予防健診部
研究活動の概要

　循環器病の予防の為には循環器病の発症要因を明らかにし、それを用いた予防法を開発することが必要である。そのために、予防健診部では主に、吹田研究から多くのエビデンスを創出してきた。
2018年は頸動脈肥厚が循環器疾患発症と関連があること（Kokubo Y, et al. J Am Heart Assoc. 2018;7(11). e007720.）、歯周病菌種と脂質異常との関連があること（Choi YH, rt al. BMC Oral Health. 2018 May 4;18(1):77.）
などを報告した。

研究業績
  1. Nakamura Y, Asaumi Y, Miyagi T, Nakai M, Nishimura K, Sugane H, Matama H, Kataoka Y, Miyamoto Y, Takeishi Y, Noguchi T, Yasuda S. Comparison of Long-Term Mortality in Patients With Previous Coronary Artery Bypass Grafting Who Underwent Percutaneous Coronary Intervention With Versus Without Optimal Medical Therapy. American Journal of Cardiology. 122, 206-212, 2018.
  2. Choi YH, Kosaka T, Ojima M, Sekine S, Kokubo Y, Watanabe M, Miyamoto Y, Ono T, Amano A. Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study. BMC Oral Health. 18, 77, 2018.
  3. Kanaoka K, Okayama S, Yoneyama K, Nakai M, Nishimura K, Kawata H, Horii M, Kawakami R, Okura H, Miyamoto Y, Akashi Y, Saito Y. Number of Board-Certified Cardiologists and Acute Myocardial Infarction-Related Mortality in Japan - JROAD and JROAD-DPC Registry Analysis -. Circulation Journal. 82, 2845-2851, 2018.
  4. Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, Maruyama K, Inoue M, Sawada N, Tsugane S. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Clinical Nutrition. 37, 1602-1608, 2018.
  5. Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T. Association between alcohol consumption and incidence of impaired insulin secretion and insulin resistance in Japanese: The Saku study. Diabetes Research and Clinical Practice. 135, 43786, 2018.
  6. Matsumoto M, Asaumi Y, Nakamura Y, Nakatani T, Nagai T, Kanaya T, Kawakami S, Honda S, Kataoka Y, Nakajima S, Seguchi O, Yanase M, Nishimura K, Miyamoto Y, Kusano K, Anzai T, Noguchi T, Fujita T, Kobayashi J, Ishibashi-Ueda H, Shimokawa H, Yasuda S. Clinical determinants of successful weaning from extracorporeal membrane oxygenation in patients with fulminant myocarditis. ESC Heart Failure. 5, 675-684, 2018.
  7. Inoue YY, Aiba T, Kawata H, Sakaguchi T, Mitsuma W, Morita H, Noda T, Takaki H, Toyohara K, Kanaya Y, Itoi T, Mitsuhashi T, Sumitomo N, Cho Y, Yasuda S, Kamakura S, Kusano K, Miyamoto Y, Horie M, Shimizu W. Different responses to exercise between Andersen-Tawil syndrome and catecholaminergic polymorphic ventricular tachycardia. Europace. 20, 1675-1682, 2018.
  8. Maniwa N, Fujino M, Nakai M, Nishimura K, Miyamoto Y, Kataoka Y, Asaumi Y, Tahara Y, Nakanishi M, Anzai T, Kusano K, Akasaka T, Goto Y, Noguchi T, Yasuda S. Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction. European Heart Journal. 39, 201-208, 2018.
  9. Nakao YM, Miyamoto Y, Higashi M, Noguchi T, Ohishi M, Kubota I, Tsutsui H, Kawasaki T, Furukawa Y, Yoshimura M, Morita H, Nishimura K, Kada A, Goto Y, Okamura T, Tei C, Tomoike H, Naito H, Yasuda S. Sex differences in impact of coronary artery calcification to predict coronary artery disease. Heart. 104, 1118-1124, 2018.
  10. Hashimoto T, Ako J, Nakao K, Ozaki Y, Kimura K, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Ohshima S, Nakai M, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. A lower eicosapentaenoic acid/arachidonic acid ratio is associated with in-hospital fatal arrhythmic events in patients with acute myocardial infarction: a J-MINUET substudy. Heart and Vessels. 33, 481-488, 2018.
