagawa Y, Amano M, Hamatani Y, Okada A, Amaki M, Hasegawa T, Kanzaki H, Nishimura K, Yasuda S, Kangawa K, Anzai T, Minamino N, Izumi C. Change in the NT-proBNP/Mature BNP Molar Ratio Precedes Worsening Renal Function in Patients With Acute Heart Failure: A Novel Predictor Candidate for Cardiorenal Syndrome. Journal of the American Heart Association. 8, e011468, 2019.
  25. Nakao K, Yasuda S, Nishimura K, Noguchi T, Nakai M, Miyamoto Y, Sumita Y, Shishido T, Anzai T, Ito H, Tsutsui H, Saito Y, Komuro I, Ogawa H. Prescription Rates of Guideline-Directed Medications Are Associated With In-Hospital Mortality Among Japanese Patients With Acute Myocardial Infarction: A Report From JROAD-DPC Study. Journal of the American Heart Association. 8, e009692, 2019.
  26. Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, Takegami M, Nishimura K, Nakai M, Kiyoshige E, Hosoda K, Okamura T, Miyamoto Y. Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population: The Suita Study. Journal of the American Heart Association. 8, e010628, 2019.
  27. Kanaoka K, Okayama S, Nakai M, Sumita Y, Onoue K, Soeda T, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan. Journal of the American Heart Association. 8, e012282, 2019.
  28. Kamitani T, Yamamoto Y, Fukuma S, Ikenoue T, Kimachi M, Shimizu S, Yamamoto S, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Yamazaki S, Konno S, Kikuchi S, Fukuhara S. Association Between the Discrepancy in Self-Reported and Performance-Based Physical Functioning Levels and Risk of Future Falls Among Community-Dwelling Older Adults: The Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS). Journal of the American Medical Directors Association. 20, 195-200.e1, 2019.
  29. Yokota C, Yamamoto Y, Kamada M, Nakai M, Nishimura K, Ando D, Sato T, Kog M, Ihara M, Toyoda K, Fujimoto Y, Odani H, Minematsu K, Nakajima T. Acute stroke rehabilitation for gait training with cyborg type robot Hybrid Assistive Limb: A pilot study. Journal of the Neurological Sciences. 404, 11-15, 2019.
  30. Nakamura H, Fujinaka T, Nishida T, Kishima H, Sakai N, Sakai N; JR-NET4 study group. Endovascular Therapy for Ruptured Vertebral Artery Dissecting Aneurysms: Results from Nationwide, Retrospective, Multi-Center Registries in Japan (JR-NET3). Neurologia Medico-Chirurgica. 59, 10-18, 2019.
  31. Sakai N, Uchida K, Iihara K, Satow T, Ezura M, Hyodo A, Miyachi S, Miyamoto S, Nagai Y, Nishimura K, Toyoda K, Yoshimura S, Imamura H, Sakai C, Matsumaru Y; Japanese Registry of Neuroendovascular Therapy (JR-NET) investigators. Japanese Surveillance of Neuroendovascular Therapy in JR-NET - Part II. Japanese Registry of NeuroEndovascular Treatment 3. Main Report. Neurologia Medico-Chirurgica. 59, 106-115, 2019.
  32. Tokuda R, Yoshimura S, Uchida K, Yamada K, Satow T, Iihara K, Sakai N; Japanese Registry of NeuroEndovascular Therapy (JR-NET) investigators. Real-world Experience of Carotid Artery Stenting in Japan: Analysis of 8458 Cases from the JR-NET3 Nationwide Retrospective Multi-center Registries. Neurologia Medico-Chirurgica. 59, 117-125, 2019.
  33. Enomoto Y, Mizutani D, Yoshimura S, Sakai N, Sakai N, Iihara K, Satow T, Ezura M, Hyodo A, Miyachi S, Miyamoto S, Nagai Y, Nishimura K, Toyoda K, Fujinaka T, Higashi T, Hirohata M, Ishii A, Imamura H, Ito Y, Kuwayama N, Oishi H, Matsumaru Y, Matsumoto Y, Nakahara I, Sakai C, Sugiu K, Terada T, Yoshimura S. Changing Paradigms of Periprocedural Antithrombotic Therapy in Neuroendovascular Therapy: Analysis of JR-NET 3. Neurologia Medico-Chirurgica. 59, 247-256, 2019.
  34. Arimura K, Iihara K, Satow T, Nishimura A, Tokunaga S, Sakai N; JR-NET investigators. Safety and Feasibility of Neuroendovascular Therapy for Elderly Patients: Analysis of Japanese Registry of Neuroendovascular Therapy 3y. Neurologia Medico-Chirurgica. 59, 305-312, 2019.
  35. Onozuka D, Gasparrini A, Sera F, Hashizume M, Honda Y. Future projections of temperature-related excess out-of-hospital cardiac arrest under climate change scenarios in Japan. Science of the Total Environment. 682, 333-339, 2019.
  36. Yamagami K, Kurogi R, Kurogi A, Nishimura K, Onozuka D, Ren N, Kada A, Nishimura A, Arimura K, Ido K, Mizoguchi M, Sakamoto T, Kayama T, Suzuki M, Arai H, Hagihara A, Iihara K. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury). World Neurosurgery. 130, e26-e46, 2019.