予防医学・疫学情報部
研究活動の概要

我が国では治療技術の進歩、医薬品や医療機器の開発と普及により、循環器病による死亡率は減少傾向に なっているが、残念ながら循環器病の発症率は減少していない。循環器病の対策を立てるにあたっては循環器病の実態を把握することが肝要である。予防医学・疫学情報部は、予防健診部や循環器病統合情報センターとともに循環器に関する疫学研究や情報科学を行う。

一般住民コホート研究である吹田研究（Tatsumi, Y et al. J Epidemiol. 2015;25(7):489-95.）、神戸研究や篠山研究（Higashiyama A. et al. J Epidemiol. 2015, 25(4), 303-311.）に参画するとともに、多施設コホート研究であるEPOCH-JAPAN研究でメタコホート解析を行っている。2015年は、東日本大震災と阪神淡路大震災の循環器疾患死亡に関する違いを詳細に検討した。（Takegami, M et al. Circ J. 2015;79(5):1000-8. ）

さらに、遺伝子検査室、創薬オミックス解析センターとともに遺伝子解析研究についても行っている。

研究業績
  1. Arakawa J, Hamabe A, Aiba T, Nagai T, Yoshida M, Touya T, Ishigami N, Hisadome H, Katsushika S, Tabata H, Miyamoto Y, Shimizu W. A novel cardiac ryanodine receptor gene (RyR2) mutation in an athlete with aborted sudden cardiac death: a case of adult-onset catecholaminergic polymorphic ventricular tachycardia. Heart and Vessels. 30, 835-840, 2015.
  2. Fukumori N, Yamamoto Y, Takegami M, Yamazaki S, Onishi Y, Sekiguchi M, Otani K, Konno S, Kikuchi S, Fukuhara S. Association between hand-grip strength and depressive symptoms: Locomotive Syndrome and Health Outcomes in Aizu Cohort Study (LOHAS). Age and Ageing. 44, 592-598, 2015.
  3. Higashiyama A, Kubota Y, Marumo M, Konishi M, Yamashita Y, Nishimura K, Fukuda Y, Okamura T, Wakabayashi I. Association Between Serum Long-Chain n-3 and n-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed by Serum Creatinine and Cystatin C Levels in Japanese Community-Dwellers. Journal of Endocrinology. 25, 303-311, 2015.
  4. Hirata T, Higashiyama A, Kubota Y, Nishimura K, Sugiyama D, Kadota A, Nishida Y, Imano H, Nishikawa T, Miyamatsu N, Miyamoto Y, Okamura T. HOMA-IR Values are Associated With Glycemic Control in Japanese Subjects Without Diabetes or Obesity: The KOBE Study. Journal of Endocrinology. 25, 407-414, 2015.
  5. Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabes JP, Carrie A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri M, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B, Katsuda S, Kishimoto I, Lambert G, Makino H, Miyamoto Y, Pichelin M, Yagi K, Yamagishi M, Zair Y, Mellis S, Yancopoulos GD, Stahl N, Mendoza J, Du YL, Hamon S, Krempf M, Swergold GD. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circulation: Cardiovascular Genetics. 8, 823-831, 2015.
  6. Ishihara M, Fujino M, Ogawa H, Yasuda S, Noguchi T, Nakao K, Ozaki Y, Kimura K, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Tsujita K, Nishimura K, Miyamoto Y. Clinical Presentation, Management and Outcome of Japanese Patients With Acute Myocardial Infarction in the Troponin Era - Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET) -. Circulation Journal . 79, 1255-1262, 2015.
  7. Ishikawa H, Miyazaki K, Ikeda T, Murabayashi N, Hayashi K, Kai A, Ishikawa K, Miyamoto Y, Nishimura K, Kono Y, Kusuda S, Fujimura M. The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants. International Journal of Medical Sciences. 12, 295-300, 2015.
  8. Kataoka Y, Yasuda S, Miyamoto Y, Sase K, Kosuge M, Kimura K, Yoshimasa Y, Miyazaki S. Atheroma Progression in Obese Early-stage Diabetic Japanese Patients in Response to Glycemic Control: Sub-analysis from the DIANA Study. Journal of Atherosclerosis and Thrombosis. 22, 697-705, 2015.
