予防医学・疫学情報部
研究活動の概要

　我が国では循環器病による死亡率は減少傾向に なっているが、残念ながら循環器病の発症率は減少していない。循環器病の対策を立てるにあたっては循環器病のリスクを解明することが必要である。予防医学・疫学情報部は、予防健診部や循環器病統合情報センターとともに循環器に関する疫学研究や情報科学を行う。

　多施設コホート研究であるEPOCH-JAPAN研究で日本動脈硬化学会のリスクチャートの妥当性の検証を行った。（Nakai M, Miyamoto Y, et al. J Atheroscler Thromb. 2016;23(2):176-95.）また、神戸スタディーにて女性の体重減少と骨密度低下との関連を報告した。（Tatsumi Y, Higashiyama A, Miyamoto Y, et al. J Epidemiol. 2016; 26(11): 572-578.）さらに、遺伝子検査室とともに遺伝子解析研究についても行っている。(Kawata H, Miyamoto Y, et al. Circ J. 2016;80(9):1907-15.)

研究業績
  1. Nakamura M, Iso H, Kitamura A, Imano H, Noda H, Kiyama M, Sato S, Yamagishi K, Nishimura K, Nakai M, Vesper HW, Teramoto T, Miyamoto Y. Comparison between the triglycerides standardization of routine methods used in Japan and the chromotropic acid reference measurement procedure used by the CDC Lipid Standardization Programme. Annals of Clinical Biochemistry. 53, 632-639, 2016.
  2. Sawano M, Kohsaka S, Okamura T, Inohara T, Sugiyama D, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okud N, Murakami Y, Ohkubo T, Fujiyoshi A, Miura K, Okayama A, Ueshima H. Validation of the european SCORE risk chart in the healthy middle-aged Japanese. Atherosclerosis. 252, 116-121, 2016.
  3. Namiki S, Mitsuzuka K, Kaiho Y, Yamada S, Adachi H, Yamashita S, Saito H, Ito A, Nakagawa H, Takegami M, Arai Y. Serum luteinizing hormone concentration is significantly associated with recovery of urinary function after radical prostatectomy. BJU International. 117, 450-455, 2016.
  4. Wilde AAM, Moss AJ, Kaufman ES, Shimizu W, Peterson DR, Benhorin J, Lopes C, Towbin JA, Spazzolini C, Crotti L, Zareba W, Goldenberg I, Kanters JK, Robinson JL, Qi M, Hofman N, Tester DJ, Bezzina CR, Alders M, Aiba T, Kamakura S, Miyamoto Y, Andrews ML, McNitt S, Polonsky B, Schwartz PJ, Ackerman MJ. Clinical Aspects of Type 3 Long-QT Syndrome An International Multicenter Study. Circulation. 134, 872-882, 2016.
  5. Yasuda S, Nakao K, Nishimura K, Miyamoto Y, Sumita Y, Shishido T, Anzai T, Tsutsui H, Ito H, Komuro I, Saito Y, Ogawa H. The Current Status of Cardiovascular Medicine in Japan - Analysis of a Large Number of Health Records From a Nationwide Claim- Based Database, JROAD-DPC. Circulation Journal. 80, 2327-2335, 2016.
  6. Kawata H, Ohno S, Aiba T, Sakaguchi H, Miyazaki A, Sumitomo N, Kamakura T, Nakajima I, Inoue YY, Miyamoto K, Okamura H, Noda T, Kusano K, Kamakura S, Miyamoto Y, Shiraishi I, Horie M, Shimizu W. Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) Associated With Ryanodine Receptor (RyR2) Gene Mutations - Long-Term Prognosis After Initiation of Medical Treatment. Circulation Journal. 80, 1907-1915, 2016.
  7. Funasako M, Aiba T, Ishibashi K, Nakajima I, Miyamoto K, Inoue Y, Okamura H, Noda T, Kamakura S, Anzai T, Noguchi T, Yasuda S, Miyamoto Y, Kusano KF, Ogawa H, Shimizu W. Pronounced Shortening of QT Interval With Mexiletine Infusion Test in Patients With Type 3 Congenital Long QT Syndrome. Circulation Journal. 80, 340-345, 2016.
