National Cerebral and Cardiovascular

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Open Innovation Center

Center for Cerebral and Cardiovascular Disease Information

Member

DirectorYoshitaka Iwanaga MD, PhD
Laboratory ChiefMichikazu Nakai PhD
Makoto Watanabe MD, PhD (concurrent post)
Staff ScientistKoshiro Kanaoka MD, PhD
Shinichi Wada MD, PhD
Reina Tonegawa-Kuji MD
Hisataka Anezaki PhD
Data ManagerYoko Sumita
Yusuke Sasahara PhD

 

Research

We aim to develop and manage the real-world data of cerebral and cardiovascular diseases as well as health care and utilize them for patients and the public widely.
Our objectives and current researches are as follows:
1) to identify the cause of morbidity and other outcomes by collecting the data related to cardiovascular diseases throughout Japan using exceptional data of real-world
2) to investigate common risk factors and solution of both stroke and cardiovascular diseases by collecting the nationwide data
3) to provide the research environments for analyzing the nationwide dataset and giving back the results to the people
4) to formulate registration system and make the detailed information for clinicians
5) to utilize Personal Health Records (PHRs) for more effective prevention of cardiovascular diseases

 

Publication

2021年

  1. Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y. A Novel Risk Stratification System for Ischemic Stroke in Japanese Patients With Non-Valvular Atrial Fibrillation. Circulation Journal. 2021;85:1254-1262
  2. Ogata S, Marume K, Nakai M, Kaichi R, Ishii M, Ikebe S, Mori T, Komaki S, Kusaka H, Toida R, Kurogi K, Iwanaga Y, Yano T, Yamamoto N, Miyamoto Y. Incidence Rate of Acute Coronary Syndrome Including Acute Myocardial Infarction, Unstable Angina, and Sudden Cardiac Death in Nobeoka City for the Super-Aged Society of Japan. Circulation Journal. 2021;85:1722-1730
  3. Yamaguchi T, Nakai M, Yano T, Matsuyama M, Yoshino H, Miyamoto Y, Sumita Y, Matsuda H, Inoue Y, Okita Y, Minatoya K, Ueda Y, Ogino H. Population-based incidence and outcomes of acute aortic dissection in Japan. European Heart Journal: Acute Cardiovascular Care. 2021;10:701-709
  4. Morimoto Y, Ohuchi H, Kurosaki K, Nakai M. Exercise-induced hypoxia predicts hypobaric hypoxia during flight in patients after Fontan operation. International Journal of Cardiology. 2021;325:51-55
  5. Ohuchi H, Hayama Y, Nakajima K, Kurosaki K, Shiraishi I, Nakai M. Incidence, Predictors, and Mortality in Patients With Liver Cancer After Fontan Operation. Journal of the American Heart Association. 2021;10:e016617
  6. Takase T, Taniguchi M, Hirano Y, Nakazawa G, Miyazaki S, Iwanaga Y. Sex difference in pulmonary hypertension in the evaluation by exercise echocardiography. Pulmonary Circulation. 2021;11:2045894020988453
  7. Hashimoto S, Kosaka T, Nakai M, Kida M, Fushida S, Kokubo Y, Watanabe M, Higashiyama A, Ikebe K, Ono T, Miyamoto Y. A lower maximum bite force is a risk factor for developing cardiovascular disease: the Suita study. Scientific Reports. 2021;11:7671
  8. Yoneyama K, Nakai M, Higuma T, Teramoto K, Watanabe M, Kaihara T, Sumita Y, Miyamoto Y, Yasuda S, Ishibashi Y, Izumo M, Tanabe Y, Harada T, Ogawa H, Akashi YJ. Weather temperature and the incidence of hospitalization for cardiovascular diseases in an aging society. Scientific Reports. 2021;11:10863