  9. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, Watanabe T, Okamura T, Okayama A, Miyamoto Y. Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. American Journal of Hypertension. 28, 1355-1361, 2015.
  10. Kubota Y, Higashiyama A, Imano H, Sugiyama D, Kawamura K, Kadota A, Nishimura K, Miyamatsu N, Miyamoto Y, Okamura T. Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: The KOBE study. The journal of nutrition, health & aging. 19, 719-728, 2015.
  11. Makino H, Miyamoto Y, Kikuchi-Taura A, Soma T, Taguchi A, Kishimoto I. Decreased levels of circulating CD34(+) cells are associated with coronary heart disease in Japanese patients with type 2 diabetes. Journal of Diabetes Investigation. 6, 473-478, 2015.
  12. Maruyama K, Kokubo Y, Yamanaka T, Watanabe M, Iso H, Okamura T, Miyamoto Y. The reasonable reliability of a self-administered food frequency questionnaire for an urban, Japanese, middle-aged population: the Suita study. Nutrition Research. 35, 14-22, 2015.
  13. Matsuzono K, Yokota C, Takekawa H, Okamura T, Miyamatsu N, Nakayama H, Nishimura K, Ohyama S, Ishigami A, Okumura K, Toyoda K, Miyamoto Y, Minematsu K. Effects of Stroke Education of Junior High School Students on Stroke Knowledge of Their Parents Tochigi Project. Stroke. 46, 572-574, 2015.
  14. Miyamoto K, Aiba T, Kimura H, Hayashi H, Ohno S, Yasuoka C, Tanioka Y, Tsuchiya T, Yoshida Y, Hayashi H, Tsuboi I, Nakajima I, Ishibashi K, Okamura H, Noda T, Ishihara M, Anzai T, Yasuda S, Miyamoto Y, Kamakura S, Kusano K, Ogawa H, Horie M, Shimizu W. Efficacy and safety of flecainide for ventricular arrhythmias in patients with Andersen-Tawil syndrome with KCNJ2 mutations. Heart Rhythm. 12, 596-603, 2015.
  15. Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata KI. Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan. Circulation Journal . 79, 2017-2025, 2015.
  16. Nakamura K, Okuda N, Okamura T, Miura K, Nishimura K, Yasumura S, Sakata K, Hidaka H, Okayama A. Alcohol Consumption, Hospitalization and Medical Expenditure: A Large Epidemiological Study on the Medical Insurance System in Japan. Alcohol and Alcoholism. 50, 236-243, 2015.
  17. Nakamura M, Iso H, Kitamura A, Imano H, Kiyama M, Yokoyama S, Kayamori Y, Koyama I, Nishimura K, Nakai M, Dasti M, Vesper HW, Teramoto T, Miyamoto Y. Total cholesterol performance of Abell-Levy-Brodie-Kendall reference measurement procedure: Certification of Japanese in-vitro diagnostic assay manufacturers through CDC's Cholesterol Reference Method Laboratory Network. Clinica Chimica Acta. 445, 127-132, 2015.
  18. Nakamura M, Yokoyama S, Kayamori Y, Iso H, Kitamura A, Okamura T, Kiyama M, Noda H, Nishimura K, Nakai M, Koyama I, Dasti M, Vesper HW, Teramoto T, Miyamoto Y. HDL cholesterol performance using an ultracentrifugation reference measurement procedure and the designated comparison method. Clinica Chimica Acta. 439, 185-190, 2015.
  19. Noguchi T, Tanaka A, Kawasaki T, Goto Y, Morita Y, Asaumi Y, Nakao K, Fujiwara R, Nishimura K, Miyamoto Y, Ishihara M, Ogawa H, Koga N, Narula J, Yasuda S. Effect of Intensive Statin Therapy on Coronary High-Intensity Plaques Detected by Noncontrast T1-Weighted Imaging The AQUAMARINE Pilot Study. Journal of the American College of Cardiology. 66, 245-256, 2015.
  20. Ono R, Yamazaki S, Takegami M, Suzukamo Y, Konno S, Kikuchi S, Fukuhara S. Patient-reported disability in the general Japanese population was associated with medical care visits for low back pain, regardless of pain intensity. Journal of Orthopaedic Science. 20, 742-749, 2015.