  8. Ichikawa M, Aiba T, Ohno S, Shigemizu D, Ozawa J, Sonoda K, Fukuyama M, Itoh H, Miyamoto Y, Tsunoda T, Makiyama T, Tanaka T, Shimizu W, Horie M. Phenotypic Variability of ANK2 Mutations in Patients With Inherited Primary Arrhythmia Syndromes. Circulation Journal. 80, 2435-2442, 2016.
  9. Miyagi T, Asaumi Y, Nishimura K, Nakashima T, Sakamoto H, Nakao K, Kanaya T, Nagai T, Shimabukuro Y, Miyamoto Y, Fujita T, Kusano K, Anzai T, Kobayashi J, Noguchi T, Ogawa H, Yasuda S. Validation of the Coronary Artery Bypass Graft SYNTAX Score (Synergy Between Percutaneous Coronary Intervention With Taxus) as a Prognostic Marker for Patients With Previous Coronary Artery Bypass Graft Surgery After Percutaneous Coronary Intervention. Circulation-Cardiovasucular Interventions. 9, e003459, 2016.
  10. Makino H, Tanaka A, Hosoda H, Koezuka R, Tochiya M, Ohata Y, Tamanaha T, Miyamoto Y, Kangawa K, Kishimoto I. Effect of basal insulin therapy on vascular endothelial function and adipokine profiles in people with Type 2 diabetes. Diabetic Medicine. 33, 1737-1743, 2016.
  11. Koizumi A, Sasano T, Kimura W, Miyamoto Y, Aiba T, Ishikawa T, Nogami A, Fukamizu S, Sakurada H, Takahashi Y, Nakamura H, Ishikura T, Koseki H, Arimura T, Kimura A, Hirao K, Isobe M, Shimizu W, Miura N, Furukawa T. Genetic defects in a His-Purkinje system transcription factor, IRX3, cause lethal cardiac arrhythmias. European Heart Journal. 37, 1469-1475, 2016.
  12. Nagai T, Nishimura K, Honma T, Higashiyama A, Sugano Y, Nakai M, Honda S, Iwakami N, Okada A, Kawakami S, Kanaya T, Asaumi Y, Aiba T, Nishida Y, Kubota Y, Sugiyama D, Okamura T, Noguchi T, Kusano K, Ogawa H, Yasuda S, Anzai T. Prognostic significance of endogenous erythropoietin in long-term outcome of patients with acute decompensated heart failure. European Journal of Heart Failure. 18, 803-813, 2016.
  13. Miyamoto K, Aiba T, Arihiro S, Watanabe M, Kokubo Y, Ishibashi K, Hirose S, Wada M, Nakajima I, Okamura H, Noda T, Nagatsuka K, Noguchi T, Anzai T, Yasuda S, Ogawa H, Kamakura S, Shimizu W, Miyamoto Y, Toyoda K, Kusano K. Impact of renal function deterioration on adverse events during anticoagulation therapy using non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Heart and Vessels. 31, 1327-1336, 2016.
  14. Kogure M, Tsuchiya N, Hozawa A, Nakaya N, Nakamura T, Miyamatsu N, Tanaka H, Wakabayashi I, Higashiyama A, Okuda N, Takashima N, Fujiyoshi A, Kadota A, Ohkubo T, Okamura T, Ueshima H, Okayama A, Miura K. Does the flushing response modify the relationship between alcohol intake and hypertension in the Japanese population? NIPPON DATA2010. Hypertension Research. 39, 670-679, 2016.
  15. Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao YM, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Impact of hypertension on the lifetime risk of coronary heart disease. Hypertension Research. 39, 548-551, 2016.
  16. Watanabe T, Seguchi O, Nishimura K, Fujita T, Murata Y, Yanase M, Sato T, Sunami H, Nakajima S, Hisamatsu E, Sato T, Kuroda K, Hieda M, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T. Suppressive effects of conversion from mycophenolate mofetil to everolimus for the development of cardiac allograft vasculopathy in maintenance of heart transplant recipients. International Journal of Cardiology. 203, 307-314, 2016.
