予防健診部
研究活動の概要

　循環器病の予防の為には循環器病の発症要因を明らかにし、それを用いた予防法を開発することが必要である。そのために、予防健診部では主に、吹田研究から多くのエビデンスを創出してきた。2017年は心房細動の発症リスク（Kokubo Y, et al. Circulation Journal 2017; 81(11): 1580-1588.）、糖尿病による冠動脈疾患および脳卒中のそれぞれ生涯罹患リスク（Turin TC, et al. Prim Care Diabetes. 2017; 11(5): 461-466.; Turin TC, et al. J Diabetes Complications. 2017; 31(5): 831-835.）、都市部一般住民におけるメタボリックシンドロームと歯周病の関連（Kikui M, et al. J Atheroscler Thromb 2017; 24(5): 495-507.; Kikui M, et al. J Dent. 2017; 56: 53-57.）、出生時体重と心血管病リスクとの関連（Katsuragi S, et al. J Obstet Gynaecol Res. 2017; 43(6): 1001-1007.）などを報告した。

研究業績
  1. GBD 2015 Healthcare Access and Quality Collaborators. Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet. 390, 231-266, 2017.
  2. GBD 2015 Neurological Disorders Collaborator Group. Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Neurology. 16, 877-897, 2017.
  3. Forouzanfar MH, Liu P, Roth GA, Ng M, Biryukov S, Marczak L, Alexander L, Estep K, Abate KH, Akinyemiju TF, Ali R, Alvis-Guzman N, Azzopardi P, Banerjee A, Barnighausen T, Basu A, Bekele T, Bennett DA, Biadgilign S, Catala-Lopez F, Feigin VL, Fernandes JC, Fischer F, Gebru AA, Gona P, Gupta R, Hankey GJ, Jonas JB, Judd SE, Khang YH, Khosravi A, Kim YJ, Kimokoti RW, Kokubo Y, Kolte D, Lopez A, Lotufo PA, Malekzadeh R, Melaku YA, Mensah GA, Misganaw A, Mokdad AH, Moran AE, Nawaz H, Neal B, Ngalesoni FN, Ohkubo T, Pourmalek F, Rafay A, Rai RK, Rojas-Rueda D, Sampson UK, Santos IS, Sawhney M, Schutte AE, Sepanlou SG, Shifa GT, Shiue I, Tedla BA, Thrift AG, Tonelli M, Truelsen T, Tsilimparis N, Ukwaja KN, Uthman OA, Vasankari T, Venketasubramanian N, Vlassov VV, Vos T, Westerman R, Yan LJL, Yano Y, Yonemoto N, Zaki MES, Murray CJL. Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015. JAMA: Journal of the American Medical Association. 317, 165-182, 2017.
  4. GBD 2016 SDG Collaborators. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016. Lancet. 390, 1423-1459, 2017.
    5. "
  5. GBD 2016 Disease and Injury Incidence and Prevalence Collaborators . Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 390, 1211-1259, 2017.
    6. "
  6. GBD 2016 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 390, 1260-1344, 2017.
  7. Hoashi T, Kitano M, Kagisaki K, Ichikawa H. Successful Biventricular Conversion Late After Primary One and One-Half Ventricle Repair. Annals of Thoracic Surgery. 103, E447-E448, 2017.
  8. Hoashi T, Yazaki S, Kagisaki K, Kitano M, Shimada M, Shiraishi I, Ichikawa H. Importance of multidisciplinary management for pulmonary atresia, ventricular septal defect, major aorto-pulmonary collateral arteries and completely absent central pulmonary arteries. General Thoracic and Cardiovascular Surgery. 65, 337-342, 2017.
  9. Ishibashi K, Aiba T, Kamiya C, Miyazaki A, Sakaguchi H, Wada M, Nakajima I, Miyamoto K, Okamura H, Noda T, Yamauchi T, Itoh H, Ohno S, Motomura H, Ogawa Y, Goto H, Minami T, Yagihara N, Watanabe H, Hasegawa K, Terasawa A, Mikami H, Ogino K, Nakano Y, Imashiro S, Fukushima Y, Tsuzuki Y, Asakura K, Yoshimatsu J, Shiraishi I, Kamakura S, Miyamoto Y, Yasuda S, Akasaka T, Horie M, Shimizu W, Kusano K. Arrhythmia risk and β-blocker therapy in pregnant women with long QT syndrome. Heart. 103, 1374-1379, 2017.
  10. Ishihara M, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Fujino M, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Funayama H, Kokubu N, Kozuma K, Tobaru T, Oshima S, Nakai M, Nishimura K, Miyamoto Y, Ogawa H; J-MINUET Investigators. Long-Term Outcomes of Non-ST-Elevation Myocardial Infarction Without Creatine Kinase Elevation - The J-MINUET Study. Circulation Journal. 81, 958-965, 2017.