  11. Kubota Y, Higashiyama A, Sugiyama D, Nishida Y, Kubo S, Hirata T, Kadota A, Miyamatsu N, Wakabayashi I, Miyamoto Y, Okamura T. Association between impairment of salty taste recognition and masked hypertension based on home blood pressure in Japanese residents: the KOBE study. Hypertension Research. 41, 756-762, 2018.
  12. Horiuchi Y, Aoki J, Tanabe K, Nakao K, Ozaki Y, Kimura K, Ako J, Yasuda S, Noguchi T, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Shibata Y, Nakai M, Nishimura K, Miyamoto Y, Ishihara M. A High Level of Blood Urea Nitrogen Is a Significant Predictor for In-hospital Mortality in Patients with Acute Myocardial Infarction. International Heart Journal. 59, 263-271, 2018.
  13. Hashimoto T, Ako J, Nakao K, Ozaki Y, Kimura K, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Oshima S, Nakai M, Nishimura K, Miyamoto Y, Ogawa H, Ishihara M. Pre-Procedural Thrombolysis in Myocardial Infarction Flow in Patients with ST-Segment Elevation Myocardial Infarction A J-MINUET Substudy. International Heart Journal. 59, 920-925, 2018.
  14. GBD 2015 Eastern Mediterranean Region Mental Health Collaborators. The burden of mental disorders in the Eastern Mediterranean region, 1990-2015: findings from the global burden of disease 2015 study. International Journal of Public Health. 63, 25-37, 2018.
  15. GBD 2015 Eastern Mediterranean Region Maternal Mortality Collaborators. Maternal mortality and morbidity burden in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study. International Journal of Public Health. 63, 47-61, 2018.
  16. GBD 2015 Eastern Mediterranean Region Adolescent Health Collaborators. Adolescent health in the Eastern Mediterranean Region: findings from the global burden of disease 2015 study. International Journal of Public Health. 63, 79-96, 2018.
  17. GBD 2015 Eastern Mediterranean Region Obesity Collaborators. Burden of obesity in the Eastern Mediterranean Region: findings from the Global Burden of Disease 2015 study. International Journal of Public Health. 63, 165-176, 2018.
  18. Nakamura K, Watanabe M, Okuda N, Yoshita K, Kabayama M, Torii S, Kuribayashi T, Itai K, Kamide K, Miura K, Okayama A. The Influence of the Japanese Nationwide Cardiovascular Prevention System Health Guidance on Smoking Cessation Among Smokers: A Propensity Score Matching Analysis. Journal of Atherosclerosis and Thrombosis. 25, 323-334, 2018.
  19. Kinoshita M, Yokote K, Arai H, Iida M, Ishigaki Y, Ishibashi S, Umemoto S, Egusa G, Ohmura H, Okamura T, Kihara S, Koba S, Saito I, Shoji T, Daida H, Tsukamoto K, Deguchi J, Dohi S, Dobashi K, Hamaguchi H, Hara M, Hiro T, Biro S, Fujioka Y, Maruyama C, Miyamoto Y, Murakami Y, Yokode M, Yoshida H, Rakugi H, Wakatsuki A, Yamashita S. Japan Atherosclerosis Society (JAS) Guidelines for Prevention of Atherosclerotic Cardiovascular Diseases 2017. Journal of Atherosclerosis and Thrombosis. 25, 846-984, 2018.
  20. Kawakami H, Aiba T, Ishibashi K, Nakajima I, Wada M, Kamakura T, Inoue Y, Miyamoto K, Okamura H, Nagase S, Noda T, Kokubo Y, Miyamoto Y, Yasuda S, Kamakura S, Kusano K. Change in QRS morphology as a marker of spontaneous elimination in verapamil-sensitive idiopathic left ventricular tachycardia. Journal of Cardiovascular Electrophysiology. 29, 446-455, 2018.
