National Cerebral and Cardiovascular

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Research Institute

Department of Regenerative Medicine and Tissue Engineering

Understanding Mechanisms of Cardiac Regeneration

The capacity for regeneration is extremely limited in mammals, contributing to mortality and morbidity from a host of diseases. Our work focuses on molecular and cellular regulations that are retained in certain animals to control full regeneration of complex structures like the heart, but may be silenced or lost in mammals during evolution. We propose that major therapeutic advances can be made by understanding the mechanism of natural regeneration in zebrafish, a genetically tractable model possessing a spectacular capacity for regeneration, and that fish-like regeneration can be induced in humans to treat cardiovascular diseases.

  • Using genetic approaches to visualize gene expression and cell populations or manipulate gene function in adult zebrafish to understand endogenous mechanisms of heart regeneration
  • Using both regenerative zebrafish and non-regenerative adult mouse models to understand how roadblocks to regeneration can be removed in human hearts

last updated : 2021/10/01

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