  9. Hamaguchi T, Iwanaga Y, Nakai M, Morita Y, Inoko M. Clinical significance of atrial fibrillation status in patients with percutaneous coronary intervention. CJC open. 2021;3:1357-1364.
  10. Okune M, Yasuda M, Soejima N, Kakehi K, Kawamura T, Kurita T, Nakazawa G, Iwanaga Y. Not baseline atrial fibrillation but new-onset atrial fibrillation and loss of left atrial function are essential for predicting poor outcomes in nonischemic cardiomyopathy. Front Cardiovasc Med. 2021;8:781125
  11. Nakai M, Iwanaga Y, Sumita Y, Kanaoka K, Kawakami R, Ishii M, Uchida K, Nagano N, Nakayama T, Nishimura K, Tsuchihashi K, Kimura K, Saito Y, Tsujita K, Ogawa H, Miyamoto Y, Yasuda S; on the behalf of the JROAD Investigators. Validation of Acute Myocardial Infarction and Heart Failure Diagnoses in Hospitalized Patients With the Nationwide Claim-Based JROAD-DPC Database. Circ Rep. 2021;3:131-136
  12. Ogino H, Okita Y, Uchida N, Kato M, Miyamoto S, Matsuda H, Nakai M. Comparative study of Japanese frozen elephant trunk device for open aortic arch repairs. J Thorac Cardiovasc Surg. 2021;S0022-5223(21)00560-2
  13. Kobayashi T, Kokubo Y, Higashiyama A, Watanabe M, Nakao YM, Kamakura S, Kusano K, Miyamoto Y. Uric acid and incident atrial fibrillation of 14 years population-based cohort study: The Suita Study. Journal of Arrhythmia. 2021;37:1215-1219
  14. Kataoka Y, Harada-Shiba M, Hori M, Watanabe M, Kokubo Y, Noguchi T, Yasuda S, Miyamoto Y. Circulating Furin-Cleaved Proprotein Convertase Subtilisin/Kexin Type 9Concentration Predicts Future Coronary Events in Japanese Subjects. JACC:Asia. 2021;1:360-368
  15. Higashiyama A, Wakabayashi I, Okamura T, Kokubo Y, Watanabe M, Takegami M, Honda-Kohmo K, Okayama A, Miyamoto Y. The Risk of Fasting Triglycerides and its Related Indices for Ischemic Cardiovascular Diseases in Japanese Community Dwellers: the Suita Study. Journal of Atherosclerosis and Thrombosis. 2021;28:1275-1288
  16. Wada S, Kamei M, Uehara N, Tsuzaki K, Hamano T. Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies: A Case Report. Internal Medicine. 2021;60:1607-1610
  17. Kido K, Wada S, Oka Y, Terada Y, Inoue M, Hamano T. Multifocal motor neuropathy and visual pathway impairment: A case report. Clinical Neurophysiology Practice. 2021;6:191-193
  18. Kanaoka K, Soeda T, Terasaki S, Nishioka Y, Myojin T, Kubo S, Okada K, Noda T, Watanabe M, Kawakami R, Sakata Y, Imamura T, Saito Y. Current Status and Effect of Outpatient Cardiac Rehabilitation After Percutaneous Coronary Intervention in Japan. Circulation Report. 2021;3:122–130
  19. Tonegawa-Kuji R, Oyama-Manabe N, Aoki R, Nagayoshi S, Pawhay CMH, Kusano K and Nakajima T. T2-weighted short-tau-inversion-recovery imaging reflects disease activity of cardiac sarcoidosis. Open heart. 2021;8:e001728
  20. Tonegawa-Kuji R, Yamagata K, Suzuki S, Miyazaki Y, Ueda N and Kusano K. Prompt recognition and successful aspiration of a left atrial thrombus under intracardiac echocardiography guidance during radiofrequency catheter ablation for atrial tachycardia. Europace. 2021;23:1527

