予防健診部
研究活動の概要

　循環器病の予防の為には循環器病の発症要因を明らかにし、それを用いた予防法を開発することが必要である。そのために、予防健診部では主に、吹田研究から多くのエビデンスを創出してきた。

　2019年は空腹時の経年的な変化と心血管疾患の発症との関連などを報告（Ogata S, et al. J Am Heart Assoc. 2019;8.e010628.）するとともに、心房肥大と心房細動との関連や口腔機能に及ぼす因子の影響などの研究をおこなった。

研究業績
  1. Hori M, Ohta N, Takahashi A, Masuda H, Isoda R, Yamamoto S, Son C, Ogura M, Hosoda K, Miyamoto Y, Harada-Shiba M. Impact of LDLR and PCSK9 pathogenic variants in Japanese heterozygous familial hypercholesterolemia patients. Atherosclerosis. 289, 101-108, 2019.
  2. Kubo S, Nishida Y, Kubota Y, Higashiyama A, Sugiyama D, Hirata T, Miyamatsu N, Tanabe A, Hirata A, Tatsumi Y, Kadota A, Kuwabara K, Nishikawa T, Miyamoto Y, Okamura T. Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study. BMC Nephrology. 20, 117, 2019.
  3. Kataoka Y, Hosoda K, Makino H, Matsubara M, Matsuo M, Ohata Y, Koezuka R, Tamanaha T, Tomita T, Honda-Kohmo K, Noguchi M, Son C, Nishimura K, Asaumi Y, Miyamoto Y, Noguchi T, Yasuda S. The efficacy of glycemic control with continuous glucose monitoring on atheroma progression: rationale and design of the Observation of Coronary Atheroma Progression under Continuous Glucose Monitoring Guidance in Patients with Type 2 Diabetes Mellitus (OPTIMAL). Cardiovascular Diagnosis and Therapy. 9, 431-438, 2019.
  4. Honda S, Nishihira K, Kojima S, Takegami M, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K, Yasuda S; JAMIR investigators. Rationale, Design, and Baseline Characteristics of the Prospective Japan Acute Myocardial Infarction Registry (JAMIR). Cardiovascular Drugs and Therapy. 33, 97-103, 2019.
  5. Nishikawa T, Miyamatsu N, Higashiyama A, Hojo M, Nishida Y, Fukuda S, Hirata T, Ichiura K, Kubota Y, Kubo S, Ueba T, Kadota A, Sugiyama D, Okamura T. Daily Habit of Water Intake in Patients with Cerebral Infarction before its Onset; Comparison with a Healthy Population: A Cross-Sectional Study. Cerebrovascular Diseases. 47, 143-150, 2019.
  6. Okami Y, Ueshima H, Nakamura Y, Kondo K, Kadota A, Okuda N, Okamura T, Miura K; NIPPON DATA80/90 and NIPPON DATA2010 Research Groups. Time-Related Changes in Relationships Between the Keys Score, Dietary Lipids, and Serum Total Cholesterol in Japan - NIPPON DATA80/90/2010 -. Circulation Journal. 83, 147-155, 2019.
  7. Kanaoka K, Okayama S, Nakai M, Sumita Y, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Hospitalization Costs for Patients With Acute Congestive Heart Failure in Japan. Circulation Journal. 83, 1025-1031, 2019.
  8. Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Admission Heart Rate Is a Determinant of Effectiveness of Beta-Blockers in Acute Myocardial Infarction Patients. Circulation Journal. 83, 1054-1063, 2019.
  9. Hayashi R, Iso H, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Eshak ES, Sawada N, Tsugane S. Working Hours and Risk of Acute Myocardial Infarction and Stroke Among Middle-Aged Japanese Men - The Japan Public Health Center-Based Prospective Study Cohort II -. Circulation Journal. 83, 1072-1079, 2019.
  10. Uemura S, Okamoto H, Nakai M, Nishimura K, Miyamoto Y, Yasuda S, Tanaka N, Kohsaka S, Kadota K, Saito Y, Tsutsui H, Komuro I, Ikari Y, Ogawa H, Nakamura M. Primary Percutaneous Coronary Intervention in Elderly Patients With Acute Myocardial Infarction - An Analysis From a Japanese Nationwide Claim-Based Database -. Circulation Journal. 83, 1229-1238, 2019.
