予防医学・疫学情報部
研究活動の概要

　我が国では循環器病による死亡率は減少傾向に なっているが、残念ながら循環器病の発症率は減少していない。循環器病の対策を立てるにあたっては循環器病のリスクを解明することが必要である。予防医学・疫学情報部は、予防健診部や循環器病統合情報センターとともに循環器に関する疫学研究や情報科学を行う。

　不整脈学会の全国登録であるＪ－ＡＢなどレジストリー研究の支援などを筆頭にレジストリー研究のデータマネージメントを25個受け持っている（日本循環器学会のBPAレジストリーのデータセンターを含む）。研究計画書の作成補助、データ収集のCase Report Formの作成、データ収集のためのElectronic Data Captureシステムの構築を行っている。また院内各科（心臓内科、心臓外科、脳内科、麻酔科、周産期科など各科）および研究所の主として観察研究の統計解析を行い2017年にはEHJ、Neurology、Circulation　Researchなどで３５本の論文が受理されている。また現在JACC等でreviseおよび投稿準備中のもの１５本程度作業進行中である。

　電子カルテData Ware Houseからの自動症例抽出システムを開発した。さらに、心臓カテーテル検査レポート、超音波検査レポート、分娩台帳といった電子カルテとは直接関係ない部門システムからの情報もData Ware Houseからデータが抽出できる仕組みを開発した。ＢＭ社ワトソンなどの人工知能を応用する先進的取り組みも行っている。米国心臓病学会（AHA/ACC）の包括的循環器疾患レジストリーPINNACLに準拠した項目216項目中169項目を自動抽出することができるようになった。また心エコー、心臓カテール所見に関しては別途抽出ロジックを構築し５０項目程度が抽出可能となり、予後についても電子カルテに関して記録のあるものについては抽出可能となるよう作業中である。今後OIC入居予定のフィリップス社のグロバールR&Dセンターとの提携等により臨床研究への人工知能サポートを進めていく予定である。

研究業績
  1. Hirata T, Sugiyama D, Nagasawa S, Murakami Y, Saitoh S, Okayama A, Iso H, Irie F, Sairenchi T, Miyamoto Y, Yamada M, Ishikawa S, Miura K, Ueshima H, Okamura T; Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN) Research Group. A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan. European Journal of Epidemiology. 32, 547-557, 2017.
  2. Nakajima Y, Kawarada O, Higashimori A, Yokoi Y, Zen K, Anzai H, Doi H, Hokimoto S, Ito S, Kato T, Kume T, Shintani Y, Tanimoto S, Tsubakimoto Y, Utsunomiya M, Nishimura K, Yasuda S. Predictors of cardiac benefits of renal artery stenting from a multicentre retrospective registry. Heart Asia. 9, e010934, 2017.
  3. Akashiba T, Ishikawa Y, Ishihara H, Imanaka H, Ohi M, Ochiai R, Kasai T, Kimura K, Kondoh Y, Sakurai S, Shime N, Suzukawa M, Takegami M, Takeda S, Tasaka S, Taniguchi H, Chohnabayashi N, Chin K, Tsuboi T, Tomii K, Narui K, Hasegawa N, Hasegawa R, Ujike Y, Kubo K, Hasegawa Y, Momomura SI, Yamada Y, Yoshida M, Takekawa Y, Tachikawa R, Hamada S, Murase K. The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines (second revised edition). Respiratory Investigation. 55, 83-92, 2017.
  4. Doi T, Kataoka Y, Noguchi T, Shibata T, Nakashima T, Kawakami S, Nakao K, Fujino M, Nagai T, Kanaya T, Tahara Y, Asaumi Y, Tsuda E, Nakai M, Nishimura K, Anzai T, Kusano K, Shimokawa H, Goto Y, Yasuda S. Coronary Artery Ectasia Predicts Future Cardiac Events in Patients With Acute Myocardial Infarction. Arteriosclerosis Thrombosis and Vascular Biology. 37, 2350-2355, 2017.