 

2020年

  1. Kanaoka K, Okayama S, Terasaki S, Nakano T, Ishii M, Nakai M, Onoue K, Nishimura K, Yasuda S, Tsujita K, Kawakami R, Miyamoto Y, Tsutsui H, Komuro I, Ogawa H, Saito Y. Role of climatic factors in the incidence of Takotsubo syndrome: A nationwide study from 2012 to 2016. ESC Heart Failure. 2020;7: 2629-2636
  2. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Nagai T, Anzai T, Sakata Y, Ogino H. Impact of Endovascular Repair on the Outcomes of Octogenarians with Ruptured Abdominal Aortic Aneurysms: A Nationwide Japanese Study. European Journal of Vascular and Endovascular Surgery. 2020;59:219-225
  3. Okumura K, Tomita H, Nakai M, Kodani E, Akao M, Suzuki S, Hayashi K, Sawano M, Goya M, Yamashita T, Fukuda K, Ogawa H, Tsuda T, Isobe M, Toyoda K, Miyamoto Y, Miyata H, Okamura T, Sasahara Y. Risk Factors Associated With Ischemic Stroke in Japanese Patients With Nonvalvular Atrial Fibrillation. JAMA Network Open. 2020;3:e202881
  4. Sugiyama D, Turin TC, Yeasmin F, Rumana N, Watanabe M, Higashiyama A, Takegami M, Kokubo Y, Okamura T, Miyamoto Y. Hypercholesterolemia and Lifetime Risk of Coronary Heart Disease in the General Japanese Population: Results from the Suita Cohort Study. Journal of Atherosclerosis and Thrombosis. 2020;27:60-70
  5. Katsuragi S, Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ikeda T, Miyamoto Y. The Perinatal Condition Around Birth and Cardiovascular Risk Factors in the Japanese General Population: The Suita Study. Journal of Atherosclerosis and Thrombosis. 2020;27:204-214
  6. Nakai M, Watanabe M, Kokubo Y, Nishimura K, Higashiyama A, Takegami M, Nakao YM, Okamura T, Miyamoto Y. Development of a Cardiovascular Disease Risk Prediction Model Using the Suita Study, a Population-Based Prospective Cohort Study in Japan. Journal of Atherosclerosis and Thrombosis. 2020;27:1160-1175
  7. Higashiyama A, Kokubo Y, Watanabe M, Nakao YM, Okamura T, Okayama A, Miyamoto Y. Echocardiographic Parameters and the Risk of Incident Atrial Fibrillation: The Suita Study. Journal of Epidemiology. 2020;30:183-187
  8. Katsuragi S, Okamura T, Kokubo Y, Watanabe M, Higashiyama A, Ikeda T, Miyamoto Y. Relationship between thin physique at 6 years and metabolic disease risks in middle-aged Japanese women: The Suita study. Journal of Obstetrics and Gynaecology Research. 2020;46:517-526
  9. Kida M, Ono T, Kokubo Y, Yoshimuta Y, Kosaka T, Kikui M, Yamamoto MA, Ikebe K, Maeda Y, Nokubi T, Nishimura K, Watanabe M, Higashiyama A, Miyamoto Y. Decreased masticatory performance is related to increased intima-media thickness in a general urban Japanese population: The Suita study. Journal of Prosthodontic Research. 2020;64:346-353
  10. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Nozato T, Ashikaga T, Nagai T, Anzai T, Sakata Y, Ogino H. Sex differences in Japanese patients with ruptured aortic aneurysms. Journal of Vascular Surgery. 2020;71:1907-1912.e3
  11. Onishi K, Watanabe H, Kakehi K, Ikeda T, Takase T, Yamaji K, Ueno M, Kobuke K, Nakazawa G, Miyazaki S, Iwanaga Y. Determinants and prognostic implications of instantaneous wave-free ratio in patients with mild to intermediate coronary stenosis: Comparison with those of fractional flow reserve. PLOS ONE. 2020;15:e0237275
  12. Kagioka Y, Yasuda M, Okune M, Kakehi K, Kawamura T, Kobuke K, Miyazaki S, Iwanaga Y. Right ventricular involvement is an important prognostic factor and risk stratification tool in suspected cardiac sarcoidosis: analysis by cardiac magnetic resonance imaging. Clin Res Cardiol. 2020;109:988-998
  13. Takase T, Iwanaga Y, Yamashita Y, Morimoto T, Yoshikawa Y, Amano H, Hiramori S, Kim K, Oi M, Kobayashi Y, Nishimoto Y, Watanabe H, Yamaji K, Yasuoka R, Ueno M, Kobuke K, Kimura T, Miyazaki S; COMMAND VTE Registry Investigators. Long-term effects of non-retrieved inferior vena cava filters on recurrences of venous thromboembolism in cancer and non-cancer patients: From the COMMAND VTE registry. Eur J Intern Med. 2020;82:90-96
  14. Yamaguchi T, Nakai M Sumita Y, Miyamoto Y, Matsuda H, Inoue Y, Yoshino H, Okita Y,Minatoya K, Ueda Y, Ogino H. Current status of the management and outcomes of acute aortic dissection in Japan: Analyses of nationwide Japanese Registry of All Cardiac and Vascular Diseases-Diagnostic Procedure Combination data. Eur Heart J Acute Cardiovasc Care. 2020;9:S21-S31
  15. Morimoto Y, Ohuchi H, Kurosaki K, Nakai M. Exercise-induced hypoxia predicts hypobaric hypoxia during flight in patients after Fontan operation. Int J Cardiol. 2020
  16. Yamaguchi T, Nakai M, Sumita Y, Miyamoto Y, Matsuda H, Inoue Y, Yoshino H, Okita Y, Minatoya K, Ueda Y, Ogino H. Impact of structural and process quality indicators on the outcomes of acute aortic dissection. Eur J Cardiothorac Surg. 2020;58:1281-1288