  11. Kondo K, Miura K, Tanaka-Mizuno S, Kadota A, Arima H, Okuda N, Fujiyoshi A, Miyagawa N, Yoshita K, Okamura T, Okayama A, Ueshima H, Ueshima H, Okayama A, Ueshima H, Okamura T, Saitoh S, Sakata K, Hozawa A, Hayakawa T, Nakamura Y, Nishi N, Okuda N, Ohkubo T, Kasagi F, Murakami Y, Izumi T, Matsumura Y, Ojima T, Tamakoshi K, Nakagawa H, Kita Y, Miura K, Kadota A, Fujiyoshi A, Miyamatsu N, Nakamura Y, Yoshita K, Miyamoto Y, Kodama K, Kiyohara Y. Cardiovascular Risk Assessment Chart by Dietary Factors in Japan - NIPPON DATA80 -. Circulation Journal. 83, 1254-1260, 2019.
  12. Makino H, Tanaka A, Asakura K, Koezuka R, Tochiya M, Ohata Y, Tamanaha T, Son C, Shimabara Y, Fujita T, Miyamoto Y, Kobayashi J, Hosoda K. Addition of low-dose liraglutide to insulin therapy is useful for glycaemic control during the peri-operative period: effect of glucagon-like peptide-1 receptor agonist therapy on glycaemic control in patients undergoing cardiac surgery (GLOLIA study). Diabetic Medicine. 36, 1621-1628, 2019.
  13. Okura H, Saito Y, Soeda T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET investigators. Frequency and prognostic impact of intravascular imaging-guided urgent percutaneous coronary intervention in patients with acute myocardial infarction: results from J-MINUET. Heart and Vessels. 34, 564-571, 2019.
  14. Okuno T, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Hirata K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Tobaru T, Saku K, Ohshima S, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Association of onset-season with characteristics and long-term outcomes in acute myocardial infarction patients: results from the Japanese registry of acute myocardial infarction diagnosed by universal definition (J-MINUET) substudy. Heart and Vessels. 34, 1899-1908, 2019.
  15. Satoh M, Ohkubo T, Asayama K, Murakami Y, Sugiyama D, Yamada M, Saitoh S, Sakata K, Irie F, Sairenchi T, Ishikawa S, Kiyama M, Ohnishi H, Miura K, Imai Y, Ueshima H, Okamura T; EPOCH-JAPAN Research Group. Lifetime Risk of Stroke and Coronary Heart Disease Deaths According to Blood Pressure Level: EPOCH-JAPAN (Evidence for Cardiovascular Prevention From Observational Cohorts in Japan). Hypertension. 73, 52-59, 2019.
  16. Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T. Risk of developing type 2 diabetes according to blood pressure levels and presence or absence of hypertensive treatment: the Saku study. Hypertension Research. 42, 105-113, 2019.
  17. Matoba T, Kohro T, Fujita H, Nakayama M, Kiyosue A, Miyamoto Y, Nishimura K, Hashimoto H, Antoku Y, Nakashima N, Ohe K, Ogawa H, Tsutsui H, Nagai R. Architecture of the Japan Ischemic Heart Disease Multimodal Prospective Data Acquisition for Precision Treatment (J-IMPACT) System. International Heart Journal. 60, 264-270, 2019.
  18. Ogata S, Nishimura K, Guzman-Castillo M, Sumita Y, Nakai M, Nakao YM, Nishi N, Noguchi T, Sekikawa A, Saito Y, Watanabe T, Kobayashi Y, Okamura T, Ogawa H, Yasuda S, Miyamoto Y, Capewell S, O'Flaherty M. Explaining the decline in coronary heart disease mortality rates in Japan: Contributions of changes in risk factors and evidence-based treatments between 1980 and 2012. International Journal of Cardiology. 291, 183-188, 2019.
  19. Miyoshi T, Oku H, Asahara S, Okamoto A, Kokame K, Nakai M, Nishimura K, Otsuka F, Higashiyama A, Yoshimatsu J, Miyata T. Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study. International Journal of Hematology. 109, 641-649, 2019.
