循環器病の予防の為には循環器病の発症に関する要因を明らかにし、それを用いた予防法を開発することが必要である。

予防健診部では主に、吹田研究から多くのエビデンスを創出してきた。2015年は血圧やBMIと心房細動発症の関連（Kokubo Y et al. Am J Hypertens. 2015 28(11):1355-61.）、腹囲の変化と糖尿病発症の関連（Tatsumi, Y et al. J Epidemiol. 2015;25(7):489-95.）を明らかにした。さらに、栄養に関する研究の基礎となる食品質問票の妥当性を検証した。（Maruyama, K et al. Nutr Res. 2015 Jan;35(1):14-22）

また、脂質基準分析室では、基準分析法による総コレステロール、HDLコレステロール、トリグリセリドの値の検証を行った。（Nakamura, M et al. Clin Chim Acta. 2015, 445, 127-132; Nakamura, M et al. Clin Chim Acta. 2015, 439, 185-190; Nakamura, M et al. Ann Clin Biochem. 2015）これは我が国における脂質検査の品質の高さを示すとともに、臨床研究の妥当性を担保するものである。

1. Arakawa J, Hamabe A, Aiba T, Nagai T, Yoshida M, Touya T, Ishigami N, Hisadome H, Katsushika S, Tabata H, Miyamoto Y, Shimizu W. A novel cardiac ryanodine receptor gene (RyR2) mutation in an athlete with aborted sudden cardiac death: a case of adult-onset catecholaminergic polymorphic ventricular tachycardia. Heart and Vessels. 30, 835-840, 2015.
2. Goto A, Noda M, Matsushita Y, Goto M, Kato M, Isogawa A, Takahashi Y, Kurotani K, Oba S, Nanri A, Mizoue T, Yamagishi K, Yatsuya H, Saito I, Kokubo Y, Sawada N, Inoue M, Iso H, Kadowaki T, Tsugane S. Hemoglobin A(1c) Levels and the Risk of Cardiovascular Disease in People Without Known Diabetes A Population-Based Cohort Study in Japan. Medicine. 94, e785, 2015.
3. Hirata T, Higashiyama A, Kubota Y, Nishimura K, Sugiyama D, Kadota A, Nishida Y, Imano H, Nishikawa T, Miyamatsu N, Miyamoto Y, Okamura T. HOMA-IR Values are Associated With Glycemic Control in Japanese Subjects Without Diabetes or Obesity: The KOBE Study. Journal of Endocrinology. 25, 407-414, 2015.
4. Hopkins PN, Defesche J, Fouchier SW, Bruckert E, Luc G, Cariou B, Sjouke B, Leren TP, Harada-Shiba M, Mabuchi H, Rabes JP, Carrie A, van Heyningen C, Carreau V, Farnier M, Teoh YP, Bourbon M, Kawashiri M, Nohara A, Soran H, Marais AD, Tada H, Abifadel M, Boileau C, Chanu B, Katsuda S, Kishimoto I, Lambert G, Makino H, Miyamoto Y, Pichelin M, Yagi K, Yamagishi M, Zair Y, Mellis S, Yancopoulos GD, Stahl N, Mendoza J, Du YL, Hamon S, Krempf M, Swergold GD. Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circulation: Cardiovascular Genetics. 8, 823-831, 2015.
5. Ishikawa H, Miyazaki K, Ikeda T, Murabayashi N, Hayashi K, Kai A, Ishikawa K, Miyamoto Y, Nishimura K, Kono Y, Kusuda S, Fujimura M. The Effects of Antenatal Corticosteroids on Short- and Long-Term Outcomes in Small-for-Gestational-Age Infants. International Journal of Medical Sciences. 12, 295-300, 2015.
6. Kataoka Y, Yasuda S, Miyamoto Y, Sase K, Kosuge M, Kimura K, Yoshimasa Y, Miyazaki S. Atheroma Progression in Obese Early-stage Diabetic Japanese Patients in Response to Glycemic Control: Sub-analysis from the DIANA Study. Journal of Atherosclerosis and Thrombosis. 22, 697-705, 2015.