  11. Katsuragi S, Okamura T, Kokubo Y, Ikeda T, Miyamoto Y. Birthweight and cardiovascular risk factors in a Japanese general population. The Journal of Obstetrics and Gynaecology Research. 43, 1001-1007, 2017.
  12. Kido T, Hoashi T, Kagisaki K, Ichikawa H. Staged repair of hemitruncus without prosthetic material. Asian Cardiovascular & Thoracic Annals. 25, 55-57, 2017.
  13. Kido T, Hoashi T, Shimada M, Ohuchi H, Kurosaki K, Ichikawa H. Clinical outcomes of early scheduled Fontan completion following Kawashima operation. General Thoracic and Cardiovascular Surgery. 65, 692-697, 2017.
  14. Kikui M, Kokubo Y, Ono T, Kida M, Kosaka T, Yamamoto M, Watanabe M, Maeda Y, Miyamoto Y. Relationship between Metabolic Syndrome Components and Periodontal Disease in a Japanese General Population: the Suita Study. Journal of Atherosclerosis and Thrombosis. 24, 495-507, 2017.
  15. Kikui M, Ono T, Kokubo Y, Kida M, Kosaka T, Yamamoto M, Nokubi T, Watanabe M, Maeda Y, Miyamoto Y. Relationship between metabolic syndrome and objective masticatory performance in a Japanese general population: The Suita study. Journal of Dentistry. 56, 53-57, 2017.
  16. Kokubo Y, Matsumoto C. Hypertension Is a Risk Factor for Several Types of Heart Disease: Review of Prospective Studies. Advances in Experimental Medicine and Biology. 956, 419-426, 2017.
  17. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kusano K, Miyamoto Y. Development of a Basic Risk Score for Incident Atrial Fibrillation in a Japanese General Population ― The Suita Study ―. Circulation Journal. 81, 1580-1588, 2017.
  18. Kuji S, Kosuge M, Kimura K, Nakao K, Ozaki Y, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Hirohata A, Morita Y, Inoue T, Nishimura K, Miyamoto Y, Ishihara M; J-MINUET Investigators. Impact of Acute Kidney Injury on In-Hospital Outcomes of Patients With Acute Myocardial Infarction - Results From the Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) Substudy. Circulation Journal. 81, 733-739, 2017.
  19. Matsuda H, Fukushima N, Ichikawa H, Sawa Y. Orthotropic heart transplantation for adult congenital heart disease: a case with heterotaxy and dextrocardia. General Thoracic and Cardiovascular Surgery. 65, 47-51, 2017.
  20. Matsuda H, Ichikawa H, Ueno T, Sawa Y. Heart transplantation for adults with congenital heart disease: current status and future prospects. General Thoracic and Cardiovascular Surgery. 65, 309-320, 2017.
  21. Miida T, Nishimura K, Hirayama S, Miyamoto Y, Nakamura M, Masuda D, Yamashita S, Ushiyama M, Komori T, Fujita N, Yokoyama S, Teramoto T. Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State. Journal of Atherosclerosis and Thrombosis. 24, 583-599, 2017.
  22. Miyazaki A, Sakaguchi H, Matsumura Y, Hayama Y, Noritake K, Negishi J, Tsuda E, Miyamoto Y, Aiba T, Shimizu W, Kusano K, Shiraishi I, Ohuchi H. Mid-Term Follow-up of School-Aged Children With Borderline Long QT Interval. Circulation Journal. 81, 726-732, 2017.
  23. Miyazaki A, Sakaguchi H, Noritake K, Hayama Y, Negishi J, Kagisaki K, Yasuda K, Ichikawa H, Ohuchi H. Interventricular dyssynchrony in a patient with a biventricular physiology and a systemic right ventricle. Heart and Vessels. 32, 234-239, 2017.
  24. Nozue M, Shimazu T, Sasazuki S, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented Soy Product Intake Is Inversely Associated with the Development of High Blood Pressure: The Japan Public Health Center-Based Prospective Study. The Journal of Nutrition. 147, 1749-1756, 2017.
  25. Ohuchi H, Miyazaki A, Negishi J, Hayama Y, Nakai M, Nishimura K, Ichikawa H, Shiraishi I, Yamada O. Hemodynamic determinants of mortality after Fontan operation. American Heart Journal. 189, 9-18, 2017.
  26. Ohuchi H, Negishi J, Hayama Y, Miyazaki A, Shiraishi I, Ichikawa H. Renal resistive index reflects Fontan pathophysiology and predicts mortality. Heart. 103, 1631-1637, 2017.
  27. GBD 2015 Tobacco Collaborators. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015. Lancet. 389, 1885-1906, 2017.