  17. Yokota C, Sawamura T, Watanabe M, Kokubo Y, Fujita Y, Kakino A, Nakai M, Toyoda K, Miyamoto Y, Minematsu K. High Levels of Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in Acute Stroke: An Age- and Sex-Matched Cross-Sectional Study. Journal of Atherosclerosis and Thrombosis. 23, 1222-1226, 2016.
  18. Nakai M, Miyamoto Y, Higashiyama A, Murakami Y, Nishimura K, Yatsuya H, Saitoh S, Sakata K, Iso H, Miura K, Ueshima H, Okamura T. Calibration between the Estimated Probability of the Risk Assessment Chart of Japan Atherosclerosis Society and Actual Mortality Using External Population: Evidence for Cardiovascular Prevention from Observational Cohorts in Japan (EPOCH-JAPAN). Journal of Atherosclerosis and Thrombosis. 23, 176-195, 2016.
  19. Kuwabara K, Harada S, Sugiyama D, Kurihara A, Kubota Y, Higashiyama A, Hirata T, Nishida Y, Kawasaki M, Takebayashi T, Okamura T. Relationship between Non-High-Density Lipoprotein Cholesterol and Low-Density Lipoprotein Cholesterol in the General Population: the KOBE Study and Tsuruoka Metabolomic Cohort Study. Journal of Atherosclerosis and Thrombosis. 23, 477-490, 2016.
  20. Ohta N, Hori M, Takahashi A, Ogura M, Makino H, Tamanaha T, Fujiyama H, Miyamoto Y, Harada-Shiba M. Proprotein convertase subtilisin/kexin 9 V41 variant with LDLR mutations modifies the phenotype of familial hypercholesterolemia. Journal of Clinical Lipidology. 10, 547-555, 2016.
  21. Tatsumi Y, Higashiyama A, Kubota Y, Sugiyama D, Nishida Y, Hirata T, Kadota A, Nishimura K, Imano H, Miyamatsu N, Miyamoto Y, Okamura T. Underweight Young Women Without Later Weight Gain Are at High Risk for Osteopenia After Midlife: The KOBE Study. Journal of Epidemiology. 26, 572-578, 2016.
  22. Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Hypertension and lifetime risk of stroke. Journal of Hypertension. 34, 116-122, 2016.
  23. Kosaka T, Ono T, Kida M, Kikui M, Yamamoto M, Yasui S, Nokubi T, Maeda Y, Kokubo Y, Watanabe M, Miyamoto Y. A multifactorial model of masticatory performance: the Suita study. Journal of Oral Rehabilitation. 43, 340-347, 2016.
  24. Yagihara N, Watanabe H, Barnett P, Duboscq-Bidot L, Thomas AC, Yang P, Ohno S, Hasegawa K, Kuwano R, Chatel S, Redon R, Schott JJ, Probst V, Koopmann TT, Bezzina CR, Wilde AAM, Nakano Y, Aiba T, Miyamoto Y, Kamakura S, Darbar D, Donahue BS, Shigemizu D, Tanaka T, Tsunoda T, Suda M, Sato A, Minamino T, Endo N, Shimizu W, Horie M, Roden DM, Makita N. Variants in the SCN5A Promoter Associated With Various Arrhythmia Phenotypes. Journal of the American Heart Association. 5, e003644, 2016.
  25. Kurita N, Horie S, Yamazaki S, Otani K, Sekiguchi M, Onishi Y, Takegami M, Ono R, Konno S, Kikuchi S, Fukuhara S. Low Testosterone Levels and Reduced Kidney Function in Japanese Adult Men: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study. Journal of the American Medical Directors Association. 17, 371.e1-371.e6, 2016.