  5. Fujino M, Ishihara M, Ogawa H, Nakao K, Yasuda S, Noguchi T, Ozaki Y, Kimura K, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Ako J, Nakai M, Nishimura K, Miyamoto Y; J-MINUET Investigators. Impact of symptom presentation on in-hospital outcomes in patients with acute myocardial infarction. Journal of Cardiology. 70, 29-34, 2017.
  6. Ishigami A, Yokota C, Nishimura K, Ohyama S, Tomari S, Hino T, Arimizu T, Wada S, Toyoda K, Minematsu K. Delivering Knowledge of Stroke to Parents Through Their Children Using a Manga for Stroke Education in Elementary School. Journal of Stroke & Cerebrovascular Diseases. 26, 431-437, 2017.
  7. Ishihara M, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Fujino M, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Tobaru T, Oshima S, Nakai M, Nishimura K, Miyamoto Y, Ogawa H; J-MINUET Investigators. Long-Term Outcomes of Non-ST-Elevation Myocardial Infarction Without Creatine Kinase Elevation - The J-MINUET Study. Circulation Journal. 81, 958-965, 2017.
  8. Kada A, Nishimura K, Nakagawara J, Ogasawara K, Ono J, Shiokawa Y, Aruga T, Miyachi S, Nagata I, Toyoda K, Matsuda S, Suzuki A, Kataoka H, Nakamura F, Kamitani S, Iihara K; J-ASPECT Study Collaborators. Development and validation of a score for evaluating comprehensive stroke care capabilities: J-ASPECT Study. BMC Neurology. 17, 46, 2017.
  9. Kato K, Sekiguchi M, Nikaido T, Otoshi KI, Matsuo Y, Igari T, Kobayashi Y, Takegami M, Fukumori N, Fukuma S, Kikuchi SI, Fukuhara SI, Konno SI. Psychosocial Stress After a Disaster and Low Back Pain-Related Interference With Daily Living Among College Students A Cohort Study in Fukushima. Spine. 42, 1255-1260, 2017.
  10. Kawarada O, Kume T, Ayabe S, Nakaya T, Nakai M, Nishimura K, Noguchi T, Yokoi Y, Ogawa H, Yasuda S. Endovascular Therapy Outcomes and Intravascular Ultrasound Findings in Thromboangiitis Obliterans (Buerger's Disease). Journal of Endovascular Therapy. 24, 504-515, 2017.
  11. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kusano K, Miyamoto Y. Development of a Basic Risk Score for Incident Atrial Fibrillation in a Japanese General Population ― The Suita Study ―. Circulation Journal. 81, 1580-1588, 2017.
  12. Kubota Y, Higashiyama A, Marumo M, Konishi M, Yamashita Y, Tashiro C, Okamura T, Miyamoto Y, Wakabayashi I. Detection of Subclinical Peripheral Artery Ischemia in Healthy Male Smokers by an Ankle-Brachial Index After Exercise: Sasayama Study. Angiology. 68, 769-775, 2017.
  13. Kuji S, Kosuge M, Kimura K, Nakao K, Ozaki Y, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET Investigators. Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction - Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy. Circulation Journal. 81, 733-739, 2017.
  14. Miida T, Nishimura K, Hirayama S, Miyamoto Y, Nakamura M, Masuda D, Yamashita S, Ushiyama M, Komori T, Fujita N, Yokoyama S, Teramoto T. Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State. Journal of Atherosclerosis and Thrombosis. 24, 583-599, 2017.
  15. Miyazaki A, Sakaguchi H, Matsumura Y, Hayama Y, Noritake K, Negishi J, Tsuda E, Miyamoto Y, Aiba T, Shimizu W, Kusano K, Shiraishi I, Ohuchi H. Mid-Term Follow-up of School-Aged Children With Borderline Long QT Interval. Circulation Journal. 81, 726-732, 2017.
  16. Miyoshi T, Katsuragi S, Neki R, Kurosaki K, Shiraishi I, Nakai M, Nishimura K, Yoshimatsu J, Ikeda T. Cardiovascular profile score as a predictor of acute intrapartum non-reassuring fetal status in infants with congenital heart defects. The Journal of Maternal-Fetal & Neonatal Medicine. 30, 2831-2837, 2017.