  21. Otoshi K, Takegami M, Sekiguchi M, Onishi Y, Yamazaki S, Otani K, Shishido H, Fukuhara S, Kikuchi S, Konno S. Chronic hyperglycemia increases the risk of lateral epicondylitis: the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS). SpringerPlus. 4, 407, 2015.
  22. Sekikawa A, Miyamoto Y, Miura K, Nishimura K, Willcox BJ, Masaki KH, Rodriguez B, Tracy RP, Okamura T, Kuller LH. Continuous decline in mortality from coronary heart disease in Japan despite a continuous and marked rise in total cholesterol: Japanese experience after the Seven Countries Study. International Journal of Epidemiology. 44, 1614-1624, 2015.
  23. Shibata T, Kawakami S, Noguchi T, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, Ishibashi-Ueda H, Nishimura K, Miyamoto Y, Kusano K, Anzai T, Goto Y, Ogawa H, Yasuda S. Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism. Circulation Journal . 132, 241-250, 2015.
  24. Shigemizu D, Aiba T, Nakagawa H, Ozaki K, Miya F, Satake W, Toda T, Miyamoto Y, Fujimoto A, Suzuki Y, Kubo M, Tsunoda T, Shimizu W, Tanaka T. Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes. PLOS ONE. 10, e0130329, 2015.
  25. Sugiyama D, Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H, Miyamatsu N, Miyamoto Y, Sawamura T, Okamura T. The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study. Journal of Atherosclerosis and Thrombosis. 22, 499-508, 2015.
  26. Sugiyama D, Okamura T, Watanabe M, Higashiyama A, Okuda N, Nakamura Y, Hozawa A, Kita Y, Kadota A, Murakami Y, Miyamatsu N, Ohkubo T, Hayakawa T, Miyamoto Y, Miura K, Okayama A, Ueshima H. Risk of Hypercholesterolemia for Cardiovascular Disease and the Population Attributable Fraction in a 24-year Japanese Cohort Study. Journal of Atherosclerosis and Thrombosis. 22, 95-107, 2015.
  27. Takegami M, Miyamoto Y, Yasuda S, Nakai M, Nishimura K, Ogawa H, Hirata K, Toh R, Morino Y, Nakamura M, Takeishi Y, Shimokawa H, Naito H. Comparison of Cardiovascular Mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes - A Large-Scale Data Analysis of Death Certificates. Circulation Journal . 79, 1000-1008, 2015.
  28. Tateishi E, Noguchi T, Goto Y, Morita Y, Ishibashi-Ueda H, Yamada N, Kanzaki H, Nishimura K, Miyamoto Y, Anzai T, Ogawa H, Yasuda S. Prognostic impact of blood pressure response plus gadolinium enhancement in dilated cardiomyopathy. HEART. 101, 774-780, 2015.
  29. Tatsumi Y, Watanabe M, Nakai M, Kokubo Y, Higashiyama A, Nishimura K, Kobayashi T, Takegami M, Nakao YM, Watanabe T, Okayama A, Okamura T, Miyamoto Y. Changes in Waist Circumference and the Incidence of Type 2 Diabetes in Community-Dwelling Men and Women: The Suita Study. Journal of Endocrinology. 25, 489-495, 2015.
  30. Higashi M, Hirano K, Kobayashi K, Ikeda Y, Issiki A, Otsuka T, Suzuki A, Yamaguchi S, Zaima N, Hamada S, Hanada H, Suzuki C, Nakamura H, Nagasaka H, Miyata T, Miyamoto Y, Kobayashi K, Naito H, Toda T. Distinct cardiac phenotype between two homozygotes born in a village with accumulation of a genetic deficiency of adipose triglyceride lipase. International Journal of Cardiology. 192, 30-32, 2015.
  31. Miyamoto K, Aiba T, Arihiro S, Watanabe M, Kokubo Y, Ishibashi K, Hirose S, Wada M, Nakajima I, Okamura H, Noda T, Nagatsuka K, Noguchi T, Anzai T, Yasuda S, Ogawa H, Kamakura S, Shimizu W, Miyamoto Y, Toyoda K, Kusano K . Impact of renal function deterioration on adverse events during anticoagulation therapy using non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. Heart Vessels. Epub, , 2015.