  26. Sawano M, Kohsaka S, Okamura T, Inohara T, Sugiyama D, Shiraishi Y, Watanabe M, Nakamura Y, Higashiyama A, Kadota A, Okuda N, Murakami Y, Ohkubo T, Fujiyoshi A, Miura K, Okayama A, Ueshima H. Independent Prognostic Value of Single and Multiple Non-Specific 12-Lead Electrocardiographic Findings for Long-Term Cardiovascular Outcomes: A Prospective Cohort Study. PLoS One. 11, e0157563, 2016.
  27. Hachiya R, Shiihashi T, Shirakawa I, Iwasaki Y, Matsumura Y, Oishi Y, Nakayama Y, Miyamoto Y, Manabe I, Ochi K, Tanaka M, Goda N, Sakai J, Suganami T, Ogawa Y. The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages. Scientific Reports. 6, 28845, 2016.
  28. Tano T, Ono K, Hiratsuka Y, Otani K, Sekiguchi M, Konno S, Kikuchi S, Onishi Y, Takegami M, Yamada M, Fukuhara S, Murakami A. Retinal vessel diameters in a Japanese population: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study. Acta Ophthalmologica. 94, e432-e441, 2016.
  29. Okayama A, Okuda N, Miura K, Okamura T, Hayakawa T, Akasaka H, Ohnishi H, Saitoh S, Arai Y, Kiyohara Y, Takashima N, Yoshita K, Fujiyoshi A, Zaid M, Ohkubo T, Ueshima H, NIPPON DATA80 Research Group. Dietary sodium-to-potassium ratio as a risk factor for stroke, cardiovascular disease and all-cause mortality in Japan: the NIPPON DATA80 cohort study. BMJ Open. 6, e011632, 2016.
  30. Noguchi T, Yasuda S, Shibata T, Kawakami S, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, Ishibashi-Ueda H, Nishimura K, Miyamoto Y, Kusano K, Anzai T, Goto Y, Ogawa H. Response to Letter Regarding Article, "Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism". Circulation. 133, e379, 2016.
  31. Nakao YM, Ueshima K, Yasuno S, Sasayama S. Effects of nocturnal oxygen therapy in patients with chronic heart failure and central sleep apnea: CHF-HOT study. Heart and Vessels. 31, 165-172, 2016.
  32. Hirata T, Sugiyama D, Nagasawa SY, Murakami Y, Saitoh S, Okayama A, Iso H, Irie F, Sairenchi T, Miyamoto Y, Yamada M, Ishikawa S, Miura K, Ueshima H, Okamura T. A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan. European Journal of Epidemiology. Epub, 2016.
  33. 中尾 葉子, 宮本 恵宏. 肥満症の診断基準に必須な合併症と治療法. 内分泌・糖尿病・代謝内科. 43, 282-284, 2016.
  34. 永井 雅人, 大久保 孝義, 門田 文, 宮川 尚子, 村上 義孝, 高嶋 直敬, 奥田 奈賀子, 東山 綾, 早川 岳人, 藤 吉郎, 中村 好一, 岡村 智教, 上島 弘嗣, 岡山 明, 三浦 克之. 一般国民における循環器疾患危険因子の認知度および危険因子保有と認知度との関連：NIPPON DATA2010. 日本循環器病予防学会誌. 51, 166-175, 2016.
  35. 久保田 芳美, 丸茂 幹雄, 東山 綾, 小西 雅美, 山下 好子, 太城 力良, 岡村 智教, 宮本 恵宏, 若林 一郎. 地域住民における食習慣と動脈硬化危険因子および下肢動脈硬化早期指標との関連 : 篠山研究. 兵庫医科大学医学会雑誌. 41, 109-115, 2016.
  36. Hirata T, Higashiyama A, Kubota Y, Sugiyama D, Kuwabara K, Tatsumi Y, Hirata A, Nishida Y, Kadota A, Imano H, Nishikawa T, Miyamatsu N, Miyamoto Y, Okamuara T. Impact of Flushing Response to the Relationship between Alcohol Consumption and Gamma-glutamyl Transpeptidase : the KOBE study. 日本アルコール・薬物医学会雑誌 . 51, 173-183, 2016.
  37. 竹上 未紗. 睡眠呼吸障害と肥満・減量療法. Medical Rehabilitation . 203, 196-200, 2016.