  28. Saito I, Yamagishi K, Kokubo Y, Yatsuya H, Iso H, Sawada N, Inoue M, Tsugane S. Association of high-density lipoprotein cholesterol concentration with different types of stroke and coronary heart disease: The Japan Public Health Center-based prospective (JPHC) study. Atherosclerosis. 265, 147-154, 2017.
  29. Sato H, Kamiya CA, Sawada M, Horiuchi C, Tsuritani M, Iwanaga N, Ohuchi H, Shiraishi I, Ichikawa H, Yoshimatsu J. Changes in echocardiographic parameters and hypertensive disorders in pregnancies of women with aortic coarctation. Pregnancy Hypertension. 10, 46-50, 2017.
  30. Shimada M, Hoashi T, Tazuke Y, Kagisaki K, Ichikawa H. Simultaneous repair of Morgagni hernia and ventricular septal defect. Pediatrics International. 59, 367-368, 2017.
  31. Tatsumi Y, Nakao YM, Masuda I, Higashiyama A, Takegami M, Nishimura K, Watanabe M, Ohkubo T, Okamura T, Miyamoto Y. Risk for metabolic diseases in normal weight individuals with visceral fat accumulation: a cross-sectional study in Japan. BMJ Open. 7, e013831, 2017.
  32. Thomas B, Matsushita K, Abate KH, Al-Aly Z, Arnlov J, Asayama K, Atkins R, Badawi A, Ballew SH, Banerjee A, Barregard L, Barrett-Connor E, Basu S, Bello AK, Bensenor I, Bergstrom J, Bikbov B, Blosser C, Brenner H, Carrero JJ, Chadban S, Cirillo M, Cortinovis M, Courville K, Dandona L, Dandona R, Estep K, Fernandes J, Fischer F, Fox C, Gansevoort RT, Gona PN, Gutierrez OM, Hamidi S, Hanson SW, Himmelfarb J, Jassal SK, Jee SH, Jha V, Jimenez-Corona A, Jonas JB, Kengne AP, Khader Y, Khang YH, Kim YJ, Klein B, Klein R, Kokubo Y, Kolte D, Lee K, Levey AS, Li Y, Lotufo P, El Razek HMA, Mendoza W, Metoki H, Mok Y, Muraki I, Muntner PM, Noda H, Ohkubo T, Ortiz A, Perico N, Polkinghorne K, Al-Radaddi R, Remuzzi G, Roth G, Rothenbacher D, Satoh M, Saum KU, Sawhney M, Schottker B, Shankar A, Shlipak M, Silva DAS, Toyoshima H, Ukwaja K, Umesawa M, Vollset SE, Warnock DG, Werdecker A, Yamagishi K, Yano Y, Yonemoto N, Zaki MES, Naghavi M, Forouzanfar MH, Murray CJL, Coresh J, Vos T; Global Burden of Disease 2013 GFR Collaborators; CKD Prognosis Consortium; Global Burden of Disease Genitourinary Expert Group. Global Cardiovascular and Renal Outcomes of Reduced GFR. Journal of the American Society of Nephrology. 28, 2167-2179, 2017.
  33. Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Diabetes and lifetime risk of stroke and subtypes in an urban middle-aged population. Journal of Diabetes and Its Complications. 31, 831-835, 2017.
  34. Turin TC, Okamura T, Rumana N, Afzal AR, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Diabetes and lifetime risk of coronary heart disease. Primary Care Diabetes. 11, 461-466, 2017.
  35. Watanabe T, Seguchi O, Yanase M, Fujita T, Murata Y, Sato T, Sunami H, Nakajima S, Kataoka Y, Nishimura K, Hisamatsu E, Kuroda K, Okada N, Hori Y, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T. Donor-Transmitted Atherosclerosis Associated With Worsening Cardiac Allograft Vasculopathy After Heart Transplantation: Serial Volumetric Intravascular Ultrasound Analysis. Transplantation. 101, 1310-1319, 2017.
  36. Yamagata K, Doi A, Kawata H, Makimoto H, Yokoyama T, Inoue Y, Okamura H, Noda T, Shimizu W, Aihara N, Maki T, Kamakura S, Kusano K, Satomi K. Persistent tachycardia within isolated pulmonary veins during atrial fibrillation ablation. Heart and Vessels. 32, 1006-1012, 2017.
  37. 宮本 恵宏. わが国における肥満・肥満症の推移. The Lipid. 28, 347-353, 2017.
  38. 真殿 亜季, 由田 克士, 栗林 徹, 奥田 奈賀子, 中村 幸志, 渡邉 至, 樺山 舞, 神出 計, 三浦 克之, 板井 一好, 岡山 明. 特定保健指導における1年後・2年後の減量達成に関連する生活習慣. 人間ドック. 32, 456-462, 2017.