7. Kokubo Y, Watanabe M, Higashiyama A, Nakao YM, Kobayashi T, Watanabe T, Okamura T, Okayama A, Miyamoto Y. Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. American Journal of Hypertension. 28, 1355-1361, 2015.
8. Kubota Y, Higashiyama A, Imano H, Sugiyama D, Kawamura K, Kadota A, Nishimura K, Miyamatsu N, Miyamoto Y, Okamura T. Serum polyunsaturated fatty acid composition and serum high-sensitivity C-reactive protein levels in healthy Japanese residents: The KOBE study. The journal of nutrition, health & aging. 19, 719-728, 2015.
9. Makino H, Miyamoto Y, Kikuchi-Taura A, Soma T, Taguchi A, Kishimoto I. Decreased levels of circulating CD34(+) cells are associated with coronary heart disease in Japanese patients with type 2 diabetes. Journal of Diabetes Investigation. 6, 473-478, 2015.
10. Maruyama K, Kokubo Y, Yamanaka T, Watanabe M, Iso H, Okamura T, Miyamoto Y. The reasonable reliability of a self-administered food frequency questionnaire for an urban, Japanese, middle-aged population: the Suita study. Nutrition Research. 35, 14-22, 2015.
11. Matsuzono K, Yokota C, Takekawa H, Okamura T, Miyamatsu N, Nakayama H, Nishimura K, Ohyama S, Ishigami A, Okumura K, Toyoda K, Miyamoto Y, Minematsu K. Effects of Stroke Education of Junior High School Students on Stroke Knowledge of Their Parents Tochigi Project. Stroke. 46, 572-574, 2015.
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15. Nakamura M, Iso H, Kitamura A, Imano H, Kiyama M, Yokoyama S, Kayamori Y, Koyama I, Nishimura K, Nakai M, Dasti M, Vesper HW, Teramoto T, Miyamoto Y. Total cholesterol performance of Abell-Levy-Brodie-Kendall reference measurement procedure: Certification of Japanese in-vitro diagnostic assay manufacturers through CDC's Cholesterol Reference Method Laboratory Network. Clinica Chimica Acta. 445, 127-132, 2015.
16. Nakamura M, Yokoyama S, Kayamori Y, Iso H, Kitamura A, Okamura T, Kiyama M, Noda H, Nishimura K, Nakai M, Koyama I, Dasti M, Vesper HW, Teramoto T, Miyamoto Y. HDL cholesterol performance using an ultracentrifugation reference measurement procedure and the designated comparison method. Clinica Chimica Acta. 439, 185-190, 2015.
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19. Sato T, Seguchi O, Iwashima Y, Yanase M, Nakajima S, Hieda M, Watanabe T, Sunami H, Murata Y, Hata H, Fujita T, Kobayashi J, Nakatani T. Serum Brain Natriuretic Peptide Concentration 60 Days After Surgery as a Predictor of Long-Term Prognosis in Patients Implanted With a Left Ventricular Assist Device. ASAIO Journal. 61, 373-378, 2015.
20. Seguchi O, Saito K, Fukuma K, Shimamoto K, Sato T, Nakajima S, Sunami H, Kuroda K, Sato T, Watanabe T, Hata H, Yanase M, Fujita T, Kobayashi J, Nagatsuka K, Nakatani T. Evaluation of micro-emboli in a patient with ventricular assist device support with hemolysis. Journal of Artificial Organs. 18, 276-279, 2015.
21. Sekikawa A, Miyamoto Y, Miura K, Nishimura K, Willcox BJ, Masaki KH, Rodriguez B, Tracy RP, Okamura T, Kuller LH. Continuous decline in mortality from coronary heart disease in Japan despite a continuous and marked rise in total cholesterol: Japanese experience after the Seven Countries Study. International Journal of Epidemiology. 44, 1614-1624, 2015.