  32. Matsuzono K, Yokota C, Takekawa H, Okamura T, Miyamatsu N, Nakayama H, Nishimura K, Ohyama S, Ishigami A, Okumura K, Toyoda K, Miyamoto Y, Minematsu K. Effects of stroke education of junior high school students on stroke knowledge of their parents: Tochigi project. Stroke. 46, 572-574, 2015.
  33. Ishihara M, Fujino M, Ogawa H, Yasuda S, Noguchi T, Nakao K, Ozaki Y, Kimura K, Suwa S, Fujimoto K, Nakama Y, Morita T, Shimizu W, Saito Y, Tsujita K, Nishimura K, Miyamoto Y, Investigators J-M . Clinical Presentation, Management and Outcome of Japanese Patients With Acute Myocardial Infarction in the Troponin Era - Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition . Circulation Journal. 79, 1255-1262, 2015.
  34. Kawase Ishihara K, Kokubo Y, Yokota C, Hida E, Miyata T, Toyoda K, Matsumoto M, Minematsu K, Miyamoto Y. Effect of plasma fibrinogen, high sensitive C reactive protein, and cigarette smoking on carotid atherosclerosis: The Suita Study. Journal of Stroke and Cerebrovascular Diseases. 24, 2385-2389, 2015.
  35. Watanabe T, Seguchi O, Nishimura K, Fujita T, Murata Y, Yanase M, Sato T, Sunami H, Nakajima S, Hisamatsu E, Sato T, Kuroda K, Hieda M, Wada K, Hata H, Ishibashi-Ueda H, Miyamoto Y, Fukushima N, Kobayashi J, Nakatani T. Suppressive effects of conversion from mycophenolate mofetil to everolimus for the development of cardiac allograft vasculopathy in maintenance of heart transplant recipients. International Journal of Cardiology. Epub, , 2015.
  36. Turin TC, Okamura T, Afzal AR, Rumana N, Watanabe M, Higashiyama A, Nakao Y, Nakai M, Takegami M, Nishimura K, Kokubo Y, Okayama A, Miyamoto Y. Hypertension and lifetime risk of stroke. Journal of Hypertention. Epub, , 2015.
  37. 竹上 未紗. NPPV（非侵襲的陽圧換気療法）ガイドライン（改訂第2版）. 日本呼吸器学会、NPPVガイドライン作成委員会（南江堂）. , 1-157, 2015.
  38. 谷 昇子, 宮本 恵宏, 安斉 俊久, 桒原 健, 菅野 康夫, 中沢 一雄. 利便性を追求したシステム開発　在宅セルフケアを目的とした慢性心不全患者Web管理システム. 新医療. 42, 112-115, 2015.
  39. 西村 邦宏, 宮本 恵宏. ビックデータを活用した急性冠症候群診療の可視化と今後の展望. 日本冠疾患学会雑誌. 21, 147-152, 2015.
  40. 宮本 恵宏. 治す　女性の循環器疾患のリスク因子とその管理. Heart View. 19, 164-169, 2015.
  41. 宮本 恵宏. ゲノム科学からゲノム医療へ　ナショナルセンターのバイオバンク事業. 血管医学. 16, 187-191, 2015.
  42. 安田聡, 住田陽子, 宮本恵宏, 小川久雄. 循環器疾患診療実態調査(JROAD). 医学のあゆみ. 252, 1185-1186, 2015.
  43. 竹上 未紗. 近隣環境と健康関連QOL-日本版総合的社会調査を用いた分析. 地理学評論. 88, 591-606, 2015.
  44. 竹上 未紗. 睡眠時無呼吸症候群に対する減量療法. 呼吸と循環. 63, 739-744, 2015.
  45. 竹上 未紗. NPPV（非侵襲的陽圧換気療法）ガイドライン（改訂第2版）. 日本呼吸器学会誌. 4, 262-271, 2015.
  46. 竹上 未紗. 循環器疾患のQOL評価. 行動医学研究. 21, 17-21, 2015.
  47. 竹上 未紗. Quality　of life . 脳神経外科診療プラクティス.5　無症候性脳血管障害を解く（文光堂）. , 354-357, 2015.
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