  21. Hirata A, Sugiyama D, Watanabe M, Tamakoshi A, Iso H, Kotani K, Kiyama M, Yamada M, Ishikawa S, Murakami Y, Miura K, Ueshima H, Okamura T. Association of extremely high levels of high-density lipoprotein cholesterol with cardiovascular mortality in a pooled analysis of 9 cohort studies including 43,407 individuals: The EPOCH-JAPAN study. Journal of Clinical Lipidology. 12, 674-684, 2018.
  22. Sakurai M, Nakagawa H, Kadota A, Yoshita K, Nakamura Y, Okuda N, Nishi N, Miyamoto Y, Arima H, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K. Macronutrient Intake and Socioeconomic Status: NIPPON DATA2010. Journal of Epidemiology. 28, S17-S22, 2018.
  23. Asayama K, Ohkubo T, Satoh A, Tanaka S, Higashiyama A, Murakami Y, Yamada M, Saitoh S, Okayama A, Miura K, Ueshima H, Miyamoto Y, Okamura T. Cardiovascular risk and blood pressure lowering treatment among elderly individuals: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan. Journal of Hypertension. 36, 410-418, 2018.
  24. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Nakamura F, Miyamoto Y. Impact of Intima-Media Thickness Progression in the Common Carotid Arteries on the Risk of Incident Cardiovascular Disease in the Suita Study. Journal of the American Heart Association. 7, e007720, 2018.
  25. GBD 2017 Mortality Collaborators. Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1684-1735, 2018.
  26. GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1736-1788, 2018.
  27. GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1789-1858, 2018.
  28. GBD 2017 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1859-1922, 2018.
  29. GBD 2017 Risk Factor Collaborators. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1923-1994, 2018.
  30. GBD 2017 Population and Fertility Collaborators. Population and fertility by age and sex for 195 countries and territories, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 1995-2051, 2018.
  31. GBD 2017 SDG Collaborators. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 392, 2091-2138, 2018.
  32. GBD 2016 Healthcare Access and Quality Collaborators. Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016. Lancet. 391, 2236-2271, 2018.
  33. GBD 2016 Parkinson's Disease Collaborators. Global, regional, and national burden of Parkinson's disease, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology. 17, 939-953, 2018.
  34. GBD 2016 Headache Collaborators. Global, regional, and national burden of migraine and tension-type headache, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurology. 17, 954-976, 2018.
  35. Nakao YM, Miyamoto Y, Ueshima K, Nakao K, Nakai M, Nishimura K, Yasuno S, Hosoda K, Ogawa Y, Itoh H, Ogawa H, Kangawa K, Nakao K. Effectiveness of nationwide screening and lifestyle intervention for abdominal obesity and cardiometabolic risks in Japan: The metabolic syndrome and comprehensive lifestyle intervention study on nationwide database in Japan (MetS ACTION-J study). PLOS ONE. 13, e0190862, 2018.
  36. 小久保 喜弘, 渡邊 至, 東山 綾, 宮本 恵宏. 心房細動罹患に関する古典的危険因子. 循環器内科. 84, 3-10, 2018.
  37. 柿崎 真沙子, 澤田 典絵, 山岸 良匡, 八谷 寛, 斉藤 功, 小久保 喜弘, 磯 博康, 津金 昌一郎, 康永 秀生. DPCデータを用いた脳卒中・急性心筋梗塞発症把握の可能性の検討. 日本公衆衛生雑誌. 65, 179-186, 2018.
  38. 中尾 葉子, 宮本 恵宏, 安田 聡. 冠動脈CTからみた性差. 循環器内科. 84, 412-418, 2018.
  39. 宮本 恵宏. 女性医療における循環器疾患～心血管病予防に向けた女性のオーダーメイド医療～ 吹田研究からみた女性の循環器疾患. 日本女性医学学会雑誌. 25, 251-253, 2018.
  40. 宮本 恵宏. わが国の疫学データに基づく動脈硬化リスク評価の実際. プラクティス. 35, 257-262, 2018.
  41. 宮本 恵宏. 吹田研究と吹田スコア. Mebio. 35, 38-44, 2018.
  42. 宮本 恵宏. ビッグデータ時代のレジストリー. 医学のあゆみ. 264, 901-905, 2018.
  43. 宮本 恵宏. 吹田研究－ライフコースの観点からみた中年期住民のコホート. 医学のあゆみ. 264, 315-318, 2018.