  20. Shimizu W, Makimoto H, Yamagata K, Kamakura T, Wada M, Miyamoto K, Inoue-Yamada Y, Okamura H, Ishibashi K, Noda T, Nagase S, Miyazaki A, Sakaguchi H, Shiraishi I, Makiyama T, Ohno S, Itoh H, Watanabe H, Hayashi K, Yamagishi M, Morita H, Yoshinaga M, Aizawa Y, Kusano K, Miyamoto Y, Kamakura S, Yasuda S, Ogawa H, Tanaka T, Sumitomo N, Hagiwara N, Fukuda K, Ogawa S, Aizawa Y, Makita N, Ohe T, Horie M, Aiba T. Association of Genetic and Clinical Aspects of Congenital Long QT Syndrome With Life-Threatening Arrhythmias in Japanese Patients. JAMA Cardiology. 4, 246-254, 2019.
  21. GBD 2017 Child and Adolescent Health Collaborators. Diseases, Injuries, and Risk Factors in Child and Adolescent Health, 1990 to 2017 Findings From the Global Burden of Diseases, Injuries, and Risk Factors 2017 Study. JAMA Pediatrics. 173, e190337, 2019.
  22. Kurihara A, Okamura T, Sugiyama D, Higashiyama A, Watanabe M, Okuda N, Kadota A, Miyagawa N, Fujiyoshi A, Yoshita K, Ohkubo T, Okayama A, Miura K, Ueshima H. Vegetable Protein Intake was Inversely Associated with Cardiovascular Mortality in a 15-Year Follow-Up Study of the General Japanese Population. Journal of Atherosclerosis and Thrombosis. 26, 198-206, 2019.
  23. Kimani C, Kadota A, Miura K, Fujiyoshi A, Zaid M, Kadowaki S, Hisamatsu T, Arima H, Horie M, Ueshima H; SESSA Research Group. Differences Between Coronary Artery Calcification and Aortic Artery Calcification in Relation to Cardiovascular Disease Risk Factors in Japanese Men. Journal of Atherosclerosis and Thrombosis. 26, 452-464, 2019.
  24. Zha L, Sobue T, Kitamura T, Kitamura Y, Sawada N, Iwasaki M, Sasazuki S, Yamaji T, Shimazu T, Tsugane S. Changes in Smoking Status and Mortality From All Causes and Lung Cancer: A Longitudinal Analysis of a Population-based Study in Japan. Journal of Epidemiology. 29, 11-17, 2019.
  25. Shibata Y, Ojima T, Nakamura M, Kuwabara K, Miyagawa N, Saito Y, Nakamura Y, Kiyohara Y, Nakagawa H, Fujiyoshi A, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K. Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010. Journal of Epidemiology. 29, 133-138, 2019.
  26. Sumi M, Hisamatsu T, Fujiyoshi A, Kadota A, Miyagawa N, Kondo K, Kadowaki S, Suzuki S, Torii S, Zaid M, Sato A, Arima H, Terada T, Miura K, Ueshima H. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). Journal of Epidemiology. 29, 205-212, 2019.
  27. Li YY, Yatsuya H, Iso H, Yamagishi K, Saito I, Kokubo Y, Sawada N, Tsugane S. Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study. Journal of Epidemiology. 29, 325-333, 2019.
  28. Nakao K, Yasuda S, Nishimura K, Noguchi T, Nakai M, Miyamoto Y, Sumita Y, Shishido T, Anzai T, Ito H, Tsutsui H, Saito Y, Komuro I, Ogawa H. Prescription Rates of Guideline-Directed Medications Are Associated With In-Hospital Mortality Among Japanese Patients With Acute Myocardial Infarction: A Report From JROAD-DPC Study. Journal of the American Heart Association. 8, e009692, 2019.
  29. Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, Takegami M, Nishimura K, Nakai M, Kiyoshige E, Hosoda K, Okamura T, Miyamoto Y. Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population: The Suita Study. Journal of the American Heart Association. 8, e010628, 2019.
  30. Kanaoka K, Okayama S, Nakai M, Sumita Y, Onoue K, Soeda T, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan. Journal of the American Heart Association. 8, e012282, 2019.
  31. GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 393, 1958-1972, 2019.
  32. GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology. 18, 459-480, 2019.
  33. Kashino I, Serafini M, Kurotani K, Akter S, Mizoue T, Ishihara J, Kotemori A, Sawada N, Inoue M, Iwasaki M, Noda M, Tsugane S; Japan Public Health Center-based Prospective Study Group. Relationship between dietary non-enzymatic antioxidant capacity and type 2 diabetes risk in the Japan Public Health Center-based Prospective Study. Nutrition. 66, 62-69, 2019.