22. Shibata T, Kawakami S, Noguchi T, Tanaka T, Asaumi Y, Kanaya T, Nagai T, Nakao K, Fujino M, Nagatsuka K, Ishibashi-Ueda H, Nishimura K, Miyamoto Y, Kusano K, Anzai T, Goto Y, Ogawa H, Yasuda S. Prevalence, Clinical Features, and Prognosis of Acute Myocardial Infarction Attributable to Coronary Artery Embolism. Circulation Journal . 132, 241-250, 2015.
23. Shigemizu D, Aiba T, Nakagawa H, Ozaki K, Miya F, Satake W, Toda T, Miyamoto Y, Fujimoto A, Suzuki Y, Kubo M, Tsunoda T, Shimizu W, Tanaka T. Exome Analyses of Long QT Syndrome Reveal Candidate Pathogenic Mutations in Calmodulin-Interacting Genes. PLOS ONE. 10, , 2015.
24. Sugiyama D, Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H, Miyamatsu N, Miyamoto Y, Sawamura T, Okamura T. The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study. Journal of Atherosclerosis and Thrombosis. 22, 499-508, 2015.
25. Sugiyama D, Okamura T, Watanabe M, Higashiyama A, Okuda N, Nakamura Y, Hozawa A, Kita Y, Kadota A, Murakami Y, Miyamatsu N, Ohkubo T, Hayakawa T, Miyamoto Y, Miura K, Okayama A, Ueshima H. Risk of Hypercholesterolemia for Cardiovascular Disease and the Population Attributable Fraction in a 24-year Japanese Cohort Study. Journal of Atherosclerosis and Thrombosis. 22, 95-107, 2015.
26. Takegami M, Miyamoto Y, Yasuda S, Nakai M, Nishimura K, Ogawa H, Hirata K, Toh R, Morino Y, Nakamura M, Takeishi Y, Shimokawa H, Naito H. Comparison of Cardiovascular Mortality in the Great East Japan and the Great Hanshin-Awaji Earthquakes - A Large-Scale Data Analysis of Death Certificates. Circulation Journal . 79, 1000-1008, 2015.
27. Tateishi E, Noguchi T, Goto Y, Morita Y, Ishibashi-Ueda H, Yamada N, Kanzaki H, Nishimura K, Miyamoto Y, Anzai T, Ogawa H, Yasuda S. Prognostic impact of blood pressure response plus gadolinium enhancement in dilated cardiomyopathy. HEART. 101, 774-780, 2015.
28. Tatsumi Y, Watanabe M, Nakai M, Kokubo Y, Higashiyama A, Nishimura K, Kobayashi T, Takegami M, Nakao YM, Watanabe T, Okayama A, Okamura T, Miyamoto Y. Changes in Waist Circumference and the Incidence of Type 2 Diabetes in Community-Dwelling Men and Women: The Suita Study. Journal of Endocrinology. 25, 489-495, 2015.
29. Uno H, Nagatsuka K, Kokubo Y, Higashi M, Yamada N, Umesaki A, Toyoda K, Naritomi H. Detectability of Ischemic Lesions on Diffusion-Weighted Imaging Is Biphasic after Transient Ischemic Attack. Journal of Stroke and Cerebrovascular Diseases. 24, 1059-1064, 2015.
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32. Hosomi N, Nagai Y, Kohriyama T, Ohtsuki T, Aoki S, Nezu T, Maruyama H, Sunami N, Yokota C, Kitagawa K, Terayama Y, Takagi M, Ibayashi S, Nakamura M, Origasa H, Fukushima M, Mori E, Minematsu K, Uchiyama S, Shinohara Y, Yamaguchi T, Matsumoto M,for the J-STARS collaborators. The Japan Statin Treatment against Recurrent Stroke (J-STARS): a multicenter, randomized, open-label, parallel-group study. EBioMedicine. 6, 1071-1078, 2015.
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