  17. Nishikawa T, Fujino M, Nakajima I, Asaumi Y, Kataoka Y, Anzai T, Kusano K, Noguchi T, Goto Y, Nishimura K, Miyamoto Y, Kiso K, Yasuda S. Prognostic impact of chronic total coronary occlusion on long-term outcomes in implantable cardioverter-defibrillator recipients with ischaemic heart disease. Europace. 19, 1153-1162, 2017.
  18. Oda T, Minatoya K, Sasaki H, Tanaka H, Seike Y, Itonaga T, Inoue Y, Higashi M, Nishimura K, Kobayashi J. Surgical Indication for Chronic Aortic Dissection in Descending Thoracic and Thoracoabdominal Aorta. Circulation: Cardiovascular Interventions. 10, e004292, 2017.
  19. Ogita M, Suwa S, Ebina H, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Hokimoto S, Funayama H, Kokubu N, Kozuma K, Uemura S, Toubaru T, Saku K, Oshima S, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET investigators. Off-hours presentation does not affect in-hospital mortality of Japanese patients with acute myocardial infarction: J-MINUET substudy. Journal of Cardiology. 70, 553-558, 2017.
  20. Ohuchi H, Miyazaki A, Negishi J, Hayama Y, Nakai M, Nishimura K, Ichikawa H, Shiraishi I, Yamada O. Hemodynamic determinants of mortality after Fontan operation. American Heart Journal. 189, 9-18, 2017.
  21. Shimahara Y, Fujita T, Kobayashi J, Asaumi Y, Kanzaki S, Nishimura K, Nakai M, Nakajima H. Optimal target vessel selection for composite and sequential radial artery grafting with an in situ internal thoracic artery. Journal of Cardiac Surgery. 32, 613-620, 2017.
  22. Taniguchi Y, Miyazaki A, Sakaguchi H, Hayama Y, Ebishima N, Negishi J, Noritake K, Miyamoto Y, Shimizu W, Aiba T, Ohuchi H. Prominent QTc prolongation in a patient with a rare variant in the cardiac ryanodine receptor gene. Heart and Vessels. 32, 229-233, 2017.
  23. Tatsumi Y, Morimoto A, Asayama K, Sonoda N, Miyamatsu N, Ohno Y, Miyamoto Y, Izawa S, Ohkubo T. Association between alcohol consumption and incidence of impaired insulin secretion and insulin resistance in Japanese: The Saku study. Diabetes Research and Clinical Practice. 135, 11-17, 2017.
  24. Tatsumi Y, Nakao YM, Masuda I, Higashiyama A, Takegami M, Nishimura K, Watanabe M, Ohkubo T, Okamura T, Miyamoto Y. Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: a cross-sectional study in Japan. BMJ Open. 7, e013831, 2017.
  25. Tomari S, Yokota C, Nishimura K, Hino T, Ohyama S, Arimizu T, Wada S, Ohnishi H, Toyoda K, Minematsu K. Effects of school-based intervention by emergency medical technicians on students and their parents: a community-based prospective study of the Akashi project. BMJ Open. 7, e016780, 2017.
  26. Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Diabetes and lifetime risk of stroke and subtypes in an urban middle-aged population. Journal of Diabetes and Its Complications. 31, 831-835, 2017.
  27. Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Diabetes and lifetime risk of coronary heart disease. Primary Care Diabetes. 11, 461-466, 2017.
  28. Watanabe T, Seguchi O, Yanase M, Fujita T, Murata Y, Sato T, Sunami H, Nakajima S, Kataoka Y, Nishimura K, Hisamatsu E, Kuroda K, Okada N, Hori Y, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T. Donor-Transmitted Atherosclerosis Associated With Worsening Cardiac Allograft Vasculopathy After Heart Transplantation: Serial Volumetric Intravascular Ultrasound Analysis. Transplantation. 101, 1310-1319, 2017.
  29. Kamitani T, Yamamoto Y, Kurita N, Yamazaki S, Fukuma S, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S. Longitudinal association between subjective fatigue and future falls in community-dwelling older adults: the Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study (LOHAS). Journal of Aging and Health. Epub, 2017.