  34. Kamimura T, Okazaki S, Morimoto T, Kobayashi H, Harada K, Tomita T, Higashiyama A, Yoshimoto T, Takahashi JC, Nakagawara J, Koga M, Toyoda K, Maruyama H, Koizumi A, Ihara M. Prevalence of RNF213 p.R4810K Variant in Early-Onset Stroke With Intracranial Arterial Stenosis. Stroke. 50, 1561-1563, 2019.
  35. Nishikawa T, Miyamatsu N, Higashiyama A, Kubota Y, Nishida Y, Hirata T, Sugiyama D, Kuwabara K, Kubo S, Miyamoto Y, Okamura T. Being Conscious of Water Intake Positively Associated with Sufficient Non-Alcohol Drink Intake Regardless of Seasons and Reasons in Healthy Japanese; the KOBE Study: A Cross Sectional Study. International Journal of Environmental Research and Public Health. 16, 4151, 2019.
  36. Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T. Fasting Blood Glucose Predicts Incidence of Hypertension Independent of HbA1c Levels and Insulin Resistance in Middle-Aged Japanese: The Saku Study. American Journal of Hypertension. 32, 1178-1185, 2019.
  37. Yamane T, Inoue K, Kusano K, Takegami M, Nakao YM, Miyamoto Y, Goya M, Uno K, Shoda M, Murakawa Y, Hirao K, Nogami A; J-AB registry investigators. Study design of nationwide Japanese Catheter Ablation Registry: Protocol for a prospective, multicenter, open registry. Journal of Arrhythmia. 35, 167-170, 2019.
  38. Sekikawa A, Ihara M, Lopez O, Kakuta C, Lopresti B, Higashiyama A, Aizenstein H, Chang YF, Mathis C, Miyamoto Y, Kuller L, Cui C. Effect of S-equol and Soy Isoflavones on Heart and Brain. Current Cardiology Reviews. 15, 114-135, 2019.
  39. Yasuda S, Honda S, Takegami M, Nishihira K, Kojima S, Asaumi Y, Suzuki M, Kosuge M, Takahashi J, Sakata Y, Takayama M, Sumiyoshi T, Ogawa H, Kimura K; JAMIR Investigators. Contemporary Antiplatelet Therapy and Clinical Outcomes of Japanese Patients With Acute Myocardial Infarction - Results From the Prospective Japan Acute Myocardial Infarction Registry (JAMIR) -. Circulation Journal. 83, 1633-1643, 2019.
  40. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study. Journal of Atherosclerosis and Thrombosis. Epub, 2019.
  41. Murai U, Yamagishi K, Sata M, Kokubo Y, Saito I, Yatsuya H, Ishihara J, Inoue M, Sawada N, Iso H, Tsugane S; JPHC Study Group. Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study. The American Journal of Clinical Nutrition. 110, 1449-1455, 2019.
  42. Kokubo Y, Padmanabhan S, Iwashima Y, Yamagishi K, Goto A. Gene and environmental interactions according to the components of lifestyle modifications in hypertension guidelines. Environmental Health and Preventive Medicine. 24, 19, 2019.
  43. Nomura K, Karita K, Araki A, Nishioka E, Muto G, Iwai-Shimada M, Nishikitani M, Inoue M, Tsurugano S, Kitano N, Tsuji M, Iijima S, Ueda K, Kamijima M, Yamagata Z, Sakata K, Iki M, Yanagisawa H, Kato M, Inadera H, Kokubo Y, Yokoyama K, Koizumi A, Otsuki T. For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate. Environmental Health and Preventive Medicine. 24, 14, 2019.
  44. Kokubo Y, Higashiyama A, Watanabe M, Miyamoto Y. A comprehensive policy for reducing sugar beverages for healthy life extension. Environmental Health and Preventive Medicine. 24, 13, 2019.
  45. 宮本 恵宏, 東山 綾. 特定保健指導の対象とならない非肥満者を含む心血管疾患危険因子保有者に対する生活習慣改善指導ガイドライン【抜粋版】. 健康教育マニュアル 生活習慣病予防の保健指導 第2版. 8-1-8-11, 2019.