 

2019年

  1. Ohuchi H, Negishi J, Hayama Y, Miike H, Suzuki D, Nakajima K, Konagai N, Iwasa T, Sakaguchi H, Kurosaki K, Nakai M. Abnormal glucose metabolism in patients with Fontan circulation: Unique characteristics and associations with Fontan pathophysiology. American Heart Journal. 2019;216:125-135
  2. Kanaoka K, Okayama S, Nakai M, Sumita Y, Nishimura K, Kawakami R, Okura H, miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Hospitalization Costs for Patients With Acute Congestive Heart Failure in Japan. Circulation Journal. 2019;83:1025-1031
  3. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Tazaki J, Kyuragi R, Kinoshita O, Miyamoto T, Sakata Y, Nozato T, Ogino H. Editor's Choice - Endovascular Repair Versus Surgical Repair for Japanese Patients With Ruptured Thoracic and Abdominal Aortic Aneurysms: A Nationwide Study. European Journal of Vascular and Endovascular Surgery. 2019;57:779-786
  4. Okura H, Saito Y, Soeda T, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Yasuda S, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Hirohata A, Morita Y, Inoue T, Okamura A, Uematsu M, Hirata K, Tanabe K, Shibata Y, Owa M, Tsujita K, Nishimura K, miyamoto Y, Ishihara M, Ishihara M, Hisao O, Kokubu N, Sato T, Inoue T, Oshima S, Funayama H, Kozuma K, Kyono H, Shimizu W, Suwa S, Tanabe K, Tobaru T, Kimura K, Ako J, Owa M, Morita Y, Ozaki Y, Yasuda S, Noguchi T, Fujino M, Morita T, Okamura A, Saito Y, Uematsu M, Okura H, Hirohata A, Nakama Y, Saku K, Hokimoto S, Fujimoto K, Shibata Y, Hirata K, Miyamoto Y, Nishimura K, Nakai M. Frequency and prognostic impact of intravascular imaging-guided urgent percutaneous coronary intervention in patients with acute myocardial infarction: results from J-MINUET. Heart and Vessels. 2019;34:564-571
  5. Yamaguchi T, Nakai M, Sumita Y, Nishimura K, Miyamoto T, Sakata Y, Nozato T, Ogino H. The impact of institutional case volume on the prognosis of ruptured aortic aneurysms: a Japanese nationwide study. Interactive Cardiovascular and Thoracic Surgery. 2019;29:109-116
  6. Ohuchi H, Negishi J, Miike H, Toyoshima Y, Morimoto H, Fukuyama M, Iwasa T, Sakaguchi H, Miyazaki A, Shiraishi I, Kurosaki K, Nakai M. Positive pediatric exercise capacity trajectory predicts better adult Fontan physiology rationale for early establishment of exercise habits. International Journal of Cardiology. 2019;274:80-87
  7. Ogata S, Watanabe M, Kokubo Y, Higashiyama A, Nakao YM, Takegami M, Nishimura K, Nakai M, Kiyoshige E, Hosoda K, Okamura T, Miyamoto Y. Longitudinal Trajectories of Fasting Plasma Glucose and Risks of Cardiovascular Diseases in Middle Age to Elderly People Within the General Japanese Population: The Suita Study. Journal of the American Heart Association. 2019;8:e010628
  8. Kanaoka K, Okayama S, Nakai M, Sumita Y, Onoue K, Soeda T, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y. Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan. Journal of the American Heart Association. 2019;8:e012282
  9. Kawarada O, Nakai M, Nishimura K, Miwa H, Iwasaki Y, Kanno D, Nakama T, Yamamoto Y, Ogata N, Nakamura M, Yasuda S. Antithrombotic therapy after femoropopliteal artery stenting: 12-month results from Japan Postmarketing Surveillance. HEART ASIA. 2019;11:e011114
  10. Yoneyama K, Kanaoka K, Okayama S, Nishimura K, Nakai M, Matsushita K, Miyamoto Y, Kida K, Ishibashi Y, Izumo M, Watanabe M, Soeda T, Okura H, Harada T, Yasuda S, Murohara T, Ogawa H, Saito Y, Akashi YJ. Association between the number of board-certified cardiologists and the risk of in-hospital mortality: a nationwide study involving the Japanese registry of all cardiac and vascular diseases. BMJ Open. 2019;9:e024657

last updated:2022/03/01

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